Computer Vision-Based Recognition of Parathyroid Glands and Recurrent Laryngeal Nerves in Endoscopic Surgery (PTAIR)
Prospective Multicenter Model Validation Study of the PTAIR Computer Vision Model for Recognition of Parathyroid Glands and Recurrent Laryngeal Nerves During Endoscopic Thyroid Surgery
This study aims to evaluate the performance of the PTAIR computer vision model for recognizing parathyroid glands and recurrent laryngeal nerves during endoscopic thyroid surgery. Multicenter intraoperative endoscopic surgery videos will be prospectively collected. Using the video recorder timeline as the unified time reference, the first recognition time of parathyroid glands and recurrent laryngeal nerves by PTAIR, junior physicians, and senior physicians will be recorded during surgery. The continuous recognition time of parathyroid glands and recurrent laryngeal nerves by PTAIR will also be recorded.
This study focuses on the recognition performance of PTAIR in real-world multicenter endoscopic thyroid surgery settings. At this stage, PTAIR will not be used to guide intraoperative surgical decision-making, and the study will not evaluate the effect of PTAIR on clinical outcomes. The collected video data will be used to assess the performance of PTAIR under different centers, surgeons, equipment conditions, and surgical field conditions, and may provide data support for future model optimization.
Descripción general del estudio
Estado
Condiciones
Intervención / Tratamiento
Descripción detallada
Identification of the parathyroid glands and recurrent laryngeal nerves is an important component of safe thyroid surgery. Parathyroid glands are small and may resemble surrounding fat, lymph nodes, or soft tissue. The recurrent laryngeal nerve has a complex anatomical course and may be partially covered by fascia or insufficiently exposed in some cases, which may increase the difficulty of intraoperative recognition. Computer vision-based artificial intelligence models may help recognize these structures in endoscopic surgical images, but their performance in multicenter real-world surgical settings requires further validation.
Previous PTAIR studies mainly focused on parathyroid gland recognition in endoscopic thyroid surgery videos. Based on these prior studies, the present study will further evaluate the PTAIR model in a prospective multicenter setting, with a focus on recognition of parathyroid glands and recurrent laryngeal nerves. This stage of the study is designed as a model performance validation study and will not evaluate whether PTAIR changes intraoperative surgical decisions, parathyroid management, or postoperative clinical outcomes.
During endoscopic thyroid surgery, PTAIR, junior physicians, and senior physicians will identify parathyroid glands and recurrent laryngeal nerves based on the same intraoperative endoscopic visual field. All time-related outcomes will use the video recorder timeline as the unified reference. The study will record the first recognition time of the recurrent laryngeal nerve and parathyroid gland by PTAIR, junior physicians, and senior physicians, as well as the continuous recognition time of these structures by PTAIR. Expert-reviewed annotations will be used as the reference for subsequent model performance evaluation and confirmation of recognition results.
The study will also evaluate PTAIR performance under different exposure conditions, including cases with fascial coverage, incomplete exposure, or complex surgical field conditions. Multicenter video data will be used to assess model performance across different centers, surgeons, equipment settings, and operative field conditions, and may provide data for future model improvement and iteration.
Tipo de estudio
Inscripción (Estimado)
Contactos y Ubicaciones
Estudio Contacto
- Nombre: Bo Wang Professor, MD
- Número de teléfono: 86+13959123550
- Correo electrónico: wangbo@fjmu.edu.cn
Ubicaciones de estudio
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Fujian
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Fuzhou, Fujian, Porcelana, 350001
- Fujian Medical University Union Hospital
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Contacto:
- Bo Wang Porfessor, MD
- Número de teléfono: 86+13959123550
- Correo electrónico: wangbo@fjmu.edu.cn
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Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
- Niño
- Adulto
- Adulto Mayor
Acepta Voluntarios Saludables
Método de muestreo
Población de estudio
Descripción
Inclusion Criteria:
- Age 18 years or older.
- Patients with benign or malignant thyroid disease who are scheduled to undergo endoscopic thyroid surgery.
- Standardized recorder-based intraoperative video collection is planned during surgery.
- Patients agree to intraoperative video recording, de-identification, and research use.
- Basic perioperative clinical data are available.
- The participating center is able to follow the standardized procedures for video collection, data upload, data security, and annotation quality control.
Exclusion Criteria:
- Refusal to provide informed consent.
- Patients scheduled to undergo conventional open thyroid surgery.
- Standardized recorder-based intraoperative video collection cannot be performed.
- Intraoperative video quality is insufficient for model analysis or expert review.
- Key surgical phases are missing from the video recording.
- Expert annotation or review of the parathyroid glands or recurrent laryngeal nerves cannot be completed.
- Video de-identification fails.
- Severe missing perioperative clinical data.
- Other conditions judged by the investigators to be unsuitable for study inclusion.
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
Cohortes e Intervenciones
Grupo / Cohorte |
Intervención / Tratamiento |
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Multicenter Endoscopic Thyroid Surgery Video Cohort
This cohort includes adult patients with thyroid disease who are scheduled to undergo endoscopic thyroid surgery and consent to intraoperative video recording and research use.
Recorder-based intraoperative videos will be collected to evaluate the recognition performance of PTAIR for parathyroid glands and recurrent laryngeal nerves.
The recognition results of PTAIR will be compared with those of junior and senior physicians based on the same intraoperative endoscopic visual field and the same video recording timeline.
