Comparing Upper GI Marshmallow Tests and High Resolution Manometry for Esophageal Motility Assessment

May 14, 2025 updated by: Marc Antonetti, MD, Lexington Health Incorporated

Identifying esophageal motility disorders before surgery is crucial for determining the best surgical approach and minimizing postoperative complications. This study compares two diagnostic methods: High Resolution Manometry (HRM) and Upper Gastrointestinal Marshmallow (UGIMM) studies, to establish a reliable standard for preoperative assessment.

Why This Study Matters
HRM is currently the gold standard for evaluating esophageal motility. It measures pressure and muscle contractions in the esophagus during swallowing, helping diagnose disorders that could affect surgical outcomes. However, discrepancies have been noted between HRM and UGIMM results, prompting the need for further investigation.

How HRM Works
During HRM, a thin probe is inserted through the nose into the stomach. Patients swallow saline while pressure sensors record esophageal activity. The test provides detailed data on motility and sphincter function, but it requires skilled interpretation due to potential variability in results.

The UGIMM Alternative
The UGIMM study is a less invasive option using fluoroscopy to visualize swallowing in real time. Patients swallow a barium-coated marshmallow, and radiographs track its movement. While UGIMM lacks a standardized classification system, it offers valuable insights into motility and anatomy.

Study Goals
This research aims to:

  • Compare HRM and UGIMM results to identify correlations
  • Evaluate testing standards and procedural outcomes
  • Strengthen evidence-based practices for preoperative assessments

Who Can Participate
The study includes adults aged 18+ undergoing preoperative testing for upper GI surgery. Exclusions apply for certain medications or prior surgeries that could affect results.

Potential Impact
By clarifying the relationship between HRM and UGIMM, this study could improve surgical planning and patient outcomes, ensuring the most accurate preoperative assessments.

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