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Bevacizumab, Sorafenib Tosylate, and Temsirolimus in Treating Patients With Metastatic Kidney Cancer

2018년 10월 15일 업데이트: National Cancer Institute (NCI)

The BeST Trial: A Randomized Phase II Study of VEGF, RAF Kinase, and mTOR Combination Targeted Therapy (CTT) With Bevacizumab, Sorafenib, and Temsirolimus in Advanced Renal Cell Carcinoma

This randomized phase II trial studies different combinations of bevacizumab, temsirolimus, and sorafenib tosylate to see how well they work compared with bevacizumab alone in treating patients with kidney cancer that has spread to other places in the body. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Bevacizumab and sorafenib tosylate may stop the growth of tumor cells by blocking blood flow to the tumor. Temsirolimus and sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving different combinations of bevacizumab, sorafenib tosylate, and temsirolimus may be more effective than bevacizumab alone in treating metastatic kidney cancer.

연구 개요

상태

완전한

정황

개입 / 치료

상세 설명

PRIMARY OBJECTIVES:

I. To assess progression-free survival on each arm of combination targeted therapy (CTT) compared to that of bevacizumab alone.

SECONDARY OBJECTIVES:

I. To assess the significance of changes in tumor size over early time points as a predictor of progression-free survival (PFS).

II. To quantify the number and percent of patients who have stable disease at 6 months of therapy (failure to progress) in each treatment arm of CTT in patients with metastatic renal cell carcinoma (RCC).

III. To evaluate the safety of each treatment arm of combination targeted therapy (CTT) in patients with metastatic RCC.

IV. To assess overall survival in each arm of the study. V. To assess the objective response rate in each treatment arm of CTT in patients with metastatic RCC.

VI. To assess pathology, angiogenesis histology and to assess activation status of mitogen activated protein (MAP) kinase and vascular endothelial growth factor receptor 2 (VEGFR2) pathways and relate to clinical outcome.

TERTIARY OBJECTIVES:

I. To analyze the pharmacokinetic and pharmacogenetic properties of sorafenib (sorafenib tosylate) including angiogenesis, monooxygenases polymorphisms and multi-drug resistance (MDR).

II. To relate changes in tumor perfusion and vascular permeability on serial dynamic contrast-enhanced magnetic resonance imaging (MRI) to clinical outcome and radiologic regression detected by other standard methods.

III. To assess the potential of dynamic contrast-enhanced (DCE)-MRI imaging as a biomarker for response to therapy and/or as a prognostic indicator of disease progression.

IV. To assess site readiness and ability in acquiring DCE-MRI data. V. To determine the relationship between tumor and blood biomarkers and clinical outcomes of patients treated with the combination of targeted agents.

OUTLINE: Patients are randomized to 1 of 4 treatment arms.

ARM A: Patients receive bevacizumab intravenously (IV) over 30-90 minutes on days 1 and 15.

ARM B: Patients receive temsirolimus IV over 30 minutes on days 1, 8, 15, and 22 and bevacizumab as in Arm A.

ARM C: Patients receive bevacizumab as in Arm A and sorafenib tosylate orally (PO) twice daily (BID) on days 1-5, 8-12, 15-19, and 22-26.

ARM D: Patients receive sorafenib tosylate PO BID on days 1-28 and temsirolimus as in Arm B.

In all arms, courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up periodically for 5 years.

연구 유형

중재적

등록 (실제)

361

단계

  • 2 단계

연락처 및 위치

이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.

