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비소세포폐암에서 1차 치료 및 유지 관리로서 펨브롤리주맙 단독 또는 화학요법의 시기 테스트

2026년 10월 23일 업데이트: National Cancer Institute (NCI)

EA5163/S1709 INSIGNA: A Randomized, Phase III Study of Firstline Immunotherapy Alone or in Combination With Chemotherapy in Induction/Maintenance or Postprogression in Advanced Nonsquamous Non-Small Cell Lung Cancer (NSCLC) With Immunobiomarker Signature-Driven Analysis

This phase III trial studies whether pembrolizumab alone as a first-line treatment, followed by pemetrexed and carboplatin with or without pembrolizumab after disease progression is superior to induction with pembrolizumab, pemetrexed and carboplatin followed by pembrolizumab and pemetrexed maintenance in treating patients with stage IV non-squamous non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as pemetrexed, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. It is not yet known whether giving first-line pembrolizumab followed by pemetrexed and carboplatin with or without pembrolizumab works better in treating patients with non-squamous non-small cell cancer.

연구 개요

상태

모집하지 않고 적극적으로

정황

개입 / 치료

상세 설명

PRIMARY OBJECTIVE:

I. To evaluate overall survival (OS) in each of the 2 experimental arms (Arms A and B) to control (Arm C).

SECONDARY OBJECTIVES:

I. To evaluate progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 for Arm C versus each of Arms A and B.

II. To evaluate best objective response rates per RECIST 1.1 for Arm C versus each of Arms A and B.

III. To estimate toxicity within each of the treatment arms via the Common Terminology Criteria for Adverse Events (CTCAE) criteria.

IV. To compare outcomes between Arms A and B. V. To compare outcomes by treatment arm within subgroups defined by a cutpoint of PD-L1 expression at >= 50%.

BIOMARKER OBJECTIVE:

I. To collect and bank tissue and blood for future research studies, including potential development of a prognostic and predictive signature for pembrolizumab (MK-3475) in combination with chemotherapy versus pembrolizumab (MK-3475) alone.

EXPLORATORY IMAGING OBJECTIVES:

I. To collect and bank standard of care computed tomography (CT) imaging at baseline and first three follow-up post-treatment scans on first line treatment for validating the radiomic risk score with the following exploratory objectives:

Ia. To determine the negative predictive value (NPV) by validating the Radiomic Risk score on pre-treatment scans as well as compute differences between pre- and post- treatment scans (delta features) in determining which patients will benefit from first line pembrolizumab in the metastatic setting in both low (< 50%) and high (> 50%) PD-L1 cohorts using patients in Arm 1 and Arm 2 of the trial where pembrolizumab is used as first line treatment.

Ib. To determine the positive predictive value (PPV) by validating the Radiomic Risk score in order to predict which patients would benefit from combination pembrolizumab and subsequent chemotherapy versus (vs.) immunotherapy alone in both low (< 50%) and high (> 50%) PD-L1 cohorts using patients who went on to receive chemotherapy as second line and stratifying the patients based on those who received benefit from pembrolizumab plus chemotherapy vs.pembrolizumab alone.

OUTLINE: Patients are randomized to 1 of 3 arms.

ARM A: Patients receive pembrolizumab intravenously (IV) over 30 minutes on day 1. Cycles repeat every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity. Within 6 weeks of disease progression, patients receive pemetrexed IV over 10 minutes and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients then may receive pemetrexed IV over 10 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive pembrolizumab IV over 30 minutes on day 1. Cycles repeat every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity. Within 6 weeks of disease progression, patients receive pembrolizumab IV over 30 minutes, pemetrexed IV over 10 minutes, and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive pembrolizumab IV over 30 minutes and pemetrexed IV over 10 minutes on day 1. Cycles repeat every 21 days for up to 2 years for pembrolizumab in the absence of disease progression or unacceptable toxicity and until to disease progression for pemetrexed.

ARM C: Patients receive pembrolizumab IV over 30 minutes, pemetrexed IV over 10 minutes, and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive pembrolizumab IV over 30 minutes and pemetrexed IV over 10 minutes on day 1. Cycles repeat every 21 days for up to 2 years for pembrolizumab in the absence of disease progression or unacceptable toxicity and until to disease progression for pemetrexed.

Patients undergo magnetic resonance imaging (MRI) during screening, CT scan and blood sample collection throughout the study, and may undergo position emission tomography (PET) scan throughout the study.

After completion of study treatment, patients are followed up for 5 years.

연구 유형

중재적

등록 (추정된)

