Computer Vision-Based Recognition of Parathyroid Glands and Recurrent Laryngeal Nerves in Endoscopic Surgery (PTAIR)
Prospective Multicenter Model Validation Study of the PTAIR Computer Vision Model for Recognition of Parathyroid Glands and Recurrent Laryngeal Nerves During Endoscopic Thyroid Surgery
This study aims to evaluate the performance of the PTAIR computer vision model for recognizing parathyroid glands and recurrent laryngeal nerves during endoscopic thyroid surgery. Multicenter intraoperative endoscopic surgery videos will be prospectively collected. Using the video recorder timeline as the unified time reference, the first recognition time of parathyroid glands and recurrent laryngeal nerves by PTAIR, junior physicians, and senior physicians will be recorded during surgery. The continuous recognition time of parathyroid glands and recurrent laryngeal nerves by PTAIR will also be recorded.
This study focuses on the recognition performance of PTAIR in real-world multicenter endoscopic thyroid surgery settings. At this stage, PTAIR will not be used to guide intraoperative surgical decision-making, and the study will not evaluate the effect of PTAIR on clinical outcomes. The collected video data will be used to assess the performance of PTAIR under different centers, surgeons, equipment conditions, and surgical field conditions, and may provide data support for future model optimization.
調査の概要
詳細な説明
Identification of the parathyroid glands and recurrent laryngeal nerves is an important component of safe thyroid surgery. Parathyroid glands are small and may resemble surrounding fat, lymph nodes, or soft tissue. The recurrent laryngeal nerve has a complex anatomical course and may be partially covered by fascia or insufficiently exposed in some cases, which may increase the difficulty of intraoperative recognition. Computer vision-based artificial intelligence models may help recognize these structures in endoscopic surgical images, but their performance in multicenter real-world surgical settings requires further validation.
Previous PTAIR studies mainly focused on parathyroid gland recognition in endoscopic thyroid surgery videos. Based on these prior studies, the present study will further evaluate the PTAIR model in a prospective multicenter setting, with a focus on recognition of parathyroid glands and recurrent laryngeal nerves. This stage of the study is designed as a model performance validation study and will not evaluate whether PTAIR changes intraoperative surgical decisions, parathyroid management, or postoperative clinical outcomes.
During endoscopic thyroid surgery, PTAIR, junior physicians, and senior physicians will identify parathyroid glands and recurrent laryngeal nerves based on the same intraoperative endoscopic visual field. All time-related outcomes will use the video recorder timeline as the unified reference. The study will record the first recognition time of the recurrent laryngeal nerve and parathyroid gland by PTAIR, junior physicians, and senior physicians, as well as the continuous recognition time of these structures by PTAIR. Expert-reviewed annotations will be used as the reference for subsequent model performance evaluation and confirmation of recognition results.
The study will also evaluate PTAIR performance under different exposure conditions, including cases with fascial coverage, incomplete exposure, or complex surgical field conditions. Multicenter video data will be used to assess model performance across different centers, surgeons, equipment settings, and operative field conditions, and may provide data for future model improvement and iteration.
研究の種類
入学 (推定)
連絡先と場所
研究連絡先
- 名前：Bo Wang Professor, MD
- 電話番号：86+13959123550
- メール：wangbo@fjmu.edu.cn
研究場所
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Fujian
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Fuzhou、Fujian、中国、350001
- Fujian Medical University Union Hospital
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コンタクト：
- Bo Wang Porfessor, MD
- 電話番号：86+13959123550
- メール：wangbo@fjmu.edu.cn
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-
参加基準
適格基準
就学可能な年齢
- 子
- 大人
- 高齢者
健康ボランティアの受け入れ
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Age 18 years or older.
- Patients with benign or malignant thyroid disease who are scheduled to undergo endoscopic thyroid surgery.
- Standardized recorder-based intraoperative video collection is planned during surgery.
- Patients agree to intraoperative video recording, de-identification, and research use.
- Basic perioperative clinical data are available.
- The participating center is able to follow the standardized procedures for video collection, data upload, data security, and annotation quality control.
Exclusion Criteria:
- Refusal to provide informed consent.
- Patients scheduled to undergo conventional open thyroid surgery.
- Standardized recorder-based intraoperative video collection cannot be performed.
- Intraoperative video quality is insufficient for model analysis or expert review.
- Key surgical phases are missing from the video recording.
- Expert annotation or review of the parathyroid glands or recurrent laryngeal nerves cannot be completed.
- Video de-identification fails.
- Severe missing perioperative clinical data.
- Other conditions judged by the investigators to be unsuitable for study inclusion.
研究計画
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
介入・治療 |
|---|---|
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Multicenter Endoscopic Thyroid Surgery Video Cohort
This cohort includes adult patients with thyroid disease who are scheduled to undergo endoscopic thyroid surgery and consent to intraoperative video recording and research use.
Recorder-based intraoperative videos will be collected to evaluate the recognition performance of PTAIR for parathyroid glands and recurrent laryngeal nerves.
The recognition results of PTAIR will be compared with those of junior and senior physicians based on the same intraoperative endoscopic visual field and the same video recording timeline.