연구 장소

  • 미국
    • Alabama
      • Birmingham, Alabama, 미국, 35233
        • University of Alabama at Birmingham Cancer Center
      • Mobile, Alabama, 미국, 36608
        • Providence Hospital
    • Arizona
      • Scottsdale, Arizona, 미국, 85259
        • Mayo Clinic in Arizona
      • Tucson, Arizona, 미국, 85724
        • The University of Arizona Medical Center-University Campus
    • Arkansas
      • Fort Smith, Arkansas, 미국, 72903
        • Mercy Hospital Fort Smith
      • Jonesboro, Arkansas, 미국, 72401
        • NEA Baptist Memorial Hospital
      • Little Rock, Arkansas, 미국, 72205
        • University of Arkansas for Medical Sciences
    • California
      • Berkeley, California, 미국, 94704
        • Alta Bates Summit Medical Center-Herrick Campus
      • Burbank, California, 미국, 91505
        • Providence Saint Joseph Medical Center/Disney Family Cancer Center
      • Burlingame, California, 미국, 94010
        • Mills-Peninsula Medical Center
      • Castro Valley, California, 미국, 94546
        • Eden Hospital Medical Center
      • Castro Valley, California, 미국, 94546
        • East Bay Radiation Oncology Center
      • Castro Valley, California, 미국, 94546
        • Valley Medical Oncology Consultants-Castro Valley
      • Emeryville, California, 미국, 94608
        • Bay Area Breast Surgeons Inc
      • Fremont, California, 미국, 94538
        • Valley Medical Oncology Consultants-Fremont
      • Glendale, California, 미국, 91204
        • Glendale Memorial Hospital and Health Center
      • Greenbrae, California, 미국, 94904
        • Marin Cancer Care Inc
      • Greenbrae, California, 미국, 94904
        • Marin General Hospital
      • La Jolla, California, 미국, 92093
        • UC San Diego Moores Cancer Center
      • Los Angeles, California, 미국, 90033
        • USC / Norris Comprehensive Cancer Center
      • Martinez, California, 미국, 94553-3156
        • Contra Costa Regional Medical Center
      • Marysville, California, 미국, 95901
        • Fremont - Rideout Cancer Center
      • Mountain View, California, 미국, 94040
        • El Camino Hospital
      • Mountain View, California, 미국, 94040
        • Palo Alto Medical Foundation-Camino Division
      • Novato, California, 미국, 94945
        • Sutter Cancer Research Consortium
      • Oakland, California, 미국, 94609
        • Alta Bates Summit Medical Center - Summit Campus
      • Oakland, California, 미국, 94609
        • Hematology and Oncology Associates-Oakland
      • Oakland, California, 미국, 94602
        • Highland General Hospital
      • Oakland, California, 미국, 94609
        • Tom K Lee Inc
      • Oakland, California, 미국, 94609
        • Bay Area Tumor Institute
      • Orange, California, 미국, 92868
        • Saint Joseph Hospital - Orange
      • Palo Alto, California, 미국, 94301
        • Palo Alto Medical Foundation Health Care
      • Pleasanton, California, 미국, 94588
        • Valley Care Health System - Pleasanton
      • Pleasanton, California, 미국, 94588
        • Valley Medical Oncology Consultants
      • Sacramento, California, 미국, 95817
        • University of California Davis Comprehensive Cancer Center
      • San Diego, California, 미국, 92103
        • University of California San Diego
      • San Diego, California, 미국, 92161
        • Veterans Administration-San Diego Medical Center
      • San Francisco, California, 미국, 94115
        • California Pacific Medical Center-Pacific Campus
      • San Pablo, California, 미국, 94806
        • Doctors Medical Center- JC Robinson Regional Cancer Center
      • Truckee, California, 미국, 96161
        • Gene Upshaw Memorial Tahoe Forest Cancer Center
      • Vallejo, California, 미국, 94589
        • Sutter Solano Medical Center/Cancer Center
    • Colorado
      • Aurora, Colorado, 미국, 80045
        • University Of Colorado Hospital
      • Aurora, Colorado, 미국, 80012
        • The Medical Center of Aurora
      • Boulder, Colorado, 미국, 80301
        • Boulder Community Hospital
      • Colorado Springs, Colorado, 미국, 80907
        • Penrose-Saint Francis Healthcare
      • Colorado Springs, Colorado, 미국, 80909
        • UCHealth Memorial Hospital Central
      • Denver, Colorado, 미국, 80210
        • Porter Adventist Hospital
      • Denver, Colorado, 미국, 80217-3364
        • University of Colorado
      • Denver, Colorado, 미국, 80218
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, 미국, 80218
        • SCL Health Saint Joseph Hospital
      • Denver, Colorado, 미국, 80220
        • Rose Medical Center
      • Denver, Colorado, 미국, 80222
        • Colorado Cancer Research Program NCORP
      • Edwards, Colorado, 미국, 81632
        • The Shaw Regional Cancer Center
      • Englewood, Colorado, 미국, 80113
        • Swedish Medical Center
      • Fort Collins, Colorado, 미국, 80524
        • Poudre Valley Hospital
      • Glenwood Springs, Colorado, 미국, 81601
        • Valley View Hospital Cancer Center
      • Grand Junction, Colorado, 미국, 81501
        • Saint Mary's Hospital and Regional Medical Center
      • Greeley, Colorado, 미국, 80631
        • North Colorado Medical Center
      • Lakewood, Colorado, 미국, 80228
        • Saint Anthony Hospital
      • Lone Tree, Colorado, 미국, 80124
        • Sky Ridge Medical Center
      • Longmont, Colorado, 미국, 80501
        • Longmont United Hospital
      • Loveland, Colorado, 미국, 80539
        • McKee Medical Center
      • Montrose, Colorado, 미국, 81401
        • Montrose Memorial Hospital
      • Pueblo, Colorado, 미국, 81004
        • Saint Mary Corwin Medical Center
      • Thornton, Colorado, 미국, 80229
        • North Suburban Medical Center
      • Wheat Ridge, Colorado, 미국, 80033
        • SCL Health Lutheran Medical Center
    • Connecticut
      • Hartford, Connecticut, 미국, 06102
        • Hartford Hospital
    • Delaware
      • Lewes, Delaware, 미국, 19958
        • Beebe Medical Center
      • Newark, Delaware, 미국, 19718
        • Christiana Care Health System-Christiana Hospital
    • Florida
      • Boca Raton, Florida, 미국, 33486
        • Boca Raton Regional Hospital
      • Jacksonville, Florida, 미국, 32224-9980
        • Mayo Clinic in Florida
      • Orlando, Florida, 미국, 32806
        • UF Cancer Center at Orlando Health
    • Georgia
      • Columbus, Georgia, 미국, 31904
        • John B Amos Cancer Center
      • Gainesville, Georgia, 미국, 30501
        • Northeast Georgia Medical Center-Gainesville
      • Macon, Georgia, 미국, 31201
        • Medical Center of Central Georgia
    • Idaho
      • Post Falls, Idaho, 미국, 83854
        • Kootenai Cancer Center
    • Illinois
      • Alton, Illinois, 미국, 62002
        • Saint Anthony's Health
      • Aurora, Illinois, 미국, 60504
        • Rush - Copley Medical Center
      • Berwyn, Illinois, 미국, 60402
        • MacNeal Hospital and Cancer Center
      • Bloomington, Illinois, 미국, 61704
        • Illinois CancerCare-Bloomington
      • Bloomington, Illinois, 미국, 61701
        • Saint Joseph Medical Center
      • Canton, Illinois, 미국, 61520
        • Illinois CancerCare-Canton
      • Canton, Illinois, 미국, 61520
        • Graham Hospital Association
      • Carthage, Illinois, 미국, 62321
        • Illinois CancerCare-Carthage
      • Carthage, Illinois, 미국, 62321
        • Memorial Hospital
      • Chicago, Illinois, 미국, 60611
        • Northwestern University
      • Chicago, Illinois, 미국, 60637
        • University of Chicago Comprehensive Cancer Center
      • Chicago, Illinois, 미국, 60612
        • University of Illinois
      • Chicago, Illinois, 미국, 60611
        • Hematology and Oncology Associates
      • Chicago, Illinois, 미국, 60631
        • Presence Resurrection Medical Center
      • Chicago, Illinois, 미국, 60612
        • Jesse Brown Veterans Affairs Medical Center
      • Decatur, Illinois, 미국, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, 미국, 62526
        • Heartland Cancer Research NCORP
      • Elgin, Illinois, 미국, 60123
        • Advocate Sherman Hospital
      • Elk Grove Village, Illinois, 미국, 60007
        • AMITA Health Alexian Brothers Medical Center
      • Eureka, Illinois, 미국, 61530
        • Illinois CancerCare-Eureka
      • Eureka, Illinois, 미국, 61530
        • Eureka Hospital
      • Evanston, Illinois, 미국, 60201
        • NorthShore University HealthSystem-Evanston Hospital
      • Galesburg, Illinois, 미국, 61401
        • Illinois CancerCare-Galesburg
      • Galesburg, Illinois, 미국, 61401
        • Galesburg Cottage Hospital
      • Galesburg, Illinois, 미국, 61401
        • Illinois CancerCare-Cottage
      • Harvey, Illinois, 미국, 60426
        • Ingalls Memorial Hospital
      • Havana, Illinois, 미국, 62644
        • Mason District Hospital
      • Havana, Illinois, 미국, 62644
        • Illinois CancerCare-Havana
      • Highland Park, Illinois, 미국, 60035
        • Hematology Oncology Associates of Illinois-Highland Park
      • Hopedale, Illinois, 미국, 61747
        • Hopedale Medical Complex - Hospital
      • Joliet, Illinois, 미국, 60435
        • Joliet Oncology-Hematology Associates Limited
      • Joliet, Illinois, 미국, 60432
        • Midwest Center for Hematology Oncology
      • Kewanee, Illinois, 미국, 61443
        • Illinois CancerCare-Kewanee Clinic
      • Kewanee, Illinois, 미국, 61443
        • Kewanee Hospital
      • La Grange, Illinois, 미국, 60525
