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The Effects of GLP-1 Receptor Agonists on Chemosensory Function and Ingestive Behavior

2026年5月20日 更新者：Richard Mattes、Purdue University

The Effects of GLP-1 Receptor Agonists on Sensory Systems and Ingestive Behavior

The goal of this study is to explore whether of GLP-1 receptor agonist use is associated with differences in taste, smell, food preferences, appetite, food cravings, and responses to food cues in adults. The study includes adults who are not currently taking a GLP-1 receptor agonist but may be eligible to use one, and adults who are already taking a GLP-1 receptor agonist as part of their regular medical care for approximately 1 month or approximately 6 months.

The main questions it aims to answer are:

Are taste and smell function different among adults who are not taking a GLP-1 receptor agonist and adults who have been taking one for different lengths of time? Are food preferences, appetite, food cravings, food reward, attention to food cues, and salivary responses to food cues different among these groups? Researchers will compare adults not currently taking a GLP-1 receptor agonist with adults taking a GLP-1 receptor agonist for approximately 1 month or approximately 6 months. The research team will not prescribe, assign, or provide GLP-1 receptor agonist medications.

People in the study will attend two in-person study visits, complete taste and smell tests, complete food preference and computer-based tasks, and provide saliva samples during a food cue task. Questionnaires about appetite, cravings, food cues, and eating behavior will be completed at home over approximately 2 weeks.

研究概览

地位

完全的

条件

详细说明

This cross-sectional study examines associations between GLP-1 receptor agonist use, chemosensory function, and ingestive behavior in adults. People enrolled in the study are classified into groups based on GLP-1 receptor agonist use status and duration of use: adults who are not currently taking a GLP-1 receptor agonist but may be eligible to use one, adults taking a GLP-1 receptor agonist for approximately 1 month, and adults taking a GLP-1 receptor agonist for approximately 6 months.

GLP-1 receptor agonist use is not assigned by the research team. People who are taking these medications are using them as part of their regular medical care. The study team does not prescribe, administer, or change GLP-1 receptor agonist treatment.

Study procedures include assessments of taste and smell function, food preferences, food reward, appetite, food cravings, food cue responsivity, attentional responses to food cues, and salivary responses to a food cue. Outcomes will be compared across groups to explore whether GLP-1 receptor agonist use and duration of use are associated with differences in chemosensory function and ingestive behavior.

研究类型

观察性的

注册 (实际的)

90

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 美国
    • Indiana
      • West Lafayette、Indiana、美国、47906
        • Purdue University

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

  • 成人
  • 年长者

接受健康志愿者

是的

取样方法

非概率样本

研究人群

Adults aged 18 to 65 years with a Body Mass Index (BMI) greater than 30 kg/m² will be recruited. The study population includes individuals who are eligible to take GLP-1 receptor agonists but have not yet started treatment, and individuals who have been taking GLP-1 receptor agonists for weight management for approximately 1 month or approximately 6 months as part of their regular medical care. Participants will be recruited from the general population and through healthcare providers at IU Health.

描述

Inclusion Criteria:

  • Ages 18 to 65 years.
  • Any sex or gender.
  • Body Mass Index (BMI) >30 kg/m².
  • Stable medication use, excluding weight management medications other than GLP-1 receptor agonist use as part of regular medical care.
  • Eligible to take GLP-1 receptor agonists but not yet started treatment, or currently taking GLP-1 receptor agonists for weight management for approximately 1 month (±0.5 months) or approximately 6 months (±0.5 months).
  • No known sensitivity or allergy to study solutions or foods, including sweet solutions, salty solutions, sour solutions, bitter solutions, fatty stimuli, common food flavors used in testing, milk, and fruit-flavored beverages.

Exclusion Criteria:

  • Younger than 18 years or older than 65 years.
  • Previous bariatric surgery or planned bariatric surgery within the next year.
  • Sensitivity or allergy to study foods, taste solutions, odor stimuli, or food-related test materials.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

队列和干预

团体/队列
Pre-use / Not Currently Taking GLP-1RA
Adults who are not currently taking a GLP-1 receptor agonist but may be eligible to use one based on body weight criteria (BMI > 30). Participants in this group are not assigned to GLP-1 receptor agonist treatment by the study team.
Approximately 1 Month GLP-1RA Use
Adults who have been taking a GLP-1 receptor agonist as part of their regular medical care for approximately 1 month. GLP-1 receptor agonist use is not assigned, prescribed, or modified by the study team.
Approximately 6 Months GLP-1RA Use
Adults who have been taking a GLP-1 receptor agonist as part of their regular medical care for approximately 6 months. GLP-1 receptor agonist use is not assigned, prescribed, or modified by the study team.

