The Effects of GLP-1 Receptor Agonists on Chemosensory Function and Ingestive Behavior
20 de mayo de 2026 actualizado por: Richard Mattes, Purdue University
The Effects of GLP-1 Receptor Agonists on Sensory Systems and Ingestive Behavior
The goal of this study is to explore whether of GLP-1 receptor agonist use is associated with differences in taste, smell, food preferences, appetite, food cravings, and responses to food cues in adults. The study includes adults who are not currently taking a GLP-1 receptor agonist but may be eligible to use one, and adults who are already taking a GLP-1 receptor agonist as part of their regular medical care for approximately 1 month or approximately 6 months.
The main questions it aims to answer are:
Are taste and smell function different among adults who are not taking a GLP-1 receptor agonist and adults who have been taking one for different lengths of time? Are food preferences, appetite, food cravings, food reward, attention to food cues, and salivary responses to food cues different among these groups? Researchers will compare adults not currently taking a GLP-1 receptor agonist with adults taking a GLP-1 receptor agonist for approximately 1 month or approximately 6 months. The research team will not prescribe, assign, or provide GLP-1 receptor agonist medications.
People in the study will attend two in-person study visits, complete taste and smell tests, complete food preference and computer-based tasks, and provide saliva samples during a food cue task. Questionnaires about appetite, cravings, food cues, and eating behavior will be completed at home over approximately 2 weeks.
Descripción general del estudio
Estado
Terminado
Descripción detallada
This cross-sectional study examines associations between GLP-1 receptor agonist use, chemosensory function, and ingestive behavior in adults. People enrolled in the study are classified into groups based on GLP-1 receptor agonist use status and duration of use: adults who are not currently taking a GLP-1 receptor agonist but may be eligible to use one, adults taking a GLP-1 receptor agonist for approximately 1 month, and adults taking a GLP-1 receptor agonist for approximately 6 months.
GLP-1 receptor agonist use is not assigned by the research team. People who are taking these medications are using them as part of their regular medical care. The study team does not prescribe, administer, or change GLP-1 receptor agonist treatment.
Study procedures include assessments of taste and smell function, food preferences, food reward, appetite, food cravings, food cue responsivity, attentional responses to food cues, and salivary responses to a food cue. Outcomes will be compared across groups to explore whether GLP-1 receptor agonist use and duration of use are associated with differences in chemosensory function and ingestive behavior.
Tipo de estudio
De observación
Inscripción (Actual)
90
Contactos y Ubicaciones
Esta sección proporciona los datos de contacto de quienes realizan el estudio e información sobre dónde se lleva a cabo este estudio.
Ubicaciones de estudio
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Indiana
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West Lafayette, Indiana, Estados Unidos, 47906
- Purdue University
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Criterios de participación
Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.
Criterio de elegibilidad
Edades elegibles para estudiar
- Adulto
- Adulto Mayor
Acepta Voluntarios Saludables
Sí
Método de muestreo
Muestra no probabilística
Población de estudio
Adults aged 18 to 65 years with a Body Mass Index (BMI) greater than 30 kg/m² will be recruited.
The study population includes individuals who are eligible to take GLP-1 receptor agonists but have not yet started treatment, and individuals who have been taking GLP-1 receptor agonists for weight management for approximately 1 month or approximately 6 months as part of their regular medical care.
Participants will be recruited from the general population and through healthcare providers at IU Health.
Descripción
Inclusion Criteria:
- Ages 18 to 65 years.
- Any sex or gender.
- Body Mass Index (BMI) >30 kg/m².
- Stable medication use, excluding weight management medications other than GLP-1 receptor agonist use as part of regular medical care.
- Eligible to take GLP-1 receptor agonists but not yet started treatment, or currently taking GLP-1 receptor agonists for weight management for approximately 1 month (±0.5 months) or approximately 6 months (±0.5 months).
- No known sensitivity or allergy to study solutions or foods, including sweet solutions, salty solutions, sour solutions, bitter solutions, fatty stimuli, common food flavors used in testing, milk, and fruit-flavored beverages.
Exclusion Criteria:
- Younger than 18 years or older than 65 years.
- Previous bariatric surgery or planned bariatric surgery within the next year.
- Sensitivity or allergy to study foods, taste solutions, odor stimuli, or food-related test materials.
Plan de estudios
Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.
¿Cómo está diseñado el estudio?