        • AMITA Health Adventist Medical Center
      • Libertyville, Illinois, 미국, 60048
        • NorthShore Hematology Oncology-Libertyville
      • Macomb, Illinois, 미국, 61455
        • Illinois CancerCare-Macomb
      • Macomb, Illinois, 미국, 61455
        • Mcdonough District Hospital
      • Moline, Illinois, 미국, 61265
        • Garneau, Stewart C MD (UIA Investigator)
      • Moline, Illinois, 미국, 61265
        • Porubcin, Michael MD (UIA Investigator)
      • Moline, Illinois, 미국, 61265
        • Spector, David MD (UIA Investigator)
      • Moline, Illinois, 미국, 61265
        • Trinity Medical Center
      • Moline, Illinois, 미국, 61265
        • Sharis, Christine M MD (UIA Investigator)
      • Moline, Illinois, 미국, 61265
        • Stoffel, Thomas J MD (UIA Investigator)
      • Monmouth, Illinois, 미국, 61462
        • Illinois CancerCare-Monmouth
      • Monmouth, Illinois, 미국, 61462
        • Holy Family Medical Center
      • Mount Vernon, Illinois, 미국, 62864
        • Good Samaritan Regional Health Center
      • Naperville, Illinois, 미국, 60563
        • DuPage Medical Group-Ogden
      • Naperville, Illinois, 미국, 60540
        • AMG Oncology - Naperville
      • Niles, Illinois, 미국, 60714
        • Illinois Cancer Specialists-Niles
      • Normal, Illinois, 미국, 61761
        • Community Cancer Center Foundation
      • Normal, Illinois, 미국, 61761
        • Bromenn Regional Medical Center
      • Normal, Illinois, 미국, 61761
        • Illinois CancerCare-Community Cancer Center
      • Ottawa, Illinois, 미국, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Ottawa, Illinois, 미국, 61350
        • Ottawa Regional Hospital and Healthcare Center
      • Pekin, Illinois, 미국, 61554
        • Illinois CancerCare-Pekin
      • Pekin, Illinois, 미국, 61554
        • OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
      • Pekin, Illinois, 미국, 61554
        • Pekin Hospital
      • Peoria, Illinois, 미국, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, 미국, 61637
        • OSF Saint Francis Medical Center
      • Peoria, Illinois, 미국, 61615
        • Illinois CancerCare-Peoria
      • Peoria, Illinois, 미국, 61614
        • Proctor Hospital
      • Peru, Illinois, 미국, 61354
        • Illinois CancerCare-Peru
      • Peru, Illinois, 미국, 61354
        • Illinois Valley Hospital
      • Princeton, Illinois, 미국, 61356
        • Illinois CancerCare-Princeton
      • Princeton, Illinois, 미국, 61356
        • Perry Memorial Hospital
      • Rockford, Illinois, 미국, 61114
        • SwedishAmerican Regional Cancer Center/ACT
      • Rockford, Illinois, 미국, 61104
        • Swedish American Hospital
      • Skokie, Illinois, 미국, 60076
        • Hematology Oncology Associates of Illinois - Skokie
      • Spring Valley, Illinois, 미국, 61362
        • Saint Margaret's Hospital
      • Spring Valley, Illinois, 미국, 61362
        • Illinois CancerCare-Spring Valley
      • Springfield, Illinois, 미국, 62781
        • Memorial Medical Center
      • Urbana, Illinois, 미국, 61801
        • Carle Cancer Center
    • Indiana
      • Beech Grove, Indiana, 미국, 46107
        • Franciscan Saint Francis Health-Beech Grove
      • Elkhart, Indiana, 미국, 46515
        • Elkhart General Hospital
      • Elkhart, Indiana, 미국, 46514
        • Michiana Hematology Oncology PC-Elkhart
      • Elkhart, Indiana, 미국, 46514-2098
        • Elkhart Clinic
      • Fort Wayne, Indiana, 미국, 46845
        • Fort Wayne Medical Oncology and Hematology Inc-Parkview
      • Indianapolis, Indiana, 미국, 46202
        • Indiana University/Melvin and Bren Simon Cancer Center
      • Indianapolis, Indiana, 미국, 46202
        • Sidney and Lois Eskenazi Hospital
      • Indianapolis, Indiana, 미국, 46202
        • Richard L. Roudebush Veterans Affairs Medical Center
      • Kokomo, Indiana, 미국, 46904
        • Community Howard Regional Health
      • La Porte, Indiana, 미국, 46350
        • IU Health La Porte Hospital
      • Lafayette, Indiana, 미국, 47905
        • Horizon Oncology Research LLC
      • Michigan City, Indiana, 미국, 46360
        • Franciscan Saint Anthony Health-Michigan City
      • Mishawaka, Indiana, 미국, 46545
        • Michiana Hematology Oncology PC-Mishawaka
      • Mishawaka, Indiana, 미국, 46545
        • Saint Joseph Regional Medical Center-Mishawaka
      • Plymouth, Indiana, 미국, 46563
        • Michiana Hematology Oncology PC-Plymouth
      • Richmond, Indiana, 미국, 47374
        • Reid Health
      • South Bend, Indiana, 미국, 46601
        • Memorial Hospital of South Bend
      • South Bend, Indiana, 미국, 46601
        • Michiana Hematology Oncology PC-South Bend
      • South Bend, Indiana, 미국, 46628
        • Northern Indiana Cancer Research Consortium
      • South Bend, Indiana, 미국, 46617
        • South Bend Clinic
      • Westville, Indiana, 미국, 46391
        • Michiana Hematology Oncology PC-Westville
    • Iowa
      • Ames, Iowa, 미국, 50010
        • McFarland Clinic PC - Ames
      • Bettendorf, Iowa, 미국, 52722
        • Constantinou, Costas L MD (UIA Investigator)
      • Bettendorf, Iowa, 미국, 52722
        • University of Iowa Healthcare Cancer Services Quad Cities
      • Cedar Rapids, Iowa, 미국, 52403
        • Mercy Hospital
      • Cedar Rapids, Iowa, 미국, 52403
        • Oncology Associates at Mercy Medical Center
      • Davenport, Iowa, 미국, 52803
        • Genesis Medical Center - East Campus
      • Davenport, Iowa, 미국, 52804
        • Genesis Medical Center - West Campus
      • Des Moines, Iowa, 미국, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, 미국, 50314
        • Mercy Medical Center - Des Moines
      • Des Moines, Iowa, 미국, 50309
        • Medical Oncology and Hematology Associates-Des Moines
      • Des Moines, Iowa, 미국, 50316
        • Iowa Lutheran Hospital
      • Des Moines, Iowa, 미국, 50309
        • Iowa-Wide Oncology Research Coalition NCORP
      • Des Moines, Iowa, 미국, 50314
        • Medical Oncology and Hematology Associates-Laurel
      • Des Moines, Iowa, 미국, 50307
        • Mercy Capitol
      • Iowa City, Iowa, 미국, 52242
        • University of Iowa/Holden Comprehensive Cancer Center
      • Mason City, Iowa, 미국, 50401
        • Mercy Medical Center - North Iowa
      • Ottumwa, Iowa, 미국, 52501
        • Ottumwa Regional Health Center
      • Sioux City, Iowa, 미국, 51101
        • Siouxland Regional Cancer Center
      • Sioux City, Iowa, 미국, 51104
        • Saint Luke's Regional Medical Center
      • Sioux City, Iowa, 미국, 51104
        • Mercy Medical Center-Sioux City
    • Kansas
      • Anthony, Kansas, 미국, 67003
        • Hospital District Sixth of Harper County
      • Chanute, Kansas, 미국, 66720
        • Cancer Center of Kansas - Chanute
      • Dodge City, Kansas, 미국, 67801
        • Cancer Center of Kansas - Dodge City
      • El Dorado, Kansas, 미국, 67042
        • Cancer Center of Kansas - El Dorado
      • Fort Scott, Kansas, 미국, 66701
        • Cancer Center of Kansas - Fort Scott
      • Independence, Kansas, 미국, 67301
        • Cancer Center of Kansas-Independence
      • Kingman, Kansas, 미국, 67068
        • Cancer Center of Kansas-Kingman
      • Lawrence, Kansas, 미국, 66044
        • Lawrence Memorial Hospital
      • Liberal, Kansas, 미국, 67901
        • Southwest Medical Center
      • Newton, Kansas, 미국, 67114
        • Cancer Center of Kansas - Newton
      • Overland Park, Kansas, 미국, 66209
        • Menorah Medical Center
      • Overland Park, Kansas, 미국, 66213
        • Saint Luke's South Hospital
      • Overland Park, Kansas, 미국, 66210
        • Radiation Oncology Practice Corporation Southwest
      • Parsons, Kansas, 미국, 67357
        • Cancer Center of Kansas - Parsons
      • Pratt, Kansas, 미국, 67124
        • Cancer Center of Kansas - Pratt
      • Salina, Kansas, 미국, 67401
        • Cancer Center of Kansas - Salina
      • Shawnee Mission, Kansas, 미국, 66204
        • Shawnee Mission Medical Center-KCCC
      • Topeka, Kansas, 미국, 66606
        • Cotton O'Neil Cancer Center / Stormont Vail Health
      • Topeka, Kansas, 미국, 66606
        • Saint Francis Hospital and Medical Center - Topeka
      • Wellington, Kansas, 미국, 67152
        • Cancer Center of Kansas - Wellington
      • Wichita, Kansas, 미국, 67208
        • Cancer Center of Kansas-Wichita Medical Arts Tower
      • Wichita, Kansas, 미국, 67214
        • Cancer Center of Kansas - Wichita
      • Wichita, Kansas, 미국, 67208
        • Associates In Womens Health
      • Wichita, Kansas, 미국, 67214
        • Wichita NCI Community Oncology Research Program
      • Wichita, Kansas, 미국, 67214
        • Via Christi Regional Medical Center
      • Winfield, Kansas, 미국, 67156
        • Cancer Center of Kansas - Winfield
    • Kentucky
      • Louisville, Kentucky, 미국, 40215
        • Doctors Carrol, Sheth, Raghavan
    • Louisiana
      • Baton Rouge, Louisiana, 미국, 70809
        • Mary Bird Perkins Cancer Center
      • Baton Rouge, Louisiana, 미국, 70809
        • Ochsner Health Center-Summa
      • Baton Rouge, Louisiana, 미국, 70806
        • Baton Rouge General Medical Center
      • New Orleans, Louisiana, 미국, 70121
        • Ochsner Medical Center Jefferson
      • New Orleans, Louisiana, 미국, 70112
        • University Medical Center New Orleans
      • New Orleans, Louisiana, 미국, 70112
