Adiponectin is Positively Associated With Insulin Resistance in Subjects With Type 2 Diabetic Nephropathy and Effects by Angiotensin Type 1 Receptor Blocker Losartan

Adiponectin and Insulin Resistance in Diabetic Nephropathy


Lead sponsor: Health Science Center of Xi’an Jiaotong University

Collaborator: Shanghai Jiao Tong University School of Medicine

Source Health Science Center of Xi’an Jiaotong University
Brief Summary

Plasma adiponectin concentration is inversely associated with renal function. There is little literature on adiponectin levels and regulation by antihypertensive medication with an angiotensin II-receptor blocker (ARB), especially in subjects with type 2 diabetes in different stage of chronic kidney disease (CKD).

Overall Status Completed
Start Date April 2007
Completion Date November 2007
Primary Completion Date October 2007
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
GFR, HbA1c and the adiponectin concentration 6 month
Enrollment 80

Intervention type: Drug

Intervention name: Losartan

Description: Angiotensin II Type 1 Receptor Blockers



Inclusion Criteria:

- Type 2 diabetic nephropathy

- CKD at stage 1~4

Exclusion Criteria:

- Type 1 diabetes or nondiabetic renal disease

- An elevated plasma K level.

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

facility Shanghai No.3 people's hospital
Location Countries


Verification Date

October 2008

Responsible Party

Name title: hui min Jin

Organization: shanghai No 3 people's hospital

Has Expanded Access No
Condition Browse
Study Design Info

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Treatment

Masking: None (Open Label)