600

단계

3단계

연락처 및 위치

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연구 장소

괌
- - Tamuning, 괌, 96913
    - FHP Health Center-Guam
미국
- Alabama
  - Mobile, Alabama, 미국, 36688
    - University of South Alabama Mitchell Cancer Institute
- Alaska
  - Anchorage, Alaska, 미국, 98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage, Alaska, 미국, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, 미국, 99508
    - Alaska Oncology and Hematology LLC
  - Anchorage, Alaska, 미국, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, 미국, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, 미국, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, 미국, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, 미국, 99504
    - Anchorage Radiation Therapy Center
  - Fairbanks, Alaska, 미국, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Kingman, Arizona, 미국, 86401
    - Kingman Regional Medical Center
  - Phoenix, Arizona, 미국, 85004
    - Cancer Center at Saint Joseph's
  - Tucson, Arizona, 미국, 85704
    - University of Arizona Cancer Center-Orange Grove Campus
  - Tucson, Arizona, 미국, 85719
    - Banner University Medical Center - Tucson
  - Tucson, Arizona, 미국, 85719
    - University of Arizona Cancer Center-North Campus
- Arkansas
  - Fort Smith, Arkansas, 미국, 72903
    - Mercy Hospital Fort Smith
  - Hot Springs, Arkansas, 미국, 71913
    - CHI Saint Vincent Cancer Center Hot Springs
  - Jonesboro, Arkansas, 미국, 72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
  - Little Rock, Arkansas, 미국, 72205
    - CARTI Cancer Center
- California
  - Anaheim, California, 미국, 92806
    - Kaiser Permanente-Anaheim
  - Antioch, California, 미국, 94531
    - Kaiser Permanente-Deer Valley Medical Center
  - Arroyo Grande, California, 미국, 93420
    - PCR Oncology
  - Arroyo Grande, California, 미국, 93420
    - Mission Hope Medical Oncology - Arroyo Grande
  - Auburn, California, 미국, 95602
    - Sutter Auburn Faith Hospital
  - Auburn, California, 미국, 95603
    - Sutter Cancer Centers Radiation Oncology Services-Auburn
  - Baldwin Park, California, 미국, 91706
    - Kaiser Permanente-Baldwin Park
  - Bellflower, California, 미국, 90706
    - Kaiser Permanente-Bellflower
  - Berkeley, California, 미국, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Beverly Hills, California, 미국, 90211
    - Tower Cancer Research Foundation
  - Burbank, California, 미국, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame, California, 미국, 94010
    - Mills-Peninsula Medical Center
  - Cameron Park, California, 미국, 95682
    - Sutter Cancer Centers Radiation Oncology Services-Cameron Park
  - Carmichael, California, 미국, 95608
    - Mercy San Juan Medical Center
  - Carmichael, California, 미국, 95608
    - Mercy Cancer Center - Carmichael
  - Castro Valley, California, 미국, 94546
    - Eden Hospital Medical Center
  - Davis, California, 미국, 95616
    - Sutter Davis Hospital
  - Dublin, California, 미국, 94568
    - Kaiser Permanente Dublin
  - El Segundo, California, 미국, 90245
    - 21st Century Oncology - El Segundo
  - Elk Grove, California, 미국, 95758
    - Mercy Cancer Center - Elk Grove
  - Fontana, California, 미국, 92335
    - Kaiser Permanente-Fontana
  - Fremont, California, 미국, 94538
    - Kaiser Permanente-Fremont
  - Fremont, California, 미국, 94538
    - Palo Alto Medical Foundation-Fremont
  - Fresno, California, 미국, 93720
    - Kaiser Permanente-Fresno
  - Fresno, California, 미국, 93720
    - Fresno Cancer Center
  - Harbor City, California, 미국, 90710
    - Kaiser Permanente South Bay
  - Irvine, California, 미국, 92618
    - Kaiser Permanente-Irvine
  - Los Angeles, California, 미국, 90048
    - Cedars-Sinai Medical Center
  - Los Angeles, California, 미국, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles, California, 미국, 90034
    - Kaiser Permanente West Los Angeles
  - Marysville, California, 미국, 95901
    - Fremont - Rideout Cancer Center
  - Merced, California, 미국, 95340
    - Mercy Cancer Center
  - Modesto, California, 미국, 95355
    - Memorial Medical Center
  - Modesto, California, 미국, 95356
    - Kaiser Permanente-Modesto
  - Mountain View, California, 미국, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View, California, 미국, 94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Novato, California, 미국, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, 미국, 94611
    - Kaiser Permanente-Oakland
  - Oakland, California, 미국, 94611
    - Kaiser Permanente Oakland-Broadway
  - Ontario, California, 미국, 91761
    - Kaiser Permanente-Ontario
  - Orange, California, 미국, 92868
    - Saint Joseph Hospital - Orange
  - Palo Alto, California, 미국, 94304
    - VA Palo Alto Health Care System
  - Palo Alto, California, 미국, 94301
    - Palo Alto Medical Foundation Health Care
  - Panorama City, California, 미국, 91402
    - Kaiser Permanente - Panorama City
  - Rancho Cordova, California, 미국, 95670
    - Kaiser Permanente-Rancho Cordova Cancer Center
  - Redwood City, California, 미국, 94063
    - Kaiser Permanente-Redwood City
  - Redwood City, California, 미국, 94063
    - Kaiser Permanente- Marshall Medical Offices
  - Richmond, California, 미국, 94801
    - Kaiser Permanente-Richmond
  - Riverside, California, 미국, 92505
    - Kaiser Permanente-Riverside
  - Rocklin, California, 미국, 95765
    - Mercy Cancer Center - Rocklin
  - Rohnert Park, California, 미국, 94928
    - Rohnert Park Cancer Center
  - Roseville, California, 미국, 95678
    - The Permanente Medical Group-Roseville Radiation Oncology
  - Roseville, California, 미국, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, 미국, 95661
    - Sutter Cancer Centers Radiation Oncology Services-Roseville
  - Roseville, California, 미국, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, 미국, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, 미국, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, 미국, 95814
    - Kaiser Permanente Downtown Commons
  - Sacramento, California, 미국, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, 미국, 95823
    - South Sacramento Cancer Center
  - Sacramento, California, 미국, 95816
    - Mercy Cancer Center - Sacramento
  - San Diego, California, 미국, 92120
    - Kaiser Permanente-San Diego Zion
  - San Diego, California, 미국, 92108
    - Kaiser Permanente-Rio San Diego
  - San Francisco, California, 미국, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, 미국, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Francisco, California, 미국, 94110
    - Zuckerberg San Francisco General Hospital
  - San Jose, California, 미국, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro, California, 미국, 94577
    - Kaiser Permanente San Leandro
  - San Luis Obispo, California, 미국, 93401
    - Pacific Central Coast Health Center-San Luis Obispo
  - San Marcos, California, 미국, 92078
    - Kaiser Permanente-San Marcos
  - San Rafael, California, 미국, 94903
    - Kaiser San Rafael-Gallinas
  - Santa Clara, California, 미국, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Cruz, California, 미국, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Maria, California, 미국, 93444
    - Mission Hope Medical Oncology - Santa Maria
  - Santa Rosa, California, 미국, 95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa, California, 미국, 95403
    - Sutter Pacific Medical Foundation
  - South San Francisco, California, 미국, 94080
    - Kaiser Permanente Cancer Treatment Center
  - South San Francisco, California, 미국, 94080
    - Kaiser Permanente-South San Francisco
  - St. Helena, California, 미국, 94574
    - Saint Helena Hospital
  - Stockton, California, 미국, 95210
    - Kaiser Permanente-Stockton
  - Sunnyvale, California, 미국, 94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Tarzana, California, 미국, 91356
    - Cedars-Sinai Cancer - Tarzana
  - Torrance, California, 미국, 90509
    - Torrance Memorial Medical Center
  - Torrance, California, 미국, 90505
    - Torrance Memorial Physician Network - Cancer Care
  - Vacaville, California, 미국, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vallejo, California, 미국, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, 미국, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, 미국, 94596
    - Kaiser Permanente-Walnut Creek
  - Woodland, California, 미국, 95695
    - Woodland Memorial Hospital
  - Woodland Hills, California, 미국, 91367
    - Kaiser Permanente-Woodland Hills
- Colorado
  - Aurora, Colorado, 미국, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, 미국, 80012
    - The Medical Center of Aurora
  - Aurora, Colorado, 미국, 80045
    - UCHealth University of Colorado Hospital
  - Boulder, Colorado, 미국, 80303
    - Boulder Community Foothills Hospital
  - Boulder, Colorado, 미국, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Centennial, Colorado, 미국, 80112
    - Rocky Mountain Cancer Centers - Centennial
  - Colorado Springs, Colorado, 미국, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, 미국, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Colorado Springs, Colorado, 미국, 80923
    - Saint Francis Cancer Center
  - Denver, Colorado, 미국, 80205
    - Kaiser Permanente-Franklin
  - Denver, Colorado, 미국, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, 미국, 80220
    - Rose Medical Center
  - Denver, Colorado, 미국, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, 미국, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, 미국, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, 미국, 80204
    - Cancer Center of Colorado at Sloan's Lake
  - Denver, Colorado, 미국, 80209
    - The Women's Imaging Center
  - Denver, Colorado, 미국, 80206
    - National Jewish Health-Main Campus
  - Denver, Colorado, 미국, 80220
    - Western Surgical Care
  - Denver, Colorado, 미국, 80218
    - Saint Joseph Hospital - Cancer Centers of Colorado
  - Denver, Colorado, 미국, 80210
    - AdventHealth Porter
  - Durango, Colorado, 미국, 81301
    - Mercy Medical Center
  - Durango, Colorado, 미국, 81301
    - CommonSpirit Cancer Center Mercy
  - Englewood, Colorado, 미국, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, 미국, 80113
    - Swedish Medical Center
  - Englewood, Colorado, 미국, 80113
    - Rocky Mountain Cancer Centers - Swedish
  - Englewood, Colorado, 미국, 80113
    - The Melanoma and Skin Cancer Institute
  - Fort Collins, Colorado, 미국, 80524
    - Poudre Valley Hospital
  - Fort Collins, Colorado, 미국, 80528
    - Cancer Care and Hematology-Fort Collins
  - Golden, Colorado, 미국, 80401
    - Mountain Blue Cancer Care Center
  - Golden, Colorado, 미국, 80401
    - National Jewish Health-Western Hematology Oncology
  - Grand Junction, Colorado, 미국, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Grand Junction, Colorado, 미국, 81505
    - Grand Valley Oncology
  - Greeley, Colorado, 미국, 80631
    - UCHealth Greeley Hospital
  - Greeley, Colorado, 미국, 80631
    - Banner North Colorado Medical Center
  - Highlands Ranch, Colorado, 미국, 80129
    - UCHealth Highlands Ranch Hospital
  - Lafayette, Colorado, 미국, 80026
    - Kaiser Permanente-Rock Creek
  - Lafayette, Colorado, 미국, 80026
    - Good Samaritan Hospital - Cancer Centers of Colorado
  - Lakewood, Colorado, 미국, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Lakewood, Colorado, 미국, 80228
    - CommonSpirit Saint Anthony Hospital Cancer Center
  - Littleton, Colorado, 미국, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, 미국, 80122
    - AdventHealth Littleton
  - Lone Tree, Colorado, 미국, 80124
    - Kaiser Permanente-Lone Tree
  - Lone Tree, Colorado, 미국, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, 미국, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, 미국, 80501
    - Longmont United Hospital
  - Longmont, Colorado, 미국, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, 미국, 80538
    - Medical Center of the Rockies
  - Loveland, Colorado, 미국, 80539
    - Banner North Colorado Medical Center - Loveland Campus
  - Parker, Colorado, 미국, 80138
    - Rocky Mountain Cancer Centers-Parker
  - Parker, Colorado, 미국, 80138
    - AdventHealth Parker
  - Pueblo, Colorado, 미국, 81004
    - Saint Mary Corwin Medical Center
  - Pueblo, Colorado, 미국, 81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton, Colorado, 미국, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton, Colorado, 미국, 80260
    - National Jewish Health-Northern Hematology Oncology
  - Wheat Ridge, Colorado, 미국, 80401
    - Intermountain Health Lutheran Hospital
- Connecticut
  - Derby, Connecticut, 미국, 06418
    - Smilow Cancer Hospital-Derby Care Center
  - Fairfield, Connecticut, 미국, 06824
    - Smilow Cancer Hospital Care Center-Fairfield
  - Guilford, Connecticut, 미국, 06437
    - Smilow Cancer Hospital Care Center - Guilford
  - Hartford, Connecticut, 미국, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - New Haven, Connecticut, 미국, 06520
    - Yale University
  - New Haven, Connecticut, 미국, 06510
    - Smilow Cancer Center/Yale-New Haven Hospital
  - North Haven, Connecticut, 미국, 06473
    - Yale-New Haven Hospital North Haven Medical Center
  - Orange, Connecticut, 미국, 06477
    - Smilow Cancer Hospital-Orange Care Center
  - Stamford, Connecticut, 미국, 06904
    - Stamford Hospital/Bennett Cancer Center
  - Stamford, Connecticut, 미국, 06902
    - Smilow Cancer Hospital Care Center at Long Ridge
  - Torrington, Connecticut, 미국, 06790
    - Smilow Cancer Hospital-Torrington Care Center
  - Trumbull, Connecticut, 미국, 06611
    - Smilow Cancer Hospital Care Center-Trumbull
  - Waterbury, Connecticut, 미국, 06708
    - Smilow Cancer Hospital-Waterbury Care Center
  - Waterford, Connecticut, 미국, 06385
    - Smilow Cancer Hospital Care Center - Waterford
  - West Haven, Connecticut, 미국, 06516
    - Veterans Affairs Connecticut Healthcare System-West Haven Campus
- Delaware
  - Lewes, Delaware, 미국, 19958
    - Beebe Medical Center
  - Millville, Delaware, 미국, 19967
    - Beebe South Coastal Health Campus
  - Newark, Delaware, 미국, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, 미국, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, 미국, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, 미국, 19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach, Delaware, 미국, 19971
    - Beebe Health Campus
  - Seaford, Delaware, 미국, 19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington, Delaware, 미국, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C., District of Columbia, 미국, 20037
    - George Washington University Medical Center
  - Washington D.C., District of Columbia, 미국, 20010
    - MedStar Washington Hospital Center
  - Washington D.C., District of Columbia, 미국, 20007
    - MedStar Georgetown University Hospital
  - Washington D.C., District of Columbia, 미국, 20016
    - Sibley Memorial Hospital
- Florida
  - Aventura, Florida, 미국, 33180
    - Mount Sinai Comprehensive Cancer Center at Aventura
  - Aventura, Florida, 미국, 33180
    - GenesisCare USA - Aventura FP
  - Aventura, Florida, 미국, 33180
    - GenesisCare USA - Aventura
  - Boca Raton, Florida, 미국, 33428
    - GenesisCare USA - Boca Raton FP02
  - Boca Raton, Florida, 미국, 33431
    - GenesisCare USA - Boca Ration FP06
  - Fort Lauderdale, Florida, 미국, 33308
    - Holy Cross Hospital
  - Fort Myers, Florida, 미국, 33908
    - GenesisCare USA - Gladiolus
  - Gainesville, Florida, 미국, 32610
    - UF Health Cancer Institute - Gainesville
  - Jacksonville, Florida, 미국, 32224-9980
    - Mayo Clinic in Florida
  - Key West, Florida, 미국, 33040
    - GenesisCare USA - Key West
  - Lakewood Rch, Florida, 미국, 34202
    - GenesisCare USA - Lakewood Ranch
  - Miami Beach, Florida, 미국, 33140
    - Mount Sinai Medical Center
  - Palm Beach Gardens, Florida, 미국, 33410
    - GenesisCare USA - Palm Beach Gardens
  - Pensacola, Florida, 미국, 32504
    - Sacred Heart Hospital
  - Plantation, Florida, 미국, 33324
    - GenesisCare USA - Plantation
  - Tampa, Florida, 미국, 33612
    - Moffitt Cancer Center
  - Tampa, Florida, 미국, 33607
    - Moffitt Cancer Center-International Plaza
  - Tampa, Florida, 미국, 33612
    - Moffitt Cancer Center - McKinley Campus
  - West Palm Beach, Florida, 미국, 33401
    - Good Samaritan Medical Center
  - Weston, Florida, 미국, 33331
    - Cleveland Clinic-Weston
- Georgia
  - Athens, Georgia, 미국, 30607
    - University Cancer and Blood Center LLC
  - Atlanta, Georgia, 미국, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, 미국, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, 미국, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, 미국, 30342
