123I-MIBG SPECT/CT for Assessment of Cardiac Sympathetic Innervation

August 17, 2011 updated by: Rambam Health Care Campus

Quantitative 123I-MIBG SPECT/CT Assessment of Cardiac Sympathetic Innervation

Myocardial scintigraphy with 123I-MIBG allows for visual and semi-quantitative assessment of sympathetic cardiac innervation using the hear to mediastinum ratio (HMR). Impaired cardiac MIBG clearance may occur in patients with congestive heart failure (CHF). The purpose of present study was to develop and validate a quantitative index for the assessment of cardiac MIBG uptake kinetics using SPECT/CT for diagnosis of CHF

Study Overview

Status

Completed

Conditions

Cardiac Diseases

Intervention / Treatment

Device: SPECT/CT

Study Type

Observational

Enrollment (Actual)

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Israel
- - Haifa, Israel
    - Rambam Medical Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

40 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Patients refered for neuroendocrine diseases

Description

Inclusion Criteria:

age>40

Exclusion Criteria:

none

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
The impact of the imaging modality on patient management Time Frame: 2 years	2 years

Secondary Outcome Measures

Outcome Measure	Time Frame
The impact on patient management Time Frame: 2 years	2 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Rambam Health Care Campus

Investigators

Principal Investigator: Shmuel Rispler, MD PhD, Rambam Health Care Campus

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2007

Primary Completion (Actual)

August 1, 2009

Study Completion (Actual)

May 1, 2010

Study Registration Dates

First Submitted

February 24, 2006

First Submitted That Met QC Criteria