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Using Personalized Rehabilitation to Reduce Disease and Increase Activity of Patients With Polymyalgia Rheumatica

2026年8月4日更新者：Washington University School of Medicine

Using Personalized Rehabilitation to Reduce Disease and Increase Activity of Patients With Polymyalgia Rheumatica: a Feasibility Randomized Clinical Trial

Polymyalgia rheumatica (PMR) is a condition that causes joint pain and stiffness, making it hard for people to do everyday tasks. Movement pattern training is a special, personalized rehabilitation program that aims to reduce pain by improving how people move during their daily activities. The investigators plan to test if it's possible to conduct a detailed study to find out how effective Movement pattern training is for people with PMR. The investigators will look at whether it helps them perform activities they want to do, reduce their use of certain medications, and strengthen their muscles. The investigators will also gather feedback from patients about their experience with Movement pattern training. This study will help us understand if carrying out a larger study on Movement pattern training's effectiveness is practical.

研究概览

地位

尚未招聘

条件

风湿性多肌痛 (PMR)

干预/治疗

研究类型

介入性

注册 (估计的)

阶段

不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习联系方式

姓名：Marcie Harris-Hayes, DPT, MSCI
电话号码：314-286-1435
邮箱：harrisma@wustl.edu

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

成人
年长者

接受健康志愿者

不

描述

Inclusion Criteria:

Patient reports a diagnosis or flare of polymyalgia rheumatica (PMR) < 5 months before the screening contact
Diagnosis or flare of PMR according to the European League against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria as follows (must satisfy all criteria)10:
- Age ≥50 years at time of diagnosis
- Presence of bilateral shoulder pain
- Elevated acute phase reactants C-reactive protein (CRP) >10 milligram/Liter and/or Erythrocyte Sedimentation Rate (ESR) >30 millimeters/hour*
- A score ≥4 at the time of diagnosis based on the following (without ultrasound):
  - Duration of morning stiffness >45 minutes: 2 points
  - Hip pain or limited range of motion: 1 point
  - Seronegative for rheumatoid factor and anti-cyclic citrullinated peptide: 2 points
  - Absence of other joint involvement: 1 point
Initiated pharmacological treatment
Able to give informed consent
Physician's clearance to participate in physical activity

Exclusion Criteria:

Diagnosis of fibromyalgia, neuropathic muscular disease, complex regional pain syndrome, or small fiber neuropathy
planned major surgical procedure during the study
Current active uncontrolled infection

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

主要用途：其他
分配：随机化
介入模型：并行分配
屏蔽：双倍的

手臂数量

武器和干预

参与者组/臂	干预/治疗
有源比较器：Usual Care Patients will be encouraged to complete their treatment as described by their physician.	其他：Usual Care Basic education about polymyalgia rheumatica, benefits of physical activity Patients will be encouraged to participate in physical activity as tolerated Medication as prescribed by their physician
实验性的：Movement Pattern Training (MoveTrain) Movement pattern Training (MoveTrain) is progressive activity-specific training to improve altered joint motion during patient-specific tasks. At baseline, each patient identifies specific activities (e.g., getting out of bed), work (e.g., reaching overhead), and physical activities (e.g., cycling) that are difficult due to their pain. A movement examination is performed to identify the altered joint motion on associated with movement-evoked pain and the motion modification that reduces their pain. The treatment provider then instructs the patient in activity-specific training, which includes practicing multiple repetitions of the modified activity as their home exercise program. Patients also are instructed to use the trained modified motion during their daily activities to maximize their use in daily routines. This encourages frequent practice and potentially greater program sustainability.	行为的：Movement Pattern Training (MoveTrain) 6 individualized treatment sessions over 10 weeks Motivational interviewing to determine personal goals and strengthen motivation and commitment to change Activity-specific training to practice modified motion during patient-specific tasks, defined as activities reported by each patient as pain-provoking Home exercise program 3 times/week consisting of activities or exercises assigned in the supervised sessions Patient's independence and adherence in performing home exercise program will be documented Patients are encouraged to use modified motion during daily and physical activities Based on patient performance, activity difficulty is progressed by increasing repetitions performed or increasing load or speed

参与者组/臂

干预/治疗

有源比较器：Usual Care

Patients will be encouraged to complete their treatment as described by their physician.

