Eye Care Benefits of Anti-Aging Compound Capsules in Healthy Adults (Eye Care)
Exploring the Eye Care Benefits of Anti-aging Compound Capsules
This study aims to evaluate the eye care benefits of anti-aging compound capsules in healthy adults. Participants will consume anti-aging compound capsules containing botanical extracts, omega-3 fatty acids, vitamins, minerals, and hyaluronic acid for four weeks.
The primary outcome is the improvement of ocular discomfort and eye fatigue symptoms assessed using the Ocular Surface Disease Index (OSDI). Secondary outcomes include visual acuity, accommodative function, tear film stability, macular pigment optical density, intraocular pressure, and photostress recovery time. The study will investigate whether daily supplementation with anti-aging compound capsules can improve visual comfort and support ocular health.
연구 개요
상세 설명
Visual fatigue and ocular discomfort have become increasingly prevalent due to prolonged use of digital devices, environmental stressors, and age-related changes in visual function. Nutritional supplementation containing antioxidants, carotenoids, omega-3 fatty acids, vitamins, minerals, and other bioactive compounds may help maintain ocular health and visual performance.
This prospective, single-arm, open-label clinical study aims to evaluate the eye care benefits of anti-aging compound capsules in healthy adults. Twenty-five participants will be enrolled and instructed to consume anti-aging compound capsules for four consecutive weeks.
Each capsule contains 550 mg of a proprietary formulation consisting of grape skin extract, marigold flower extract, red algae extract, fish oil, black soybean seed coat extract, Streptococcus fermentation products containing sodium hyaluronate, black pepper extract, zinc glycinate, selenium yeast, vitamins A, B1, B2, B6, B12, niacin, vitamin E, soybean lecithin, and glycerol fatty acid esters.
Participants will consume two capsules twice daily for a total daily intake of 2,200 mg. Ophthalmic assessments will be performed at baseline, Week 2, and Week 4.
The primary outcome measure is the Ocular Surface Disease Index (OSDI) score. Secondary outcome measures include distance visual acuity, near visual acuity, accommodative response, accommodative facility, tear film break-up time, macular pigment optical density, intraocular pressure, and photostress recovery time.
The study aims to determine whether supplementation with anti-aging compound capsules can improve eye fatigue symptoms and support ocular health in healthy adults.
연구 유형
등록 (실제)
단계
- 해당 없음
연락처 및 위치
연구 장소
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Taichung, 대만
- Department of Optometry, Chung Shan Medical University
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참여기준
자격 기준
공부할 수 있는 나이
- 성인
건강한 자원 봉사자를 받아들입니다
설명
Inclusion Criteria:
- Adults aged 20 to 60 years. Willing to participate in the study and able to provide written informed consent.
Spherical equivalent refractive error less than 700 diopters of myopia (i.e., < -7.00 D).
Exclusion Criteria:
- Regular consumption within the past 1 month of dietary supplements primarily indicated for eye health, or products containing active ocular health-related ingredients that may influence study outcomes (e.g., high-dose lutein ≥10 mg/day or zeaxanthin ≥2 mg/day). Use of general multivitamins or non-eye-specific supplements containing low-dose related ingredients (≤2 mg) may be allowed at the discretion of the investigators.
History of ocular infection or ocular surgery within the past 3 months. Clinically diagnosed ocular diseases, including but not limited to glaucoma, cataract, age-related macular degeneration, or diabetic retinopathy, or a history of ocular procedures such as cataract surgery, retinal laser therapy, or refractive surgery (e.g., LASIK).
Known or self-reported hypersensitivity or allergic reaction to any component of the investigational product, including but not limited to fish oil, soybean-derived products, gelatin (bovine source), yeast, or any other listed ingredients.
Individuals with direct affiliation, supervisory, evaluative, or dependent relationships with the research team, including but not limited to:
Students taught, supervised, or evaluated by members of the research team; Laboratory or research assistants, staff, or collaborators within the same research unit; Interns, part-time workers, or employees under the supervision of the research team.
