Farm-originated Antimicrobial Resistance Modeling: Exploring Humans-to-Animal Dissemination (FARMHAND)
Farm-originated Antimicrobial Resistance Modeling: Exploring Humans-to-Animal Dissemination - FARMHAND
Antimicrobial resistance is a major public health issue. Methicillin resistance in Staphylococcus aureus (MRSA) is one of the indicators that is monitored particularly closely. In animals, pig farms, among others, have been identified as reservoirs of MRSA, with a risk of transmission to humans, particularly to individuals in direct contact with livestock. In France, the prevalence of MRSA in pig farms has increased markedly in recent years.
While cross-species transmission between pigs and humans in professional settings is well-documented, the temporal dynamics, the actual incidence of acquisition, and the associated determinants remain insufficiently characterized in France.
Adopting a "One Health" approach, this project aims to gain a better understanding of the mechanisms by which MRSA spreads between animal and human subpopulations and to incorporate these insights into a mathematical modeling framework.
調査の概要
状態
介入・治療
詳細な説明
The participants in this project will be farmers representing 20 different pig farms, the majority of which will be located in Brittany-a region recognized as the leading pork-producing area in France.
Participants will be asked to provide two types of samples, only one of which will contain personally identifiable data.
- Nasal swabs: Participants in the study will be asked to perform a self-administered nasal swab once a month, at approximately the same time each month. This method was selected because it has demonstrated an acceptable level of participant compliance, as well as satisfactory validity for detecting S. aureus carriage in humans.
- Dust samples: Participants will be asked to collect dust samples from the production floor-specifically in the room within the finishing facility that houses the oldest animals-by wiping surfaces with a small cloth. This method was chosen because dust in livestock-rearing environments has been identified as a reliable indicator of MRSA carriage status in pigs.
These successive samplings will be carried out over time in order to analyze carriage dynamics and estimate epidemiological parameters of interest. A modeling component will be incorporated to make use of the data collected.
研究の種類
入学 (推定)
段階
- 適用できない
連絡先と場所
研究連絡先
- 名前：Fanny BEGUIER
- 電話番号：+33 0296018165
- メール：recherche.clinique@armorsante.bzh
研究連絡先のバックアップ
- 名前：Marie-Pierre DUBAN
- メール：recherche.clinique@armorsante.bzh
研究場所
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Ploufragan、フランス、22440
- Anses Ploufragan - Plouzané - Niort, site de Ploufragan
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コンタクト：
- Claire CHAUVIN, Dr
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Saint-Brieuc、フランス、22000
- Centre Hospitalier de Saint-Brieuc - Paimpol - Tréguier, site de Saint-Brieuc
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コンタクト：
- Clarisse DUPIN, Dr
- メール：clarisse.dupin@armorsante.bzh
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- 18 years of age or older,
- Work full-time as a pig farmer on the participating farm,
- Have regular contact with the animals, defined as at least 4 days per week,
- Be willing to participate in the study and sign an informed consent form,
- Agree to perform monthly self-administered nasal swab sampling and to provide data via a questionnaire.
Exclusion Criteria:
- Refusal to participate or inability to provide informed consent,
- Inability to perform monthly self-administered nasal swabs in accordance with the protocol,
- Employment on a part-time basis, or status as an intern or apprentice within the operation,
- No inclusion of persons targeted by Articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the Public Health Code (e.g., minors, legally protected adults, etc.)
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：基礎科学
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
実験的：Farmers representing 20 different pig farms
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Participants will be asked to provide two types of samples, only one of which will contain personally identifiable information.
|
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
To estimate the prevalence of nasal carriage of MRSA among pig farmers during the study period.
時間枠：From enrollment to the end of the study : 24 months
|
The primary outcome measure is the prevalence of nasal carriage of MRSA among pig farmers during the study period, as determined by microbiological detection from self-collected nasal swabs. |
From enrollment to the end of the study : 24 months
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Describe the temporal dynamics of nasal carriage of Staphylococcus aureus among pig farmers and within farms.
時間枠：From enrollment to the end of the study : 24 months
|
The prevalence of nasal carriage of MSSA among pig farmers. |
From enrollment to the end of the study : 24 months
|
|
Estimate the incidence of acquisition and clearance of MRSA and MSSA among pig farmers and within farms, based on repeated longitudinal measurements.
時間枠：From enrollment to the end of the study : 24 months
|
The incidence of acquisition and clearance of MRSA and MSSA among pig farmers, estimated from repeated longitudinal measurements of nasal carriage. |
From enrollment to the end of the study : 24 months
|
|
Identify factors associated with the carriage and acquisition of MRSA among pig farmers.
時間枠：From enrollment to the end of the study : 24 months
|
The prevalence and incidence of MSSA and MRSA within the pig farm environment. |
From enrollment to the end of the study : 24 months
|
協力者と研究者
研究記録日
主要日程の研究
研究開始 (推定)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。