    - Northside Hospital
  - Augusta, Georgia, 미국, 30912
    - Augusta University Medical Center
  - Augusta, Georgia, 미국, 30901
    - Augusta Oncology Associates PC-D'Antignac
  - Augusta, Georgia, 미국, 30909
    - Augusta Oncology Associates PC-Wheeler
  - Braselton, Georgia, 미국, 30517
    - Northeast Georgia Medical Center Braselton
  - Decatur, Georgia, 미국, 30033
    - Atlanta VA Medical Center
  - Duluth, Georgia, 미국, 30096
    - Northside Hospital - Duluth
  - Gainesville, Georgia, 미국, 30501
    - Northeast Georgia Medical Center-Gainesville
  - Gainesville, Georgia, 미국, 30501
    - The Longstreet Clinic - Gainesville
  - Lawrenceville, Georgia, 미국, 30046
    - Northside Hospital - Gwinnett
  - Savannah, Georgia, 미국, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah, Georgia, 미국, 31405
    - Summit Cancer Care-Candler
  - Snellville, Georgia, 미국, 30078
    - Suburban Hematology Oncology Associates - Snellville
  - Thomasville, Georgia, 미국, 31792
    - Lewis Hall Singletary Oncology Center
  - Valdosta, Georgia, 미국, 31602
    - South Georgia Medical Center/Pearlman Cancer Center
- Hawaii
  - Honolulu, Hawaii, 미국, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, 미국, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, 미국, 96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu, Hawaii, 미국, 96813
    - Queen's Cancer Cenrer - POB I
  - Honolulu, Hawaii, 미국, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, 미국, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, 미국, 96817
    - Hawaii Cancer Care Inc-Liliha
  - Honolulu, Hawaii, 미국, 96817
    - Kuakini Medical Center
  - Honolulu, Hawaii, 미국, 96817
    - Queen's Cancer Center - Kuakini
  - Honolulu, Hawaii, 미국, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, 미국, 96813
    - Island Urology
  - Honolulu, Hawaii, 미국, 96819
    - Kaiser Permanente Moanalua Medical Center
  - Honolulu, Hawaii, 미국, 96817
    - Hawaii Diagnostic Radiology Services LLC
  - Kahului, Hawaii, 미국, 96732
    - Straub Medical Center - Kahului Clinic
  - Kailua, Hawaii, 미국, 96734
    - Castle Medical Center
  - Lihue, Hawaii, 미국, 96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
  - ‘Aiea, Hawaii, 미국, 96701
    - Hawaii Cancer Care - Westridge
  - ‘Aiea, Hawaii, 미국, 96701
    - Pali Momi Medical Center
  - ‘Aiea, Hawaii, 미국, 96701
    - Queen's Cancer Center - Pearlridge
  - ‘Aiea, Hawaii, 미국, 96701
    - The Cancer Center of Hawaii-Pali Momi
  - ‘Aiea, Hawaii, 미국, 96701
    - Straub Pearlridge Clinic
  - ‘Ewa Beach, Hawaii, 미국, 96706
    - The Queen's Medical Center - West Oahu
- Idaho
  - Boise, Idaho, 미국, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, 미국, 83712
    - Saint Luke's Cancer Institute - Boise
  - Caldwell, Idaho, 미국, 83605
    - Saint Alphonsus Cancer Care Center-Caldwell
  - Coeur d'Alene, Idaho, 미국, 83814
    - Kootenai Health - Coeur d'Alene
  - Emmett, Idaho, 미국, 83617
    - Walter Knox Memorial Hospital
  - Fruitland, Idaho, 미국, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian, Idaho, 미국, 83642
    - Idaho Urologic Institute-Meridian
  - Meridian, Idaho, 미국, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, 미국, 83687
    - Saint Alphonsus Cancer Care Center-Nampa
  - Nampa, Idaho, 미국, 83687
    - Saint Luke's Cancer Institute - Nampa
  - Post Falls, Idaho, 미국, 83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Sandpoint, Idaho, 미국, 83864
    - Kootenai Clinic Cancer Services - Sandpoint
  - Twin Falls, Idaho, 미국, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Alton, Illinois, 미국, 62002
    - OSF Saint Anthony's Health Center
  - Aurora, Illinois, 미국, 60504
    - Rush-Copley Medical Center
  - Barrington, Illinois, 미국, 60010
    - Advocate Good Shepherd Hospital
  - Bloomington, Illinois, 미국, 61704
    - Illinois CancerCare-Bloomington
  - Burr Ridge, Illinois, 미국, 60527
    - Loyola Center for Health at Burr Ridge
  - Canton, Illinois, 미국, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, 미국, 62902
    - Memorial Hospital of Carbondale
  - Carterville, Illinois, 미국, 62918
    - SIH Cancer Institute
  - Carthage, Illinois, 미국, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, 미국, 62801
    - Centralia Oncology Clinic
  - Centralia, Illinois, 미국, 62801
    - Saint Mary's Hospital
  - Chicago, Illinois, 미국, 60611
    - Northwestern University
  - Chicago, Illinois, 미국, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, 미국, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, 미국, 60625
    - Swedish Covenant Hospital
  - Chicago, Illinois, 미국, 60657
    - Advocate Illinois Masonic Medical Center
  - Chicago, Illinois, 미국, 60612
    - Jesse Brown Veterans Affairs Medical Center
  - Chicago, Illinois, 미국, 60612
    - Rush MD Anderson Cancer Center
  - Crystal Lake, Illinois, 미국, 60014
    - AMG Crystal Lake - Oncology
  - Danville, Illinois, 미국, 61832
    - Carle at The Riverfront
  - Decatur, Illinois, 미국, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, 미국, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Dixon, Illinois, 미국, 61021
    - Illinois CancerCare-Dixon
  - Downers Grove, Illinois, 미국, 60515
    - Advocate Good Samaritan Hospital
  - Effingham, Illinois, 미국, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, 미국, 62401
    - Carle Physician Group-Effingham
  - Elgin, Illinois, 미국, 60123
    - Advocate Sherman Hospital
  - Elmhurst, Illinois, 미국, 60126
    - Elmhurst Memorial Hospital
  - Eureka, Illinois, 미국, 61530
    - Illinois CancerCare-Eureka
  - Evanston, Illinois, 미국, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Freeport, Illinois, 미국, 61032
    - Freeport Memorial Hospital/Leonard C Ferguson Cancer Center
  - Galesburg, Illinois, 미국, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, 미국, 61401
    - Illinois CancerCare-Galesburg
  - Glenview, Illinois, 미국, 60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Hazel Crest, Illinois, 미국, 60429
    - Advocate South Suburban Hospital
  - Highland Park, Illinois, 미국, 60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Hines, Illinois, 미국, 60141
    - Edward Hines Jr VA Hospital
  - Hinsdale, Illinois, 미국, 60521
    - UChicago Medicine AdventHealth Cancer Institute Hinsdale
  - Homer Glen, Illinois, 미국, 60491
    - Loyola Medicine Homer Glen
  - Joliet, Illinois, 미국, 60435
    - Duly Health and Care Joliet
  - Kewanee, Illinois, 미국, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Lake Forest, Illinois, 미국, 60045
    - Northwestern Medicine Lake Forest Hospital
  - Libertyville, Illinois, 미국, 60048
    - Condell Memorial Hospital
  - Libertyville, Illinois, 미국, 60048
    - AMG Libertyville - Oncology
  - Macomb, Illinois, 미국, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, 미국, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Maywood, Illinois, 미국, 60153
    - Loyola University Medical Center
  - Melrose Park, Illinois, 미국, 60160
    - Marjorie Weinberg Cancer Center at Loyola-Gottlieb
  - Mount Vernon, Illinois, 미국, 62864
    - SSM Health Good Samaritan
  - Naperville, Illinois, 미국, 60540
    - Edward Hospital/Cancer Center
  - New Lenox, Illinois, 미국, 60451
    - UC Comprehensive Cancer Center at Silver Cross
  - O'Fallon, Illinois, 미국, 62269
    - Cancer Care Center of O'Fallon
  - O'Fallon, Illinois, 미국, 62269
    - HSHS Saint Elizabeth's Hospital
  - Oak Lawn, Illinois, 미국, 60453-2699
    - Advocate Christ Medical Center
  - Orland Park, Illinois, 미국, 60462
    - University of Chicago Medicine-Orland Park
  - Orland Park, Illinois, 미국, 60462
    - Northwestern Medicine Orland Park
  - Ottawa, Illinois, 미국, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Park Ridge, Illinois, 미국, 60068
    - Advocate Lutheran General Hospital
  - Pekin, Illinois, 미국, 61554
    - Illinois CancerCare-Pekin
  - Peoria, Illinois, 미국, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, 미국, 61615
    - Illinois CancerCare-Peoria
  - Peru, Illinois, 미국, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, 미국, 61354
    - Valley Radiation Oncology
  - Plainfield, Illinois, 미국, 60585
    - Edward Hospital/Cancer Center?Plainfield
  - Princeton, Illinois, 미국, 61356
    - Illinois CancerCare-Princeton
  - Rockford, Illinois, 미국, 61114
    - UW Health Carbone Cancer Center Rockford
  - Springfield, Illinois, 미국, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, 미국, 62702
    - Springfield Clinic
  - Springfield, Illinois, 미국, 62781
    - Springfield Memorial Hospital
  - Swansea, Illinois, 미국, 62226
    - Southwest Illinois Health Services LLP
  - Urbana, Illinois, 미국, 61801
    - Carle Cancer Center
  - Urbana, Illinois, 미국, 61801
    - The Carle Foundation Hospital
  - Washington, Illinois, 미국, 61571
    - Illinois CancerCare - Washington
  - Yorkville, Illinois, 미국, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Richmond, Indiana, 미국, 47374
    - Reid Health
- Iowa
  - Ames, Iowa, 미국, 50010
    - Mary Greeley Medical Center
  - Ames, Iowa, 미국, 50010
    - McFarland Clinic - Ames
  - Ankeny, Iowa, 미국, 50023
    - UI Health Care Mission Cancer and Blood - Ankeny Clinic
  - Bettendorf, Iowa, 미국, 52722
    - University of Iowa Healthcare Cancer Services Quad Cities
  - Boone, Iowa, 미국, 50036
    - McFarland Clinic - Boone
  - Carroll, Iowa, 미국, 51401
    - Saint Anthony Regional Hospital
  - Cedar Rapids, Iowa, 미국, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, 미국, 52403
    - Oncology Associates at Mercy Medical Center
  - Clive, Iowa, 미국, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, 미국, 50325
    - UI Health Care Mission Cancer and Blood - West Des Moines Clinic
  - Council Bluffs, Iowa, 미국, 51503
    - Alegent Health Mercy Hospital
  - Council Bluffs, Iowa, 미국, 51503
    - Heartland Oncology and Hematology LLP
  - Council Bluffs, Iowa, 미국, 51503
    - Methodist Jennie Edmundson Hospital
  - Creston, Iowa, 미국, 50801
    - Greater Regional Medical Center
  - Des Moines, Iowa, 미국, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, 미국, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, 미국, 50314
    - Broadlawns Medical Center
  - Des Moines, Iowa, 미국, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, 미국, 50309
    - UI Health Care Mission Cancer and Blood - Des Moines Clinic
  - Des Moines, Iowa, 미국, 50314
    - UI Health Care Mission Cancer and Blood - Laurel Clinic
  - Fort Dodge, Iowa, 미국, 50501
    - McFarland Clinic - Trinity Cancer Center
  - Fort Dodge, Iowa, 미국, 50501
    - UI Healthcare Mission Cancer and Blood - Fort Dodge
  - Iowa City, Iowa, 미국, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - Jefferson, Iowa, 미국, 50129
    - McFarland Clinic - Jefferson
  - Marshalltown, Iowa, 미국, 50158
    - McFarland Clinic - Marshalltown
  - Sioux City, Iowa, 미국, 51101
    - Siouxland Regional Cancer Center
  - Waterloo, Iowa, 미국, 50702
    - MercyOne Waterloo Cancer Center
  - West Des Moines, Iowa, 미국, 50266-7700
    - Methodist West Hospital
  - West Des Moines, Iowa, 미국, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute, Kansas, 미국, 66720
    - Cancer Center of Kansas - Chanute
  - Coffeyville, Kansas, 미국, 67337
    - Coffeyville Regional Medical Center
  - Dodge City, Kansas, 미국, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, 미국, 67042
    - Cancer Center of Kansas - El Dorado
  - Fairway, Kansas, 미국, 66205
    - University of Kansas Clinical Research Center
  - Garden City, Kansas, 미국, 67846
    - Central Care Cancer Center - Garden City
  - Great Bend, Kansas, 미국, 67530
    - Central Care Cancer Center - Great Bend
  - Hays, Kansas, 미국, 67601
    - HaysMed
  - Independence, Kansas, 미국, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, 미국, 66112
    - University of Kansas Cancer Center-West
  - Kingman, Kansas, 미국, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, 미국, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, 미국, 67905
    - Cancer Center of Kansas-Liberal
  - Manhattan, Kansas, 미국, 66502
    - Cancer Center of Kansas-Manhattan
  - McPherson, Kansas, 미국, 67460
    - Cancer Center of Kansas - McPherson
  - Newton, Kansas, 미국, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, 미국, 66061
    - The University of Kansas Cancer Center - Olathe
  - Overland Park, Kansas, 미국, 66210
    - University of Kansas Cancer Center-Overland Park
  - Overland Park, Kansas, 미국, 66213
    - Saint Luke's South Hospital
  - Parsons, Kansas, 미국, 67357
    - Cancer Center of Kansas - Parsons
  - Pittsburg, Kansas, 미국, 66762
    - Freeman Physician Group of Pittsburg
  - Pittsburg, Kansas, 미국, 66762
    - Mercy Hospital Pittsburg
  - Pratt, Kansas, 미국, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, 미국, 67401
    - Salina Regional Health Center
  - Salina, Kansas, 미국, 67401
    - Cancer Center of Kansas - Salina
  - Topeka, Kansas, 미국, 66606
    - University of Kansas Health System Saint Francis Campus
  - Wellington, Kansas, 미국, 67152
    - Cancer Center of Kansas - Wellington
  - Westwood, Kansas, 미국, 66205
    - University of Kansas Hospital-Westwood Cancer Center
  - Wichita, Kansas, 미국, 67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita, Kansas, 미국, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, 미국, 67214
    - Cancer Center of Kansas - Wichita
  - Winfield, Kansas, 미국, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Bardstown, Kentucky, 미국, 40004
    - CommonSpirit Saint Joseph Hospital - Bardstown
  - Corbin, Kentucky, 미국, 40701
    - Commonwealth Cancer Center-Corbin
  - Lexington, Kentucky, 미국, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, 미국, 40509
    - CommonSpirit Saint Joseph Medical Center - East Lexington
  - Lexington, Kentucky, 미국, 40504
    - CommonSpirit Saint Joseph Hospital - Lexington
  - London, Kentucky, 미국, 40741
    - CommonSpirit Saint Joseph Hospital London
  - Louisville, Kentucky, 미국, 40202
    - Jewish Hospital
  - Louisville, Kentucky, 미국, 40245
    - UofL Health Medical Center Northeast
  - Louisville, Kentucky, 미국, 40215
    - Saints Mary and Elizabeth Hospital
  - Mount Sterling, Kentucky, 미국, 40353
    - CommonSpirit Saint Joseph Hospital Mount Sterling
  - Paducah, Kentucky, 미국, 42003
    - Mercy Health - Paducah Cancer Center
  - Shepherdsville, Kentucky, 미국, 40165
    - Jewish Hospital Medical Center South
- Louisiana
  - Marrero, Louisiana, 미국, 70072
    - West Jefferson Medical Center
  - Monroe, Louisiana, 미국, 71202
    - Ochsner LSU Health Monroe Medical Center
  - New Orleans, Louisiana, 미국, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, 미국, 70112
    - Louisiana State University Health Science Center
  - New Orleans, Louisiana, 미국, 70112
    - Veteran's Administration Medical Center - New Orleans
  - Shreveport, Louisiana, 미국, 71103
    - LSU Health Sciences Center at Shreveport
- Maine
  - Bangor, Maine, 미국, 04401
    - Eastern Maine Medical Center
  - Brewer, Maine, 미국, 04412
    - Lafayette Family Cancer Center-EMMC
- Maryland
  - Baltimore, Maryland, 미국, 21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore, Maryland, 미국, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, 미국, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, 미국, 21239
    - MedStar Good Samaritan Hospital
  - Easton, Maryland, 미국, 21601
    - University of Maryland Shore Medical Center at Easton
  - Elkton, Maryland, 미국, 21921
    - Christiana Care - Union Hospital
- Massachusetts
  - Beverly, Massachusetts, 미국, 01915
    - Beverly Hospital
  - Burlington, Massachusetts, 미국, 01805
    - Lahey Clinic
  - Gloucester, Massachusetts, 미국, 01930
    - Addison Gilbert Hospital
  - Lowell, Massachusetts, 미국, 01854
    - Lowell General Hospital
  - Peabody, Massachusetts, 미국, 01960
    - Lahey Clinic Peabody
  - Springfield, Massachusetts, 미국, 01199
    - Baystate Medical Center
  - Springfield, Massachusetts, 미국, 01104
    - Mercy Medical Center
  - Winchester, Massachusetts, 미국, 01890
    - Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care
  - Worcester, Massachusetts, 미국, 01655
    - UMass Memorial Medical Center - University Campus
- Michigan
  - Adrian, Michigan, 미국, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, 미국, 48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Battle Creek, Michigan, 미국, 49017
    - Bronson Battle Creek
  - Brighton, Michigan, 미국, 48114
    - Trinity Health IHA Medical Group Hematology Oncology - Brighton
