Clinical Phenotype and Prevalence of VEXAS Syndrome in Internal Medicine (FIND-VEXAS)
FIND-VEXAS Project (Friuli Internal Medicine Network for Detection of VEXAS Syndrome): Clinical Phenotype and Prevalence of VEXAS Syndrome in Internal Medicine
The FIND-VEXAS project is a multicenter, cross-sectional observational study conducted in Internal Medicine departments in the Friuli Venezia Giulia region of Italy.
The study aims to estimate how frequently VEXAS syndrome occurs among adults older than 50 years who are admitted to Internal Medicine units with otherwise unexplained systemic inflammation or hematologic abnormalities, such as fever, elevated inflammatory markers, macrocytic anemia, thrombocytopenia, or other cytopenias.
Participants will be assessed using clinical information, physical examination findings, routine laboratory tests, and imaging data. Patients with findings suggestive of VEXAS syndrome will be selected for confirmatory genetic testing of the UBA1 gene using blood or bone marrow samples.
In addition to estimating the prevalence of genetically confirmed VEXAS syndrome, the study will describe the clinical manifestations, hematologic abnormalities, inflammatory profile, and organ involvement of patients with suspected or confirmed disease.
연구 개요
상세 설명
VEXAS syndrome is an adult-onset autoinflammatory disease caused by acquired somatic mutations in the UBA1 gene. The condition is characterized by systemic inflammation, cytopenias, and multiorgan involvement, which may affect the skin, lungs, joints, cartilage, and blood vessels. VEXAS syndrome may also overlap with hematologic disorders, including myelodysplastic syndromes.
The disorder mainly affects men older than 50 years, a population frequently admitted to Internal Medicine departments. Patients with VEXAS syndrome may initially present with nonspecific findings such as unexplained fever, persistently elevated C-reactive protein or erythrocyte sedimentation rate, macrocytic anemia, thrombocytopenia, other cytopenias, or systemic inflammation without an identifiable infectious, neoplastic, or other clear cause.
The FIND-VEXAS project is a multicenter, cross-sectional observational study involving Internal Medicine departments affiliated with the FADOI Friuli Venezia Giulia network. The planned study duration is 24 months. Eligible participants will be adults older than 50 years who are admitted with unexplained inflammatory and hematologic abnormalities.
Participating centers will use routinely available clinical, laboratory, and imaging information to identify patients with features suggestive of VEXAS syndrome. The assessment may include medical history, physical examination, standard blood tests, and radiological examinations performed as part of routine clinical care. A structured screening pathway will be used to support diagnostic suspicion and identify patients who should undergo molecular confirmation.
Blood or bone marrow samples from patients with suspected VEXAS syndrome will be sent to the Immunology Laboratory at IRCCS Burlo Garofolo in Trieste, which will act as the regional reference center for UBA1 sequencing. Suspected cases identified across participating Internal Medicine departments will therefore be centralized for genetic confirmation.
The primary objective is to estimate the prevalence of genetically confirmed VEXAS syndrome in the Internal Medicine setting. Additional objectives are to describe the clinical presentation, hematologic features, inflammatory profile, and patterns of organ involvement among patients with suspected or genetically confirmed VEXAS syndrome.
The study is expected to improve recognition of VEXAS syndrome through clinically applicable screening criteria and to strengthen collaboration between Internal Medicine departments and specialized Immunology and Hematology laboratories.
연구 유형
등록 (추정된)
연락처 및 위치
연구 연락처
- 이름: Giacomo Emmi, MD, PhD
- 전화번호: +393286852815
- 이메일: giacomo.emmi@chuv.ch
연구 연락처 백업
- 이름: Maria Letizia Urban, MD, PhD
- 전화번호: +393478732241
- 이메일: marialetizia.urban@units.it
참여기준
자격 기준
공부할 수 있는 나이
- 성인
- 고령자
건강한 자원 봉사자를 받아들입니다
샘플링 방법
연구 인구
설명
Inclusion Criteria:
- Age older than 50 years.
