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Lower Limb Strength and Power as Predictors of Brain Blood Flow During Exercise (LLSPP)

2026年5月4日 更新者：Linjun Liu、Lincoln University College

Lower Limb Muscle Strength and Power Predict Exercise-Induced Prefrontal Hemodynamic Response: An Interpretable Machine Learning Study Using fNIRS Data

This study aims to investigate the predictive value of lower limb muscle strength and explosive power on exercise-induced prefrontal hemodynamic responses. Using an interpretable machine learning framework (GCAT-Net), the research analyzes how various physical performance indicators-such as isokinetic muscle strength, 1RM leg press, and vertical jump metrics-can predict oxygenated hemoglobin (ΔHbO) changes in the bilateral dorsolateral prefrontal cortex (DLPFC) during moderate-intensity cycling.

研究概览

地位

完全的

条件

干预/治疗

研究类型

介入性

注册 (实际的)

256

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 俄罗斯
      • Moscow、俄罗斯、117519
        • Moscow State University of Sport and Tourism

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

  • 成人

接受健康志愿者

是的

描述

Inclusion Criteria:

  1. Healthy adults aged between 18.00 and 60.00 years.
  2. Must be able to perform standardized lower-limb physical assessments, including isokinetic strength testing and explosive power tests (e.g., CMJ, SJ, and 30m sprints).
  3. Capability to complete a 6-minute aerobic cycling task at a moderate intensity (60% VO_2max).
  4. Physically cleared for exercise as determined by a Physical Activity Readiness Questionnaire (PAR-Q).
  5. Willingness to undergo functional near-infrared spectroscopy (fNIRS) monitoring with a Scalp Coupling Index (SCI) ≥ 0.7.

Exclusion Criteria:

  1. History of musculoskeletal injuries to the lower limbs within the past 6 months that would impede maximum voluntary contraction (MVC) or high-intensity efforts.
  2. Known cardiovascular, respiratory, or neurological conditions that contraindicate maximal exercise testing (VO_2max ramp protocol).
  3. Body Mass Index (BMI) or health status that prevents the safe completion of high-impact explosive power tests like the 30cm drop jump (RSI assessment).
  4. Presence of excessive motion artifacts or poor fNIRS signal quality, specifically a Signal-to-Noise Ratio (SNR) < 5 dB or motion artifact frame ratio ≥$ 10%.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：基础科学
  • 分配：不适用
  • 介入模型：单组作业
  • 屏蔽：无（打开标签）

武器和干预

参与者组/臂
干预/治疗
其他：Standardized Physical Performance and Hemodynamic Observation Group
Observational Study Arm
其他：Standardized Lower-Limb Physical Performance Assessment and Aerobic Exercise Task
Participants undergo a comprehensive physiological and biomechanical assessment protocol divided into three phases. First, demographic and morphological data (Age, Sex, BMI, and Body Fat %) are collected, followed by a maximal oxygen consumption (VO_2max) test using a Bruce-modified ramp protocol on a cycle ergometer. Second, participants complete a standardized lower-limb neuromuscular battery, including isokinetic strength testing at 60°/s (peak torque for knee, hip, and ankle) via a Biodex System 4 Pro, a 1RM leg press, and explosive power assessments comprising Countermovement Jumps (CMJ), Squat Jumps (SJ), and 30m sprints. Finally, cortical hemodynamic activity is monitored using a 16-channel fNIRS system (NIRSport2) over the bilateral dorsolateral prefrontal cortex (DLPFC) during a 6-minute constant-load cycling task at 60% VO_2max.

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Area Under the Curve of Oxygenated Hemoglobin (Δ HbO AUC) during Aerobic Exercise
大体时间：Measured during the 6-minute constant-load cycling task (60%VO_2max), which occurs approximately 120 minutes after the start of the experimental session.
Cortical hemodynamics are measured using the NIRSport2 fNIRS system over the bilateral dorsolateral prefrontal cortex (DLPFC).
Measured during the 6-minute constant-load cycling task (60%VO_2max), which occurs approximately 120 minutes after the start of the experimental session.

次要结果测量

结果测量
措施说明
大体时间
Demographic and Morphological Baseline Profile
大体时间：Baseline (Minutes 0-20 of the session).
Collection of foundational participant data including Age, Height (InBody H20N), Weight, BMI, and Body Fat % (InBody 770 via multi-frequency bioelectrical impedance). Resting Heart Rate (RHR) is recorded after 5 minutes of quiet rest.
Baseline (Minutes 0-20 of the session).
Isokinetic Neuromuscular Strength Battery
大体时间：Post-baseline assessment (Minutes 30-60 of the session).
Evaluation of lower-limb strength using a Biodex System 4 Pro at an angular velocity of 60°/s. Metrics include peak torque for knee extension/flexion, hip extension, and ankle plantarflexion, as well as the 1RM leg press and Hamstring/Quadriceps (H:Q) ratio.
Post-baseline assessment (Minutes 30-60 of the session).
Explosive Power and Functional Performance Metric
大体时间：Following isokinetic testing (Minutes 70-90 of the session).
Assessment of neuromuscular power through Countermovement Jump (CMJ), Squat Jump (SJ), Reactive Strength Index (RSI via 30cm drop jump), 30m sprint time, and standing long jump. Functional strength is measured using the Five Times Sit-to-Stand (FiveTSTS) test.
Following isokinetic testing (Minutes 70-90 of the session).
Peak Cardiorespiratory Capacity (VO_2max)
大体时间：Final physical assessment before the hemodynamic task (Minutes 100-120 of the session).
Maximal oxygen consumption determined through a Bruce-modified ramp protocol (25 W starting load, increasing 25 W/min) on a cycle ergometer until volitional exhaustion.
Final physical assessment before the hemodynamic task (Minutes 100-120 of the session).

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Lincoln University College

合作者

Wuhan Technical University

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2025年3月1日

初级完成 (实际的)

2025年3月15日

研究完成 (实际的)

2025年3月15日

研究注册日期

首次提交

2026年5月4日

首先提交符合 QC 标准的

2026年5月4日

首次发布 (实际的)

2026年5月8日

研究记录更新

最后更新发布 (实际的)

2026年5月8日

上次提交的符合 QC 标准的更新

2026年5月4日

最后验证

2026年5月1日

更多信息

与本研究相关的术语

关键字

其他研究编号

  • WSUST-IRB-070225

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

不

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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