Genomic Search for Childhood Obesity Genes-A Pilot Study
January 5, 2021 updated by: Children's Mercy Hospital Kansas City
The purpose of this study is to screen a pediatric population (ages 2-8) for genes associated with childhood obesity.
Study Overview
Detailed Description
The incidence of childhood obesity has been growing at an epidemic rate for the past several years, in part due to the lack of understanding of mechanisms at a molecular level.
This study will screen a healthy general pediatric population age 2 to 8 for potential genes associated with childhood obesity using whole genomic gene arrays.
Patients with BMI values equal to or greater than the 85th percentile will be compared to patients with a BMI below or equal to the 15th percentile.
The INSIG2 gene will be specifically studied because of its identification in several populations of obese subjects.
The differences in gene expression of the 2 groups will then be used to identify new genes for investigation in childhood obesity.
Study Type
Observational
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Missouri
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Kansas City, Missouri, United States, 64108
- Children's Mercy Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
2 years to 8 years (Child)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Children aged 2-8 years old
Description
Inclusion Criteria:
- Ages 2-8, predominately Caucasian to minimize population stratification
Exclusion Criteria:
- Chronic diseases (diabetes, cancer, etc) and known syndromes
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Merlin G Butler, M.D., Ph.D., Children's Mercy Hospital Kansas City
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
June 1, 2007
Primary Completion (Actual)
June 1, 2008
Study Completion (Actual)
June 1, 2008
Study Registration Dates
First Submitted
June 7, 2007
First Submitted That Met QC Criteria
June 7, 2007
First Posted (Estimate)
June 8, 2007
Study Record Updates
Last Update Posted (Actual)
January 6, 2021
Last Update Submitted That Met QC Criteria
January 5, 2021
Last Verified
January 1, 2021
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 07 03-045E
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.