- Admission to a participating Internal Medicine department within the FADOI Friuli Venezia Giulia network.
- Presence of otherwise unexplained systemic inflammation and/or hematologic abnormalities.
- At least one of the following clinical or laboratory findings:
- unexplained fever;
- elevated C-reactive protein and/or erythrocyte sedimentation rate;
- macrocytic anemia;
- thrombocytopenia or other cytopenias;
- systemic inflammatory manifestations without a clearly identified cause.
- Availability of clinical, laboratory, and imaging data required for assessment according to the study screening pathway.
- Provision of informed consent, where required by the approved study protocol and applicable regulations.
Exclusion Criteria:
- Systemic inflammation adequately explained by an active infection.
- Systemic inflammation adequately explained by a solid malignancy.
- Clinical or laboratory abnormalities with another clearly established etiology.
- Insufficient clinical or laboratory information to assess eligibility according to the study screening pathway.
- Inability or refusal to provide informed consent, where consent is required.
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
코호트 및 개입
그룹/코호트 |
개입 / 치료 |
|---|---|
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Patients With Suspected VEXAS Syndrome
Adults older than 50 years admitted to participating Internal Medicine departments with otherwise unexplained systemic inflammation and hematologic abnormalities, including fever, elevated inflammatory markers, macrocytic anemia, thrombocytopenia, or other cytopenias.
Participants will be assessed using routinely available clinical, laboratory, and imaging data.
Patients meeting the predefined criteria for suspected VEXAS syndrome will undergo molecular testing for UBA1 mutations
|
Blood or bone marrow samples from participants with clinical features suggestive of VEXAS syndrome will be analyzed for somatic mutations in the UBA1 gene.
Molecular testing will be performed centrally at the Immunology Laboratory of IRCCS Burlo Garofolo in Trieste.
다른 이름들:
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Prevalence of Genetically Confirmed VEXAS Syndrome
기간: Through study completion, up to 24 months
|
Proportion of enrolled participants with a somatic pathogenic mutation in the UBA1 gene confirming the diagnosis of VEXAS syndrome.
Prevalence will be calculated as the number of genetically confirmed VEXAS cases divided by the total number of participants included in the study and evaluated according to the study screening pathway.
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Through study completion, up to 24 months
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Clinical Characteristics of Participants With Suspected or Genetically Confirmed VEXAS Syndrome
기간: At study inclusion
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Frequency and distribution of clinical manifestations among participants with suspected or genetically confirmed VEXAS syndrome, including fever and involvement of the skin, lungs, joints, cartilage, and blood vessels.
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At study inclusion
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Hematologic Characteristics of Participants With Suspected or Genetically Confirmed VEXAS Syndrome
기간: At study inclusion
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Frequency and distribution of hematologic abnormalities, including macrocytic anemia, thrombocytopenia, other cytopenias, and associated hematologic disorders such as myelodysplastic syndrome.
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At study inclusion
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Inflammatory Profile of Participants With Suspected or Genetically Confirmed VEXAS Syndrome
기간: At study inclusion
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Description of inflammatory laboratory findings, including C-reactive protein and erythrocyte sedimentation rate values, in participants with suspected or genetically confirmed VEXAS syndrome.
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At study inclusion
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공동 작업자 및 조사자
수사관
- 수석 연구원: Giacomo Emmi, MD, PhD, CHUV Service d'immunologie et allergie, Lausanne, Switzerland
- 연구 의자: Francesco Zaja, University of Trieste
- 연구 의자: Fabio Fiammengo, FADOI-Friuli Venezia Giulia Network)
- 연구 의자: Alberto Tommasini, IRCCS Burlo Garofolo
- 연구 의자: Maria Letizia Urban, University of Trieste
연구 기록 날짜
연구 주요 날짜
연구 시작 (추정된)
기본 완료 (추정된)
연구 완료 (추정된)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
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IPD 계획 설명
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