        • Louisiana State University Health Science Center
    • Maine
      • Bangor, Maine, 미국, 04401
        • Eastern Maine Medical Center
      • Lewiston, Maine, 미국, 04240
        • Saint Mary's Regional Medical Center
    • Maryland
      • Baltimore, Maryland, 미국, 21215
        • Sinai Hospital of Baltimore
      • Baltimore, Maryland, 미국, 21204
        • Greater Baltimore Medical Center
      • Elkton, Maryland, 미국, 21921
        • Union Hospital of Cecil County
      • Frederick, Maryland, 미국, 21701
        • Frederick Memorial Hospital
    • Massachusetts
      • Boston, Massachusetts, 미국, 02215
        • Beth Israel Deaconess Medical Center
    • Michigan
      • Adrian, Michigan, 미국, 49221
        • Bixby Medical Center
      • Adrian, Michigan, 미국, 49221
        • Hickman Cancer Center
      • Ann Arbor, Michigan, 미국, 48106
        • Saint Joseph Mercy Hospital
      • Ann Arbor, Michigan, 미국, 48106
        • Michigan Cancer Research Consortium NCORP
      • Battle Creek, Michigan, 미국, 49017
        • Bronson Battle Creek
      • Big Rapids, Michigan, 미국, 49307
        • Spectrum Health Big Rapids Hospital
      • Dearborn, Michigan, 미국, 48124
        • Beaumont Hospital-Dearborn
      • Detroit, Michigan, 미국, 48236
        • Ascension Saint John Hospital
      • Escanaba, Michigan, 미국, 49829
        • Green Bay Oncology - Escanaba
      • Flint, Michigan, 미국, 48532
        • Genesys Regional Medical Center-West Flint Campus
      • Flint, Michigan, 미국, 48503
        • Hurley Medical Center
      • Flint, Michigan, 미국, 48503
        • Genesys Hurley Cancer Institute
      • Grand Rapids, Michigan, 미국, 49503
        • Spectrum Health at Butterworth Campus
      • Grand Rapids, Michigan, 미국, 49503
        • Mercy Health Saint Mary's
      • Grand Rapids, Michigan, 미국, 49503
        • Cancer Research Consortium of West Michigan NCORP
      • Iron Mountain, Michigan, 미국, 49801
        • Green Bay Oncology - Iron Mountain
      • Jackson, Michigan, 미국, 49201
        • Allegiance Health
      • Kalamazoo, Michigan, 미국, 49007
        • West Michigan Cancer Center
      • Kalamazoo, Michigan, 미국, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, 미국, 49048
        • Borgess Medical Center
      • Lansing, Michigan, 미국, 48912
        • Sparrow Hospital
      • Livonia, Michigan, 미국, 48154
        • Saint Mary Mercy Hospital
      • Monroe, Michigan, 미국, 48162
        • Mercy Memorial Hospital
      • Monroe, Michigan, 미국, 48162
        • Toledo Clinic Cancer Centers-Monroe
      • Muskegon, Michigan, 미국, 49444
        • Mercy Health Mercy Campus
      • Muskegon, Michigan, 미국, 49442
        • Mercy Health Partners-Hackley Campus
      • Niles, Michigan, 미국, 49120
        • Lakeland Hospital Niles
      • Pontiac, Michigan, 미국, 48341
        • Saint Joseph Mercy Oakland
      • Port Huron, Michigan, 미국, 48060
        • Lake Huron Medical Center
      • Saginaw, Michigan, 미국, 48601
        • Saint Mary's of Michigan
      • Saint Joseph, Michigan, 미국, 49085
        • Lakeland Medical Center Saint Joseph
      • Saint Joseph, Michigan, 미국, 49085
        • Marie Yeager Cancer Center
      • Saint Joseph, Michigan, 미국, 49085
        • Oncology Care Associates PLLC
      • Southfield, Michigan, 미국, 48075
        • Providence Hospital-Southfield Cancer Center
      • Traverse City, Michigan, 미국, 49684
        • Munson Medical Center
      • Warren, Michigan, 미국, 48093
        • Saint John Macomb-Oakland Hospital
      • Wyoming, Michigan, 미국, 49519
        • Metro Health Hospital
    • Minnesota
      • Alexandria, Minnesota, 미국, 56308
        • Medini, Eitan MD (UIA Investigator)
      • Burnsville, Minnesota, 미국, 55337
        • Fairview Ridges Hospital
      • Coon Rapids, Minnesota, 미국, 55433
        • Mercy Hospital
      • Duluth, Minnesota, 미국, 55805
        • Essentia Health Cancer Center
      • Duluth, Minnesota, 미국, 55805
        • Essentia Health Saint Mary's Medical Center
      • Duluth, Minnesota, 미국, 55805
        • Miller-Dwan Hospital
      • Edina, Minnesota, 미국, 55435
        • Fairview-Southdale Hospital
      • Fergus Falls, Minnesota, 미국, 56537
        • Etzell, Paul S MD (UIA Investigator)
      • Fergus Falls, Minnesota, 미국, 56537
        • Swenson, Wade II, MD (UIA Investigator)
      • Fridley, Minnesota, 미국, 55432
        • Unity Hospital
      • Hutchinson, Minnesota, 미국, 55350
        • Hutchinson Area Health Care
      • Litchfield, Minnesota, 미국, 55355
        • Meeker County Memorial Hospital
      • Maplewood, Minnesota, 미국, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, 미국, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, 미국, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, 미국, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, 미국, 55407
        • Virginia Piper Cancer Institute
      • Robbinsdale, Minnesota, 미국, 55422
        • North Memorial Medical Health Center
      • Rochester, Minnesota, 미국, 55905
        • Mayo Clinic
      • Saint Cloud, Minnesota, 미국, 56303
        • Coborn Cancer Center at Saint Cloud Hospital
      • Saint Cloud, Minnesota, 미국, 56303
        • Saint Cloud Hospital
      • Saint Louis Park, Minnesota, 미국, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Louis Park, Minnesota, 미국, 55416
        • Metro Minnesota Community Oncology Research Consortium
      • Saint Paul, Minnesota, 미국, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, 미국, 55102
        • United Hospital
      • Saint Paul, Minnesota, 미국, 55102
        • Saint Joseph's Hospital - Healtheast
      • Shakopee, Minnesota, 미국, 55379
        • Saint Francis Regional Medical Center
      • Waconia, Minnesota, 미국, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, 미국, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, 미국, 55125
        • Minnesota Oncology Hematology PA-Woodbury
      • Woodbury, Minnesota, 미국, 55125
        • Woodwinds Health Campus
    • Mississippi
      • Jackson, Mississippi, 미국, 39216
        • University of Mississippi Medical Center
      • Pascagoula, Mississippi, 미국, 39581
        • Singing River Hospital
    • Missouri
      • Cape Girardeau, Missouri, 미국, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, 미국, 63701
        • Southeast Missouri Hospital
      • Independence, Missouri, 미국, 64057
        • Centerpoint Medical Center LLC
      • Joplin, Missouri, 미국, 64804
        • Mercy Hospital Joplin
      • Kansas City, Missouri, 미국, 64116
        • North Kansas City Hospital
      • Kansas City, Missouri, 미국, 64111
        • Saint Luke's Hospital of Kansas City
      • Kansas City, Missouri, 미국, 64132
        • Research Medical Center
      • Kansas City, Missouri, 미국, 64108
        • Truman Medical Center
      • Kansas City, Missouri, 미국, 64118
        • Heartland Hematology and Oncology Associates Incorporated
      • Kansas City, Missouri, 미국, 64114
        • Saint Joseph Health Center
      • Kansas City, Missouri, 미국, 64114
        • Radiation Oncology Practice Corporation South
      • Kansas City, Missouri, 미국, 64154
        • Radiation Oncology Practice Corporation - North
      • Lee's Summit, Missouri, 미국, 64086
        • Saint Luke's East - Lee's Summit
      • Liberty, Missouri, 미국, 64068
        • Liberty Radiation Oncology Center
      • Saint Joseph, Missouri, 미국, 64507
        • Saint Joseph Oncology Inc
      • Saint Joseph, Missouri, 미국, 64507
        • Heartland Regional Medical Center
      • Saint Louis, Missouri, 미국, 63110
        • Washington University School of Medicine
      • Saint Louis, Missouri, 미국, 63110
        • Saint Louis University Hospital
      • Saint Louis, Missouri, 미국, 63131
        • Missouri Baptist Medical Center
      • Saint Louis, Missouri, 미국, 63141
        • Mercy Hospital Saint Louis
      • Saint Louis, Missouri, 미국, 63109
        • Saint Louis Cancer and Breast Institute-South City
      • Saint Louis, Missouri, 미국, 63141
        • Saint Louis-Cape Girardeau CCOP
      • Saint Louis, Missouri, 미국, 63141
        • Center for Cancer Care and Research
      • Springfield, Missouri, 미국, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, 미국, 65804
        • Mercy Hospital Springfield
    • Montana
      • Billings, Montana, 미국, 59101
        • Billings Clinic Cancer Center
      • Billings, Montana, 미국, 59101
        • Saint Vincent Healthcare
      • Billings, Montana, 미국, 59102
        • Montana Cancer Consortium NCORP
      • Billings, Montana, 미국, 59101
        • Northern Rockies Radiation Oncology Center
      • Billings, Montana, 미국, 59102
        • Saint Vincent Frontier Cancer Center
      • Bozeman, Montana, 미국, 59715
        • Bozeman Deaconess Hospital
      • Butte, Montana, 미국, 59701
        • Saint James Community Hospital and Cancer Treatment Center
      • Great Falls, Montana, 미국, 59405
        • Great Falls Clinic
      • Great Falls, Montana, 미국, 59405
        • Benefis Healthcare- Sletten Cancer Institute
      • Great Falls, Montana, 미국, 59405
        • Berdeaux, Donald MD (UIA Investigator)
      • Great Falls, Montana, 미국, 59405
        • Big Sky Oncology
      • Havre, Montana, 미국, 59501
        • Northern Montana Hospital
      • Helena, Montana, 미국, 59601
        • Saint Peter's Community Hospital
      • Kalispell, Montana, 미국, 59901
