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Effects of GABA Modulator AZD7325 on Cutaneous Sensation

2016年7月26日 更新者:University College, London

A Phase I Single Site, Single Dose, Randomized, Double-blind, Placebo Controlled, 2-way Cross-over Biomarker Study Investigating the Effect of the GABA Modulator AZD7325 on Cutaneous Sensation in Healthy Volunteers

GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the human brain. For years, drugs that enhance its effects (e.g., benzodiazepines such as diazepam/Valium) have been used to treat various diseases such as epilepsy, insomnia, anxiety or movement disorders. However, the use of these medications is often compromised because of their side effects, such as sleepiness, memory problems, and addiction.

Therefore, effort has been made to develop drugs that act more selectively in the brain to exert the positive therapeutic effects and are devoid of the unwanted side effects. AZD7325 is one of these drugs. It has been tested in more than 700 people and so far proved to be generally well tolerated. Positron emission tomography (PET) study in humans demonstrated that AZD7325 binds to GABA A receptors in the brain after a single dose. Early clinical studies have shown that it has less sedative and cognitive adverse events as compared with a benzodiazepine lorazepam.

The investigators now wish to evaluate if effects of AZD7325 can be objectively measured in healthy volunteers and to establish which of the drug's outcomes could be utilised for further studies in patients with neurological diseases.

The investigators are especially interested in the effects of AZD7325 on manual dexterity and skin sensation of the hand. This can be assessed by a number of simple non-invasive tests of object manipulation and detection of different sensory stimuli such as touch, vibration, or temperature. Recent studies show that healthy individuals who performed better in similar tasks had more GABA in relevant areas of their brain. If performance in these tasks in healthy volunteers can be improved by enhancing GABA effects in the brain with AZD7325, this would create the grounds for the use of this medication to treat symptoms of certain neurological disorders in which motor control and sensation of the hand is impaired (e.g., polyneuropathy).

研究概览

地位

完全的

条件

研究类型

介入性

注册 (实际的)

12

阶段

  • 阶段1

联系人和位置

本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。

学习地点

      • London、英国、WC1N 3BG
        • National Hospital For Neurology and Neurosurgery

参与标准

研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年 至 55年 (成人)

接受健康志愿者

是的

有资格学习的性别

男性

描述

Inclusion Criteria:

  • Male adults aged 18 to 55 years (extremes are included)
  • A body weight resulting in a body mass index (BMI) of 18-30 kg/m2 (extremes included) using the formula BMI = body-weight [in kg] / body-height [in m]2
  • Able and willing to sign the Informed Consent Form prior to screening evaluations.
  • History of good physical and mental health as determined by history taking and laboratory examinations, ECG, blood pressure and heart rate recordings as judged by the investigator
  • Willing not to consume alcohol or to smoke or chew tobacco on days of assessments
  • Subjects must be willing to avoid unprotected vaginal intercourse with women of child bearing potential (see above under 3.5) or donating sperm for the duration of the study and a further 1 week after drug administration.

Exclusion Criteria:

  • History of allergy/idiosyncrasy to AZD7325 or chemically related compounds or excipients which may be employed in the study or to any other drug used in the past
  • Subject has taken systemically (po, iv) any potent or moderate CYP3A4 or CYP2C9 inhibitor, 1 month prior to screening (topical or inhaled are permitted) such as: aprepitant, barbiturates, carbamazepine, clarithromycin, erythromycin, cyclosporine, diltiazem, efavirenz, fluconazole, HIV protease inhibitors, glucocorticoids, itraconazole (oral/IV), ketoconazole, nefazodone, nevirapine, phenytoin, pioglitazone, primidone, rifabutin, rifampicin, telithromycin, St. John's wort, verapamil
  • Use of any prescription drug judged by the investigator as potentially interfering with this trial within two weeks prior to the first dosing, except for topical medication without systemic exposure
  • Clinically relevant history or presence of any medical disorder, potentially interfering with this trial
  • Clinically relevant abnormal laboratory, ECG, HR or BP at screening as judged by the investigator
  • History of or current abuse of drugs (including prescription medication) or alcohol or solvents
  • Smoking in excess of 5 cigarettes per day or the equivalent within 28 days prior to the screening visit
  • Smoking or chewing of tobacco or consume of alcohol, 24 hours before and on the days of assessment
  • Subject is family member or in the employment line management of study personnel
  • Subject has abnormal screening laboratory values
  • Subject's partner is planning pregnancy within 3 months of last dosing
  • Participation in an IMP intervention trial within last month or more than four in the previous 12 months
  • Abnormal responses in the object manipulation task and psychophysical measures, SDMT, VAS outside 95% confidence interval of normal at screening visit
  • Subjects with a history of epilepsy, seizures or episodes of unexplained and unprovoked loss of consciousness

学习计划

本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。

研究是如何设计的?

