- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT01903915
Social Dysfunction and Brain Dysfunction in Patients With Schizophrenia
Resting-state Magnetic Resonance Imaging of Brain in Patients With Schizophrenia Compared With Healthy Controls to Prove the Association Between Social Cognition Dysfunction and Abnormality of Brain Function
연구 개요
연구 유형
등록 (예상)
연락처 및 위치
연구 장소
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Seoul, 대한민국, 138-736
- 모병
- Department of psychiatry, Asan Medical Center
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연락하다:
- Jung-Sun Lee, MD
- 전화번호: 82 2 3010 3422
- 이메일: js_lee@amc.seoul.kr
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
샘플링 방법
연구 인구
설명
Patients group inclusion criteria:
- Right-handed
- Intelligent Quotient(IQ) above 80
- can read and understand the informed consent
- schizophrenia patients who was diagnosed from Structured Clinical Interview for Diagnostical and Statistical Manual of Mental Disorder 4th edition(DSM-IV, nonpatient version(SCID-NP) scales
- patient who has had reality distortion symptoms (like delusion or hallucination) in 5 years
Control group inclusion criteria :
- Right-handed
- IQ above 80
- do not have any diagnosis from SCID-NP scales
- do not have any family members who have psychiatric disorder
Exclusion criteria:
- have Illness which can affect brain structures and functions
- can't be taken magnetic resonance imaging(MRI)
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
코호트 및 개입
그룹/코호트 |
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제어
건강한 대조군
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Patients
Schizophrenia group
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Comparison of resting state functional MRI between schizophrenia patients and healthy controls
기간: Baseline
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After subjects are enrolled the study, functional MRI of the brain will be measured on rest. They will lie down in MRI machine and just open their eyes. There is no tasks for functional MRI. Unless the subject don't have any contraindication for MRI, they can be take MRI of brain safely. Resting-state functional brain MRI Data from subjects will be analysed statistically. We will use programs for image processing and statistical work, such as REST, Statistical Parametric Mapping(SPM), Freesurfer. For comparison between two groups, student t-test will be used. |
Baseline
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공동 작업자 및 조사자
수사관
- 수석 연구원: Jung-Sun Lee, MD, Department of psychiatry, Asan Medical Center
간행물 및 유용한 링크
일반 간행물
- Garrity AG, Pearlson GD, McKiernan K, Lloyd D, Kiehl KA, Calhoun VD. Aberrant "default mode" functional connectivity in schizophrenia. Am J Psychiatry. 2007 Mar;164(3):450-7. doi: 10.1176/ajp.2007.164.3.450. Erratum In: Am J Psychiatry. 2007 Jul;164(7):1123.
- Hans S, Vaissiere J, Crevier-Buchman L, Laccourreye O, Brasnu D. Aerodynamic and acoustic parameters in CO2 laser posterior transverse cordotomy for bilateral vocal fold paralysis. Acta Otolaryngol. 2000 Mar;120(2):330-5. doi: 10.1080/000164800750001206.
- Amodio DM, Kubota JT, Harmon-Jones E, Devine PG. Alternative mechanisms for regulating racial responses according to internal vs external cues. Soc Cogn Affect Neurosci. 2006 Jun;1(1):26-36. doi: 10.1093/scan/nsl002.
- Newton DE, Thornton C, Konieczko KM, Jordan C, Webster NR, Luff NP, Frith CD, Dore CJ. Auditory evoked response and awareness: a study in volunteers at sub-MAC concentrations of isoflurane. Br J Anaesth. 1992 Aug;69(2):122-9. doi: 10.1093/bja/69.2.122.
- Klee EW, Finlay JA, McDonald C, Attewell JR, Hebrink D, Dyer R, Love B, Vasmatzis G, Li TM, Beechem JM, Klee GG. Bioinformatics methods for prioritizing serum biomarker candidates. Clin Chem. 2006 Nov;52(11):2162-4. doi: 10.1373/clinchem.2006.072868. No abstract available.
- Tan HY, Chen Q, Goldberg TE, Mattay VS, Meyer-Lindenberg A, Weinberger DR, Callicott JH. Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory. J Neurosci. 2007 Dec 5;27(49):13393-401. doi: 10.1523/JNEUROSCI.4041-07.2007.
- Keefe RS. Cognitive deficits in patients with schizophrenia: effects and treatment. J Clin Psychiatry. 2007;68 Suppl 14:8-13.
- Fox MD, Snyder AZ, Zacks JM, Raichle ME. Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses. Nat Neurosci. 2006 Jan;9(1):23-5. doi: 10.1038/nn1616. Epub 2005 Dec 11.
- Bogialli S, Curini R, Di Corcia A, Nazzari M, Sergi M. Confirmatory analysis of sulfonamide antibacterials in bovine liver and kidney: extraction with hot water and liquid chromatography coupled to a single- or triple-quadrupole mass spectrometer. Rapid Commun Mass Spectrom. 2003;17(11):1146-56. doi: 10.1002/rcm.1031.
- Rieger JW, Kim A, Argyelan M, Farber M, Glazman S, Liebeskind M, Meyer T, Bodis-Wollner I. Cortical functional anatomy of voluntary saccades in Parkinson disease. Clin EEG Neurosci. 2008 Oct;39(4):169-74. doi: 10.1177/155005940803900404.
- Barros M, Dempster EL, Illott N, Chabrawi S, Maior RS, Tomaz C, Silva MA, Huston JP, Mill J, Muller CP. Decreased methylation of the NK3 receptor coding gene (TACR3) after cocaine-induced place preference in marmoset monkeys. Addict Biol. 2013 May;18(3):452-4. doi: 10.1111/j.1369-1600.2011.00409.x. Epub 2011 Nov 9.
연구 기록 날짜
연구 주요 날짜
연구 시작
기본 완료 (예상)
연구 완료 (예상)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (추정)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
추가 관련 MeSH 약관
기타 연구 ID 번호
- 07052012
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .