IL-6 and Cortisol Responses to Cycling Exercise
Interleukin-6 and Cortisol Responses Following Short- and Long-Term Cycling Tests in Team Athletes With Different Cardiorespiratory Fitness Levels
調査の概要
状態
詳細な説明
Exercise-induced physiological stress activates numerous neuroendocrine and inflammatory pathways, including the hypothalamic-pituitary-adrenal axis and cytokine-mediated responses. Cortisol and interleukin-6 (IL-6) are among the most commonly investigated biomarkers of exercise stress and adaptation. However, the influence of cardiorespiratory fitness on acute hormonal and inflammatory responses to exercise remains incompletely understood.
This study employed a randomized crossover design involving team athletes aged 18-35 years. Participants completed two cycling exercise protocols: a short-term anaerobic test (Wingate) and a long-term aerobic test (YMCA submaximal cycling test). The two testing sessions were separated by a seven-day washout period and were performed at the same time of day to minimize circadian variation.
Saliva samples were collected before exercise, immediately after exercise, and 30 minutes post-exercise. Salivary IL-6 and cortisol concentrations were analyzed to determine acute physiological responses to both exercise modalities. Participants were categorized according to cardiorespiratory fitness level based on estimated VO₂max values, and biomarker responses were compared between fitness groups.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Samsun
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Samsun、Samsun、トルコ（Türkiye）、55139
- Ondokuz Mayis University Faculty of Sport Sciences
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参加基準
適格基準
就学可能な年齢
- 大人
健康ボランティアの受け入れ
説明
Inclusion Criteria:
Team athletes aged 18 to 35 years Participation in organized team sports (e.g., volleyball, basketball, soccer, or handball) Minimum of 3 training sessions per week, with each session lasting at least 1 hour Sports participation history of at least 2 years Apparently healthy and free from known cardiovascular, metabolic, endocrine, or respiratory diseases Willingness to provide written informed consent
Exclusion Criteria:
Current musculoskeletal injury or illness affecting exercise performance Use of medications known to influence hormonal or inflammatory responses Smoking or use of tobacco products Acute infection within the previous two weeks Failure to complete both exercise testing sessions Failure to comply with pre-test instructions
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：基礎科学
- 割り当て：ランダム化
- 介入モデル：クロスオーバー割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Long-Term Cycling Test
Participants performed a YMCA submaximal cycling test to assess cardiorespiratory fitness.
Saliva samples were collected before exercise, immediately after exercise, and 30 minutes after exercise for the assessment of cortisol and interleukin-6 responses.
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Participants performed a YMCA submaximal cycling test to assess cardiorespiratory fitness and exercise-induced physiological responses.
Saliva samples were collected before exercise, immediately after exercise, and 30 minutes after exercise for cortisol and interleukin-6 analysis.
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実験的：Short-Term Cycling Test
Participants performed a 30-second Wingate anaerobic cycling test.
Saliva samples were collected before exercise, immediately after exercise, and 30 minutes after exercise for the assessment of cortisol and interleukin-6 responses.
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Participants performed a 30-second all-out Wingate anaerobic cycling test to evaluate acute physiological responses.
Saliva samples were collected before exercise, immediately after exercise, and 30 minutes after exercise for cortisol and interleukin-6 analysis.
他の名前：
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Salivary Cortisol Response
時間枠：Pre-exercise, immediately post-exercise, and 30 minutes post-exercise
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Change in salivary cortisol concentrations measured before exercise, immediately after exercise, and 30 minutes after exercise following short-term and long-term cycling tests.
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Pre-exercise, immediately post-exercise, and 30 minutes post-exercise
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Salivary Interleukin-6 (IL-6) Response
時間枠：Pre-exercise, immediately post-exercise, and 30 minutes post-exercise
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Change in salivary interleukin-6 concentrations measured before exercise, immediately after exercise, and 30 minutes after exercise following short-term and long-term cycling tests.
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Pre-exercise, immediately post-exercise, and 30 minutes post-exercise
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協力者と研究者
スポンサー
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- OMU-IL6-CORT-2024-01
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
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