Genetic Variant in Apolipoprotein C3 Gene and Fatty Liver in Obese Children
The Influence of Apolipoprotein C3 Variants on Liver Steatosis and Serum Liver Enzyme Values in Obese Children
In the past decades, obesity in children is much more prevalent in the world. Given the increasing prevalence of pediatric obesity worldwide, fatty liver incidence is on the rise.
Genetic variant in apolipoprotein C3 (APOC3) gene is associated with increased liver fat content in adults.
The aim of this study is to find out whether APOC3 single nucleotide polymorphism (SNP) influence fatty liver in obese children and adolescent.
研究概览
详细说明
The primary aim of this study is to assess the associations between to investigate the association of rs2854117 C > T and rs2854116 T > C SNPs of the APOC3 gene with liver steatosis, as measured by liver ultrasound.
As a secondary aim, the investigators will examine the associations between APOC3 rs2854117 C > T and rs2854116 T > C SNPs and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. In addition, the investigators will further analyze the association with other biomarkers, such as body mass index, adiponectin and insulin resistance.
研究类型
注册 (实际的)
联系人和位置
学习地点
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New Taipei City、台湾、220
- Far Eastern Memorial Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Age 6-18 years old
- Obesity definition: BMI > 95% according to the age- and gender-specific standard suggested by National Health Institute in Taiwan
- Willing to give written informed consent by parents
Exclusion Criteria:
- Alcohol consumption
- Chronic liver diseases, including hepatitis B, hepatitis C, Wilson disease and autoimmune hepatitis
- Major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and psychotic disorder
学习计划
研究是如何设计的？
设计细节
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without liver steatosis
大体时间：Oct 2013 ~ Dec 2014
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Oct 2013 ~ Dec 2014
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without insulin resistance
大体时间：Oct 2013 ~ Dec 2014
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Oct 2013 ~ Dec 2014
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合作者和调查者
调查人员
- 首席研究员：Yu-Cheng Lin, MD, PhD、Far Eastern Memorial Hospital
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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