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PTAIR is a computer vision model used to recognize parathyroid glands and recurrent laryngeal nerves in endoscopic thyroid surgery videos.
In this observational study, PTAIR will be used to analyze recorder-based intraoperative videos and evaluate first recognition time, continuous recognition time, and recognition performance.
PTAIR results will be compared with recognition by junior and senior physicians based on the same intraoperative endoscopic visual field and the same video recording timeline.
At this stage, PTAIR will not be used to guide intraoperative surgical decision-making.
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¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
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First Recognition Time of the Recurrent Laryngeal Nerve
Periodo de tiempo: Intraoperative period
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Using the video recorder timeline as the unified time reference, the first recognition time of the recurrent laryngeal nerve by PTAIR, junior physicians, and senior physicians will be recorded during surgery.
All recognitions will be based on the same intraoperative endoscopic visual field.
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Intraoperative period
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First Recognition Time of the Parathyroid Gland
Periodo de tiempo: Intraoperative period
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Using the video recorder timeline as the unified time reference, the first recognition time of the parathyroid gland by PTAIR, junior physicians, and senior physicians will be recorded during surgery.
All recognitions will be based on the same intraoperative endoscopic visual field.
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Intraoperative period
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Continuous Recognition Time of the Recurrent Laryngeal Nerve
Periodo de tiempo: Intraoperative period
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Using the video recorder timeline as the unified time reference, the continuous recognition time of the recurrent laryngeal nerve by PTAIR will be recorded during surgery.
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Intraoperative period
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Continuous Recognition Time of the Parathyroid Gland
Periodo de tiempo: Intraoperative period
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Using the video recorder timeline as the unified time reference, the continuous recognition time of the parathyroid gland by PTAIR will be recorded during surgery.
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Intraoperative period
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Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
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AP50 for Recurrent Laryngeal Nerve Recognition
Periodo de tiempo: From completion of intraoperative video collection to completion of expert annotation and model analysis
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Based on expert-reviewed annotations, AP50 will be calculated for PTAIR recognition of the recurrent laryngeal nerve.
AP50 refers to the average precision at an intersection-over-union threshold of 0.50.
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From completion of intraoperative video collection to completion of expert annotation and model analysis
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AP50 for Parathyroid Gland Recognition
Periodo de tiempo: From completion of intraoperative video collection to completion of expert annotation and model analysis
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Based on expert-reviewed annotations, AP50 will be calculated for PTAIR recognition of the parathyroid gland.
AP50 refers to the average precision at an intersection-over-union threshold of 0.50.
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From completion of intraoperative video collection to completion of expert annotation and model analysis
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Comparison of First Recognition Time of the Recurrent Laryngeal Nerve Between PTAIR and Physicians
Periodo de tiempo: Intraoperative period
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The first recognition time of the recurrent laryngeal nerve will be compared among PTAIR, junior physicians, and senior physicians during surgery.
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Intraoperative period
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Comparison of First Recognition Time of the Parathyroid Gland Between PTAIR and Physicians
Periodo de tiempo: Intraoperative period
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The first recognition time of the parathyroid gland will be compared among PTAIR, junior physicians, and senior physicians during surgery.
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Intraoperative period
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In Situ Recognition Rate of the Parathyroid Gland
Periodo de tiempo: From completion of intraoperative video collection to completion of expert review
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Based on intraoperative videos and expert review, the in situ recognition rate of parathyroid glands by PTAIR will be recorded.
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From completion of intraoperative video collection to completion of expert review
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Detection Rate of Parathyroid Glands on the Surgical Specimen
Periodo de tiempo: Intraoperative period, before removal of the surgical specimen from the body
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After completion of endoscopic dissection and before removal of the surgical specimen from the body, PTAIR will be used within the endoscopic visual field to examine whether parathyroid tissue is attached to or located around the surgical specimen.
The detection result will be recorded.
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Intraoperative period, before removal of the surgical specimen from the body
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Colaboradores e Investigadores
Patrocinador
Colaboradores
Investigadores
- Investigador principal: Bo Wang MD, Principal Investigator, Fujian Medical University Union Hospital
Publicaciones y enlaces útiles
Publicaciones Generales
- Wang B, Zheng J, Yu JF, Lin SY, Yan SY, Zhang LY, Wang SS, Cai SJ, Abdelhamid Ahmed AH, Lin LQ, Chen F, Randolph GW, Zhao WX. Development of Artificial Intelligence for Parathyroid Recognition During Endoscopic Thyroid Surgery. Laryngoscope. 2022 Dec;132(12):2516-2523. doi: 10.1002/lary.30173. Epub 2022 May 31.
- Wang B, Yu JF, Lin SY, Li YJ, Huang WY, Yan SY, Wang SS, Zhang LY, Cai SJ, Wu SB, Li MY, Wang TY, Abdelhamid Ahmed AH, Randolph GW, Chen F, Zhao WX. Intraoperative AI-assisted early prediction of parathyroid and ischemia alert in endoscopic thyroid surgery. Head Neck. 2024 Aug;46(8):1975-1987. doi: 10.1002/hed.27629. Epub 2024 Feb 13.
Fechas de registro del estudio
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Finalización del estudio (Estimado)
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Publicado por primera vez (Actual)
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Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- PTAIR 3.0
Plan de datos de participantes individuales (IPD)
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Información sobre medicamentos y dispositivos, documentos del estudio
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