Impact of Perioperative Antibiotic Use on Surgical Scarring (PASS)
2026年7月30日 更新者：Nanfang Hospital, Southern Medical University
Perioperative Antibiotic Use and Its Impact on Postoperative Scarring: A Retrospective Study
This retrospective observational cohort study will evaluate whether perioperative antibiotic use is associated with long-term surgical scar outcomes. The study will include adult patients who underwent body surface surgery at Nanfang Hospital between January 1, 2005 and January 1, 2025 and have available surgical, medication, and scar-related clinical records.
The study will not assign participants to any treatment. Researchers will review existing medical records, perioperative antibiotic exposure, surgical characteristics, complications, and scar assessments or photographs. Scar outcomes will be assessed using modified visual analogue scale scores, scar width, scar type, and scar-related complications.
調査の概要
研究の種類
観察的
入学 (推定)
5000
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究連絡先
- 名前：Gaofeng Wang, Principal Investigator
- 電話番号：+86 13242749806
- メール：Wenzhenli0526@163.com
研究場所
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Guangdong
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Guangzhou、Guangdong、中国、510515
- Nanfang Hospital, Southern Medical University
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コンタクト：
- Gaofeng Wang, MD
- 電話番号：86-13242749806
- メール：wenzhenli0526@163.com
-
-
参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
いいえ
サンプリング方法
非確率サンプル
調査対象母集団
The study population will include adult patients who underwent body surface surgery at Nanfang Hospital between January 1, 2005 and January 1, 2025, developed a linear surgical incision scar, and later presented to the Department of Plastic Surgery for scar-related care.
Eligible patients must have available surgical records, perioperative medication records, and scar outcome information.
説明
Inclusion Criteria:
- Age 18 years or older.
- Underwent body surface surgery at Nanfang Hospital between January 1, 2005 and January 1, 2025, with a linear surgical incision scar.
- Presented to the Department of Plastic Surgery at Nanfang Hospital for surgical scar-related care.
- Had no medical encounter record at Nanfang Hospital from January 1, 2025 to the time of study screening.
- Available clear surgical records and perioperative medication records.
Exclusion Criteria:
- Known tendency for pathological scarring or scar constitution.
- History of chronic skin disease in the surgical area, such as psoriasis or eczema.
- Uncontrolled diabetes mellitus, malnutrition, hypoalbuminemia, or long-term use of immunosuppressive agents or glucocorticoids.
- Target scar received any scar-specific treatment after surgery, such as laser therapy, radiotherapy, drug injection, or surgical revision.
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
介入・治療 |
|---|---|
|
Retrospective Surgical Scar Cohort
Adult patients who underwent body surface surgery at Nanfang Hospital between January 1, 2005 and January 1, 2025 and have available surgical records, perioperative medication records, and scar outcome information.
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Patterns of perioperative antibiotic use documented in existing medical records, including timing, indication, antibiotic type, duration, frequency, and route of administration.
No antibiotic treatment will be assigned or provided by the study.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Overall Scar Appearance Score Assessed Using a Modified Visual Analogue Scale
時間枠：Scar photographs were taken during postoperative clinical follow-up, with an overall range from 3 months to 20 years after surgery. Given the wide span, the assessments will be stratified and reported according to the actual time of photography, for exam
|
Overall scar appearance will be evaluated from scar photographs by three blinded physicians or trained study personnel using a modified visual analogue scale.
Scores range from 1 to 10, with 1 indicating appearance similar to normal skin and 10 indicating the worst imaginable scar appearance.
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Scar photographs were taken during postoperative clinical follow-up, with an overall range from 3 months to 20 years after surgery. Given the wide span, the assessments will be stratified and reported according to the actual time of photography, for exam
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Scar Color Score Assessed Using a Modified Visual Analogue Scale
時間枠：Scar photographs were taken during postoperative clinical follow-up, with an overall range from 3 months to 20 years after surgery. Given the wide span, the assessments will be stratified and reported according to the actual time of photography, for exam
|
Scar color will be evaluated from scar photographs by three blinded physicians or trained study personnel using a modified visual analogue scale.
Scores range from 1 to 10, with lower scores indicating color more similar to normal skin and higher scores indicating worse scar color.
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Scar photographs were taken during postoperative clinical follow-up, with an overall range from 3 months to 20 years after surgery. Given the wide span, the assessments will be stratified and reported according to the actual time of photography, for exam
|
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Scar Texture Score Assessed Using a Modified Visual Analogue Scale
時間枠：Scar photographs were taken during postoperative clinical follow-up, with an overall range from 3 months to 20 years after surgery. Given the wide span, the assessments will be stratified and reported according to the actual time of photography, for exam
|
Scar texture will be evaluated from scar photographs by three blinded physicians or trained study personnel using a modified visual analogue scale.
Scores range from 1 to 10, with lower scores indicating texture more similar to normal skin and higher scores indicating worse scar texture.
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Scar photographs were taken during postoperative clinical follow-up, with an overall range from 3 months to 20 years after surgery. Given the wide span, the assessments will be stratified and reported according to the actual time of photography, for exam
|
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Scar Width
時間枠：Scar photographs were taken during postoperative clinical follow-up, with an overall range from 3 months to 20 years after surgery. Given the wide span, the assessments will be stratified and reported according to the actual time of photography, for exam
|
Scar width will be calculated from scar photographs by outlining the scar boundary and using ImageJ to measure scar area and scar length.
Scar width will be calculated as scar area divided by scar length.
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Scar photographs were taken during postoperative clinical follow-up, with an overall range from 3 months to 20 years after surgery. Given the wide span, the assessments will be stratified and reported according to the actual time of photography, for exam
|
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Scar-Related Complications
時間枠：Postoperative days 0 to 30 (inclusive). The timing of each complication was determined from medical records.
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Scar-related complications will be identified from medical records and scar assessments, including wound dehiscence, suture reaction, necrosis, hematoma, infection, persistent itching, persistent pain, and sensory abnormalities.
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Postoperative days 0 to 30 (inclusive). The timing of each complication was determined from medical records.
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協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始 (推定)
2026年8月3日
一次修了 (推定)
2026年8月15日
研究の完了 (推定)
2026年8月15日
試験登録日
最初に提出
2026年7月23日
QC基準を満たした最初の提出物
2026年7月30日
最初の投稿 (実際)
2026年8月3日
学習記録の更新
投稿された最後の更新 (実際)
2026年8月3日
QC基準を満たした最後の更新が送信されました
2026年7月30日
最終確認日
2026年7月1日
詳しくは
本研究に関する用語
その他の研究ID番号
- NFEC-2026-164
- MR-44-26-022534 (その他の識別子：National Health Commission, China)
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
いいえ
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
いいえ
米国FDA規制機器製品の研究
いいえ
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