        • Kalispell Regional Medical Center
      • Kalispell, Montana, 미국, 59901
        • Glacier Oncology PLLC
      • Kalispell, Montana, 미국, 59901
        • Kalispell Medical Oncology
      • Missoula, Montana, 미국, 59804
        • Community Medical Hospital
      • Missoula, Montana, 미국, 59802
        • Saint Patrick Hospital - Community Hospital
      • Missoula, Montana, 미국, 59804
        • Guardian Oncology and Center for Wellness
      • Missoula, Montana, 미국, 59802
        • Montana Cancer Specialists
    • Nebraska
      • Grand Island, Nebraska, 미국, 68803
        • CHI Health Saint Francis
      • Kearney, Nebraska, 미국, 68847
        • CHI Health Good Samaritan
      • North Platte, Nebraska, 미국, 69101
        • Great Plains Health Callahan Cancer Center
      • Omaha, Nebraska, 미국, 68198
        • University of Nebraska Medical Center
    • Nevada
      • Las Vegas, Nevada, 미국, 89102
        • University Medical Center of Southern Nevada
      • Las Vegas, Nevada, 미국, 89106
        • Nevada Cancer Research Foundation CCOP
    • New Hampshire
      • Portsmouth, New Hampshire, 미국, 03802
        • Portsmouth Regional Hospital
    • New Jersey
      • Camden, New Jersey, 미국, 08103
        • Cooper Hospital University Medical Center
      • East Orange, New Jersey, 미국, 07018-1095
        • Veterans Adminstration New Jersey Health Care System
      • Morristown, New Jersey, 미국, 07960
        • Morristown Medical Center
      • Mount Holly, New Jersey, 미국, 08060
        • Virtua Memorial
      • Newark, New Jersey, 미국, 07101
        • Rutgers New Jersey Medical School
      • Summit, New Jersey, 미국, 07902
        • Overlook Hospital
      • Vineland, New Jersey, 미국, 08360
        • Inspira Medical Center Vineland
      • Voorhees, New Jersey, 미국, 08043
        • Virtua Voorhees
    • New York
      • Bronx, New York, 미국, 10467
        • Montefiore Medical Center - Moses Campus
      • Bronx, New York, 미국, 10466
        • Montefiore Medical Center-Wakefield Campus
      • Brooklyn, New York, 미국, 11203
        • Kings County Hospital
      • Brooklyn, New York, 미국, 11203
        • State University of New York Downstate Medical Center
      • Buffalo, New York, 미국, 14263
        • Roswell Park Cancer Institute
      • Cooperstown, New York, 미국, 13326
        • Mary Imogene Bassett Hospital
      • East Syracuse, New York, 미국, 13057
        • Hematology Oncology Associates of Central New York-East Syracuse
      • Glens Falls, New York, 미국, 12801
        • Glens Falls Hospital
      • Lake Success, New York, 미국, 11042
        • Northwell Health NCORP
      • Manhasset, New York, 미국, 11030
        • North Shore University Hospital
      • Middletown, New York, 미국, 10940
        • Orange Regional Medical Center
      • New Hyde Park, New York, 미국, 11040
        • Long Island Jewish Medical Center
      • New York, New York, 미국, 10032
        • Columbia University/Herbert Irving Cancer Center
      • Rochester, New York, 미국, 14642
        • University of Rochester
    • North Carolina
      • Asheville, North Carolina, 미국, 28801
        • Mission Hospital Inc-Memorial Campus
      • Burlington, North Carolina, 미국, 27215
        • Cone Health Cancer Center at Alamance Regional
      • Charlotte, North Carolina, 미국, 28204
        • Novant Health Presbyterian Medical Center
      • Goldsboro, North Carolina, 미국, 27534
        • Southeastern Medical Oncology Center-Goldsboro
      • Goldsboro, North Carolina, 미국, 27534
        • Wayne Memorial Hospital
      • Hendersonville, North Carolina, 미국, 28791
        • Margaret R Pardee Memorial Hospital
      • Kinston, North Carolina, 미국, 28501
        • Vidant Oncology-Kinston
      • Pinehurst, North Carolina, 미국, 28374
        • FirstHealth of the Carolinas-Moore Regional Hospital
      • Rutherfordton, North Carolina, 미국, 28139
        • Rutherford Hospital
      • Winston-Salem, North Carolina, 미국, 27157
        • Wake Forest University Health Sciences
      • Winston-Salem, North Carolina, 미국, 27104
        • Southeast Clinical Oncology Research (SCOR) Consortium NCORP
    • North Dakota
      • Bismarck, North Dakota, 미국, 58501
        • Sanford Bismarck Medical Center
      • Bismarck, North Dakota, 미국, 58501
        • Mid Dakota Clinic
      • Bismarck, North Dakota, 미국, 58501
        • Saint Alexius Medical Center
    • Ohio
      • Akron, Ohio, 미국, 44307
        • Cleveland Clinic Akron General
      • Bellefontaine, Ohio, 미국, 43311
        • Mary Rutan Hospital
      • Bowling Green, Ohio, 미국, 43402
        • Toledo Clinic Cancer Centers-Bowling Green
      • Canton, Ohio, 미국, 44710
        • Aultman Health Foundation
      • Canton, Ohio, 미국, 44708
        • Mercy Medical Center
      • Chillicothe, Ohio, 미국, 45601
        • Adena Regional Medical Center
      • Cincinnati, Ohio, 미국, 45219
        • The Christ Hospital
      • Cleveland, Ohio, 미국, 44109
        • MetroHealth Medical Center
      • Clyde, Ohio, 미국, 43410
        • North Coast Cancer Care-Clyde
      • Columbus, Ohio, 미국, 43214
        • Riverside Methodist Hospital
      • Columbus, Ohio, 미국, 43228
        • Doctors Hospital
      • Columbus, Ohio, 미국, 43215
        • Grant Medical Center
      • Columbus, Ohio, 미국, 43222
        • Mount Carmel Health Center West
      • Columbus, Ohio, 미국, 43215
        • Columbus NCI Community Oncology Research Program
      • Dayton, Ohio, 미국, 45406
        • Good Samaritan Hospital - Dayton
      • Dayton, Ohio, 미국, 45409
        • Miami Valley Hospital
      • Dayton, Ohio, 미국, 45415
        • Samaritan North Health Center
      • Dayton, Ohio, 미국, 45420
        • Dayton NCI Community Oncology Research Program
      • Dayton, Ohio, 미국, 45405
        • Grandview Hospital
      • Dayton, Ohio, 미국, 45428
        • Veteran Affairs Medical Center
      • Delaware, Ohio, 미국, 43015
        • Grady Memorial Hospital
      • Elyria, Ohio, 미국, 44035
        • Mercy Cancer Center-Elyria
      • Elyria, Ohio, 미국, 44035
        • Hematology Oncology Center Incorporated
      • Findlay, Ohio, 미국, 45840
        • Blanchard Valley Hospital
      • Franklin, Ohio, 미국, 45005-1066
        • Atrium Medical Center-Middletown Regional Hospital
      • Fremont, Ohio, 미국, 43420
        • Fremont Memorial Hospital
      • Greenville, Ohio, 미국, 45331
        • Wayne Hospital
      • Kettering, Ohio, 미국, 45429
        • Kettering Medical Center
      • Lancaster, Ohio, 미국, 43130
        • Fairfield Medical Center
      • Lima, Ohio, 미국, 45801
        • Saint Rita's Medical Center
      • Lima, Ohio, 미국, 45804
        • Lima Memorial Hospital
      • Marietta, Ohio, 미국, 45750
        • Marietta Memorial Hospital
      • Maumee, Ohio, 미국, 43537
        • Toledo Clinic Cancer Centers-Maumee
      • Maumee, Ohio, 미국, 43537
        • Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
      • Maumee, Ohio, 미국, 43537
        • Saint Luke's Hospital
      • Mount Vernon, Ohio, 미국, 43050
        • Knox Community Hospital
      • Newark, Ohio, 미국, 43055
        • Licking Memorial Hospital
      • Norwalk, Ohio, 미국, 44857
        • Fisher-Titus Medical Center
      • Oregon, Ohio, 미국, 43616
        • Saint Charles Hospital
      • Oregon, Ohio, 미국, 43616
        • Toledo Clinic Cancer Centers-Oregon
      • Sandusky, Ohio, 미국, 44870
        • North Coast Cancer Care
      • Sandusky, Ohio, 미국, 44870
        • Firelands Regional Medical Center
      • Springfield, Ohio, 미국, 45505
        • Springfield Regional Medical Center
      • Sylvania, Ohio, 미국, 43560
        • ProMedica Flower Hospital
      • Tiffin, Ohio, 미국, 44883
        • Mercy Hospital of Tiffin
      • Toledo, Ohio, 미국, 43608
        • Saint Vincent Mercy Medical Center
      • Toledo, Ohio, 미국, 43623
        • Toledo Clinic Cancer Centers-Toledo
      • Toledo, Ohio, 미국, 43614
        • University of Toledo
      • Toledo, Ohio, 미국, 43617
        • Toledo Community Hospital Oncology Program CCOP
      • Toledo, Ohio, 미국, 43606
        • The Toledo Hospital/Toledo Children's Hospital
      • Toledo, Ohio, 미국, 43623
        • Mercy Saint Anne Hospital
      • Troy, Ohio, 미국, 45373
        • Upper Valley Medical Center
      • Wauseon, Ohio, 미국, 43567
        • Fulton County Health Center
      • Westerville, Ohio, 미국, 43081
        • Saint Ann's Hospital
      • Wilmington, Ohio, 미국, 45177
        • Clinton Memorial Hospital
      • Xenia, Ohio, 미국, 45385
        • Greene Memorial Hospital
      • Zanesville, Ohio, 미국, 43701
        • Genesis Healthcare System Cancer Care Center
    • Oklahoma
      • Oklahoma City, Oklahoma, 미국, 73104
        • University of Oklahoma Health Sciences Center
      • Tulsa, Oklahoma, 미국, 74136
        • Natalie Warren Bryant Cancer Center at Saint Francis
    • Oregon
      • Coos Bay, Oregon, 미국, 97420
        • Bay Area Hospital
      • Portland, Oregon, 미국, 97227
        • Kaiser Permanente Northwest
    • Pennsylvania
      • Allentown, Pennsylvania, 미국, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Bethlehem, Pennsylvania, 미국, 18015
        • Saint Luke's University Hospital-Bethlehem Campus
      • Bryn Mawr, Pennsylvania, 미국, 19010
        • Bryn Mawr Hospital
      • Danville, Pennsylvania, 미국, 17822
        • Geisinger Medical Center
      • Hazleton, Pennsylvania, 미국, 18201
