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Sleep Architecture, Cognitive Function, and Quality of Life During Early Recovery From Substance Use Disorder

2026年9月25日 更新者：Hussein Ragab Mohamed Abdrahman、Assiut University

Sleep Architecture, Cognitive Function, and Quality of Life During Early Recovery From Substance Use Disorder: A Controlled Prospective Cohort Study With Three-Month Follow-Up

This prospective cohort study investigates how sleep disturbances affect cognitive recovery and quality of life during early recovery from substance use disorder (SUD). Chronic substance use frequently alters normal sleep architecture, which may impair attention, memory, and everyday functioning. The primary aim is to characterize baseline sleep patterns in adults with SUD compared to healthy control participants and determine whether baseline sleep disruptions predict cognitive and functional recovery over three months of monitored abstinence.

The study includes two groups of participants aged 18 to 45 years: adults diagnosed with a primary substance use disorder undergoing treatment and monitored abstinence, and a comparison group of healthy volunteers matched for age, sex, education, work schedule, and caffeine or nicotine use.

At the beginning of the study, all participants complete:

  • Structured diagnostic interviews and clinical assessments for mood, anxiety, and attention.
  • Questionnaires evaluating subjective sleep quality (Pittsburgh Sleep Quality Index) and quality of life (WHOQOL-BREF).
  • A global cognitive screening test (Montreal Cognitive Assessment) and a computerized attention test (Continuous Performance Task).
  • An overnight sleep study (polysomnography) conducted in a sleep laboratory following an initial adaptation night to objectively record brain waves, sleep stages, oxygen levels, and sleep continuity.

Participants in the substance use disorder group undergo supervised abstinence monitoring via periodic clinical check-ins and random urine drug screens. At 1 month and 3 months post-baseline, participants repeat the cognitive tests, quality-of-life questionnaires, and mood/sleep assessments to track recovery trajectories over time (no repeat overnight sleep studies are performed).

研究概览

地位

尚未招聘

条件

研究类型

观察性的

注册 (估计的)

34

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年 至 45年 (成人)

接受健康志愿者

不适用

有资格学习的性别

全部

取样方法

非概率样本

研究人群

Adult patients aged 18 to 45 years diagnosed with a primary Substance Use Disorder according to DSM-5 criteria, admitted to inpatient wards or followed at outpatient clinics of the Neuropsychiatry Department at Assiut University Hospitals. A comparison group of age-, sex-, and education-matched adults without a substance use disorder is recruited from the local community, screened for the same psychiatric and sleep disorder exclusions, and matched on shift-work status as well as caffeine and nicotine consumption.

描述

Inclusion Criteria:

Substance Use Disorder (SUD) Cohort:

  • Age between 18 and 45 years.
  • Fulfillment of DSM-5 diagnostic criteria for a primary Substance Use Disorder.
  • Admitted to inpatient wards or followed in outpatient neuropsychiatry services.
  • Resolution of acute intoxication and clinically significant withdrawal prior to sleep assessment.
  • Availability and willingness to complete baseline evaluations and prospective 1-month and 3-month follow-up assessments.

Matched Control Cohort:

  • Age between 18 and 45 years.
  • Absence of current or lifetime Substance Use Disorder.
  • Matched to the SUD cohort by age, sex, education level, shift-work status, and caffeine/nicotine use.
  • Availability and willingness to complete baseline and follow-up assessments.

Exclusion Criteria:

  • Primary major independent psychiatric disorders predating the onset of substance use (e.g., schizophrenia, bipolar disorder).
  • Pre-existing primary sleep disorders independent of substance use (e.g., previously diagnosed severe obstructive sleep apnea, narcolepsy).
  • Current intake of prescription medications known to severely alter sleep architecture or cognitive function (e.g., chronic benzodiazepines, high-dose antipsychotics, antiepileptics).
  • History of severe traumatic brain injury, neurological illness, or structural brain lesions.
  • Acute psychiatric instability requiring urgent emergency clinical intervention.
  • Impaired capacity to provide informed consent or conditions preventing valid completion of sleep studies or cognitive testing.
  • Refusal to participate or withdrawal of consent.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 观测模型：COHORT
  • 时间观点：PROSPECTIVE

队列和干预

团体/队列
Substance Use Disorder (SUD) Group

Adult patients aged 18 to 45 years fulfilling DSM-5 diagnostic criteria for a primary Substance Use Disorder recruited from the inpatient wards and outpatient clinics of the Neuropsychiatry Department at Assiut University Hospitals. Participants undergo monitored abstinence and receive baseline clinical evaluations, structured psychiatric assessment (SCID-5, PHQ-9, GAD-7, ASRS), subjective sleep quality assessment (PSQI), and overnight polysomnography (PSG). Follow-up prospective assessments of cognitive function (Continuous Performance Task, MoCA), quality of life (WHOQOL-BREF), and subjective sleep are completed at 1 month and 3 months.
Matched Healthy Control Group

Adult volunteers aged 18 to 45 years without a Substance Use Disorder, matched to the SUD cohort by age, sex, education level, shift-work status, and caffeine/nicotine use. Participants are screened to rule out primary sleep, psychiatric, or neurological disorders and complete baseline clinical evaluations, psychiatric questionnaires, subjective sleep assessment (PSQI), and overnight polysomnography (PSG), followed by cognitive and quality of life assessments at 1 month and 3 months.

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Change From Baseline in Continuous Performance Task (CPT) Reaction-Time Variability
大体时间：Baseline and 3 months

Assessed using a 14-minute computerized Continuous Performance Task (CPT) to evaluate sustained attention. It is calculated as the change in reaction-time standard deviation (in milliseconds) on correct target trials from baseline to the 3-month follow-up. A negative change score indicates improved stability of sustained attention.
Baseline and 3 months

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Assiut University

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (估计的)

2026年10月1日

初级完成 (估计的)

2027年10月1日

研究完成 (估计的)

2027年11月1日

研究注册日期

首次提交

2026年9月25日

首先提交符合 QC 标准的

2026年9月25日

首次发布 (实际的)

2026年10月1日

研究记录更新

最后更新发布 (实际的)

2026年10月1日

上次提交的符合 QC 标准的更新

2026年9月25日

最后验证

2026年9月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • Sleep in SUD Early Recovery

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