Safety Study of Deep Brain Stimulation to Manage Thalamic Pain Syndrome (DBS)
2017年5月1日 更新者:Andre Machado
Deep Brain Stimulation for Thalamic Pain Syndrome
The purpose of this study is to determine the safety and efficacy of Deep Brian Stimulation (DBS) of the ventral capsular/ventral striatal as a treatment for patients with Thalamic Pain Syndrome (TPS).
The central hypothesis to be tested in this investigation is that VC/VS stimulation will modulate the affective component of TPS and, consequently, improve pain related disability.
研究概览
详细说明
This is a pilot clinical study of the therapeutic benefits of ventral capsular/ventral striatal deep brain stimulation (DBS) as a treatment for 10 patients with medically refractory thalamic pain syndrome.
Patients to be enrolled under this protocol will have experienced severe pain for more than six months and will be considered medically refractory.
Study subjects may have undergone and failed other surgical procedures or interventional procedures.
Study subjects will have chronic, medically refractory pain of disabling severity, refractory to treatment attempts with conventional medications.
Patients that are enrolled in the study will have bilateral DBS surgery, with implantation of one Medtronic 3391 DBS lead on either side of the brain.
These leads will then be connected at first to a single Medtronic PC pulse generator to be implanted in the infraclavicular region on one side.
Once the PC pulse generator is depleted, and the patient has completed the blinded phase of the study, the PC pulse generator will be replaced for an RC pulse generator.
The RC pulse generator has a battery life of 9 years and is a good option for the open label phase and for continued stimulation after the study is completed.
However, the RC is not ideal for the blinded phase because patients may be able to tell if they are receiving active or sham stimulation.
For this reason, patients enrolled in this study will receive, initially, the implant with the PC generator.
Patients will have at least 6 months of stable chronic pain associated with TPS.
研究类型
介入性
注册 (实际的)
10
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
-
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Ohio
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Cleveland、Ohio、美国、44195
- Cleveland Clinic Foundation
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参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
21年 及以上 (成人、年长者)
接受健康志愿者
不
有资格学习的性别
全部
描述
Inclusion Criteria:
- Clinical diagnosis of thalamic pain syndrome
- with allodynia or dysesthesia
- with pinprick anesthesia or hypoesthesia on the affected hemibody (anesthesia dolorosa).
- Six months or more of medically refractory severe pain (see below).
- Pain disability reported by the pain index >30 points at the time of enrollment.
- Average daily pain for the past 30 days reported as >5 on a 0-10 scale
- Failure to respond adequately to at least one antidepressant, one anti-seizure medication and one oral narcotic.
- MRI done within one year of the first visit showing a lesion that involves the posterior thalamic region or a lesion in the dorsal or ventral vicinity of the thalamus (i.e. semi oval white matter or brain stem). The lesion will be contralateral to the hemibody affected by chronic pain or will involve cortical-subcortical areas in topography consistent with sensory thalamocortical connections. This will include patients with infarcts in the territory of the middle cerebral artery. A more recent MRI may be required if the patient's condition changed within the previous year.
- Capable of understanding and providing informed consent
- Age ≥ 21 years
- Women of childbearing age must be on regular use of an accepted contraceptive method(s).
- Previous surgical procedures: Patients with severe and refractory thalamic pain syndrome may have undergone other interventional or surgical procedures, as an attempt to alleviate the thalamic pain syndrome. Surgical procedure may include blocks, spinal cord stimulation, thalamic DBS, posterior limb of the internal capsule DBS or periaqueductal gray / periventricular gray DBS, cortical stimulation, peripheral ablative procedures or cerebral ablative procedures. In this study, patients with previously implanted cortical stimulation systems, or spinal and peripheral nervous system stimulation systems may be included. However, patients with previous motor cortex stimulation must have had the cortical stimulation system before being considered a candidate for this protocol. Removal of the cortical stimulation system will not be covered under this protocol. Patients with spinal or peripheral neuromodulation system may be included in the research provided that the implanted systems are compatible with the all research protocols (including fMRI) to be performed during the research. Patients with pervious DBS implants will not be considered candidates.
Exclusion Criteria:
- Not capable of understanding or providing informed consent.
- Aphasia severe enough to limit the consent process or communication between the investigators and the patient. Patients with mild or recovering aphasia may be considered candidates at the discretion of the PI.
- Coagulopathy. Patients will be excluded unless assessed and cleared by hematology
- Inability to stop Coumadin or platelet anti-aggregation therapy for surgery and after surgery. Patients taking these medications will need to discuss the need/risk of continuing these medications with their physicians and the PI or study personnel may contact the treating physician(s) as well to discuss the risks of anticoagulation / antiaggregation therapy discontinuation.
- Uncontrolled hypertension.
- Malignancy with < 5 years life expectancy.
- Major medical co-morbidities: end stage renal failure, heart failure, severe congestive heart disease, severe respiratory problems, liver failure or other significant medical co morbidities.
- Major neurological disorder other than the one that led to the TPS.
- MRI (done within one year of the first visit) with abnormalities other than those associated with the neurological disorder causing TPS.
- Age < 21 years.
- Pregnancy or lack of regular use of contraceptives. Patients who become pregnant after enrollment may be excluded from the study. Patients who become pregnant prior to the surgical implantation of the DBS systems will be excluded from the study.