        • Geisinger Medical Center-Cancer Center Hazleton
      • Lancaster, Pennsylvania, 미국, 17604
        • Lancaster General Hospital
      • Lemoyne, Pennsylvania, 미국, 17043
        • Central PA Hematology-Medical Oncology Associates PC
      • Media, Pennsylvania, 미국, 19063
        • Riddle Memorial Hospital
      • Paoli, Pennsylvania, 미국, 19301
        • Paoli Memorial Hospital
      • Philadelphia, Pennsylvania, 미국, 19111
        • Fox Chase Cancer Center
      • Philadelphia, Pennsylvania, 미국, 19107
        • Thomas Jefferson University Hospital
      • Philadelphia, Pennsylvania, 미국, 19104
        • University of Pennsylvania/Abramson Cancer Center
      • Philadelphia, Pennsylvania, 미국, 19141
        • Einstein Medical Center Philadelphia
      • Philadelphia, Pennsylvania, 미국, 19107
        • Pennsylvania Hospital
      • Pittsburgh, Pennsylvania, 미국, 15232
        • University of Pittsburgh Cancer Institute (UPCI)
      • Scranton, Pennsylvania, 미국, 18510
        • Scranton Hematology Oncology
      • Scranton, Pennsylvania, 미국, 18501
        • Mercy Hospital
      • Scranton, Pennsylvania, 미국, 18508
        • Hematology and Oncology Associates of North East Pennsylvania
      • State College, Pennsylvania, 미국, 16801
        • Geisinger Medical Group
      • West Reading, Pennsylvania, 미국, 19611
        • Reading Hospital
      • Wilkes-Barre, Pennsylvania, 미국, 18711
        • Geisinger Wyoming Valley/Henry Cancer Center
      • Wilkes-Barre, Pennsylvania, 미국, 18765
        • Geisinger South Wilkes-Barre
      • Wynnewood, Pennsylvania, 미국, 19096
        • Lankenau Medical Center
    • Rhode Island
      • Pawtucket, Rhode Island, 미국, 02860
        • Memorial Hospital of Rhode Island
    • South Carolina
      • Anderson, South Carolina, 미국, 29621
        • AnMed Health Hospital
      • Spartanburg, South Carolina, 미국, 29303
        • Spartanburg Medical Center
    • South Dakota
      • Rapid City, South Dakota, 미국, 57701
        • Rapid City Regional Hospital
      • Sioux Falls, South Dakota, 미국, 57105
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, 미국, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, 미국, 57104
        • Sanford Cancer Center Oncology Clinic
      • Sioux Falls, South Dakota, 미국, 57105
        • Medical X-Ray Center
      • Sioux Falls, South Dakota, 미국, 57105
        • Avera McKennan Hospital and University Health Center
    • Tennessee
      • Franklin, Tennessee, 미국, 37067
        • Vanderbilt-Ingram Cancer Center Cool Springs
      • Jackson, Tennessee, 미국, 38301
        • Jackson-Madison County General Hospital
      • Knoxville, Tennessee, 미국, 37916
        • Thompson Cancer Survival Center
      • Knoxville, Tennessee, 미국, 37920
        • University of Tennessee - Knoxville
      • Knoxville, Tennessee, 미국, 37909
        • Tennessee Cancer Specialists-Dowell Springs
      • Knoxville, Tennessee, 미국, 37920
        • East Tennessee Baptist Hospital-Mercy Health Partners
      • Memphis, Tennessee, 미국, 38163
        • University of Tennessee Health Science Center
      • Nashville, Tennessee, 미국, 37232
        • Vanderbilt University/Ingram Cancer Center
    • Texas
      • Amarillo, Texas, 미국, 79106
        • The Don and Sybil Harrington Cancer Center
      • Austin, Texas, 미국, 78705
        • Texas Oncology-Austin Midtown
      • Austin, Texas, 미국, 78731
        • Texas Oncology - Central Austin Cancer Center
      • Austin, Texas, 미국, 78745
        • Texas Oncology - South Austin Cancer Center
      • Austin, Texas, 미국, 78758
        • Texas Oncology-Austin North
      • Austin, Texas, 미국, 78759
        • Texas Oncology Seton Northwest
      • Burleson, Texas, 미국, 76115
        • The Center for Cancer and Blood Disorders-Burleson
      • Cedar Park, Texas, 미국, 78613
        • Texas Oncology-Cedar Park
      • Cleburne, Texas, 미국, 76033
        • The Center for Cancer and Blood Disorders-Cleburne
      • Fort Worth, Texas, 미국, 76104
        • The Center for Cancer and Blood Disorders-Fort Worth
      • Houston, Texas, 미국, 77030
        • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
      • Houston, Texas, 미국, 77030
        • Michael E DeBakey VA Medical Center
      • Houston, Texas, 미국, 77030
        • The Methodist Hospital System
      • Houston, Texas, 미국, 77030
        • Ben Taub General Hospital
      • Houston, Texas, 미국, 77030
        • Baylor Saint Luke's Medical Center
      • Mineral Wells, Texas, 미국, 76067
        • The Center for Cancer and Blood Disorders-Mineral Wells
      • Round Rock, Texas, 미국, 78665
        • Texas Oncology-Seton Williamson
      • Round Rock, Texas, 미국, 78681
        • Texas Oncology - Round Rock Cancer Center
      • San Marcos, Texas, 미국, 78666
        • Texas Oncology- San Marcos
      • Weatherford, Texas, 미국, 76086
        • The Center for Cancer and Blood Disorders-Weatherford
    • Virginia
      • Danville, Virginia, 미국, 24541
        • Danville Regional Medical Center
      • Fredericksburg, Virginia, 미국, 22401
        • Fredericksburg Oncology Inc
      • Martinsville, Virginia, 미국, 24115
        • Sovah Health Martinsville
      • Richmond, Virginia, 미국, 23298
        • Virginia Commonwealth University/Massey Cancer Center
    • Washington
      • Bellingham, Washington, 미국, 98225
        • PeaceHealth Saint Joseph Medical Center
      • Bremerton, Washington, 미국, 98310
        • Harrison HealthPartners Hematology and Oncology-Bremerton
      • Kennewick, Washington, 미국, 99336
        • Kadlec Clinic Hematology and Oncology
      • Mount Vernon, Washington, 미국, 98274
        • Skagit Valley Hospital
      • Poulsbo, Washington, 미국, 98370
        • Harrison HealthPartners Hematology and Oncology-Poulsbo
      • Seattle, Washington, 미국, 98195
        • University of Washington Medical Center
      • Seattle, Washington, 미국, 98112
        • Kaiser Permanente Washington
      • Seattle, Washington, 미국, 98104
        • Minor and James Medical PLLC
      • Seattle, Washington, 미국, 98122-4307
        • Swedish Medical Center-First Hill
      • Spokane, Washington, 미국, 99218
        • Evergreen Hematology and Oncology PS
      • Spokane, Washington, 미국, 99202
        • Cancer Care Northwest - Spokane South
      • Spokane, Washington, 미국, 99220
        • Rockwood Clinic
      • Wenatchee, Washington, 미국, 98801
        • Wenatchee Valley Hospital and Clinics
    • West Virginia
      • Charleston, West Virginia, 미국, 25304
        • West Virginia University Charleston Division
    • Wisconsin
      • Appleton, Wisconsin, 미국, 54913
        • Fox Valley Hematology and Oncology SC-Appleton
      • Chippewa Falls, Wisconsin, 미국, 54729
        • Marshfield Clinic-Chippewa Center
      • Eau Claire, Wisconsin, 미국, 54701
        • HSHS Sacred Heart Hospital
      • Eau Claire, Wisconsin, 미국, 54701
        • Marshfield Clinic Cancer Center at Sacred Heart
      • Green Bay, Wisconsin, 미국, 54301
        • Saint Vincent Hospital Cancer Center Green Bay
      • Green Bay, Wisconsin, 미국, 54303
        • Saint Vincent Hospital Cancer Center at Saint Mary's
      • Green Bay, Wisconsin, 미국, 54303
        • Green Bay Oncology Limited at Saint Mary's Hospital
      • Green Bay, Wisconsin, 미국, 54301-3526
        • Green Bay Oncology at Saint Vincent Hospital
      • Johnson Creek, Wisconsin, 미국, 53038
        • UW Cancer Center Johnson Creek
      • La Crosse, Wisconsin, 미국, 54601
        • Gundersen Lutheran Medical Center
      • Madison, Wisconsin, 미국, 53792
        • University of Wisconsin Hospital and Clinics
      • Madison, Wisconsin, 미국, 53717
        • Dean Hematology and Oncology Clinic
      • Madison, Wisconsin, 미국, 53715
        • UW Health Oncology-One South Park
      • Manitowoc, Wisconsin, 미국, 54221
        • Holy Family Memorial Hospital
      • Marinette, Wisconsin, 미국, 54143
        • Bay Area Medical Center
      • Marshfield, Wisconsin, 미국, 54449
        • Marshfield Clinic
      • Marshfield, Wisconsin, 미국, 54449
        • Marshfield Medical Center
      • Milwaukee, Wisconsin, 미국, 53226
        • Froedtert and The Medical College of Wisconsin
      • Minocqua, Wisconsin, 미국, 54548
        • Marshfield Clinic-Minocqua Center
      • Oconto Falls, Wisconsin, 미국, 54154
        • Green Bay Oncology - Oconto Falls
      • Rhinelander, Wisconsin, 미국, 54501
        • Ascension Saint Mary's Hospital
      • Rice Lake, Wisconsin, 미국, 54868
        • Marshfield Clinic-Rice Lake Center
      • Stevens Point, Wisconsin, 미국, 54481
        • Saint Michael's Hospital
      • Sturgeon Bay, Wisconsin, 미국, 54235
        • Green Bay Oncology - Sturgeon Bay
      • Wausau, Wisconsin, 미국, 54401
        • Marshfield Clinic-Wausau Center
      • Weston, Wisconsin, 미국, 54476
        • Diagnostic and Treatment Center
      • Weston, Wisconsin, 미국, 54476
        • Marshfield Clinic - Weston Center
      • Wisconsin Rapids, Wisconsin, 미국, 54494
        • Marshfield Clinic - Wisconsin Rapids Center
      • Wisconsin Rapids, Wisconsin, 미국, 54494
        • Aspirus UW Cancer Center
    • Wyoming
      • Casper, Wyoming, 미국, 82609
        • Rocky Mountain Oncology
      • Sheridan, Wyoming, 미국, 82801
        • Welch Cancer Center
  • 페루
      • Lima, 페루, Lima 34
        • Instituto Nacional de Enfermedades Neoplasicas

