Lower Limb Strength and Power as Predictors of Brain Blood Flow During Exercise (LLSPP)
4. maj 2026 opdateret af: Linjun Liu, Lincoln University College
Lower Limb Muscle Strength and Power Predict Exercise-Induced Prefrontal Hemodynamic Response: An Interpretable Machine Learning Study Using fNIRS Data
This study aims to investigate the predictive value of lower limb muscle strength and explosive power on exercise-induced prefrontal hemodynamic responses.
Using an interpretable machine learning framework (GCAT-Net), the research analyzes how various physical performance indicators-such as isokinetic muscle strength, 1RM leg press, and vertical jump metrics-can predict oxygenated hemoglobin (ΔHbO) changes in the bilateral dorsolateral prefrontal cortex (DLPFC) during moderate-intensity cycling.
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
256
Fase
- Ikke anvendelig
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Moscow, Rusland, 117519
- Moscow State University of Sport and Tourism
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
Tager imod sunde frivillige
Ja
Beskrivelse
Inclusion Criteria:
- Healthy adults aged between 18.00 and 60.00 years.
- Must be able to perform standardized lower-limb physical assessments, including isokinetic strength testing and explosive power tests (e.g., CMJ, SJ, and 30m sprints).
- Capability to complete a 6-minute aerobic cycling task at a moderate intensity (60% VO_2max).
- Physically cleared for exercise as determined by a Physical Activity Readiness Questionnaire (PAR-Q).
- Willingness to undergo functional near-infrared spectroscopy (fNIRS) monitoring with a Scalp Coupling Index (SCI) ≥ 0.7.
Exclusion Criteria:
- History of musculoskeletal injuries to the lower limbs within the past 6 months that would impede maximum voluntary contraction (MVC) or high-intensity efforts.
- Known cardiovascular, respiratory, or neurological conditions that contraindicate maximal exercise testing (VO_2max ramp protocol).
- Body Mass Index (BMI) or health status that prevents the safe completion of high-impact explosive power tests like the 30cm drop jump (RSI assessment).
- Presence of excessive motion artifacts or poor fNIRS signal quality, specifically a Signal-to-Noise Ratio (SNR) < 5 dB or motion artifact frame ratio ≥$ 10%.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Grundvidenskab
- Tildeling: N/A
- Interventionel model: Enkelt gruppeopgave
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
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Andet: Standardized Physical Performance and Hemodynamic Observation Group
Observational Study Arm
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Participants undergo a comprehensive physiological and biomechanical assessment protocol divided into three phases.
First, demographic and morphological data (Age, Sex, BMI, and Body Fat %) are collected, followed by a maximal oxygen consumption (VO_2max) test using a Bruce-modified ramp protocol on a cycle ergometer.
Second, participants complete a standardized lower-limb neuromuscular battery, including isokinetic strength testing at 60°/s (peak torque for knee, hip, and ankle) via a Biodex System 4 Pro, a 1RM leg press, and explosive power assessments comprising Countermovement Jumps (CMJ), Squat Jumps (SJ), and 30m sprints.
Finally, cortical hemodynamic activity is monitored using a 16-channel fNIRS system (NIRSport2) over the bilateral dorsolateral prefrontal cortex (DLPFC) during a 6-minute constant-load cycling task at 60% VO_2max.
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
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Area Under the Curve of Oxygenated Hemoglobin (Δ HbO AUC) during Aerobic Exercise
Tidsramme: Measured during the 6-minute constant-load cycling task (60%VO_2max), which occurs approximately 120 minutes after the start of the experimental session.
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Cortical hemodynamics are measured using the NIRSport2 fNIRS system over the bilateral dorsolateral prefrontal cortex (DLPFC).
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Measured during the 6-minute constant-load cycling task (60%VO_2max), which occurs approximately 120 minutes after the start of the experimental session.
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Demographic and Morphological Baseline Profile
Tidsramme: Baseline (Minutes 0-20 of the session).
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Collection of foundational participant data including Age, Height (InBody H20N), Weight, BMI, and Body Fat % (InBody 770 via multi-frequency bioelectrical impedance).
Resting Heart Rate (RHR) is recorded after 5 minutes of quiet rest.
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Baseline (Minutes 0-20 of the session).
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Isokinetic Neuromuscular Strength Battery
Tidsramme: Post-baseline assessment (Minutes 30-60 of the session).
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Evaluation of lower-limb strength using a Biodex System 4 Pro at an angular velocity of 60°/s.
Metrics include peak torque for knee extension/flexion, hip extension, and ankle plantarflexion, as well as the 1RM leg press and Hamstring/Quadriceps (H:Q) ratio.
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Post-baseline assessment (Minutes 30-60 of the session).
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Explosive Power and Functional Performance Metric
Tidsramme: Following isokinetic testing (Minutes 70-90 of the session).
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Assessment of neuromuscular power through Countermovement Jump (CMJ), Squat Jump (SJ), Reactive Strength Index (RSI via 30cm drop jump), 30m sprint time, and standing long jump.
Functional strength is measured using the Five Times Sit-to-Stand (FiveTSTS) test.
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Following isokinetic testing (Minutes 70-90 of the session).
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Peak Cardiorespiratory Capacity (VO_2max)
Tidsramme: Final physical assessment before the hemodynamic task (Minutes 100-120 of the session).
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Maximal oxygen consumption determined through a Bruce-modified ramp protocol (25 W starting load, increasing 25 W/min) on a cycle ergometer until volitional exhaustion.
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Final physical assessment before the hemodynamic task (Minutes 100-120 of the session).
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
1. marts 2025
Primær færdiggørelse (Faktiske)
15. marts 2025
Studieafslutning (Faktiske)
15. marts 2025
Datoer for studieregistrering
Først indsendt
4. maj 2026
Først indsendt, der opfyldte QC-kriterier
4. maj 2026
Først opslået (Faktiske)
8. maj 2026
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
8. maj 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
4. maj 2026
Sidst verificeret
1. maj 2026
Mere information
Begreber relateret til denne undersøgelse
Andre undersøgelses-id-numre
- WSUST-IRB-070225
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