- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00001363
PET Scan to Map the Areas of the Brain Involved in Planning
Functional Brain Mapping of Planning Activities With [015] Water PET Blood Flow Technique
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain.
When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also. Knowing these facts, researchers can use radioactive water (H215O) and PET scans to observe what areas of the brain are receiving more blood flow.
This study will attempt to determine the areas of the brain activated by planning processes and decision making. Researchers will ask patients to participate in tests and games (chess) that will stimulate the areas of the brain involved with decision making and planning while undergoing the water PET blood flow technique.
Study Overview
Status
Conditions
Detailed Description
Study Type
Enrollment
Contacts and Locations
Study Locations
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Maryland
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Bethesda, Maryland, United States, 20892
- National Institute of Neurological Disorders and Stroke (NINDS)
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Normal Controls:
Males and female subjects from two age ranges: 18-30 and 50-65 years of age.
Individuals with a history of neurological or psychiatric disorder will not be included nor will individuals currently taking psychoactive medication.
Patients:
Patients with outstanding problems in planning.
Patients must have a diagnosed CNS disorder with lesion localization verified by MRI scanning available from the referring physician or completed at the NIH Clinical Center.
Patients with unilateral or bilateral lesions that meet the behavioral criteria for selection (planning disorder).
Patients will be medication free (or taking medication with no known central nervous system effects) and be able to understand instructions and task demands.
Study Plan
How is the study designed?
Collaborators and Investigators
Publications and helpful links
General Publications
- Nichelli P, Grafman J, Pietrini P, Alway D, Carton JC, Miletich R. Brain activity in chess playing. Nature. 1994 May 19;369(6477):191. doi: 10.1038/369191a0. No abstract available.
- Partiot A, Grafman J, Sadato N, Flitman S, Wild K. Brain activation during script event processing. Neuroreport. 1996 Feb 29;7(3):761-6. doi: 10.1097/00001756-199602290-00020.
- Flitman S, O'Grady J, Cooper V, Grafman J. PET imaging of maze processing. Neuropsychologia. 1997 Apr;35(4):409-20. doi: 10.1016/s0028-3932(96)00086-3.
Study record dates
Study Major Dates
Study Start
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 930077
- 93-N-0077
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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