设计细节

  • 主要用途:基础科学
  • 分配:随机化
  • 介入模型:交叉作业
  • 屏蔽:双倍的

武器和干预

参与者组/臂
干预/治疗
实验性的:20 mg AZD7325
10 mg AZD7325 in orange capsule, Size 0, 2 capsules as a single oral dose
单次口服
A single 20 mg oral dose of AZD7325
安慰剂比较:Placebo
10 mg Microcrystalline cellulose in orange capsule, Size 0, 2 capsules as a single oral dose
单次口服
A single 20 mg oral dose of AZD7325

研究衡量的是什么?

主要结果指标

结果测量
大体时间
Change in peak grip force in an object manipulation task
大体时间:from baseline at 1, 2, and 3 hours after the study medication
from baseline at 1, 2, and 3 hours after the study medication

次要结果测量

结果测量
措施说明
大体时间
Changes in parameters of object manipulation in a object manipulation task (grip force rate)
大体时间:from baseline at 1, 2, and 3 hours after the study medication
Parameters: grip force rate
from baseline at 1, 2, and 3 hours after the study medication
Changes in parameters of object manipulation in a object manipulation task (load force rate)
大体时间:from baseline at 1, 2, and 3 hours after the study medication
Parameters: load force rate
from baseline at 1, 2, and 3 hours after the study medication
Changes in parameters of object manipulation in a object manipulation task (static load force)
大体时间:from baseline at 1, 2, and 3 hours after the study medication
Parameters: static load force
from baseline at 1, 2, and 3 hours after the study medication
Changes in parameters of object manipulation in a object manipulation task (static grip force)
大体时间:from baseline at 1, 2, and 3 hours after the study medication
Parameters: static grip force
from baseline at 1, 2, and 3 hours after the study medication
Changes in parameters of object manipulation in a object manipulation task (9-hole pegboard test)
大体时间:from baseline at 1, 2, and 3 hours after the study medication
Parameters: 9-hole pegboard test
from baseline at 1, 2, and 3 hours after the study medication
Changes in performance in the psychophysical tests of cutaneous sensation ("bumps" test)
大体时间:from baseline at 1, 2, and 3 hours after the study medication
Parameters: "bumps" test
from baseline at 1, 2, and 3 hours after the study medication
Changes in performance in the psychophysical tests of cutaneous sensation (grating orientation task)
大体时间:from baseline at 1, 2, and 3 hours after the study medication
Parameters: grating orientation task
from baseline at 1, 2, and 3 hours after the study medication
Changes in performance in the psychophysical tests of cutaneous sensation (vibrotactile sensitivity)
大体时间:from baseline at 1, 2, and 3 hours after the study medication
Parameters: vibrotactile sensitivity
from baseline at 1, 2, and 3 hours after the study medication
Changes in performance in the psychophysical tests of cutaneous sensation (thermal sensitivity)
大体时间:from baseline at 1, 2, and 3 hours after the study medication
Parameters: thermal sensitivity
from baseline at 1, 2, and 3 hours after the study medication
Change in the rating on a 0-100 mm Visual Analogue Scale (VAS) of degree of sedation
大体时间:from baseline at 1, 2, and 3 hours after the study medication
from baseline at 1, 2, and 3 hours after the study medication
Change in the score of Symbol Digit Modalities Test (SDMT)
大体时间:from baseline at 1, 2, and 3 hours after the study medication
from baseline at 1, 2, and 3 hours after the study medication
Safety and tolerability of a single dose of AZD7325 by assessment of adverse events, vital signs, physical examination, ECG, and laboratory variables
大体时间:3 times during the trial period, an expected average of 4 weeks (before each dose and 48-96 hours after the last dose of study medication). Adverse events also at follow-up telephone call within a week after the last dose of study medication
Composite outcome measure
3 times during the trial period, an expected average of 4 weeks (before each dose and 48-96 hours after the last dose of study medication). Adverse events also at follow-up telephone call within a week after the last dose of study medication

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

调查人员

  • 首席研究员:Martin Koltzenburg, Prof、Institute of Neurology, University College London

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2016年2月1日

初级完成 (实际的)

2016年7月1日

研究完成 (实际的)

2016年7月1日

研究注册日期

首次提交

2015年8月3日

首先提交符合 QC 标准的

2015年8月19日

首次发布 (估计)

2015年8月21日

研究记录更新

最后更新发布 (估计)

2016年7月27日

上次提交的符合 QC 标准的更新

2016年7月26日

最后验证

2016年7月1日

更多信息

与本研究相关的术语

其他研究编号

  • 13/0261
  • 2015-000642-35 (EudraCT编号)

此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.

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