  - Brighton, Michigan, 미국, 48114
    - Trinity Health Medical Center - Brighton
  - Canton, Michigan, 미국, 48188
    - Trinity Health IHA Medical Group Hematology Oncology - Canton
  - Canton, Michigan, 미국, 48188
    - Trinity Health Medical Center - Canton
  - Caro, Michigan, 미국, 48723
    - Caro Cancer Center
  - Chelsea, Michigan, 미국, 48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Chelsea, Michigan, 미국, 48118
    - Chelsea Hospital
  - Clarkston, Michigan, 미국, 48346
    - Hematology Oncology Consultants-Clarkston
  - Clarkston, Michigan, 미국, 48346
    - Newland Medical Associates-Clarkston
  - Clarkston, Michigan, 미국, 48346
    - Michigan Healthcare Professionals Clarkston
  - Detroit, Michigan, 미국, 48236
    - Henry Ford Health Saint John Hospital
  - East China Township, Michigan, 미국, 48054
    - Henry Ford River District Hospital
  - Escanaba, Michigan, 미국, 49829
    - OSF Saint Francis Hospital and Medical Group
  - Farmington Hills, Michigan, 미국, 48334
    - Michigan Healthcare Professionals Farmington
  - Flint, Michigan, 미국, 48503
    - Hurley Medical Center
  - Flint, Michigan, 미국, 48503
    - Genesee Hematology Oncology PC
  - Flint, Michigan, 미국, 48503
    - Genesys Hurley Cancer Institute
  - Flint, Michigan, 미국, 48503
    - Cancer Hematology Centers - Flint
  - Grand Rapids, Michigan, 미국, 49503
    - Trinity Health Grand Rapids Hospital
  - Grand Rapids, Michigan, 미국, 49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Grand Rapids, Michigan, 미국, 49503
    - Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
  - Grosse Pointe Woods, Michigan, 미국, 48236
    - Henry Ford Saint John Hospital - Academic
  - Grosse Pointe Woods, Michigan, 미국, 48236
    - Henry Ford Saint John Hospital - Breast
  - Grosse Pointe Woods, Michigan, 미국, 48236
    - Henry Ford Saint John Hospital - Van Elslander
  - Kalamazoo, Michigan, 미국, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, 미국, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, 미국, 49009
    - Beacon Kalamazoo Cancer Center
  - Kalamazoo, Michigan, 미국, 49048
    - Beacon Kalamazoo
  - Lansing, Michigan, 미국, 48912
    - University of Michigan Health - Sparrow Lansing
  - Livonia, Michigan, 미국, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Livonia, Michigan, 미국, 48154
    - Hope Cancer Clinic
  - Macomb, Michigan, 미국, 48044
    - Michigan Healthcare Professionals Macomb
  - Macomb, Michigan, 미국, 48044
    - Henry Ford Warren Hospital - Breast Macomb
  - Macomb, Michigan, 미국, 48044
    - Henry Ford Saint John Hospital - Macomb Medical
  - Madison Heights, Michigan, 미국, 48071
    - Michigan Healthcare Professionals Madison Heights
  - Marlette, Michigan, 미국, 48453
    - Saint Mary's Oncology/Hematology Associates of Marlette
  - Monroe, Michigan, 미국, 48162
    - Toledo Clinic Cancer Centers-Monroe
  - Muskegon, Michigan, 미국, 49444
    - Trinity Health Muskegon Hospital
  - Niles, Michigan, 미국, 49120
    - Corewell Health Lakeland Hospitals - Niles Hospital
  - Norton Shores, Michigan, 미국, 49444
    - Cancer and Hematology Centers of Western Michigan - Norton Shores
  - Novi, Michigan, 미국, 48374
    - Henry Ford Health Providence Novi Hospital
  - Pontiac, Michigan, 미국, 48341
    - Hope Cancer Center
  - Pontiac, Michigan, 미국, 48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Pontiac, Michigan, 미국, 48341
    - Michigan Healthcare Professionals Pontiac
  - Pontiac, Michigan, 미국, 48341
    - Trinity Health IHA Medical Group-Alice Gustafson Center
  - Port Huron, Michigan, 미국, 48060
    - Lake Huron Medical Center
  - Port Huron, Michigan, 미국, 48060
    - Huron Medical Center PC
  - Reed City, Michigan, 미국, 49677
    - Corewell Health Reed City Hospital
  - Rochester Hills, Michigan, 미국, 48309
    - Henry Ford Rochester Hospital
  - Saginaw, Michigan, 미국, 48604
    - Oncology Hematology Associates of Saginaw Valley PC
  - Saginaw, Michigan, 미국, 48601
    - MyMichigan Medical Center Saginaw
  - Saint Joseph, Michigan, 미국, 49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, 미국, 49085
    - Corewell Health Lakeland Hospitals - Saint Joseph Hospital
  - Southfield, Michigan, 미국, 48075
    - Henry Ford Health Providence Southfield Hospital
  - Sterling Heights, Michigan, 미국, 48312
    - Bhadresh Nayak MD PC-Sterling Heights
  - Tawas City, Michigan, 미국, 48764
    - MyMichigan Medical Center Tawas
  - Traverse City, Michigan, 미국, 49684
    - Munson Medical Center
  - Troy, Michigan, 미국, 48098
    - Michigan Healthcare Professionals Troy
  - Warren, Michigan, 미국, 48088
    - Advanced Breast Care Center PLLC
  - Warren, Michigan, 미국, 48093
    - Macomb Hematology Oncology PC
  - Warren, Michigan, 미국, 48093
    - Henry Ford Madison Heights Hospital - Breast
  - Warren, Michigan, 미국, 48093
    - Henry Ford Health Warren Hospital
  - Warren, Michigan, 미국, 48093
    - Henry Ford Warren Hospital - GLCMS
  - West Branch, Michigan, 미국, 48661
    - Saint Mary's Oncology/Hematology Associates of West Branch
  - Wyoming, Michigan, 미국, 49519
    - University of Michigan Health - West
  - Ypsilanti, Michigan, 미국, 48197
    - Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
  - Ypsilanti, Michigan, 미국, 48106
    - Huron Gastroenterology PC
- Minnesota
  - Aitkin, Minnesota, 미국, 56431
    - Riverwood Healthcare Center
  - Albert Lea, Minnesota, 미국, 56007
    - Mayo Clinic Health System in Albert Lea
  - Baxter, Minnesota, 미국, 56425
    - Essentia Health - Baxter Clinic
  - Bemidji, Minnesota, 미국, 56601
    - Sanford Joe Lueken Cancer Center
  - Brainerd, Minnesota, 미국, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville, Minnesota, 미국, 55337
    - Fairview Ridges Hospital
  - Burnsville, Minnesota, 미국, 55337
    - Minnesota Oncology - Burnsville
  - Cambridge, Minnesota, 미국, 55008
    - Cambridge Medical Center
  - Coon Rapids, Minnesota, 미국, 55433
    - Mercy Hospital
  - Deer River, Minnesota, 미국, 56636
    - Essentia Health - Deer River Clinic
  - Detroit Lakes, Minnesota, 미국, 56501
    - Essentia Health Saint Mary's - Detroit Lakes Clinic
  - Duluth, Minnesota, 미국, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, 미국, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, 미국, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, 미국, 55435
    - Fairview Southdale Hospital
  - Ely, Minnesota, 미국, 55731
    - Essentia Health - Ely Clinic
  - Fergus Falls, Minnesota, 미국, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fosston, Minnesota, 미국, 56542
    - Essentia Health - Fosston
  - Fridley, Minnesota, 미국, 55432
    - Unity Hospital
  - Hibbing, Minnesota, 미국, 55746
    - Essentia Health Hibbing Clinic
  - International Falls, Minnesota, 미국, 56649
    - Essentia Health - International Falls Clinic
  - Mankato, Minnesota, 미국, 56001
    - Mayo Clinic Health Systems-Mankato
  - Maple Grove, Minnesota, 미국, 55369
    - Fairview Clinics and Surgery Center Maple Grove
  - Maplewood, Minnesota, 미국, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, 미국, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, 미국, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, 미국, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, 미국, 55454
    - Health Partners Inc
  - Minneapolis, Minnesota, 미국, 55417
    - Minneapolis VA Medical Center
  - Monticello, Minnesota, 미국, 55362
    - Monticello Cancer Center
  - Moose Lake, Minnesota, 미국, 55767
    - Essentia Health - Moose Lake Clinic
  - New Ulm, Minnesota, 미국, 56073
    - New Ulm Medical Center
  - Park Rapids, Minnesota, 미국, 56470
    - Essentia Health - Park Rapids
  - Princeton, Minnesota, 미국, 55371
    - Fairview Northland Medical Center
  - Robbinsdale, Minnesota, 미국, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, 미국, 55905
    - Mayo Clinic in Rochester
  - Saint Louis Park, Minnesota, 미국, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, 미국, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, 미국, 55102
    - United Hospital
  - Sandstone, Minnesota, 미국, 55072
    - Essentia Health Sandstone
  - Shakopee, Minnesota, 미국, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, 미국, 55082
    - Lakeview Hospital
  - Thief River Falls, Minnesota, 미국, 56701
    - Sanford Thief River Falls Medical Center
  - Virginia, Minnesota, 미국, 55792
    - Essentia Health Virginia Clinic
  - Waconia, Minnesota, 미국, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, 미국, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, 미국, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Worthington, Minnesota, 미국, 56187
    - Sanford Cancer Center Worthington
  - Wyoming, Minnesota, 미국, 55092
    - Fairview Lakes Medical Center
- Mississippi
  - Columbus, Mississippi, 미국, 39705
    - Baptist Memorial Hospital and Cancer Center-Golden Triangle
  - Grenada, Mississippi, 미국, 38901
    - Baptist Cancer Center-Grenada
  - New Albany, Mississippi, 미국, 38652
    - Baptist Memorial Hospital and Cancer Center-Union County
  - Oxford, Mississippi, 미국, 38655
    - Baptist Memorial Hospital and Cancer Center-Oxford
  - Pascagoula, Mississippi, 미국, 39581
    - Singing River Hospital
  - Southhaven, Mississippi, 미국, 38671
    - Baptist Memorial Hospital and Cancer Center-Desoto
- Missouri
  - Ballwin, Missouri, 미국, 63011
    - Mercy Oncology and Hematology - Clayton-Clarkson
  - Bolivar, Missouri, 미국, 65613
    - Central Care Cancer Center - Bolivar
  - Bonne Terre, Missouri, 미국, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, 미국, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, 미국, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, 미국, 63703
    - Mercy Cancer Center - Cape Girardeau
  - Chesterfield, Missouri, 미국, 63017
    - Saint Luke's Hospital
  - Farmington, Missouri, 미국, 63640
    - Parkland Health Center - Farmington
  - Jefferson City, Missouri, 미국, 65109
    - MU Health Care Goldschmidt Cancer Center
  - Joplin, Missouri, 미국, 64804
    - Freeman Health System
  - Joplin, Missouri, 미국, 64804
    - Mercy Hospital Joplin
  - Kansas City, Missouri, 미국, 64154
    - University of Kansas Cancer Center - North
  - Kansas City, Missouri, 미국, 64131
    - The University of Kansas Cancer Center-South
  - Kansas City, Missouri, 미국, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, 미국, 64108
    - University Health Truman Medical Center
  - Lee's Summit, Missouri, 미국, 64064
    - University of Kansas Cancer Center - Lee's Summit
  - Lee's Summit, Missouri, 미국, 64086
    - Saint Luke's East - Lee's Summit
  - North Kansas City, Missouri, 미국, 64116
    - University of Kansas Cancer Center at North Kansas City Hospital
  - Osage Beach, Missouri, 미국, 65065
    - Lake Regional Hospital
  - Rolla, Missouri, 미국, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Rolla, Missouri, 미국, 65401
    - Phelps Health Delbert Day Cancer Institute
  - Saint Joseph, Missouri, 미국, 64506
    - Heartland Regional Medical Center
  - Sainte Genevieve, Missouri, 미국, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, 미국, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, 미국, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, 미국, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, 미국, 63109
    - Mercy Infusion Center - Chippewa
  - St Louis, Missouri, 미국, 63141
    - Mercy Hospital Saint Louis
  - St Louis, Missouri, 미국, 63128
    - Mercy Hospital South
  - Sullivan, Missouri, 미국, 63080
    - Missouri Baptist Sullivan Hospital
  - Washington, Missouri, 미국, 63090
    - Mercy Hospital Washington
- Montana
  - Anaconda, Montana, 미국, 59711
    - Community Hospital of Anaconda
  - Billings, Montana, 미국, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, 미국, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, 미국, 59102
    - Saint Vincent Frontier Cancer Center
  - Bozeman, Montana, 미국, 59715
    - Bozeman Health Deaconess Hospital
  - Butte, Montana, 미국, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, 미국, 59405
    - Great Falls Clinic
  - Great Falls, Montana, 미국, 59405
    - Benefis Sletten Cancer Institute
  - Helena, Montana, 미국, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, 미국, 59901
    - Logan Health Medical Center
  - Missoula, Montana, 미국, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, 미국, 59804
    - Community Medical Center
- Nebraska
  - Bellevue, Nebraska, 미국, 68123
    - Nebraska Medicine-Bellevue
  - Grand Island, Nebraska, 미국, 68803
    - Nebraska Cancer Specialists/Oncology Hematology West PC
  - Kearney, Nebraska, 미국, 68847
    - CHI Health Good Samaritan
  - Kearney, Nebraska, 미국, 68845
    - Fred and Pamela Buffett Cancer Center - Kearney
  - Lincoln, Nebraska, 미국, 68510
    - Saint Elizabeth Regional Medical Center
  - Omaha, Nebraska, 미국, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, 미국, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, 미국, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, 미국, 68118
    - Nebraska Medicine-Village Pointe
  - Omaha, Nebraska, 미국, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, 미국, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, 미국, 68122
    - Hematology and Oncology Consultants PC
  - Omaha, Nebraska, 미국, 68114
    - Oncology Associates PC
  - Omaha, Nebraska, 미국, 68114
    - Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
  - Papillion, Nebraska, 미국, 68046
    - Midlands Community Hospital
- Nevada
  - Carson City, Nevada, 미국, 89703
    - Carson Tahoe Regional Medical Center
  - Henderson, Nevada, 미국, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, 미국, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, 미국, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, 미국, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, 미국, 89052
    - Comprehensive Cancer Centers of Nevada-Horizon Ridge
  - Henderson, Nevada, 미국, 89074
    - Las Vegas Urology - Green Valley
  - Henderson, Nevada, 미국, 89074
    - Las Vegas Urology - Pebble
  - Henderson, Nevada, 미국, 89074
    - Urology Specialists of Nevada - Green Valley
  - Henderson, Nevada, 미국, 89074
    - Oncology Las Vegas - Henderson
  - Las Vegas, Nevada, 미국, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, 미국, 89109
    - Sunrise Hospital and Medical Center
  - Las Vegas, Nevada, 미국, 89102
    - OptumCare Cancer Care at Charleston
  - Las Vegas, Nevada, 미국, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, 미국, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, 미국, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, 미국, 89128
    - OptumCare Cancer Care at MountainView
  - Las Vegas, Nevada, 미국, 89135
    - Alliance for Childhood Diseases/Cure 4 the Kids Foundation
  - Las Vegas, Nevada, 미국, 89144
    - Comprehensive Cancer Centers of Nevada - Town Center
  - Las Vegas, Nevada, 미국, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, 미국, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, 미국, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, 미국, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, 미국, 89106
    - Cancer and Blood Specialists-Shadow
  - Las Vegas, Nevada, 미국, 89109
    - HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
  - Las Vegas, Nevada, 미국, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, 미국, 89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas, Nevada, 미국, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas, Nevada, 미국, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, 미국, 89149
    - HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
  - Las Vegas, Nevada, 미국, 89128
    - Ann M Wierman MD LTD
  - Las Vegas, Nevada, 미국, 89074
    - Las Vegas Urology - Pecos
  - Las Vegas, Nevada, 미국, 89102
    - Desert West Surgery
  - Las Vegas, Nevada, 미국, 89103
    - Hope Cancer Care of Nevada
  - Las Vegas, Nevada, 미국, 89106
    - Urology Specialists of Nevada - Central
  - Las Vegas, Nevada, 미국, 89113
    - Las Vegas Prostate Cancer Center
  - Las Vegas, Nevada, 미국, 89113
    - Las Vegas Urology - Sunset
  - Las Vegas, Nevada, 미국, 89128
    - Las Vegas Urology - Cathedral Rock
  - Las Vegas, Nevada, 미국, 89128
    - Las Vegas Urology - Smoke Ranch
  - Las Vegas, Nevada, 미국, 89128
    - Urology Specialists of Nevada - Northwest
  - Las Vegas, Nevada, 미국, 89169
    - University Cancer Center
  - Las Vegas, Nevada, 미국, 89113
    - Urology Specialists of Nevada - Southwest
  - Las Vegas, Nevada, 미국, 89128
    - Oncology Las Vegas - Tenaya