Detalles de diseño
Cohortes e Intervenciones
Grupo / Cohorte |
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Pre-use / Not Currently Taking GLP-1RA
Adults who are not currently taking a GLP-1 receptor agonist but may be eligible to use one based on body weight criteria (BMI > 30).
Participants in this group are not assigned to GLP-1 receptor agonist treatment by the study team.
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Approximately 1 Month GLP-1RA Use
Adults who have been taking a GLP-1 receptor agonist as part of their regular medical care for approximately 1 month.
GLP-1 receptor agonist use is not assigned, prescribed, or modified by the study team.
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Approximately 6 Months GLP-1RA Use
Adults who have been taking a GLP-1 receptor agonist as part of their regular medical care for approximately 6 months.
GLP-1 receptor agonist use is not assigned, prescribed, or modified by the study team.
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¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
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Taste Detection Thresholds
Periodo de tiempo: During study participation, up to 2 weeks
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Taste detection thresholds will be assessed for sweet, salty, sour, and bitter stimuli (sucrose, sodium chloride, citric acid, and urea, respectively) using a two-alternative forced-choice staircase procedure, in which participants identify which of two samples contains the taste stimulus.
Separate outcomes will be reported for each taste quality: sweet, salty, sour, and bitter.
For each taste quality, the threshold will be calculated as the geometric mean concentration at which the stimulus is reliably detected and will be reported in mmol/L.
Lower threshold values indicate greater taste sensitivity.
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During study participation, up to 2 weeks
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Suprathreshold Taste Intensity
Periodo de tiempo: During study participation, up to 2 weeks
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Suprathreshold taste intensity will be assessed for sweet, salty, sour, and bitter stimuli (sucrose, sodium chloride, citric acid, and urea, respectively) using the general Labeled Magnitude Scale.
Separate outcomes will be reported for each taste quality and stimulus concentration.
For each taste quality, participants will rate the perceived intensity of suprathreshold stimulus concentrations.
The scale ranges from 0 to 100, with 0 anchored by "no sensation" and 100 anchored by "strongest imaginable sensation of any kind."
Higher scores indicate greater perceived taste intensity.
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During study participation, up to 2 weeks
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Taste Hedonics
Periodo de tiempo: During study participation, up to 2 weeks
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Taste hedonics will be assessed using a food modification task in which participants create preferred concentrations for sweet, salty, sour, bitter, and fatty stimuli.
Separate outcomes will be reported for each stimulus type: sweet, salty, sour, bitter, and fatty.
For each stimulus type, the outcome will be the preferred concentration selected by the participant.
Higher values indicate preference for a higher concentration of that stimulus and do not necessarily indicate a better or worse outcome.
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During study participation, up to 2 weeks
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Fat Taste Intensity Rating
Periodo de tiempo: During study participation, up to 2 weeks
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Fat taste perception will be assessed using edible strips containing different concentrations of linoleic acid.
Participants will rate the perceived intensity of each strip using the general Labeled Magnitude Scale.
Separate outcomes will be reported for each linoleic acid concentration.
The scale ranges from 0 to 100, with 0 anchored by "no sensation" and 100 anchored by "strongest imaginable sensation of any kind."
Higher scores indicate greater perceived fat taste intensity.
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During study participation, up to 2 weeks
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ArOMa-T Olfactory Test Performance
Periodo de tiempo: During study participation, up to 2 weeks
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Olfactory function will be assessed using the ArOMa-T test.
Participants will smell odor stimuli and provide computer-based responses to questions assessing olfactory performance.
The outcome will be the ArOMa-T test score, with higher scores indicating better olfactory performance.
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During study participation, up to 2 weeks
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SCENTinel Olfactory Test Performance
Periodo de tiempo: During study participation, up to 2 weeks
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Olfactory function will be assessed using the SCENTinel test.
Participants will smell odor stimuli and provide computer-based responses to questions assessing odor detection, odor identification, odor intensity, and odor pleasantness.
Separate outcomes will be reported for each SCENTinel component.
Higher scores indicate better odor detection or identification performance, greater perceived odor intensity, or greater perceived odor pleasantness, depending on the component assessed.
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During study participation, up to 2 weeks
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Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Food Preferences
Periodo de tiempo: During study participation, up to 2 weeks
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Food preferences will be assessed using the Leeds Food Preference Questionnaire.
Participants will view food images and rate how much they like and want to eat each food item.
Ratings will be used to assess explicit liking and wanting for foods.
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During study participation, up to 2 weeks
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Attentional Bias to Food Cues
Periodo de tiempo: During study participation, up to 2 weeks
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Attentional bias to food cues will be assessed using a Food Stroop Task.