참여기준

연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.

자격 기준

공부할 수 있는 나이

18년 이상 (성인, 고령자)

건강한 자원 봉사자를 받아들입니다

아니

연구 대상 성별

모두

설명

Inclusion Criteria:

  • Patients will be required to have the clear cell variant of renal cell carcinoma with less than 25% of any other histology (including, but not limited to, papillary or chromophobe or oncocytic); there must be histologic confirmation by treating center of either primary or metastatic lesion
  • Patients will be required to have measurable metastatic disease that is not curable by standard radiation therapy or surgery; all sites must be assessed within 4 weeks prior to study entry

  • Previous nephrectomy is required with the following exceptions:

    • Primary tumor =< 5 cm, or
    • Extensive liver (> 30% of liver parenchymal) or multiple (> 5) bone metastases, making nephrectomy a clinically questionable procedure
    • Unresectable primary tumor due to invasion into adjacent organs or encasing the aorta or vena cava
  • No prior cytotoxic chemotherapy; a maximum of one prior regimen of either vaccine or cytokine-based immunotherapy disease is permitted
  • No prior anti-angiogenic therapy including, but not limited to, SU11248, ZD6474 or VEGF Trap; no prior therapy with bevacizumab, mammalian target of rapamycin (mTOR) inhibitors (including, but not limited to, temsirolimus), or sorafenib will be allowed; thalidomide or interferon alpha (IFNalpha) are allowed either for adjuvant therapy or stage IV disease
  • No immunotherapy within 4 weeks of randomization; toxicities from immunotherapy must have resolved and a minimum of two weeks must pass prior to enrollment
  • Prior radiation therapy is permitted, but toxicities from radiation must have resolved and a minimum of 2 weeks must pass prior to randomization
  • No history or clinical evidence of central nervous system (CNS) disease, including primary brain tumor, seizures not controlled with standard medical therapy, any brain metastasis, or history of stroke within the past 48 weeks
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
  • Life expectancy of greater than 12 weeks
  • Hemoglobin (Hgb) >= 9.0 g/dL (transfusions allowed prior to enrollment)
  • White blood count (WBC) >= 3,000/mm^3
  • Absolute granulocyte count (AGC) >= 1,200/mm^3
  • Platelet count >= 100,000/mm^3
  • Serum creatinine =< 1.5 x upper limit of normal (ULN) or serum creatinine clearance (CrCl) >= 55 ml/min
  • Total bilirubin =< 1.5 x ULN
  • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x ULN (or =< 5.0 x ULN in the presence of liver metastases)
  • International normalized ratio (INR) =< 1.5
  • Activated partial thromboplastin time (aPTT) within normal limits
  • Fasting cholesterol < 350 mg/dL (9.0 mmol/L)
  • Fasting triglycerides < 400 mg/dL (4.56 mmol/L)
  • Patients must not have other current malignancies, other than basal cell skin cancer, squamous cell skin cancer, in situ cervical cancer, and ductal or lobular carcinoma in situ of the breast; patients with other malignancies are eligible if they have been continuously disease-free for >= 5 years prior to the time of randomization
  • No history of allergic reactions attributed to Chinese hamster ovary cell products, other recombinant human antibodies, or compounds of similar chemical or biologic composition to sorafenib, temsirolimus or bevacizumab
  • No history of bleeding diathesis or coagulopathy
  • Any condition that impairs patient's ability to swallow pills will make patient ineligible
  • No major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to randomization
  • No anticipated need for major surgery during the course of the study
  • No current or recent (within 4 weeks of enrollment) use of full-dose of anticoagulants or thrombolytic agents (except as required to maintain patency of preexisting or permanent indwelling IV catheters, for those patients receiving warfarin, INR must be =< 1.5)

  • No clinically significant cardiovascular disease, defined as one of the following:

    • Patients with uncontrolled hypertension (blood pressure > 150/100 mm/Hg at the time of enrollment); patients with hypertension and blood pressure =< 150/100 mm/Hg on stable antihypertensive regimen are eligible
    • Myocardial infarction or unstable angina < 24 weeks prior to registration
    • New York Heart Association grade II or greater congestive heart failure, serious cardiac arrhythmia requiring medication, unstable angina pectoris
    • Grade II or greater peripheral vascular disease
  • No serious, non-healing wound, ulcer, or bone fracture

  • No significant proteinuria at baseline; urine protein must be screened within 2 weeks prior to randomization by urine analysis for urine protein creatinine (UPC) ratio; if UPC ratio is > 0.5, 24-hour urine protein is to be obtained and the level must be < 1000 mg for patient enrollment

    • NOTE: UPC ratio of spot urine is an estimation of the 24 urine protein excretion; a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of 1 gm
  • No uncontrolled intercurrent illness including, but not limited to, ongoing or active infection requiring parenteral antibiotics on day 0 or psychiatric illness/social situations that would limit compliance with study requirements

  • Patients currently taking any of the following cytochrome P450 enzyme-inducing drugs are ineligible:

    • Phenytoin
    • Carbamazepine
    • Phenobarbital
    • Rifampin
  • Pregnant and breastfeeding women are excluded from the study; breastfeeding should be discontinued while receiving therapy; patients must have pregnancy test within 7 days prior to patient randomization if woman is of child-bearing capacity
  • Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study

공부 계획

이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.