  - Las Vegas, Nevada, 미국, 89183
    - OptumCare Cancer Care at Fort Apache
  - Pahrump, Nevada, 미국, 89048
    - Hope Cancer Care of Nevada-Pahrump
  - Reno, Nevada, 미국, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, 미국, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, 미국, 89509
    - Radiation Oncology Associates
- New Hampshire
  - Concord, New Hampshire, 미국, 03301
    - New Hampshire Oncology Hematology PA-Concord
  - Lebanon, New Hampshire, 미국, 03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
  - Manchester, New Hampshire, 미국, 03103
    - Solinsky Center for Cancer Care
  - Manchester, New Hampshire, 미국, 03103
    - Elliot Hospital
- New Jersey
  - Moorestown, New Jersey, 미국, 08057
    - Virtua Samson Cancer Center
  - Morristown, New Jersey, 미국, 07960
    - Morristown Medical Center
  - Mullica Hill, New Jersey, 미국, 08062
    - Inspira Medical Center Mullica Hill
  - Summit, New Jersey, 미국, 07902
    - Overlook Hospital
  - Voorhees Township, New Jersey, 미국, 08043
    - Virtua Voorhees
- New Mexico
  - Albuquerque, New Mexico, 미국, 87106
    - University of New Mexico Cancer Center
- New York
  - Auburn, New York, 미국, 13021
    - Hematology Oncology Associates of Central New York-Auburn
  - Binghamton, New York, 미국, 13905
    - Lourdes Hospital
  - Camillus, New York, 미국, 13031
    - Hematology Oncology Associates of CNY at Camillus
  - East Syracuse, New York, 미국, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Glens Falls, New York, 미국, 12801
    - Glens Falls Hospital
  - New York, New York, 미국, 10019
    - Mount Sinai West
  - New York, New York, 미국, 10029
    - Mount Sinai Hospital
  - New York, New York, 미국, 10011
    - Mount Sinai Chelsea
  - New York, New York, 미국, 10016
    - Laura and Isaac Perlmutter Cancer Center at NYU Langone
  - Oswego, New York, 미국, 13126
    - Upstate Cancer Center at Oswego
  - Rochester, New York, 미국, 14642
    - University of Rochester
  - Stony Brook, New York, 미국, 11794
    - Stony Brook University Medical Center
  - Syracuse, New York, 미국, 13210
    - State University of New York Upstate Medical University
  - Syracuse, New York, 미국, 13215
    - SUNY Upstate Medical Center-Community Campus
  - The Bronx, New York, 미국, 10461
    - Montefiore Medical Center-Einstein Campus
  - The Bronx, New York, 미국, 10467
    - Montefiore Medical Center - Moses Campus
  - The Bronx, New York, 미국, 10461
    - Montefiore Medical Center-Weiler Hospital
  - The Bronx, New York, 미국, 10468
    - James J Peters VA Medical Center
  - Verona, New York, 미국, 13478
    - Upstate Cancer Center at Verona
  - Webster, New York, 미국, 14580
    - Wilmot Cancer Institute at Webster
- North Carolina
  - Albemarle, North Carolina, 미국, 28002
    - Atrium Health Stanly/LCI-Albemarle
  - Asheville, North Carolina, 미국, 28801
    - Mission Hospital
  - Asheville, North Carolina, 미국, 28803
    - AdventHealth Infusion Center Asheville
  - Chapel Hill, North Carolina, 미국, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte, North Carolina, 미국, 28203
    - Carolinas Medical Center/Levine Cancer Institute
  - Charlotte, North Carolina, 미국, 28210
    - Atrium Health Pineville/LCI-Pineville
  - Charlotte, North Carolina, 미국, 28262
    - Atrium Health University City/LCI-University
  - Charlotte, North Carolina, 미국, 28211
    - Levine Cancer Institute-SouthPark
  - Charlotte, North Carolina, 미국, 28277
    - Levine Cancer Institute-Ballantyne
  - Clinton, North Carolina, 미국, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Clyde, North Carolina, 미국, 28721
    - AdventHealth Infusion Center Haywood
  - Concord, North Carolina, 미국, 28025
    - Atrium Health Cabarrus/LCI-Concord
  - Durham, North Carolina, 미국, 27705
    - Durham VA Medical Center
  - Forest City, North Carolina, 미국, 28043
    - Levine Cancer Institute - Rutherford
  - Gastonia, North Carolina, 미국, 28054
    - Levine Cancer Institute-Gaston
  - Goldsboro, North Carolina, 미국, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Greenville, North Carolina, 미국, 27834
    - East Carolina University
  - Hendersonville, North Carolina, 미국, 28791
    - Margaret R Pardee Memorial Hospital
  - Hendersonville, North Carolina, 미국, 28792
    - AdventHealth Hendersonville
  - Jacksonville, North Carolina, 미국, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Kenansville, North Carolina, 미국, 28349
    - ECU Health Oncology Kenansville
  - Kinston, North Carolina, 미국, 28501
    - ECU Health Oncology Kinston
  - Lincolnton, North Carolina, 미국, 28092
    - Atrium Health Lincoln/LCI-Lincolnton
  - Matthews, North Carolina, 미국, 28104
    - Levine Cancer Institute - Union West
  - Monroe, North Carolina, 미국, 28112
    - Atrium Health Union/LCI-Union
  - Richlands, North Carolina, 미국, 28574
    - ECU Health Oncology Richlands
  - Salisbury, North Carolina, 미국, 28144
    - WG Hefner VA Medical Center
  - Shelby, North Carolina, 미국, 28150
    - Atrium Health Cleveland/LCI-Cleveland
  - Weaverville, North Carolina, 미국, 28787
    - AdventHealth Infusion Center Weaverville
- North Dakota
  - Bismarck, North Dakota, 미국, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, 미국, 58122
    - Sanford Roger Maris Cancer Center
  - Fargo, North Dakota, 미국, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo, North Dakota, 미국, 58122
    - Sanford Broadway Medical Center
  - Fargo, North Dakota, 미국, 58103
    - Sanford South University Medical Center
  - Fargo, North Dakota, 미국, 58103
    - Southpointe-Sanford Medical Center Fargo
  - Fargo, North Dakota, 미국, 58104
    - Sanford Medical Center Fargo
  - Jamestown, North Dakota, 미국, 58401
    - Essentia Health - Jamestown Clinic
- Ohio
  - Avon, Ohio, 미국, 44011
    - UH Seidman Cancer Center at UH Avon Health Center
  - Beachwood, Ohio, 미국, 44122
    - UHHS-Chagrin Highlands Medical Center
  - Beavercreek, Ohio, 미국, 45431
    - Indu and Raj Soin Medical Center
  - Belpre, Ohio, 미국, 45714
    - Strecker Cancer Center-Belpre
  - Boardman, Ohio, 미국, 44512
    - Saint Elizabeth Boardman Hospital
  - Canton, Ohio, 미국, 44708
    - Cleveland Clinic Mercy Hospital
  - Centerville, Ohio, 미국, 45459
    - Miami Valley Hospital South
  - Centerville, Ohio, 미국, 45459
    - Dayton Physicians LLC-Miami Valley South
  - Chardon, Ohio, 미국, 44024
    - Geauga Hospital
  - Chillicothe, Ohio, 미국, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, 미국, 45219
    - University of Cincinnati Cancer Center-UC Medical Center
  - Cincinnati, Ohio, 미국, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, 미국, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, 미국, 45236
    - Oncology Hematology Care Inc-Kenwood
  - Cincinnati, Ohio, 미국, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, 미국, 45255
    - TriHealth Cancer Institute-Anderson
  - Cleveland, Ohio, 미국, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, 미국, 44109
    - MetroHealth Medical Center
  - Cleveland, Ohio, 미국, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, 미국, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Columbus, Ohio, 미국, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, 미국, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, 미국, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, 미국, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, 미국, 43228
    - Doctors Hospital
  - Columbus, Ohio, 미국, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, 미국, 43215
    - Grant Medical Center
  - Columbus, Ohio, 미국, 43222
    - Mount Carmel Health Center West
  - Dayton, Ohio, 미국, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, 미국, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, 미국, 45415
    - Miami Valley Hospital North
  - Dayton, Ohio, 미국, 45415
    - Dayton Physician LLC - Englewood
  - Dayton, Ohio, 미국, 45409
    - Premier Blood and Cancer Center
  - Delaware, Ohio, 미국, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, 미국, 43015
    - Grady Memorial Hospital
  - Dublin, Ohio, 미국, 43016
    - Dublin Methodist Hospital
  - Dublin, Ohio, 미국, 43016
    - Columbus Oncology and Hematology Associates
  - Elyria, Ohio, 미국, 44035
    - Mercy Cancer Center-Elyria
  - Findlay, Ohio, 미국, 45840
    - Blanchard Valley Hospital
  - Findlay, Ohio, 미국, 45840
    - Armes Family Cancer Center
  - Findlay, Ohio, 미국, 45840
    - Orion Cancer Care
  - Franklin, Ohio, 미국, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Franklin, Ohio, 미국, 45005
    - Dayton Physicians LLC-Atrium
  - Gahanna, Ohio, 미국, 43230
    - Central Ohio Breast and Endocrine Surgery
  - Greenville, Ohio, 미국, 45331
    - Wayne Hospital
  - Greenville, Ohio, 미국, 45331
    - Dayton Physicians LLC-Wayne
  - Greenville, Ohio, 미국, 45331
    - Miami Valley Cancer Care and Infusion
  - Grove City, Ohio, 미국, 43123
    - Mount Carmel Grove City Hospital
  - Grove City, Ohio, 미국, 43123
    - Zangmeister Center Grove City
  - Independence, Ohio, 미국, 44131
    - Cleveland Clinic Cancer Center Independence
  - Kettering, Ohio, 미국, 45429
    - Kettering Medical Center
  - Kettering, Ohio, 미국, 45409
    - Greater Dayton Cancer Center
  - Kettering, Ohio, 미국, 45420
    - First Dayton Cancer Care
  - Lancaster, Ohio, 미국, 43130
    - Fairfield Medical Center
  - Lima, Ohio, 미국, 45801
    - Saint Rita's Medical Center
  - Mansfield, Ohio, 미국, 44906
    - Cleveland Clinic Cancer Center Mansfield
  - Mansfield, Ohio, 미국, 44903
    - OhioHealth Mansfield Hospital
  - Marietta, Ohio, 미국, 45750
    - Marietta Memorial Hospital
  - Marion, Ohio, 미국, 43302
    - OhioHealth Marion General Hospital
  - Marysville, Ohio, 미국, 43040
    - Memorial Hospital
  - Maumee, Ohio, 미국, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Mayfield Heights, Ohio, 미국, 44124
    - Hillcrest Hospital Cancer Center
  - Mayfield Heights, Ohio, 미국, 44124
    - UH Seidman Cancer Center at Landerbrook Health Center
  - Mentor, Ohio, 미국, 44060
    - UH Seidman Cancer Center at Lake Health Mentor Campus
  - Middleburg Heights, Ohio, 미국, 44130
    - UH Seidman Cancer Center at Southwest General Hospital
  - Mount Vernon, Ohio, 미국, 43050
    - Knox Community Hospital
  - New Albany, Ohio, 미국, 43054
    - Mount Carmel New Albany Surgical Hospital
  - Newark, Ohio, 미국, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, 미국, 43055
    - Newark Radiation Oncology
  - Parma, Ohio, 미국, 44129
    - University Hospitals Parma Medical Center
  - Perrysburg, Ohio, 미국, 43551
    - Mercy Health - Perrysburg Hospital
  - Portsmouth, Ohio, 미국, 45662
    - Southern Ohio Medical Center
  - Ravenna, Ohio, 미국, 44266
    - University Hospitals Portage Medical Center
  - Sandusky, Ohio, 미국, 44870
    - North Coast Cancer Care
  - Sandusky, Ohio, 미국, 44870
    - UH Seidman Cancer Center at Firelands Regional Medical Center
  - Springfield, Ohio, 미국, 45504
    - Springfield Regional Cancer Center
  - Springfield, Ohio, 미국, 45504
    - Springfield Regional Medical Center
  - Steubenville, Ohio, 미국, 43952
    - Trinity's Tony Teramana Cancer Center
  - Strongsville, Ohio, 미국, 44136
    - Cleveland Clinic Cancer Center Strongsville
  - Toledo, Ohio, 미국, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, 미국, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, 미국, 43608
    - Mercy Health - Saint Vincent Hospital
  - Toledo, Ohio, 미국, 43623
    - Mercy Health Sylvania Radiation Oncology Center
  - Troy, Ohio, 미국, 45373
    - Upper Valley Medical Center
  - Troy, Ohio, 미국, 45373
    - Dayton Physicians LLC - Troy
  - Wadsworth, Ohio, 미국, 44281
    - University Hospitals Sharon Health Center
  - Warren, Ohio, 미국, 44484
    - Saint Joseph Warren Hospital
  - Warrensville Heights, Ohio, 미국, 44122
    - South Pointe Hospital
  - West Chester, Ohio, 미국, 45069
    - University of Cincinnati Cancer Center-West Chester
  - Westerville, Ohio, 미국, 43081
    - Saint Ann's Hospital
  - Westlake, Ohio, 미국, 44145
    - UH Seidman Cancer Center at Saint John Medical Center
  - Westlake, Ohio, 미국, 44145
    - UHHS-Westlake Medical Center
  - Wilmington, Ohio, 미국, 45177
    - Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center
  - Wooster, Ohio, 미국, 44691
    - Cleveland Clinic Wooster Family Health and Surgery Center
  - Wright-Patterson Air Force Base, Ohio, 미국, 45433
    - Wright-Patterson Medical Center
  - Youngstown, Ohio, 미국, 44501
    - Saint Elizabeth Youngstown Hospital
  - Zanesville, Ohio, 미국, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Oklahoma City, Oklahoma, 미국, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, 미국, 73120
    - Mercy Hospital Oklahoma City
  - Tulsa, Oklahoma, 미국, 74146
    - Oklahoma Cancer Specialists and Research Institute-Tulsa
- Oregon
  - Baker City, Oregon, 미국, 97814
    - Saint Alphonsus Cancer Care Center-Baker City
  - Bend, Oregon, 미국, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, 미국, 97015
    - Clackamas Radiation Oncology Center
  - Clackamas, Oregon, 미국, 97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay, Oregon, 미국, 97420
    - Bay Area Hospital
  - Newberg, Oregon, 미국, 97132
    - Providence Newberg Medical Center
  - Ontario, Oregon, 미국, 97914
    - Saint Alphonsus Cancer Care Center-Ontario
  - Oregon City, Oregon, 미국, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, 미국, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, 미국, 97225
    - Providence Saint Vincent Medical Center
  - Redmond, Oregon, 미국, 97756
    - Saint Charles Health System-Redmond
- Pennsylvania
  - Allentown, Pennsylvania, 미국, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Altoona, Pennsylvania, 미국, 16601
    - UPMC Altoona
  - Bethel Park, Pennsylvania, 미국, 15102
    - UPMC Cancer Center-Bethel Park
  - Bethlehem, Pennsylvania, 미국, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bryn Mawr, Pennsylvania, 미국, 19010
    - Bryn Mawr Hospital
  - Camp Hill, Pennsylvania, 미국, 17011
    - UPMC Camp Hill
  - Carlisle, Pennsylvania, 미국, 17015
    - Carlisle Regional Cancer Center
  - Chadds Ford, Pennsylvania, 미국, 19317
    - Christiana Care Health System-Concord Health Center
  - Chambersburg, Pennsylvania, 미국, 17201
    - Chambersburg Hospital
  - Chambersburg, Pennsylvania, 미국, 17201
    - WellSpan Medical Oncology and Hematology
  - East Stroudsburg, Pennsylvania, 미국, 18301
    - Pocono Medical Center
  - Ephrata, Pennsylvania, 미국, 17522
    - Ephrata Cancer Center
  - Ephrata, Pennsylvania, 미국, 17522
    - Ephrata Community Hospital
  - Erie, Pennsylvania, 미국, 16505
    - UPMC Hillman Cancer Center Erie
  - Gettysburg, Pennsylvania, 미국, 17325
    - Adams Cancer Center
  - Greensburg, Pennsylvania, 미국, 15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Hanover, Pennsylvania, 미국, 17331
    - WellSpan Medical Oncology and Hematology
  - Harrisburg, Pennsylvania, 미국, 17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Harrisburg, Pennsylvania, 미국, 17101
    - UPMC Pinnacle Harrisburg
  - Hazleton, Pennsylvania, 미국, 18201
    - Lehigh Valley Hospital-Hazleton
  - Lebanon, Pennsylvania, 미국, 17042
    - Sechler Family Cancer Center
  - McKeesport, Pennsylvania, 미국, 15132
    - UPMC Cancer Center at UPMC McKeesport
  - Mechanicsburg, Pennsylvania, 미국, 17050
    - UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
  - Media, Pennsylvania, 미국, 19063
    - Riddle Memorial Hospital
  - N. Huntingdon, Pennsylvania, 미국, 15642
    - Arnold Palmer Cancer Center Medical Oncology Norwin
  - Paoli, Pennsylvania, 미국, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, 미국, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, 미국, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia, Pennsylvania, 미국, 19140
    - Temple University Hospital
  - Philadelphia, Pennsylvania, 미국, 19104
    - Penn Presbyterian Medical Center
  - Pittsburgh, Pennsylvania, 미국, 15232
    - UPMC Hillman Cancer Center
  - Pittsburgh, Pennsylvania, 미국, 15215
    - UPMC-Saint Margaret
  - Pittsburgh, Pennsylvania, 미국, 15237
    - UPMC-Passavant Hospital
  - Pittsburgh, Pennsylvania, 미국, 15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pittsburgh, Pennsylvania, 미국, 15215
    - Oncology Hematology Association
  - Pittsburgh, Pennsylvania, 미국, 15219
    - UPMC-Mercy Hospital
  - Pottstown, Pennsylvania, 미국, 19464
    - Pottstown Hospital
  - Seneca, Pennsylvania, 미국, 16346
    - UPMC Cancer Center at UPMC Northwest
  - Washington, Pennsylvania, 미국, 15301
    - UPMC Cancer Center-Washington