Participants will view food-related and non-food words and respond to the color of each word while ignoring the meaning of the word.
Response patterns will be used to assess attentional bias toward food-related cues.
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During study participation, up to 2 weeks
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Questionnaire-Based Measures of Food Cravings, Food Cue Responsivity, Food Noise, and Eating Behavior
Periodo de tiempo: During study participation, up to 2 weeks
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Questionnaire-based measures will be used to assess food cravings, food cue responsivity, food-related intrusive thoughts, perceived food reward, and eating behavior.
Participants will complete the Food Cue Responsivity Scale, the Modified Trait and State Food Cravings Questionnaires, the Power of Food Scale, the Food Noise Questionnaire, and the Reasons Individuals Stop Eating Questionnaire.
These questionnaires will assess sensitivity to food-related cues, typical and momentary food cravings, food-related intrusive thoughts, perceived responsiveness to the food environment, and reasons for stopping eating, including motivations and physical cues related to meal termination and satisfaction.
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During study participation, up to 2 weeks
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Dietary Intake
Periodo de tiempo: During study participation, up to 2 weeks
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Dietary intake will be assessed using ASA24, the Automated Self-Administered 24-Hour Dietary Assessment Tool.
Participants will complete three 24-hour dietary recalls on different days, including two weekdays and one weekend day, to report foods and beverages consumed over the previous 24 hours.
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During study participation, up to 2 weeks
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Cephalic-Phase Salivary Response
Periodo de tiempo: During study participation, up to 2 weeks
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Cephalic-phase salivary response will be assessed by measuring saliva production at baseline and during exposure to a food cue.
Saliva will be collected during a baseline period and again while participants simulate eating a food item by focusing on its smell, taste, and texture.
Saliva will be collected in graduated tubes and weighed to quantify salivary output.
Change in salivation from baseline to food cue exposure will be compared across groups.
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During study participation, up to 2 weeks
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Colaboradores e Investigadores
Aquí es donde encontrará personas y organizaciones involucradas en este estudio.
Patrocinador
Investigadores
- Investigador principal: Richard D Mattes, PhD, RD, MPH, Purdue University
Publicaciones y enlaces útiles
La persona responsable de ingresar información sobre el estudio proporciona voluntariamente estas publicaciones. Estos pueden ser sobre cualquier cosa relacionada con el estudio.
Fechas de registro del estudio
Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.
Fechas importantes del estudio
Inicio del estudio (Actual)
20 de febrero de 2025
Finalización primaria (Actual)
4 de mayo de 2026
Finalización del estudio (Actual)
4 de mayo de 2026
Fechas de registro del estudio
Enviado por primera vez
14 de mayo de 2026
Primero enviado que cumplió con los criterios de control de calidad
20 de mayo de 2026
Publicado por primera vez (Actual)
28 de mayo de 2026
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
28 de mayo de 2026
Última actualización enviada que cumplió con los criterios de control de calidad
20 de mayo de 2026
Última verificación
1 de mayo de 2026
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
- Manifestaciones neurológicas
- Enfermedades del Sistema Nervioso
- Trastornos Nutricionales
- Sobrenutrición
- Peso corporal
- Trastornos sensoriales
- Trastornos del olfato
- Condiciones Patológicas, Signos y Síntomas
- Comportamiento
- Enfermedades Nutricionales y Metabólicas
- Signos y síntomas
- Comportamiento, animal
- Anosmia
- Exceso de peso
- Obesidad
- Comportamiento de alimentación
- Preferencias de comida
Otros números de identificación del estudio
- IRB-2024 - 1407
Plan de datos de participantes individuales (IPD)
¿Planea compartir datos de participantes individuales (IPD)?
NO
Descripción del plan IPD
Individual participant data will not be shared because the current IRB-approved protocol does not include a formal plan for external individual participant data sharing.
Study data will be maintained in de-identified form, and identifiers/code keys will be stored separately and destroyed according to the approved protocol.
De-identified data may be used by the study team for approved secondary analyses, but individual participant data will not be made publicly available or shared externally.
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
No
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
No
Esta información se obtuvo directamente del sitio web clinicaltrials.gov sin cambios. Si tiene alguna solicitud para cambiar, eliminar o actualizar los detalles de su estudio, comuníquese con register@clinicaltrials.gov. Tan pronto como se implemente un cambio en clinicaltrials.gov, también se actualizará automáticamente en nuestro sitio web. .