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PTAIR is a computer vision model used to recognize parathyroid glands and recurrent laryngeal nerves in endoscopic thyroid surgery videos.
In this observational study, PTAIR will be used to analyze recorder-based intraoperative videos and evaluate first recognition time, continuous recognition time, and recognition performance.
PTAIR results will be compared with recognition by junior and senior physicians based on the same intraoperative endoscopic visual field and the same video recording timeline.
At this stage, PTAIR will not be used to guide intraoperative surgical decision-making.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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First Recognition Time of the Recurrent Laryngeal Nerve
時間枠：Intraoperative period
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Using the video recorder timeline as the unified time reference, the first recognition time of the recurrent laryngeal nerve by PTAIR, junior physicians, and senior physicians will be recorded during surgery.
All recognitions will be based on the same intraoperative endoscopic visual field.
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Intraoperative period
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First Recognition Time of the Parathyroid Gland
時間枠：Intraoperative period
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Using the video recorder timeline as the unified time reference, the first recognition time of the parathyroid gland by PTAIR, junior physicians, and senior physicians will be recorded during surgery.
All recognitions will be based on the same intraoperative endoscopic visual field.
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Intraoperative period
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Continuous Recognition Time of the Recurrent Laryngeal Nerve
時間枠：Intraoperative period
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Using the video recorder timeline as the unified time reference, the continuous recognition time of the recurrent laryngeal nerve by PTAIR will be recorded during surgery.
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Intraoperative period
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Continuous Recognition Time of the Parathyroid Gland
時間枠：Intraoperative period
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Using the video recorder timeline as the unified time reference, the continuous recognition time of the parathyroid gland by PTAIR will be recorded during surgery.
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Intraoperative period
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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AP50 for Recurrent Laryngeal Nerve Recognition
時間枠：From completion of intraoperative video collection to completion of expert annotation and model analysis
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Based on expert-reviewed annotations, AP50 will be calculated for PTAIR recognition of the recurrent laryngeal nerve.
AP50 refers to the average precision at an intersection-over-union threshold of 0.50.
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From completion of intraoperative video collection to completion of expert annotation and model analysis
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AP50 for Parathyroid Gland Recognition
時間枠：From completion of intraoperative video collection to completion of expert annotation and model analysis
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Based on expert-reviewed annotations, AP50 will be calculated for PTAIR recognition of the parathyroid gland.
AP50 refers to the average precision at an intersection-over-union threshold of 0.50.
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From completion of intraoperative video collection to completion of expert annotation and model analysis
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Comparison of First Recognition Time of the Recurrent Laryngeal Nerve Between PTAIR and Physicians
時間枠：Intraoperative period
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The first recognition time of the recurrent laryngeal nerve will be compared among PTAIR, junior physicians, and senior physicians during surgery.
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Intraoperative period
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Comparison of First Recognition Time of the Parathyroid Gland Between PTAIR and Physicians
時間枠：Intraoperative period
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The first recognition time of the parathyroid gland will be compared among PTAIR, junior physicians, and senior physicians during surgery.
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Intraoperative period
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In Situ Recognition Rate of the Parathyroid Gland
時間枠：From completion of intraoperative video collection to completion of expert review
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Based on intraoperative videos and expert review, the in situ recognition rate of parathyroid glands by PTAIR will be recorded.
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From completion of intraoperative video collection to completion of expert review
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Detection Rate of Parathyroid Glands on the Surgical Specimen
時間枠：Intraoperative period, before removal of the surgical specimen from the body
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After completion of endoscopic dissection and before removal of the surgical specimen from the body, PTAIR will be used within the endoscopic visual field to examine whether parathyroid tissue is attached to or located around the surgical specimen.
The detection result will be recorded.
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Intraoperative period, before removal of the surgical specimen from the body
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協力者と研究者
協力者
捜査官
- 主任研究者：Bo Wang MD, Principal Investigator、Fujian Medical University Union Hospital
出版物と役立つリンク
一般刊行物
- Wang B, Zheng J, Yu JF, Lin SY, Yan SY, Zhang LY, Wang SS, Cai SJ, Abdelhamid Ahmed AH, Lin LQ, Chen F, Randolph GW, Zhao WX. Development of Artificial Intelligence for Parathyroid Recognition During Endoscopic Thyroid Surgery. Laryngoscope. 2022 Dec;132(12):2516-2523. doi: 10.1002/lary.30173. Epub 2022 May 31.
- Wang B, Yu JF, Lin SY, Li YJ, Huang WY, Yan SY, Wang SS, Zhang LY, Cai SJ, Wu SB, Li MY, Wang TY, Abdelhamid Ahmed AH, Randolph GW, Chen F, Zhao WX. Intraoperative AI-assisted early prediction of parathyroid and ischemia alert in endoscopic thyroid surgery. Head Neck. 2024 Aug;46(8):1975-1987. doi: 10.1002/hed.27629. Epub 2024 Feb 13.
研究記録日
主要日程の研究
研究開始 (推定)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
キーワード
その他の研究ID番号
- PTAIR 3.0
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
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