Nasal Epithelium Gene Expression Profiling in Child Respiratory Allergic Disease
Nasal Epithelium Gene Expression Profiling in Child Respiratory Allergic
Using a human pangenomic microarray, the researchers established expression profiles of nasal epithelial cells, collected by brushing of patients belonging to one of four distinct groups:
- allergic rhinitis to dust mite (AR) isolated (n=12),
- AR associated with bronchial hyperreactivity (n=12),
- AR associated with asthma (n=14),
- control (n=14).
研究概览
详细说明
Context: Asthma is the most frequent chronic disease in childhood. Allergic rhinitis has been described as a risk factor to develop asthma. The objective of the study was to evaluate the contribution of the respiratory epithelium to development of allergic rhinitis and asthma and to identify the molecular mechanisms driving rhinitis toward asthma.
Methods: Using a human pangenomic microarray, we established expression profiles of nasal epithelial cells, collected by brushing of patients belonging to one of four distinct children 2 to 18 years of age groups:
- allergic rhinitis to dust mite (AR) isolated (n=12),
- AR associated with bronchial hyperreactivity (n=12),
- AR associated with asthma (n=14),
- control (n=14).
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
-
-
-
Nice、法国、06000
- Department of Pediatrics, Nice University Hospital
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
Patients:
- Patients between 6 and 17 years old
- Patients with allergic rhinitis
Witness:
- Patients between 6 and 17 years old
- Patients without allergic rhinitis and asthma
Exclusion Criteria:
- Rhino-bronchitis infection dated from less than 15 days
- Patients younger than 6 or older than 17 years
学习计划
研究是如何设计的？
设计细节
- 主要用途：放映
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
其他：A
Collection of nasal epithelial cells by brushing
|
Collection of nasal epithelial cells by brushing
|
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
Transcriptome analysis: genes statistically modulated between groups, predictive biomarkers allowing correct classification of groups
大体时间：At the sample time
|
At the sample time
|
次要结果测量
结果测量 |
大体时间 |
|---|---|
|
Validation with other techniques: Q-PCR
大体时间：At the sample time
|
At the sample time
|
合作者和调查者
合作者
调查人员
- 首席研究员：Marc Albertini, Professor、Department of Pediatrics of Nice University Hospital
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
关键字
其他研究编号
- CIR 2005
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.