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 지지 요법
- 할당: 해당 없음
- 중재 모델: 단일 그룹 할당
- 마스킹: 없음(오픈 라벨)
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
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실험적: Anti-Aging Compound Capsules
Participants will receive anti-aging compound capsules containing botanical extracts, omega-3 fatty acids, vitamins, minerals, and hyaluronic acid for 4 weeks.
Participants will take 2 capsules twice daily (total daily dose 2,200 mg).
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Participants will consume anti-aging compound capsules twice daily for 4 weeks.
Each capsule contains 550 mg of a proprietary formulation consisting of grape skin extract, marigold flower extract, red algae extract, fish oil, black soybean seed coat extract, Streptococcus fermentation products containing sodium hyaluronate, black pepper extract, zinc glycinate, selenium yeast, vitamins A, B1, B2, B6, B12, niacin, vitamin E, soybean lecithin, and glycerol fatty acid esters.
Total daily intake is 2,200 mg.
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Change in Ocular Surface Disease Index (OSDI) Score
기간: baseline / week2 / week4
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Changes in ocular discomfort and eye fatigue symptoms will be assessed using the Ocular Surface Disease Index (OSDI) questionnaire.
The OSDI is a validated 12-item questionnaire used to evaluate symptoms related to ocular surface disease and visual function.
Assessments will be performed at baseline, Week 2, and Week 4. A decrease in OSDI score indicates improvement in ocular symptoms.
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baseline / week2 / week4
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Change in Distance Visual Acuity (DVA, logMAR)
기간: baseline / week2 / week4
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Changes in distance visual acuity will be measured using a Snellen chart at 6 meters and converted to logarithm of the minimum angle of resolution (logMAR) for statistical analysis.
Assessments will be performed at baseline, Week 2, and Week 4.
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baseline / week2 / week4
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Change in Near Visual Acuity (NVA)
기간: baseline / week2 / week4
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Changes in near visual acuity will be assessed using a Snellen near-vision chart at a distance of 40 cm.
Assessments will be performed at baseline, Week 2, and Week 4.
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baseline / week2 / week4
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Change in Accommodative Response
기간: baseline / week2 / week4
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Accommodative response will be measured using a Shin-Nippon NVision-K5001 open-field autorefractor, including accommodative lag and accommodative lead.
Measurements will be conducted at baseline, Week 2, and Week 4.
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baseline / week2 / week4
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Change in Accommodative Facility (cycles per minute)
기간: baseline / week2 / week4
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Accommodative facility will be assessed using ±0.50 diopter flipper lenses with standard accommodative targets.
Results will be recorded as cycles per minute (CPM).
Assessments will be performed at baseline, Week 2, and Week 4.
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baseline / week2 / week4
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Change in Tear Film Break-Up Time (TBUT)
기간: baseline / week2 / week4
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Tear film stability will be evaluated using non-invasive tear break-up time measured by a corneal topography system (Topcon CA-800).
Assessments will be conducted at baseline, Week 2, and Week 4.
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baseline / week2 / week4
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Change in Macular Pigment Optical Density (MPOD)
기간: baseline / week2 / week4
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Macular pigment optical density will be measured using a macular pigment optical density analyzer.
Assessments will be performed at baseline, Week 2, and Week 4.
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baseline / week2 / week4
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Change in Photostress Recovery Time
기간: baseline / week2 / week4
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Photostress recovery time will be assessed by measuring the time required for visual function to return to baseline following exposure to a standardized bright light stimulus.
Assessments will be performed at baseline, Week 2, and Week 4.
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baseline / week2 / week4
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Change in Intraocular Pressure (IOP)
기간: baseline / week2 / week4
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Intraocular pressure will be measured using non-contact tonometry.
Measurements will be performed at baseline, Week 2, and Week 4.
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baseline / week2 / week4
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공동 작업자 및 조사자
수사관
- 수석 연구원: Lin, associated professor, Institute of Medical Research, Chung Shan Medical University
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
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개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
IPD 계획 설명
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