  - Wynnewood, Pennsylvania, 미국, 19096
    - Lankenau Medical Center
  - York, Pennsylvania, 미국, 17403
    - WellSpan Health-York Cancer Center
  - York, Pennsylvania, 미국, 17403
    - WellSpan Health-York Hospital
  - York, Pennsylvania, 미국, 17403
    - Cancer Care Associates of York
  - York, Pennsylvania, 미국, 17408
    - UPMC Memorial
- Rhode Island
  - Warwick, Rhode Island, 미국, 02886
    - Kent Hospital
  - Westerly, Rhode Island, 미국, 02891
    - Smilow Cancer Hospital Care Center - Westerly
- South Carolina
  - Bluffton, South Carolina, 미국, 29910
    - Saint Joseph's/Candler - Bluffton Campus
  - Boiling Springs, South Carolina, 미국, 29316
    - Prisma Health Cancer Institute - Spartanburg
  - Charleston, South Carolina, 미국, 29425
    - Medical University of South Carolina
  - Charleston, South Carolina, 미국, 29401
    - Ralph H Johnson VA Medical Center
  - Columbia, South Carolina, 미국, 29203
    - Prisma Health Richland Hospital
  - Gaffney, South Carolina, 미국, 29341
    - Gibbs Cancer Center-Gaffney
  - Georgetown, South Carolina, 미국, 29440
    - Tidelands Georgetown Memorial Hospital
  - Greenville, South Carolina, 미국, 29605
    - Prisma Health Cancer Institute - Faris
  - Greenville, South Carolina, 미국, 29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville, South Carolina, 미국, 29605
    - Prisma Health Cancer Institute - Butternut
  - Greenville, South Carolina, 미국, 29605
    - Prisma Health Greenville Memorial Hospital
  - Greenwood, South Carolina, 미국, 29646
    - Self Regional Healthcare
  - Greer, South Carolina, 미국, 29650
    - Prisma Health Cancer Institute - Greer
  - Greer, South Carolina, 미국, 29651
    - Gibbs Cancer Center-Pelham
  - Hilton Head Island, South Carolina, 미국, 29926-3827
    - South Carolina Cancer Specialists PC
  - Myrtle Beach, South Carolina, 미국, 29577
    - Carolina Regional Cancer Center
  - Rock Hill, South Carolina, 미국, 29732
    - Levine Cancer Institute-Rock Hill
  - Seneca, South Carolina, 미국, 29672
    - Prisma Health Cancer Institute - Seneca
  - Spartanburg, South Carolina, 미국, 29303
    - Spartanburg Medical Center
  - Spartanburg, South Carolina, 미국, 29307
    - Spartanburg Medical Center - Mary Black Campus
  - Spartanburg, South Carolina, 미국, 29303
    - North Grove Medical Park
  - Union, South Carolina, 미국, 29379
    - SMC Center for Hematology Oncology Union
- South Dakota
  - Rapid City, South Dakota, 미국, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, 미국, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, 미국, 57104
    - Sanford Cancer Center Oncology Clinic
- Tennessee
  - Alcoa, Tennessee, 미국, 37701
    - University Cancer Specialists - Alcoa
  - Bristol, Tennessee, 미국, 37620
    - Bristol Regional Medical Center
  - Chattanooga, Tennessee, 미국, 37404
    - Memorial Hospital
  - Collierville, Tennessee, 미국, 38017
    - Baptist Memorial Hospital and Cancer Center-Collierville
  - Franklin, Tennessee, 미국, 37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Franklin, Tennessee, 미국, 37067
    - Vanderbilt-Ingram Cancer Center at Franklin
  - Hixson, Tennessee, 미국, 37343
    - Pulmonary Medicine Center of Chattanooga-Hixson
  - Kingsport, Tennessee, 미국, 37660
    - Ballad Health Cancer Care - Kingsport
  - Kingsport, Tennessee, 미국, 37660
    - Wellmont Holston Valley Hospital and Medical Center
  - Knoxville, Tennessee, 미국, 37920
    - University of Tennessee - Knoxville
  - Memphis, Tennessee, 미국, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Nashville, Tennessee, 미국, 37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville, Tennessee, 미국, 37204
    - Vanderbilt Breast Center at One Hundred Oaks
  - Ooltewah, Tennessee, 미국, 37363
    - Memorial GYN Plus
- Texas
  - Baytown, Texas, 미국, 77521
    - Houston Methodist San Jacinto Hospital
  - Bryan, Texas, 미국, 77802
    - Saint Joseph Regional Cancer Center
  - Dallas, Texas, 미국, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, 미국, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Dallas, Texas, 미국, 75216
    - Dallas VA Medical Center
  - Dallas, Texas, 미국, 75237
    - UT Southwestern Simmons Cancer Center - RedBird
  - Fort Worth, Texas, 미국, 76104
    - UT Southwestern/Simmons Cancer Center-Fort Worth
  - Fort Worth, Texas, 미국, 76104
    - Tarrant County Hospital District/JPS Health Network
  - Houston, Texas, 미국, 77030
    - Houston Methodist Hospital
  - Houston, Texas, 미국, 77070
    - Methodist Willowbrook Hospital
  - Houston, Texas, 미국, 77094
    - Houston Methodist West Hospital
  - Nassau Bay, Texas, 미국, 77058
    - Houston Methodist Saint John Hospital
  - Richardson, Texas, 미국, 75080
    - UT Southwestern Clinical Center at Richardson/Plano
  - Sugar Land, Texas, 미국, 77479
    - Houston Methodist Sugar Land Hospital
  - The Woodlands, Texas, 미국, 77385
    - Houston Methodist The Woodlands Hospital
- Utah
  - American Fork, Utah, 미국, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, 미국, 84720
    - Sandra L Maxwell Cancer Center
  - Logan, Utah, 미국, 84321
    - Logan Regional Hospital
  - Murray, Utah, 미국, 84107
    - Intermountain Medical Center
  - Ogden, Utah, 미국, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, 미국, 84604
    - Utah Valley Regional Medical Center
  - Riverton, Utah, 미국, 84065
    - Riverton Hospital
  - Salt Lake City, Utah, 미국, 84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City, Utah, 미국, 84143
    - LDS Hospital
  - St. George, Utah, 미국, 84770
    - Saint George Regional Medical Center
- Vermont
  - Berlin Corners, Vermont, 미국, 05602
    - Central Vermont Medical Center/National Life Cancer Treatment
  - Burlington, Vermont, 미국, 05401
    - University of Vermont Medical Center
  - Burlington, Vermont, 미국, 05405
    - University of Vermont and State Agricultural College
  - Saint Johnsbury, Vermont, 미국, 05819
    - Dartmouth Cancer Center - North
- Virginia
  - Bristol, Virginia, 미국, 24201
    - Ballad Health Cancer Care - Bristol
  - Charlottesville, Virginia, 미국, 22908
    - University of Virginia Cancer Center
  - Fishersville, Virginia, 미국, 22939
    - Augusta Health Center for Cancer and Blood Disorders
  - Norton, Virginia, 미국, 24273
    - Ballad Health Cancer Care - Norton
  - Richmond, Virginia, 미국, 23235
    - VCU Massey Cancer Center at Stony Point
  - Richmond, Virginia, 미국, 23229
    - Virginia Cancer Institute
  - Richmond, Virginia, 미국, 23298
    - VCU Massey Comprehensive Cancer Center
  - South Hill, Virginia, 미국, 23970
    - VCU Community Memorial Health Center
- Washington
  - Aberdeen, Washington, 미국, 98520
    - Providence Regional Cancer System-Aberdeen
  - Auburn, Washington, 미국, 98001
    - MultiCare Auburn Medical Center
  - Bellevue, Washington, 미국, 98004
    - Overlake Medical Center
  - Bellingham, Washington, 미국, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Burien, Washington, 미국, 98166
    - Saint Anne Hospital
  - Centralia, Washington, 미국, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, 미국, 98026
    - Swedish Cancer Institute-Edmonds
  - Enumclaw, Washington, 미국, 98022
    - Saint Elizabeth Hospital
  - Everett, Washington, 미국, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, 미국, 98003
    - Saint Francis Hospital
  - Gig Harbor, Washington, 미국, 98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah, Washington, 미국, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, 미국, 99336
    - Kadlec Clinic Hematology and Oncology
  - Lacey, Washington, 미국, 98503
    - Providence Regional Cancer System-Lacey
  - Lakewood, Washington, 미국, 98499
    - Saint Clare Hospital
  - Longview, Washington, 미국, 98632
    - PeaceHealth Saint John Medical Center
  - Port Townsend, Washington, 미국, 98368
    - Jefferson Healthcare
  - Poulsbo, Washington, 미국, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Puyallup, Washington, 미국, 98372
    - MultiCare Good Samaritan Hospital
  - Renton, Washington, 미국, 98055
    - Valley Medical Center
  - Seattle, Washington, 미국, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, 미국, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, 미국, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, 미국, 98104
    - Pacific Gynecology Specialists
  - Seattle, Washington, 미국, 98122-5711
    - Swedish Medical Center-Cherry Hill
  - Sedro-Woolley, Washington, 미국, 98284
    - PeaceHealth United General Medical Center
  - Shelton, Washington, 미국, 98584
    - Providence Regional Cancer System-Shelton
  - Silverdale, Washington, 미국, 98383
    - Saint Joseph Medical Center Hematology and Oncology - Silverdale
  - Spokane, Washington, 미국, 99204
    - MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
  - Spokane, Washington, 미국, 99218
    - MultiCare Deaconess Cancer and Blood Specialty Center - North
  - Spokane Valley, Washington, 미국, 99216
    - MultiCare Deaconess Cancer and Blood Specialty Center - Valley
  - Tacoma, Washington, 미국, 98405
    - Mary Bridge Children's Hospital and Health Center
  - Tacoma, Washington, 미국, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, 미국, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, 미국, 98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Vancouver, Washington, 미국, 98664
    - PeaceHealth Southwest Medical Center
  - Walla Walla, Washington, 미국, 99362
    - Providence Saint Mary Regional Cancer Center
  - Yakima, Washington, 미국, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yelm, Washington, 미국, 98597
    - Providence Regional Cancer System-Yelm
- West Virginia
  - Charleston, West Virginia, 미국, 25304
    - Vandalia Health/CAMC Institute for Academic Medicine
  - Huntington, West Virginia, 미국, 25701
    - Edwards Comprehensive Cancer Center
- Wisconsin
  - Antigo, Wisconsin, 미국, 54409
    - Aspirus Cancer Care-Antigo-Volm Cancer Center
  - Appleton, Wisconsin, 미국, 54915
    - Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
  - Ashland, Wisconsin, 미국, 54806
    - Duluth Clinic Ashland
  - Ashland, Wisconsin, 미국, 54806
    - Northwest Wisconsin Cancer Center
  - Baraboo, Wisconsin, 미국, 53913
    - SSM Health Dean Medical Group - Baraboo
  - Brookfield, Wisconsin, 미국, 53045
    - Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
  - Burlington, Wisconsin, 미국, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chilton, Wisconsin, 미국, 53014
    - Ascension Calumet Hospital-Chilton
  - Cudahy, Wisconsin, 미국, 53110
    - Aurora Saint Luke's South Shore
  - Eau Claire, Wisconsin, 미국, 54701
    - Marshfield Medical Center-EC Cancer Center
  - Eau Claire, Wisconsin, 미국, 54701
    - HSHS Sacred Heart Hospital
  - Eau Claire, Wisconsin, 미국, 54701
    - Mayo Clinic Health System-Eau Claire Clinic
  - Eau Claire, Wisconsin, 미국, 54703
    - Mayo Clinic Health System Eau Claire Hospital-Luther Campus
  - Fond du Lac, Wisconsin, 미국, 54937
    - Aurora Health Center-Fond du Lac
  - Franklin, Wisconsin, 미국, 53132
    - Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
  - Germantown, Wisconsin, 미국, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, 미국, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, 미국, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, 미국, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, 미국, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Hayward, Wisconsin, 미국, 54843
    - Essentia Health-Hayward Clinic
  - Janesville, Wisconsin, 미국, 53548
    - Mercyhealth Hospital and Cancer Center - Janesville
  - Janesville, Wisconsin, 미국, 53546
    - SSM Health Dean Medical Group - Janesville
  - Kenosha, Wisconsin, 미국, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, 미국, 54601
    - Gundersen Lutheran Medical Center
  - La Crosse, Wisconsin, 미국, 54601
    - Mayo Clinic Health System-Franciscan Healthcare
  - Madison, Wisconsin, 미국, 53792
    - University of Wisconsin Carbone Cancer Center - University Hospital
  - Madison, Wisconsin, 미국, 53715
    - SSM Health Dean Medical Group - South Madison Campus
  - Manitowoc, Wisconsin, 미국, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, 미국, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marinette, Wisconsin, 미국, 54143
    - Saint Vincent Hospital Cancer Center at Marinette
  - Marshfield, Wisconsin, 미국, 54449
    - Marshfield Medical Center-Marshfield
  - Medford, Wisconsin, 미국, 54451
    - Aspirus Medford Hospital
  - Mequon, Wisconsin, 미국, 53097
    - Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
  - Milwaukee, Wisconsin, 미국, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, 미국, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, 미국, 53233
    - Aurora Sinai Medical Center
  - Milwaukee, Wisconsin, 미국, 53211
    - Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
  - Minocqua, Wisconsin, 미국, 54548
    - Marshfield Medical Center - Minocqua
  - Mukwonago, Wisconsin, 미국, 53149
    - ProHealth D N Greenwald Center
  - New Richmond, Wisconsin, 미국, 54017
    - Cancer Center of Western Wisconsin
  - Oconomowoc, Wisconsin, 미국, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, 미국, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, 미국, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Oshkosh, Wisconsin, 미국, 54904
    - Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh
  - Racine, Wisconsin, 미국, 53406
    - Aurora Cancer Care-Racine
  - Racine, Wisconsin, 미국, 53405
    - Ascension All Saints Hospital-Spring Street-Racine
  - Rhinelander, Wisconsin, 미국, 54501
    - Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
  - Rice Lake, Wisconsin, 미국, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, 미국, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Sheboygan, Wisconsin, 미국, 53081
    - HSHS Saint Nicholas Hospital
  - Sheboygan, Wisconsin, 미국, 53081
    - Saint Vincent Hospital Cancer Center at Sheboygan
  - Sheboygan, Wisconsin, 미국, 53081
    - Sheboygan Physicians Group
  - Spooner, Wisconsin, 미국, 54801
    - Essentia Health-Spooner Clinic
  - Stevens Point, Wisconsin, 미국, 54482
    - Marshfield Medical Center-River Region at Stevens Point
  - Stevens Point, Wisconsin, 미국, 54481
    - Aspirus Cancer Care - Stevens Point
  - Sturgeon Bay, Wisconsin, 미국, 54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Summit, Wisconsin, 미국, 53066
    - Aurora Medical Center in Summit
  - Superior, Wisconsin, 미국, 54880
    - Essentia Health Saint Mary's Hospital - Superior
  - Two Rivers, Wisconsin, 미국, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, 미국, 53188
    - UW Cancer Center at ProHealth Care
  - Waukesha, Wisconsin, 미국, 53188
    - ProHealth Waukesha Memorial Hospital
  - Wausau, Wisconsin, 미국, 54401
    - Aspirus Cancer Care-Wausau
  - Wauwatosa, Wisconsin, 미국, 53226
    - Aurora Cancer Care-Milwaukee West
  - Wauwatosa, Wisconsin, 미국, 53226
    - Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
  - West Allis, Wisconsin, 미국, 53227
    - Aurora West Allis Medical Center
  - Weston, Wisconsin, 미국, 54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids, Wisconsin, 미국, 54494
    - Aspirus Cancer Care - Wisconsin Rapids
- Wyoming
  - Cheyenne, Wyoming, 미국, 82001
    - Cheyenne Regional Medical Center-West
  - Cody, Wyoming, 미국, 82414
    - Billings Clinic-Cody
  - Sheridan, Wyoming, 미국, 82801
    - Welch Cancer Center
캐나다
- Alberta
  - Calgary, Alberta, 캐나다, T2N 5G2
    - Arthur J E Child Comprehensive Cancer Centre
  - Edmonton, Alberta, 캐나다, T6G 1Z2
    - Cross Cancer Institute
- British Columbia
  - Surrey, British Columbia, 캐나다, V3V 1Z2
    - BCCA-Fraser Valley Cancer Centre
  - Vancouver, British Columbia, 캐나다, V5Z 4E6
    - BCCA-Vancouver Cancer Centre
- New Brunswick
  - Saint John, New Brunswick, 캐나다, E2L 4L2
    - Atlantic Health Sciences Corporation-Saint John Regional Hospital
- Ontario
  - Kingston, Ontario, 캐나다, K7L 2V7
    - Kingston Health Sciences Centre
  - Saint Catharines, Ontario, 캐나다, L2S 0A9
    - Niagara Health System-Saint Catharines General
  - Thunder Bay, Ontario, 캐나다, P7B 6V4
    - Thunder Bay Regional Health Science Centre
  - Toronto, Ontario, 캐나다, M5G 2M9
    - University Health Network-Princess Margaret Hospital
- Prince Edward Island
  - Charlottetown, Prince Edward Island, 캐나다, C1A 8T5
    - PEI Cancer Treatment Centre-Queen Elizabeth Hospital
- Quebec
  - Montreal, Quebec, 캐나다, H3H 2R9
    - The Research Institute of the McGill University Health Centre (MUHC)
  - Québec, Quebec, 캐나다, G1J 1Z4
    - CHA Hopital L'Enfant-Jesus