연구는 어떻게 설계됩니까?

디자인 세부사항

  • 주 목적: 치료
  • 할당: 무작위
  • 중재 모델: 병렬 할당
  • 마스킹: 없음(오픈 라벨)

무기와 개입

참가자 그룹 / 팔
개입 / 치료
활성 비교기: Arm A (bevacizumab)
Patients receive bevacizumab IV over 30-90 minutes on days 1 and 15.
다른: 실험실 바이오마커 분석
상관 연구
다른: 약리학적 연구
상관 연구
생물학적: 베바시주맙
주어진 IV
다른 이름들:
  • 아바스틴
  • 안티-VEGF
  • 항-VEGF 인간화 단클론항체
  • 항-VEGF rhuMAb
  • 베바시주맙 바이오시밀러 BEVZ92
  • 베바시주맙 바이오시밀러 BI 695502
  • 베바시주맙 바이오시밀러 CBT 124
  • 베바시주맙 바이오시밀러 FKB238
  • 베바시주맙 바이오시밀러 MIL60
  • 베바시주맙 바이오시밀러 QL 1101
  • 면역글로불린 G1(Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF 경쇄, 이합체
  • 재조합 인간화 항-VEGF 단클론 항체
  • rhuMab-VEGF
  • 베바시주맙, 면허 보유자 미지정
실험적: Arm B (bevacizumab and temsirolimus)
Patients receive temsirolimus IV over 30 minutes on days 1, 8, 15, and 22 and bevacizumab as in Arm A.
다른: 실험실 바이오마커 분석
상관 연구
다른: 약리학적 연구
상관 연구
생물학적: 베바시주맙
주어진 IV
다른 이름들:
  • 아바스틴
  • 안티-VEGF
  • 항-VEGF 인간화 단클론항체
  • 항-VEGF rhuMAb
  • 베바시주맙 바이오시밀러 BEVZ92
  • 베바시주맙 바이오시밀러 BI 695502
  • 베바시주맙 바이오시밀러 CBT 124
  • 베바시주맙 바이오시밀러 FKB238
  • 베바시주맙 바이오시밀러 MIL60
  • 베바시주맙 바이오시밀러 QL 1101
  • 면역글로불린 G1(Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF 경쇄, 이합체
  • 재조합 인간화 항-VEGF 단클론 항체
  • rhuMab-VEGF
  • 베바시주맙, 면허 보유자 미지정
의약품: 템시롤리무스
주어진 IV
다른 이름들:
  • 토리셀
  • CCI-779
  • CCI-779 라파마이신 아날로그
  • 세포 주기 억제제 779
  • 라파마이신 아날로그
  • 라파마이신 아날로그 CCI-779
실험적: Arm C (bevacizumab and sorafenib tosylate)
Patients receive bevacizumab as in Arm A and sorafenib tosylate PO BID on days 1-5, 8-12, 15-19, and 22-26.
다른: 실험실 바이오마커 분석
상관 연구
다른: 약리학적 연구
상관 연구
생물학적: 베바시주맙
주어진 IV
다른 이름들:
  • 아바스틴
  • 안티-VEGF
  • 항-VEGF 인간화 단클론항체
  • 항-VEGF rhuMAb
  • 베바시주맙 바이오시밀러 BEVZ92
  • 베바시주맙 바이오시밀러 BI 695502
  • 베바시주맙 바이오시밀러 CBT 124
  • 베바시주맙 바이오시밀러 FKB238
  • 베바시주맙 바이오시밀러 MIL60
  • 베바시주맙 바이오시밀러 QL 1101
  • 면역글로불린 G1(Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF 경쇄, 이합체
  • 재조합 인간화 항-VEGF 단클론 항체
  • rhuMab-VEGF
  • 베바시주맙, 면허 보유자 미지정
의약품: 소라페닙 토실레이트
주어진 PO
다른 이름들:
  • 베이 54-9085
  • 넥사바
  • BAY 43-9006 토실레이트
  • 소라페닙
실험적: Arm D (sorafenib tosylate and temsirolimus)
Patients receive sorafenib tosylate PO BID on days 1-28 and temsirolimus as in Arm B.
다른: 실험실 바이오마커 분석
상관 연구
다른: 약리학적 연구
상관 연구
의약품: 템시롤리무스
주어진 IV
다른 이름들:
  • 토리셀
  • CCI-779
  • CCI-779 라파마이신 아날로그
  • 세포 주기 억제제 779
  • 라파마이신 아날로그
  • 라파마이신 아날로그 CCI-779
의약품: 소라페닙 토실레이트
주어진 PO
다른 이름들:
  • 베이 54-9085
  • 넥사바
  • BAY 43-9006 토실레이트
  • 소라페닙

연구는 무엇을 측정합니까?

주요 결과 측정

결과 측정
측정값 설명
기간
Progression-free Survival (PFS)
기간: Assessed every 2 cycles for the first 12 cycles, then every 3 cycles until treatment discontinuation, then every 8 weeks until disease progression or up to 5 years
Progression-free survival is defined as time from randomization to clinical evidence of disease progression or death from any cause without progression. Patients alive without progression were censored at the date of last disease assessment.
Assessed every 2 cycles for the first 12 cycles, then every 3 cycles until treatment discontinuation, then every 8 weeks until disease progression or up to 5 years

2차 결과 측정

결과 측정
측정값 설명
기간
Proportion of Patients With Stable Disease at 6 Months
기간: Assessed every 2 cycles for the first 12 cycles, then every 3 cycles until treatment discontinuation, then every 8 weeks until disease progression or up to 5 years
Patients whose date of progression was after 6 months or who were disease-free at last follow-up beyond 6 months were considered to be stable at 6 months and all other patients were not.
Assessed every 2 cycles for the first 12 cycles, then every 3 cycles until treatment discontinuation, then every 8 weeks until disease progression or up to 5 years
Overall Survival
기간: Assessed every 2 cycles for the first 12 cycles, then every 3 cycles until treatment discontinuation, then every 8 weeks until disease progression or up to 5 years
Overall survival was defined as the time from randomization to death. Patients alive at last contact were censored on the date of last contact.
Assessed every 2 cycles for the first 12 cycles, then every 3 cycles until treatment discontinuation, then every 8 weeks until disease progression or up to 5 years
Objective Response Rate
기간: Assessed every 2 cycles for the first 12 cycles, then every 3 cycles until treatment discontinuation, then every 8 weeks until disease progression or up to 5 years
Response was assessed using Solid Tumor Response Criteria (RECIST). Patients with complete responses or partial responses are considered having an objective response.
Assessed every 2 cycles for the first 12 cycles, then every 3 cycles until treatment discontinuation, then every 8 weeks until disease progression or up to 5 years

공동 작업자 및 조사자

여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.

스폰서

National Cancer Institute (NCI)

수사관

  • 수석 연구원: Keith Flaherty, ECOG-ACRIN Cancer Research Group

간행물 및 유용한 링크

연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.

일반 간행물

연구 기록 날짜

이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.

연구 주요 날짜

연구 시작 (실제)

2007년 9월 14일

기본 완료 (실제)

2014년 2월 7일

연구 완료 (실제)

2017년 3월 21일

연구 등록 날짜

최초 제출

2006년 9월 19일

QC 기준을 충족하는 최초 제출

2006년 9월 19일

처음 게시됨 (추정)

2006년 9월 21일

연구 기록 업데이트

마지막 업데이트 게시됨 (실제)

2018년 11월 14일

QC 기준을 충족하는 마지막 업데이트 제출

2018년 10월 15일

마지막으로 확인됨

2018년 10월 1일

추가 정보

이 연구와 관련된 용어

추가 관련 MeSH 약관

기타 연구 ID 번호

  • NCI-2009-00533 (레지스트리 식별자: CTRP (Clinical Trial Reporting Program))
  • U10CA180820 (미국 NIH 보조금/계약)
  • U10CA021115 (미국 NIH 보조금/계약)
  • ECOG-E2804
  • CDR0000499788
  • E2804 (기타 식별자: CTEP)

이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .

구독하다