其他：Usual Care

Basic education about polymyalgia rheumatica, benefits of physical activity
Patients will be encouraged to participate in physical activity as tolerated
Medication as prescribed by their physician

实验性的：Movement Pattern Training (MoveTrain)

Movement pattern Training (MoveTrain) is progressive activity-specific training to improve altered joint motion during patient-specific tasks. At baseline, each patient identifies specific activities (e.g., getting out of bed), work (e.g., reaching overhead), and physical activities (e.g., cycling) that are difficult due to their pain. A movement examination is performed to identify the altered joint motion on associated with movement-evoked pain and the motion modification that reduces their pain. The treatment provider then instructs the patient in activity-specific training, which includes practicing multiple repetitions of the modified activity as their home exercise program. Patients also are instructed to use the trained modified motion during their daily activities to maximize their use in daily routines. This encourages frequent practice and potentially greater program sustainability.

行为的：Movement Pattern Training (MoveTrain)

6 individualized treatment sessions over 10 weeks

Motivational interviewing to determine personal goals and strengthen motivation and commitment to change
Activity-specific training to practice modified motion during patient-specific tasks, defined as activities reported by each patient as pain-provoking
Home exercise program 3 times/week consisting of activities or exercises assigned in the supervised sessions
Patient's independence and adherence in performing home exercise program will be documented
Patients are encouraged to use modified motion during daily and physical activities
Based on patient performance, activity difficulty is progressed by increasing repetitions performed or increasing load or speed

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
Number of potential participants accessed. 大体时间：7 months	The total number of people with Polymyalgia rheumatica (PMR) who were recruited each week	7 months
Percent of eligible participants who were willing to be randomized 大体时间：7 months	Percent of eligible participants are willing to be randomized during the study	7 months

次要结果测量

结果测量	措施说明	大体时间
Preliminary estimates of change in polymyalgia rheumatica impact scale (PMR-IS) 大体时间：From enrollment to the end of treatment at 10 weeks	The change in polymyalgia rheumatica impact scale (PMR-IS), a self-report questionnaire specific to polymyalgia rheumatica, that represents the patients symptoms and functional ability.	From enrollment to the end of treatment at 10 weeks
Preliminary estimates of change in physical activity 大体时间：From enrollment to the end of treatment at 10 weeks	The change in physical activity as represented by the Stanford 7-DAy Physical Activity Recall survey	From enrollment to the end of treatment at 10 weeks
Preliminary estimates of change in cumulative glucocorticoid dose 大体时间：From enrollment to the end of treatment at 10 weeks	Change in cumulative glucocorticoid dose assessed by patient's self-report logs	From enrollment to the end of treatment at 10 weeks
Preliminary estimates of change in muscle strength 大体时间：From enrollment to the end of treatment at 10 weeks	change in muscle strength of the hips and shoulders, assessed using a hand dynamometer	From enrollment to the end of treatment at 10 weeks

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Washington University School of Medicine

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (估计的)

2026年8月15日

初级完成 (估计的)

2027年3月31日

研究完成 (估计的)

2027年3月31日

研究注册日期

首次提交

2026年7月24日

首先提交符合 QC 标准的

2026年8月4日

首次发布 (实际的)

2026年8月6日

研究记录更新

最后更新发布 (实际的)

2026年8月6日

上次提交的符合 QC 标准的更新

2026年8月4日

最后验证

2026年8月1日

Using Personalized Rehabilitation to Reduce Disease and Increase Activity of Patients With Polymyalgia Rheumatica