Haptoglobin and Diabetes Complications in Pregnancy
Pregnancies of patients with Diabetes are associated with increase adverse pregnancy outcome . The risk for vascular complications including: Intra uterine growth restriction (20%), hypertension (31%), preeclampsia (15%), eclampsia and placental abruption are significantly greater than those in background populations. The risk of developing vascular complications in diabetes pregnancies although is correlated with the severity and length of the disease is not fully understood. Enhanced oxidation has been suggested to be the underlying abnormality responsible for some of the complications of diabetes.
Haptoglobin (Hp) is an abundant plasma glycoprotein produced in the liver. The best understood function of Hp is to bind free hemoglobin (Hb) released from red blood cells. Extracorpuscular Hb is a potent Fenton reagent.capable of of inflicting oxidative tissue damage. Hp binds to Hb and serves to inhibit the oxidative potential of Hb by preventing the release of heme iron.
The haptoglobin (Hp) gene at chromosomal locus 16q22 is polymorphic, with two common alleles denoted 1 and 2. the prevalence of Hp 1-1, Hp 1-2 and Hp 2-2 genotypes is approximately 16%, 48% and 36%, respectively. In the western world. A total of five independent longitudinal studies have demonstrated that DM individuals with Hp 2-2 genotype have a two to five-fold increased risk of CVD as compared to DM individuals without the Hp 2-2 genotype We sought to determine whether HP genotype plays important role in development of vascular complications in pregastational pregnancies. and whether Hp genotype 2-2 is a risk factor for developing gestational diabetes (GDM)
研究概览
地位
条件
研究类型
注册 (预期的)
联系人和位置
学习地点
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Be'er Sheva'、以色列
- 招聘中
- Soroka Medical Center
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接触:
- Ofer beharier, M.D
- 电话号码:001972525398676
- 邮箱:oferbeharie@gmail.com
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副研究员:
- Ofer Beharie, M.D
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首席研究员:
- Eyal Sheiner, M.D
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Haifa、以色列
- 招聘中
- Rambam Health Care Cmpus
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首席研究员:
- Ron Beloosesky, M.D
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副研究员:
- Nizzar KHATIB, M.D
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Kfar Saba、以色列
- 招聘中
- Meir Hospital
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接触:
- Tal Biron-Shental, M.D
- 电话号码:011972528362331
- 邮箱:Tal.Biron-Shental@clalit.org.il
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首席研究员:
- Tal Biron-Shental, M/D
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参与标准
资格标准
适合学习的年龄
- 孩子
- 成人
- 年长者
接受健康志愿者
有资格学习的性别
取样方法
研究人群
- Pregastetional diabetic patients currently pregnant
- Gestational diabetes patients currently pregnant
描述
Inclusion Criteria:
- Diabetes in pregnancy
Exclusion Criteria:
- Not willing to participate
学习计划
研究是如何设计的?
设计细节
研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
---|---|
vascular complications in pregnancy
大体时间:9 months
|
9 months
|
合作者和调查者
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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