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Taste Detection Thresholds
大体时间：During study participation, up to 2 weeks
Taste detection thresholds will be assessed for sweet, salty, sour, and bitter stimuli (sucrose, sodium chloride, citric acid, and urea, respectively) using a two-alternative forced-choice staircase procedure, in which participants identify which of two samples contains the taste stimulus. Separate outcomes will be reported for each taste quality: sweet, salty, sour, and bitter. For each taste quality, the threshold will be calculated as the geometric mean concentration at which the stimulus is reliably detected and will be reported in mmol/L. Lower threshold values indicate greater taste sensitivity.
During study participation, up to 2 weeks
Suprathreshold Taste Intensity
大体时间：During study participation, up to 2 weeks
Suprathreshold taste intensity will be assessed for sweet, salty, sour, and bitter stimuli (sucrose, sodium chloride, citric acid, and urea, respectively) using the general Labeled Magnitude Scale. Separate outcomes will be reported for each taste quality and stimulus concentration. For each taste quality, participants will rate the perceived intensity of suprathreshold stimulus concentrations. The scale ranges from 0 to 100, with 0 anchored by "no sensation" and 100 anchored by "strongest imaginable sensation of any kind." Higher scores indicate greater perceived taste intensity.
During study participation, up to 2 weeks
Taste Hedonics
大体时间：During study participation, up to 2 weeks
Taste hedonics will be assessed using a food modification task in which participants create preferred concentrations for sweet, salty, sour, bitter, and fatty stimuli. Separate outcomes will be reported for each stimulus type: sweet, salty, sour, bitter, and fatty. For each stimulus type, the outcome will be the preferred concentration selected by the participant. Higher values indicate preference for a higher concentration of that stimulus and do not necessarily indicate a better or worse outcome.
During study participation, up to 2 weeks
Fat Taste Intensity Rating
大体时间：During study participation, up to 2 weeks
Fat taste perception will be assessed using edible strips containing different concentrations of linoleic acid. Participants will rate the perceived intensity of each strip using the general Labeled Magnitude Scale. Separate outcomes will be reported for each linoleic acid concentration. The scale ranges from 0 to 100, with 0 anchored by "no sensation" and 100 anchored by "strongest imaginable sensation of any kind." Higher scores indicate greater perceived fat taste intensity.
During study participation, up to 2 weeks
ArOMa-T Olfactory Test Performance
大体时间：During study participation, up to 2 weeks
Olfactory function will be assessed using the ArOMa-T test. Participants will smell odor stimuli and provide computer-based responses to questions assessing olfactory performance. The outcome will be the ArOMa-T test score, with higher scores indicating better olfactory performance.
During study participation, up to 2 weeks
SCENTinel Olfactory Test Performance
大体时间：During study participation, up to 2 weeks
Olfactory function will be assessed using the SCENTinel test. Participants will smell odor stimuli and provide computer-based responses to questions assessing odor detection, odor identification, odor intensity, and odor pleasantness. Separate outcomes will be reported for each SCENTinel component. Higher scores indicate better odor detection or identification performance, greater perceived odor intensity, or greater perceived odor pleasantness, depending on the component assessed.
During study participation, up to 2 weeks

次要结果测量

结果测量
措施说明
大体时间
Food Preferences
大体时间：During study participation, up to 2 weeks
Food preferences will be assessed using the Leeds Food Preference Questionnaire. Participants will view food images and rate how much they like and want to eat each food item. Ratings will be used to assess explicit liking and wanting for foods.
During study participation, up to 2 weeks
Attentional Bias to Food Cues
大体时间：During study participation, up to 2 weeks
Attentional bias to food cues will be assessed using a Food Stroop Task. Participants will view food-related and non-food words and respond to the color of each word while ignoring the meaning of the word. Response patterns will be used to assess attentional bias toward food-related cues.
During study participation, up to 2 weeks
Questionnaire-Based Measures of Food Cravings, Food Cue Responsivity, Food Noise, and Eating Behavior
大体时间：During study participation, up to 2 weeks
Questionnaire-based measures will be used to assess food cravings, food cue responsivity, food-related intrusive thoughts, perceived food reward, and eating behavior. Participants will complete the Food Cue Responsivity Scale, the Modified Trait and State Food Cravings Questionnaires, the Power of Food Scale, the Food Noise Questionnaire, and the Reasons Individuals Stop Eating Questionnaire. These questionnaires will assess sensitivity to food-related cues, typical and momentary food cravings, food-related intrusive thoughts, perceived responsiveness to the food environment, and reasons for stopping eating, including motivations and physical cues related to meal termination and satisfaction.
During study participation, up to 2 weeks
Dietary Intake
大体时间：During study participation, up to 2 weeks
Dietary intake will be assessed using ASA24, the Automated Self-Administered 24-Hour Dietary Assessment Tool. Participants will complete three 24-hour dietary recalls on different days, including two weekdays and one weekend day, to report foods and beverages consumed over the previous 24 hours.
During study participation, up to 2 weeks
Cephalic-Phase Salivary Response
大体时间：During study participation, up to 2 weeks
Cephalic-phase salivary response will be assessed by measuring saliva production at baseline and during exposure to a food cue. Saliva will be collected during a baseline period and again while participants simulate eating a food item by focusing on its smell, taste, and texture. Saliva will be collected in graduated tubes and weighed to quantify salivary output. Change in salivation from baseline to food cue exposure will be compared across groups.
During study participation, up to 2 weeks

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Purdue University

调查人员

  • 首席研究员：Richard D Mattes, PhD, RD, MPH、Purdue University

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2025年2月20日

初级完成 (实际的)

2026年5月4日

研究完成 (实际的)

2026年5月4日

研究注册日期

首次提交

2026年5月14日

首先提交符合 QC 标准的

2026年5月20日

首次发布 (实际的)

2026年5月28日

研究记录更新

最后更新发布 (实际的)

2026年5月28日

上次提交的符合 QC 标准的更新

2026年5月20日

最后验证

2026年5月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • IRB-2024 - 1407

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

不

IPD 计划说明

Individual participant data will not be shared because the current IRB-approved protocol does not include a formal plan for external individual participant data sharing. Study data will be maintained in de-identified form, and identifiers/code keys will be stored separately and destroyed according to the approved protocol. De-identified data may be used by the study team for approved secondary analyses, but individual participant data will not be made publicly available or shared externally.

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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