The Epidemiology of Aortic Diameter in China
2009年1月12日 更新者：Zhejiang University
Epidemiology of Aortic Dimensions in Patients With Clinically Evident Arterial Disease or Cardiovascular Risk Factors
Aortic aneurysms are the major disease processes affecting the aorta and becoming a relatively common cause of death because of rupture or dissection.
The most common location for aneurysms is the infrarenal abdominal aorta, followed by the ascending thoracic aorta.
Unlike coronary heart disease, the incidence of abdominal aortic aneurysm (AAA) in the United States and Europe has been increasing, and this increase may not be due to higher levels of screening for this condition alone.
Aortic diameter is central to the diagnosis of aortic aneurysm.
Furthermore, it was demonstrated that non-AAA patients with an enlarged diameter of the infrarenal aortic diameter are also at high risk for all-cause mortality.
And aortic root dimension was associated with several coronary artery disease (CHD) risk factors and measures of subclinical disease and was predictive of incident congestive heart failure (CHF), stroke, cardiovascular disease (CVD) mortality, and all-cause mortality, but not of incident MI.
Up to now, there are limited studies on the epidemiology of aortic diameter, especially in Chinese population.
研究概览
详细说明
The purpose of this study was to analyze the size of the entire aorta at different anatomic levels in a large group of Chinese population with clinically evident arterial disease or cardiovascular risk factors to further explored the risk factors and potential alternative pathomechanisms for the development of aortic dilatation.
Comprehensive transthoracic M-mode, 2-dimensional, and Doppler echocardiographic studies will be performed using commercially available equipment.
The aortic dimensions were assessed at end-diastole at the different levels: (1) the annulus, (2) the mid-point of the sinuses of Valsalva, (3) the sinotubular junction, (4) the ascending aorta at the level of its largest diameter, (5) the transverse arch, (6) the descending aorta posterior to the left atrium, and (7) the abdominal aorta just distal to the origin of the renal arteries.
The extension of dilation is defined as the number of dilated aortic segments.
The relations among aortic dimensions and clinical characteristics will be assessed by multiple regression analysis.
The current study was to determine the association of risk factors of CVD and atherosclerosis diseases with aortic dimension in Chinese patients with clinical event atherosclerotic disease or risk factors of atherosclerotic disease.
研究类型
观察性的
注册 (预期的)
2000
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
-
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Zhejiang
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Hangzhou、Zhejiang、中国、317000
- 招聘中
- Second Affiliated Hospital of Zhejiang University College of Medicine
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接触：
- Zhao-xia Pu
- 电话号码：86-13989488402
- 邮箱：zhaoxiapu@163.com
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首席研究员：
- Zhao-xia Pu, MD
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Taizhou、Zhejiang、中国、317000
- 招聘中
- Taizhou Hospital, Wenzhou Medical College
-
接触：
- Li-jiang Tang
- 电话号码：86-13606655138
- 邮箱：taizhoutang@hotmail.com
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首席研究员：
- Li-jiang Tang
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
40年 及以上 (成人、年长者)
接受健康志愿者
不
有资格学习的性别
全部
取样方法
非概率样本
研究人群
Chinese population with clinically evident arterial disease or cardiovascular risk factors
描述
Inclusion Criteria:
- Patients aged 40 to 100 were referred to the hospital with a recent diagnosis of clinically evident arterial disease or a cardiovascular risk factor.
Exclusion Criteria:
- Those with connective tissue disease, congenital heart disease, cardiomyopathy, congestive heart failure,rheumatic arthritis, secondary causes of hypertension, or active cancer.
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
atherosclerosis
Patients With Clinically Evident Arterial Disease or Cardiovascular Risk Factors
|
Comprehensive transthoracic M-mode, 2-dimensional, and Doppler echocardiographic studies will be performed using commercially available equipment.
The aortic dimensions were assessed at end-diastole at the different levels:
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
合作者
调查人员
- 学习椅：Jian-an Wang、Second Affiliated Hospital, School of Medicine, Zhejiang University
- 首席研究员：Li-jiang Tang、Taizhou Hospital, Wenzhou Medical College
- 首席研究员：Xiao-feng Chen、Second Affiliated Hospital, School of Medicine, Zhejiang University
- 首席研究员：Zhao-xia Pu、Second Affiliated Hospital, School of Medicine, Zhejiang University
- 首席研究员：Xian-fang Lin、Taizhou Hospital, Wenzhou Medical College
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2009年1月1日
初级完成 (预期的)
2010年12月1日
研究完成 (预期的)
2015年12月1日
研究注册日期
首次提交
2009年1月8日
首先提交符合 QC 标准的
2009年1月8日
首次发布 (估计)
2009年1月12日
研究记录更新
最后更新发布 (估计)
2009年1月14日
上次提交的符合 QC 标准的更新
2009年1月12日
最后验证
2009年1月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.