참여기준

연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.

자격 기준

공부할 수 있는 나이

18년 이상 (성인, 고령자)

건강한 자원 봉사자를 받아들입니다

아니

연구 대상 성별

모두

설명

Inclusion Criteria:

Patients must have histologically or cytologically confirmed stage IV non-squamous non-small cell lung cancer (NSCLC) (includes M1a, M1b, and M1c stage disease, American Joint Committee on Cancer [AJCC] 8th edition). Patients with stage IIIB and IIIC disease are eligible if they are not candidates for combined chemotherapy and radiation. Prior chemo-radiation therapy (RT) for stage III with recurrence is allowed
Patients must have PD-L1 expression Tumor Proportion Score (TPS) >= 1% in tumor cells. If PD-L1 expression TPS is unevaluable or the testing could not be completed, the patients are not eligible. The assay must have been performed by a Clinical Laboratory Improvement Act (CLIA) (or equivalent) certified laboratory
Patients must have measurable or non-measurable disease. The presence of malignant pleural fluid alone is sufficient to satisfy this eligibility criterion. Baseline imaging assessments and measurements used to evaluate all measurable or non-measurable sites of disease must be done within 4 weeks prior to study registration
- NOTE: If patient receives pemetrexed, follow institutional guidelines to drain fluids
- NOTE: An additional 15 days is allowed to account for any infection/exposure related logistical delays
Patients must be >= 18 years of age
Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1
Patients must NOT have received the following:
- Prior systemic chemotherapy or immunotherapy for advanced metastatic NSCLC. Patients treated with any prior checkpoint inhibitors for metastatic lung cancer are ineligible. Chemotherapy for non-metastatic disease (e.g. adjuvant therapy) or immunotherapy for locally advanced stage III disease, or treated with neoadjuvant IO is allowed if at least 6 months have elapsed between the last dose of the prior therapy and study registration. Local therapy, e.g. palliative radiation, is allowed as long as a period of 14 days has passed between completion of local therapy and the start of protocol treatment. Registration during the 14 days is allowed. Palliative radiation must be to non-target lesions. Palliative radiation to pre-existing lesions while on protocol treatment is allowed as long as these areas have not grown to RECIST defined progression. Development of any new metastasis is considered progression. Concurrent radiation and protocol treatment is not allowed; protocol treatment may resume after completion of radiation as long as patient does not have greater than grade 2 side effects from radiation per physician discretion.
- Methotrexate (MTX) given in low doses for non-malignant conditions with last dose at least 14 days prior to date of registration will be allowed. Other low dose chemotherapeutics for non-malignant conditions will be considered, but review by the study chair is required
- Palliative radiation to non-target lesions (bone metastasis) is allowed if patient develops symptoms
Patients with known EGFR mutations (except exon 20 insertion), BRAF mutations (V600) or ALK or ROS1 translocations or other driver mutations that can be treated with oral tyrosine kinase inhibitors are excluded
Patients with treated brain metastases are eligible if follow-up brain imaging obtained at least 14 days after central nervous system (CNS)-directed therapy shows no evidence of progression. CNS progression counts as progression and patients must move on to the next phase after CNS treatment. Patients with asymptomatic new (at screening) or progressive brain metastases (active brain metastases at screening) are eligible if the treating physician determines that immediate CNS specific treatment is not required and is unlikely to be required during the first cycle of therapy
- Patients are eligible if off steroids for at least 14 days prior to protocol treatment
- Anticonvulsants are allowed
- Patients with asymptomatic, sub-centimeter brain metastasis who at the discretion of investigators do not need immediate CNS directed therapies are eligible
Patients with prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
Patients must not have known pre-existing and clinically active interstitial lung disease, or a known history of (non infectious) pneumonitis that required steroids, or current pneumonitis
Patients must not have significant gastrointestinal disorders with diarrhea as a major symptom (e.g., Crohn's disease, malabsorption, etc.)
Patients must not have history of auto-immune condition (including Guillain-Barre Syndrome or Multiple Sclerosis) requiring ongoing or intermittent systemic treatment in the past 2 years prior to registration (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment
Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better
Patients must not have any other concomitant serious illness or organ system dysfunction that in the opinion of the investigator would either compromise patient safety or interfere with the evaluation of the safety of the study drug
Patients must not receive any other investigational agents during the course of therapy
Patients must not be pregnant or breast-feeding due to potential harm to the fetus or infant from cytotoxic chemotherapy and the unknown risk of pembrolizumab (MK-3475). All patients of childbearing potential must have a blood test or urine study within 72 hours prior to registration to rule out pregnancy. A patient of childbearing potential is someone, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point; 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
Patients must use accepted and effective method(s) of contraception or by abstaining from sexual intercourse from time of registration, while on study treatment, and continue for 120 days after the last dose of study treatment
Absolute neutrophil count (ANC) >= 1500/mm^3 (within 14 days prior to randomization)
Platelets >= 100,000/mm^3 (within 14 days prior to randomization)
Prothrombin time (PT)/international normalized ratio (INR) (only if on active anticoagulation with warfarin or any formulations of heparin) =< 3.0 (within 14 day prior to randomization)
Total bilirubin =< 1.5 mg/dL (obtained within 14 days prior to randomization)
Serum glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) < 5 x upper limit of normal (ULN) (obtained within 14 days prior to randomization)
Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 5 x upper limit of normal (ULN) (obtained within 14 days prior to randomization)
Calculated creatinine clearance >= 45 ml/min to be eligible to receive pemetrexed (obtained within 14 days prior to randomization)
Serum creatinine =< 1.5 x institutional upper limit of normal (ULN) (obtained within 14 days prior to randomization)
Patients must not have a known history of active tuberculosis (TB)
Patients must not have a diagnosis of immunodeficiency or receive systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of protocol treatment
Patients must not have received a live vaccine within 30 days prior to randomization. Patients are permitted to receive inactivated vaccines and any non-live vaccines including those for the seasonal influenza and COVID-19 (Note: intranasal influenza vaccines, such as Flu-Mist [registered trademark] are live attenuated vaccines and are not allowed). If possible, it is recommended to separate study drug administration from vaccine administration by about a week (primarily, in order to minimize an overlap of adverse events)
Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable or on suppressive therapy, if indicated. Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load

공부 계획

이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.

