Genetic Origin of Lipid Disorders

Several lipid disorders are without known genetic origin. The scope of this project is to sequence genes superior involved in lipid and carbohydrate metabolism in patients with severe lipid disorders. The resulting mutations will be tested in suitable in vitro systems to detect their part in development of the specific disease.

Study Overview

• Status: Unknown
• Conditions: Lipid Disorder

Detailed Description

See "brief summary" above.

• Study Type: Observational

Contacts and Locations

• Study Contact: Name: Hilde Irene Nebb, PhD; Phone Number: +47-22851510; Email: h.i.nebb@medisin.uio.no
• Study Contact Backup: Name: Kjetil Retterstøl, Dr Med; Phone Number: +47-23075603; Email: kjetil.retterstol@rikshospitalet.no

Study Locations

• Norway
  • Oslo, Norway, NO-0316
    • Department of Nutrition, University of Oslo

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 54 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• proven written informed consent prior to recruitment
• male or female
• 18-55 years old
• patients with severe lipid disorders
• fasting plasma cholesterol, triglyceride or glucose, blood pressure or waist circumference/BMI out of normal range

Exclusion Criteria:

-

Study Plan

How is the study designed?

Collaborators and Investigators

• Sponsor: University of Oslo
• Collaborators: Norwegian Institute of Public Health; Ullevaal University Hospital; Hormone Laboratory, Aker University Hospital, Oslo, Norway; Lipid Clinic, The National Hospital, Oslo, Norway; Research Institute of Internal Medicine, The National Hospital, Oslo, Norway; CIGENE, Agricultural University of Norway, Aas, Norway
• Investigators: Study Chair: Hilde I Nebb, PhD, Department of Nutrition, University of Oslo; Principal Investigator: Karianne Solaas, PhD, Department of Nutrition, University of Oslo; Principal Investigator: Monica H Carlsen, Department of Nutrition, University of Oslo; Principal Investigator: Leiv Ose, Dr med, Lipid Clinic, The National Hospital; Principal Investigator: Marit S Nenseter, PhD, Research Institute of Internal Medicine, The National Hospital; Principal Investigator: Kirsten Holven, PhD, Research Institute of Internal Medicine, The National Hospital; Principal Investigator: Bente Halvorsen, PhD, Research Institute of Internal Medicine, The National Hospital; Principal Investigator: Serena Tonstad, Dr med, Department of Preventive Medicine, Ullevål university hospital; Principal Investigator: Håkon Gjessing, PhD, Norwegian Institute of Public Health; Principal Investigator: Per Thorsby, Dr med, Hormone laboratory, Aker university hospital; Principal Investigator: Sigbjørn Lien, PhD, Agricultural university of Norway; Principal Investigator: Paul Berg, PhD, Agricultural university of Norway; Principal Investigator: Kjetil Retterstøl, Dr med, Lipid Clinic, The National Hospital

Study record dates

Study Major Dates

• Study Start: January 1, 2006

Study Registration Dates

• First Submitted: January 12, 2006
• First Submitted That Met QC Criteria: January 12, 2006
• First Posted (Estimate): January 13, 2006

Study Record Updates

• Last Update Posted (Estimate): January 13, 2006
• Last Update Submitted That Met QC Criteria: January 12, 2006
• Last Verified: January 1, 2006

More Information

Terms related to this study

• Keywords: Lipid disorder; Gene mutation
• Additional Relevant MeSH Terms: Pathologic Processes; Metabolic Diseases; Disease; Lipid Metabolism Disorders
• Other Study ID Numbers: S-03150 (REK); 02/4746 (SHdir); 10163 (NSD)