Micrometastasis in Gastrointestinal Cancer
The Process of Metastasis in Colorectal Cancer Tumour Biology and Prognostic Factors in Pancreatic Cancer
Prognostic and predictive value of assessing the patients micrometastasis status in blood and bone marrow when diagnosed GI cancer. 2 different patient subgroups are currently studied, patients with cancer of the pancreas and patients with liver metastasis secondary to colorectal cancer.
Our hypothesis is that patients with detective circulating tumor cells in the blood or disseminated tumour cells in their bone marrow at diagnosis have a more advanced disease than negative patients. This information may be of therapeutic interest.
研究概览
详细说明
研究类型
注册 (预期的)
联系人和位置
学习地点
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Oslo、挪威、0424
- 招聘中
- Oslo University Hospital
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接触：
- Gro Wiedswang, MD,PhD
- 电话号码：+47 22119550
- 邮箱：uxgrie@ous-hf.no
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首席研究员：
- Gro Wiedswang, MD,PhD
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参与标准
资格标准
适合学习的年龄
- 孩子
- 成人
- 年长者
接受健康志愿者
有资格学习的性别
取样方法
研究人群
Gastrointestinal cancer patients:
- patients with suspected adenocarcinoma in the pancreas
- patients with liver metastases secondary to colorectal cancer
描述
Inclusion Criteria:
- Histological proven adenocarcinoma of the pancreas
- Histological/radiological verified colorectal liver metastases
- Consent capable patient
- Signed written, informed consent
Exclusion Criteria:
1. Patient'history of other malignancy
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
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Gastrointestinal cancer patients
Patients with radiological suspected cancer in the pancreas Patients with radiological suspected colorectal liver metastasis
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
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Survival
大体时间：5 year
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5 year
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合作者和调查者
调查人员
- 学习椅：Bjørn Atle Bjørnbeth, MD,PhD、Oslo University Hospital, Dep of Gastrointestinal surgery
出版物和有用的链接
一般刊物
- Hugenschmidt H, Labori KJ, Brunborg C, Verbeke CS, Seeberg LT, Bendigtsen Schirmer C, Renolen A, Borgen E, Naume B, Wiedswang G. Cytokeratin-positive cells in the bone marrow from patients with pancreatic, periampullary malignancy and benign pancreatic disease show no prognostic information. BMC Cancer. 2020 Nov 16;20(1):1107. doi: 10.1186/s12885-020-07510-z.
- Hugenschmidt H, Labori KJ, Brunborg C, Verbeke CS, Seeberg LT, Schirmer CB, Renolen A, Borgen EF, Naume B, Wiedswang G. Circulating Tumor Cells are an Independent Predictor of Shorter Survival in Patients Undergoing Resection for Pancreatic and Periampullary Adenocarcinoma. Ann Surg. 2020 Mar;271(3):549-558. doi: 10.1097/SLA.0000000000003035.
- Seeberg LT, Brunborg C, Waage A, Hugenschmidt H, Renolen A, Stav I, Bjornbeth BA, Borgen E, Naume B, Brudvik KW, Wiedswang G. Survival Impact of Primary Tumor Lymph Node Status and Circulating Tumor Cells in Patients with Colorectal Liver Metastases. Ann Surg Oncol. 2017 Aug;24(8):2113-2121. doi: 10.1245/s10434-017-5818-2. Epub 2017 Mar 3.
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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