연구는 어떻게 설계됩니까?

디자인 세부사항

주 목적: 치료
할당: 무작위
중재 모델: 병렬 할당
마스킹: 없음(오픈 라벨)

팔의 수

무기와 개입

참가자 그룹 / 팔	개입 / 치료
실험적: Arm A (pembrolizumab, pemetrexed, carboplatin) Patients receive pembrolizumab IV over 30 minutes on day 1. Cycles repeat every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity. Within 6 weeks of disease progression, patients receive pemetrexed IV over 10 minutes and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients then may receive pemetrexed IV over 10 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients undergo MRI during screening, CT scan and blood sample collection throughout the study, and may undergo PET scan throughout the study.	의약품: Carboplatin Given IV 다른 이름들: 폭발탄 카르보플라트 카보플라틴 헥살 카르보플라티노 카보플라티넘 카르보신 카보솔 카보텍 CBDCA 디스플라타 에르카르 JM-8 닐로린 노보플라티넘 파라플라틴 파라플라틴 AQ 플라틴와스 리보카르보 JM8 절차: Biospecimen Collection Undergo blood sample collection 다른 이름들: 생물학적 샘플 수집 생체 표본 수집 표본 수집 샘플 수집 절차: Magnetic Resonance Imaging Undergo MRI 다른 이름들: MRI 자기 공명 자기공명영상 스캔 의료영상, 자기공명 / 핵자기공명 씨 MR 이미징 MRI 검사 NMR 이미징 NMRI 핵자기공명영상 자기공명영상(MRI) SMRI 자기공명영상(시술) 구조적 MRI 의약품: Pemetrexed Given IV 다른 이름들: MTA 다중 표적 항엽산제 펨펙시 생물학적: Pembrolizumab Given IV 다른 이름들: 키트루다 MK-3475 람브롤리주맙 SCH 900475 MK3475 SCH-900475 BCD-201 펨브롤리주맙 바이오시밀러 BCD-201 펨브롤리주맙 바이오시밀러 QL2107 QL2107 GME 751 GME751 펨브롤리주맙 바이오시밀러 GME751 MK 3475 SCH900475 펨브롤리주맙 바이오시밀러 RPH-075 RPH 075 RPH-075 RPH075 펨브 롤리 주맙 바이오시 밀러 SB27 SB 27 SB-27 SB27 절차: Computed Tomography Undergo CT scan 다른 이름들: CT 고양이 고양이 스캔 컴퓨터 축 단층 촬영 전산화 단층 촬영 CT 스캔 단층 촬영 컴퓨터 축 단층 촬영(시술) 컴퓨터 단층촬영(CT) 스캔 진단 CAT 스캔 진단 CAT 스캔 서비스 유형 절차: Positron Emission Tomography Undergo PET scan 다른 이름들: 의료 영상, 양전자 방출 단층 촬영 애완 동물 PET 스캔 양전자 방출 단층 촬영 스캔 양전자 방출 단층 촬영 PT 양전자방출단층촬영(시술)
실험적: Arm B (pembrolizumab, pemetrexed, carboplatin) Patients receive pembrolizumab IV over 30 minutes on day 1. Cycles repeat every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity. Within 6 weeks of disease progression, patients receive pembrolizumab IV over 30 minutes, pemetrexed IV over 10 minutes, and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive pembrolizumab IV over 30 minutes and pemetrexed IV over 10 minutes on day 1. Cycles repeat every 21 days for up to 2 years for pembrolizumab in the absence of disease progression or unacceptable toxicity and until to disease progression for pemetrexed. Patients undergo MRI during screening, CT scan and blood sample collection throughout the study, and may undergo PET scan throughout the study.	의약품: Carboplatin Given IV 다른 이름들: 폭발탄 카르보플라트 카보플라틴 헥살 카르보플라티노 카보플라티넘 카르보신 카보솔 카보텍 CBDCA 디스플라타 에르카르 JM-8 닐로린 노보플라티넘 파라플라틴 파라플라틴 AQ 플라틴와스 리보카르보 JM8 절차: Biospecimen Collection Undergo blood sample collection 다른 이름들: 생물학적 샘플 수집 생체 표본 수집 표본 수집 샘플 수집 절차: Magnetic Resonance Imaging Undergo MRI 다른 이름들: MRI 자기 공명 자기공명영상 스캔 의료영상, 자기공명 / 핵자기공명 씨 MR 이미징 MRI 검사 NMR 이미징 NMRI 핵자기공명영상 자기공명영상(MRI) SMRI 자기공명영상(시술) 구조적 MRI 의약품: Pemetrexed Given IV 다른 이름들: MTA 다중 표적 항엽산제 펨펙시 생물학적: Pembrolizumab Given IV 다른 이름들: 키트루다 MK-3475 람브롤리주맙 SCH 900475 MK3475 SCH-900475 BCD-201 펨브롤리주맙 바이오시밀러 BCD-201 펨브롤리주맙 바이오시밀러 QL2107 QL2107 GME 751 GME751 펨브롤리주맙 바이오시밀러 GME751 MK 3475 SCH900475 펨브롤리주맙 바이오시밀러 RPH-075 RPH 075 RPH-075 RPH075 펨브 롤리 주맙 바이오시 밀러 SB27 SB 27 SB-27 SB27 절차: Computed Tomography Undergo CT scan 다른 이름들: CT 고양이 고양이 스캔 컴퓨터 축 단층 촬영 전산화 단층 촬영 CT 스캔 단층 촬영 컴퓨터 축 단층 촬영(시술) 컴퓨터 단층촬영(CT) 스캔 진단 CAT 스캔 진단 CAT 스캔 서비스 유형 절차: Positron Emission Tomography Undergo PET scan 다른 이름들: 의료 영상, 양전자 방출 단층 촬영 애완 동물 PET 스캔 양전자 방출 단층 촬영 스캔 양전자 방출 단층 촬영 PT 양전자방출단층촬영(시술)
활성 비교기: Arm C (pembrolizumab, pembrolizumab, carboplatin) Patients receive pembrolizumab IV over 30 minutes, pemetrexed IV over 10 minutes, and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive pembrolizumab IV over 30 minutes and pemetrexed IV over 10 minutes on day 1. Cycles repeat every 21 days for up to 2 years for pembrolizumab in the absence of disease progression or unacceptable toxicity and until to disease progression for pemetrexed. Patients undergo MRI during screening, CT scan and blood sample collection throughout the study, and may undergo PET scan throughout the study.	의약품: Carboplatin Given IV 다른 이름들: 폭발탄 카르보플라트 카보플라틴 헥살 카르보플라티노 카보플라티넘 카르보신 카보솔 카보텍 CBDCA 디스플라타 에르카르 JM-8 닐로린 노보플라티넘 파라플라틴 파라플라틴 AQ 플라틴와스 리보카르보 JM8 절차: Biospecimen Collection Undergo blood sample collection 다른 이름들: 생물학적 샘플 수집 생체 표본 수집 표본 수집 샘플 수집 절차: Magnetic Resonance Imaging Undergo MRI 다른 이름들: MRI 자기 공명 자기공명영상 스캔 의료영상, 자기공명 / 핵자기공명 씨 MR 이미징 MRI 검사 NMR 이미징 NMRI 핵자기공명영상 자기공명영상(MRI) SMRI 자기공명영상(시술) 구조적 MRI 의약품: Pemetrexed Given IV 다른 이름들: MTA 다중 표적 항엽산제 펨펙시 생물학적: Pembrolizumab Given IV 다른 이름들: 키트루다 MK-3475 람브롤리주맙 SCH 900475 MK3475 SCH-900475 BCD-201 펨브롤리주맙 바이오시밀러 BCD-201 펨브롤리주맙 바이오시밀러 QL2107 QL2107 GME 751 GME751 펨브롤리주맙 바이오시밀러 GME751 MK 3475 SCH900475 펨브롤리주맙 바이오시밀러 RPH-075 RPH 075 RPH-075 RPH075 펨브 롤리 주맙 바이오시 밀러 SB27 SB 27 SB-27 SB27 절차: Computed Tomography Undergo CT scan 다른 이름들: CT 고양이 고양이 스캔 컴퓨터 축 단층 촬영 전산화 단층 촬영 CT 스캔 단층 촬영 컴퓨터 축 단층 촬영(시술) 컴퓨터 단층촬영(CT) 스캔 진단 CAT 스캔 진단 CAT 스캔 서비스 유형 절차: Positron Emission Tomography Undergo PET scan 다른 이름들: 의료 영상, 양전자 방출 단층 촬영 애완 동물 PET 스캔 양전자 방출 단층 촬영 스캔 양전자 방출 단층 촬영 PT 양전자방출단층촬영(시술)

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주요 결과 측정

결과 측정	측정값 설명	기간
Overall survival (OS) 기간: From randomization to death from any cause, assessed up to 5 years post treatment	OS distributions will be estimated using the Kaplan-Meier method.	From randomization to death from any cause, assessed up to 5 years post treatment

2차 결과 측정

결과 측정	측정값 설명	기간
Progression-free survival (PFS) 기간: From randomization to documented disease progression or death from any cause, assessed up to 5 years post treatment	PFS distributions will be estimated using the Kaplan-Meier method.	From randomization to documented disease progression or death from any cause, assessed up to 5 years post treatment
Best objective response 기간: Up to 5 years post treatment	Best objective response will be evaluated via Response Evaluation Criteria in Solid Tumors 1.1 criteria.	Up to 5 years post treatment
Incidence of adverse events 기간: Up to 30 days post treatment	Toxicities will be reported via the Common Terminology Criteria for Adverse Events criteria version 5.0. Toxicity rates between arms in the overall population will be compared using Fisher's exact tests with a one-sided type I error rate of 1.25%; multivariable logistic regression modeling will be used to adjust for the effect of any covariates that are associated with these categorical outcomes.	Up to 30 days post treatment
PD-L1 positivity 기간: At baseline	PD-L1 positivity will be defined as >= 1% Tumor Proportion Score (TPS) for the purpose of enrollment onto the trial. Strongly PD-L1 positive is defined as >= 50% TPS; weakly positive is defined as 1% - 49% TPS.	At baseline

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스폰서

National Cancer Institute (NCI)

수사관

수석 연구원: Hossein Borghaei, ECOG-ACRIN Cancer Research Group

연구 기록 날짜

이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.

연구 주요 날짜

연구 시작 (실제)

2019년 4월 5일

기본 완료 (추정된)

2027년 9월 30일

연구 완료 (추정된)

2027년 9월 30일

연구 등록 날짜

최초 제출

2019년 1월 3일

QC 기준을 충족하는 최초 제출

2019년 1월 3일

처음 게시됨 (실제)

2019년 1월 4일

연구 기록 업데이트

마지막 업데이트 게시됨 (실제)

2026년 10월 26일

QC 기준을 충족하는 마지막 업데이트 제출

2026년 10월 23일

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2026년 9월 1일

추가 정보

이 연구와 관련된 용어

추가 관련 MeSH 약관

기타 연구 ID 번호

NCI-2018-03695
U10CA180820 (미국 NIH 보조금/계약)
NCI-2018-03695 (레지스트리 식별자: CTRP (Clinical Trial Reporting Program))
EA5163 (기타 식별자: CTEP)
EA5163 (기타 식별자: ECOG-ACRIN Cancer Research Group)

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예

IPD 계획 설명

NCI is committed to sharing data in accordance with NIH policy. For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page

약물 및 장치 정보, 연구 문서

미국 FDA 규제 의약품 연구

예

미국 FDA 규제 기기 제품 연구

아니

이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .

비소세포폐암에서 1차 치료 및 유지 관리로서 펨브롤리주맙 단독 또는 화학요법의 시기 테스트

EA5163/S1709 INSIGNA: A Randomized, Phase III Study of Firstline Immunotherapy Alone or in Combination With Chemotherapy in Induction/Maintenance or Postprogression in Advanced Nonsquamous Non-Small Cell Lung Cancer (NSCLC) With Immunobiomarker Signature-Driven Analysis

연구 개요

상태

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상세 설명

연구 유형

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연락처 및 위치

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디자인 세부사항

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연구는 무엇을 측정합니까?

주요 결과 측정

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2차 결과 측정

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측정값 설명

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공동 작업자 및 조사자

스폰서

수사관

연구 기록 날짜

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연구 시작 (실제)

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최초 제출

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연구 기록 업데이트

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추가 정보

이 연구와 관련된 용어

추가 관련 MeSH 약관

기타 연구 ID 번호

개별 참가자 데이터(IPD) 계획

개별 참가자 데이터(IPD)를 공유할 계획입니까?

IPD 계획 설명

약물 및 장치 정보, 연구 문서

미국 FDA 규제 의약품 연구

미국 FDA 규제 기기 제품 연구