Neurological Effects of Chemotherapy and Radiation Therapy in Patients With Colon Cancer

Neurological Effects of Chemotherapy and Radiation Treatment: Colon Cancer

RATIONALE: Learning about the long-term effects of chemotherapy and radiation therapy on brain function may help doctors plan cancer treatments.

PURPOSE: This clinical trial is looking at the neurological effects of chemotherapy and radiation therapy in patients with colon cancer.

Study Overview

• Status: Completed
• Conditions: Colorectal Cancer; Cognitive/Functional Effects; Long-term Effects Secondary to Cancer Therapy in Adults
• Intervention / Treatment: Procedure: cognitive assessment; Procedure: management of therapy complications; Procedure: magnetic resonance imaging

Detailed Description

OBJECTIVES:

Primary

• Identify the nature and long-term ramifications of CNS injury as a result of cancer treatment in patients with colon cancer.

Secondary

• Analyze differences in cognitive measures and MRI data in these patients.
• Correlate MRI measures with cognitive performance in these patients.

OUTLINE: Patients undergo cognitive performance assessment and MRI.

PROJECTED ACCRUAL: A total of 42 patients will be accrued for this study.

• Study Type: Observational
• Enrollment (Actual): 42

Contacts and Locations

Study Locations

• United States
  • Arizona
    • Tucson, Arizona, United States, 85724-5024
      • Arizona Cancer Center at University of Arizona Health Sciences Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Colon cancer

Description

DISEASE CHARACTERISTICS:

• Diagnosis of colon cancer
• Received chemotherapy and radiotherapy for colon cancer

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Nature and long-term ramifications of CNS injury as a result of cancer treatment

Secondary Outcome Measures

Outcome Measure
Differences in cognitive measures and MRI data
Relationship between MRI measures and cognitive performance

Collaborators and Investigators

• Sponsor: University of Arizona
• Collaborators: National Cancer Institute (NCI)
• Investigators: Study Chair: Sheryl Reminger, MD, University of Arizona

Study record dates

Study Major Dates

• Study Start: April 1, 2003
• Primary Completion (Actual): August 1, 2006
• Study Completion (Actual): August 1, 2006

Study Registration Dates

• First Submitted: December 11, 2006
• First Submitted That Met QC Criteria: December 11, 2006
• First Posted (Estimate): December 13, 2006

Study Record Updates

• Last Update Posted (Actual): July 6, 2018
• Last Update Submitted That Met QC Criteria: July 3, 2018
• Last Verified: August 1, 2012

More Information

Terms related to this study

• Keywords: stage IV colon cancer; recurrent colon cancer; stage III colon cancer; cognitive/functional effects; long-term effects secondary to cancer therapy in adults; stage II colon cancer; stage I colon cancer
• Additional Relevant MeSH Terms: Digestive System Diseases; Neoplasms; Neoplasms by Site; Gastrointestinal Neoplasms; Digestive System Neoplasms; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Intestinal Neoplasms; Colorectal Neoplasms; Colonic Neoplasms
• Other Study ID Numbers: HSCB0213; P30CA023074 (U.S. NIH Grant/Contract); P50CA095060 (U.S. NIH Grant/Contract); UARIZ-BSC-02-13 (Other Identifier: University of Arizona)