IL-6 and Cortisol Responses to Cycling Exercise
Interleukin-6 and Cortisol Responses Following Short- and Long-Term Cycling Tests in Team Athletes With Different Cardiorespiratory Fitness Levels
Visão geral do estudo
Status
Intervenção / Tratamento
Descrição detalhada
Exercise-induced physiological stress activates numerous neuroendocrine and inflammatory pathways, including the hypothalamic-pituitary-adrenal axis and cytokine-mediated responses. Cortisol and interleukin-6 (IL-6) are among the most commonly investigated biomarkers of exercise stress and adaptation. However, the influence of cardiorespiratory fitness on acute hormonal and inflammatory responses to exercise remains incompletely understood.
This study employed a randomized crossover design involving team athletes aged 18-35 years. Participants completed two cycling exercise protocols: a short-term anaerobic test (Wingate) and a long-term aerobic test (YMCA submaximal cycling test). The two testing sessions were separated by a seven-day washout period and were performed at the same time of day to minimize circadian variation.
Saliva samples were collected before exercise, immediately after exercise, and 30 minutes post-exercise. Salivary IL-6 and cortisol concentrations were analyzed to determine acute physiological responses to both exercise modalities. Participants were categorized according to cardiorespiratory fitness level based on estimated VO₂max values, and biomarker responses were compared between fitness groups.
Tipo de estudo
Inscrição (Real)
Estágio
- Não aplicável
Contactos e Locais
Locais de estudo
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Samsun
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Samsun, Samsun, Turquia (Türkiye), 55139
- Ondokuz Mayis University Faculty of Sport Sciences
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Critérios de participação
Critérios de elegibilidade
Idades elegíveis para estudo
- Adulto
Aceita Voluntários Saudáveis
Descrição
Inclusion Criteria:
Team athletes aged 18 to 35 years Participation in organized team sports (e.g., volleyball, basketball, soccer, or handball) Minimum of 3 training sessions per week, with each session lasting at least 1 hour Sports participation history of at least 2 years Apparently healthy and free from known cardiovascular, metabolic, endocrine, or respiratory diseases Willingness to provide written informed consent
Exclusion Criteria:
Current musculoskeletal injury or illness affecting exercise performance Use of medications known to influence hormonal or inflammatory responses Smoking or use of tobacco products Acute infection within the previous two weeks Failure to complete both exercise testing sessions Failure to comply with pre-test instructions
Plano de estudo
Como o estudo é projetado?
Detalhes do projeto
- Finalidade Principal: Ciência básica
- Alocação: Randomizado
- Modelo Intervencional: Atribuição cruzada
- Mascaramento: Nenhum (rótulo aberto)
Armas e Intervenções
Grupo de Participantes / Braço |
Intervenção / Tratamento |
|---|---|
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Experimental: Long-Term Cycling Test
Participants performed a YMCA submaximal cycling test to assess cardiorespiratory fitness.
Saliva samples were collected before exercise, immediately after exercise, and 30 minutes after exercise for the assessment of cortisol and interleukin-6 responses.
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Participants performed a YMCA submaximal cycling test to assess cardiorespiratory fitness and exercise-induced physiological responses.
Saliva samples were collected before exercise, immediately after exercise, and 30 minutes after exercise for cortisol and interleukin-6 analysis.
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Experimental: Short-Term Cycling Test
Participants performed a 30-second Wingate anaerobic cycling test.
Saliva samples were collected before exercise, immediately after exercise, and 30 minutes after exercise for the assessment of cortisol and interleukin-6 responses.
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Participants performed a 30-second all-out Wingate anaerobic cycling test to evaluate acute physiological responses.
Saliva samples were collected before exercise, immediately after exercise, and 30 minutes after exercise for cortisol and interleukin-6 analysis.
Outros nomes:
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O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
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Salivary Cortisol Response
Prazo: Pre-exercise, immediately post-exercise, and 30 minutes post-exercise
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Change in salivary cortisol concentrations measured before exercise, immediately after exercise, and 30 minutes after exercise following short-term and long-term cycling tests.
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Pre-exercise, immediately post-exercise, and 30 minutes post-exercise
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Medidas de resultados secundários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
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Salivary Interleukin-6 (IL-6) Response
Prazo: Pre-exercise, immediately post-exercise, and 30 minutes post-exercise
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Change in salivary interleukin-6 concentrations measured before exercise, immediately after exercise, and 30 minutes after exercise following short-term and long-term cycling tests.
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Pre-exercise, immediately post-exercise, and 30 minutes post-exercise
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Colaboradores e Investigadores
Patrocinador
Datas de registro do estudo
Datas Principais do Estudo
Início do estudo (Real)
Conclusão Primária (Real)
Conclusão do estudo (Real)
Datas de inscrição no estudo
Enviado pela primeira vez
Enviado pela primeira vez que atendeu aos critérios de CQ
Primeira postagem (Real)
Atualizações de registro de estudo
Última Atualização Postada (Real)
Última atualização enviada que atendeu aos critérios de controle de qualidade
Última verificação
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Termos MeSH relevantes adicionais
Outros números de identificação do estudo
- OMU-IL6-CORT-2024-01
Plano para dados de participantes individuais (IPD)
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