- Previous ablative intracranial surgery for the management of the TPS.
- Previously implanted with deep brain stimulation system.
- Concurrent enrolment in any other trial / study for TPS.
- Implantable hardware not compatible with MRI or with the study.
- Patients may be excluded from enrollment due to a condition that, in the judgment of the PI, significantly increases risk or reduces significantly the likelihood of benefit from VC/VS DBS.
- Untreated / uncontrolled (severe at the time of enrolment) depression or other psychiatric disorder.
- Bipolar disorder, current PTSD, severe personality disorder, active psychosis, Severe OCD.
- Psychological co-morbidities that indicates higher risk to the patient and / or higher risk of failure.
- Suicide attempt </= 12 months
- Communication of a plan for suicide, prior to implant, should the study treatment fail
- Imminent suicide risk
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
- 主要用途:治疗
- 分配:随机化
- 介入模型:交叉作业
- 屏蔽:三倍
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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有源比较器:Treatment group
Active stimulation and programmed to the settings found to be optimal during the titration process.
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Patients will be randomized in a 1:1 ratio to one of two groups: the Treatment Group (active stimulation and programmed to the settings found to be optimal during the titration phase) and the Control Group (sham stimulation - IPG is set to ON but the voltage is set to 0V).
In order to prevent too many patients from being randomized to ON or to sham early in the study, we will use, for the first 4 patients, randomization blocks of four or six.
In this fashion, the first four consecutive patients will have two patients randomized to the Treatment Group and two patients in the Control Group.
In the same fashion, the final six patients will have three patients randomized to the treatment group and three patients to the control group.
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假比较器:Control group
IPG is set to ON but the voltage is set to 0V.
|
Patients will be randomized in a 1:1 ratio to one of two groups: the Treatment Group (active stimulation and programmed to the settings found to be optimal during the titration phase) and the Control Group (sham stimulation - IPG is set to ON but the voltage is set to 0V).
In order to prevent too many patients from being randomized to ON or to sham early in the study, we will use, for the first 4 patients, randomization blocks of four or six.
In this fashion, the first four consecutive patients will have two patients randomized to the Treatment Group and two patients in the Control Group.
In the same fashion, the final six patients will have three patients randomized to the treatment group and three patients to the control group.
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Number of Participants With 50% Improvement in Pain Related Disability (as Assessed by the Pain Disability Index)
大体时间:Blinded stimulation phase (3 Months)
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Pain Disability Index (PDI) directly measures disability related to the main components of daily life function and has been validated for thalamic pain syndrome.
Range is 0 (no disability) to 10 (worst disability).
The components are Family/Home Responsibilities, Recreation, Social Activity, Sexual Behavior, Life-support Activity, Occupation, & Self-care.
This is an average score of the 3 month period for each Active and Sham phase.
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Blinded stimulation phase (3 Months)
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Number of Participants Who Had 50% Improvement in PDI
大体时间:24 months post randomization follow up
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A 50% improvement in pain related disability (as assessed by the pain disability index) at the end of the open label phase compared to the pre-implantation baseline.
The PDI ranges from 0-10 with 0 equaling no disability and 10 equaling worst disability.
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24 months post randomization follow up
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Number of Participants Who Would Undergo the Procedure Again.
大体时间:End of Open Label Phase (24 months)
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A positive answer from patients receiving active stimulation at the end of the open label phase of the study to the question: 'would you undergo this procedure again if you were to get the same benefits you experienced?'
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End of Open Label Phase (24 months)
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Number of Patient Who Had >50% Reduction in VAS.
大体时间:Baseline and 24 months
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Patients report reduction in the VAS (Visual Analogue Scale Ranging from 0-10, 0 meaning no pain and 10 meaning worst pain imaginable) at the end of the open label phase (24 months post randomization f/u) compared to the pre-implantation baseline.
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Baseline and 24 months
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员:Andre G Machado, MD、The Cleveland Clinic
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Gopalakrishnan R, Burgess RC, Lempka SF, Gale JT, Floden DP, Machado AG. Pain anticipatory phenomena in patients with central poststroke pain: a magnetoencephalography study. J Neurophysiol. 2016 Sep 1;116(3):1387-95. doi: 10.1152/jn.00215.2016. Epub 2016 Jun 29.
- Gopalakrishnan R, Burgess RC, Plow EB, Floden DP, Machado AG. Early event related fields during visually evoked pain anticipation. Clin Neurophysiol. 2016 Mar;127(3):1855-63. doi: 10.1016/j.clinph.2015.11.019. Epub 2015 Dec 5.
- Plow EB, Malone DA Jr, Machado A. Deep brain stimulation of the ventral striatum/anterior limb of the internal capsule in thalamic pain syndrome: study protocol for a pilot randomized controlled trial. Trials. 2013 Jul 31;14:241. doi: 10.1186/1745-6215-14-241.
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2010年5月1日
初级完成 (实际的)
2014年8月1日
研究完成 (实际的)
2016年3月1日
研究注册日期
首次提交
2010年2月19日
首先提交符合 QC 标准的
2010年2月19日
首次发布 (估计)
2010年2月22日
研究记录更新
最后更新发布 (实际的)
2017年6月9日
上次提交的符合 QC 标准的更新
2017年5月1日
最后验证
2017年5月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.