- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01758016
Haptoglobin and Diabetes Complications in Pregnancy
Pregnancies of patients with Diabetes are associated with increase adverse pregnancy outcome . The risk for vascular complications including: Intra uterine growth restriction (20%), hypertension (31%), preeclampsia (15%), eclampsia and placental abruption are significantly greater than those in background populations. The risk of developing vascular complications in diabetes pregnancies although is correlated with the severity and length of the disease is not fully understood. Enhanced oxidation has been suggested to be the underlying abnormality responsible for some of the complications of diabetes.
Haptoglobin (Hp) is an abundant plasma glycoprotein produced in the liver. The best understood function of Hp is to bind free hemoglobin (Hb) released from red blood cells. Extracorpuscular Hb is a potent Fenton reagent.capable of of inflicting oxidative tissue damage. Hp binds to Hb and serves to inhibit the oxidative potential of Hb by preventing the release of heme iron.
The haptoglobin (Hp) gene at chromosomal locus 16q22 is polymorphic, with two common alleles denoted 1 and 2. the prevalence of Hp 1-1, Hp 1-2 and Hp 2-2 genotypes is approximately 16%, 48% and 36%, respectively. In the western world. A total of five independent longitudinal studies have demonstrated that DM individuals with Hp 2-2 genotype have a two to five-fold increased risk of CVD as compared to DM individuals without the Hp 2-2 genotype We sought to determine whether HP genotype plays important role in development of vascular complications in pregastational pregnancies. and whether Hp genotype 2-2 is a risk factor for developing gestational diabetes (GDM)
Study Overview
Status
Conditions
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: ron beloosesky, M.D
- Phone Number: 011972509205759
- Email: tomor2304@yahoo.com
Study Locations
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Be'er Sheva', Israel
- Recruiting
- Soroka Medical Center
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Contact:
- Ofer beharier, M.D
- Phone Number: 001972525398676
- Email: oferbeharie@gmail.com
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Sub-Investigator:
- Ofer Beharie, M.D
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Principal Investigator:
- Eyal Sheiner, M.D
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Haifa, Israel
- Recruiting
- Rambam Health Care Cmpus
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Principal Investigator:
- Ron Beloosesky, M.D
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Sub-Investigator:
- Nizzar KHATIB, M.D
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Kfar Saba, Israel
- Recruiting
- Meir Hospital
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Contact:
- Tal Biron-Shental, M.D
- Phone Number: 011972528362331
- Email: Tal.Biron-Shental@clalit.org.il
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Principal Investigator:
- Tal Biron-Shental, M/D
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
- Pregastetional diabetic patients currently pregnant
- Gestational diabetes patients currently pregnant
Description
Inclusion Criteria:
- Diabetes in pregnancy
Exclusion Criteria:
- Not willing to participate
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
vascular complications in pregnancy
Time Frame: 9 months
|
9 months
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2304-2000-RMB CTIL
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