Study of Blood and Tumor Samples From Men With an Inherited Risk of Prostate Cancer

UK Genetic Prostate Cancer Study

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify genes related to cancer.

PURPOSE: This clinical trial is studying blood and tumor samples from men with an inherited risk of prostate cancer.

Study Overview

• Status: Unknown
• Conditions: Prostate Cancer
• Intervention / Treatment: Other: medical chart review; Other: laboratory biomarker analysis; Other: questionnaire administration

Detailed Description

OBJECTIVES:

• To find genes that predispose to prostate cancer (using genetic linkage and other molecular biology techniques).
• To determine if genes that predispose to prostate cancer are associated with disease and treatment parameters.
• To determine if genes that predispose to prostate cancer are associated with environmental factors.
• To estimate the percentage of prostate cancer patients who have a positive family history of the disease.
• To estimate the relative risk of developing prostate cancer in a currently unaffected member of a prostate cancer family.
• To ascertain whether relatives of prostate cancer patients are at increased risk of developing cancers other than prostate cancer.
• To build up a large blood and tumor (both fresh and preserved) bank from patients with prostate cancer to identify prostate cancer predisposition gene(s), determine the prevalence and penetrance of prostate cancer predisposition genes in prostate cancer patients, correlate changes in prostate cancer predisposition gene(s) with disease and treatment parameters by matching with clinical data from clinical databases already held as part of the medical record on these patients, and correlate changes in prostate cancer predisposition gene(s) with environmental factors collected by questionnaire from these patients.
• To use the blood and tumor bank for marker studies (DNA, RNA, serum, plasma, protein, and other molecules) to define the role of these markers in disease prediction and progression.
• To develop microarrays from prostate cancers to determine their genetic profile and correlate this with prostate cancer genetic predisposition genes.
• To collect tissue from other unaffected and affected members of the family in cases where a genetic alteration is found, in order to ascertain whether this alteration is associated with disease risk.
• To collect tissue samples from unaffected family members who show an interest in taking part in the study.

OUTLINE: Patients are assessed by a family history and epidemiology questionnaire and undergo a medical record review.

Patients and relatives with prostate cancer may undergo blood sample collection for genetic analysis of prostate cancer predisposition genes and measurement of markers of associations with genetic changes associated with prostate cancer. Blood and tumor samples are stored for future studies.

• Study Type: Observational
• Enrollment (Anticipated): 21000

Contacts and Locations

Study Locations

• United Kingdom
  • Morecambe, United Kingdom, LA4 5NN
    • Recruiting
    • Queen Victoria Hospital
    • Contact: Contact Person; Phone Number: 44-1524-405-700
  • Peterborough, United Kingdom, PE3 9GZ
    • Recruiting
    • Edith Cavell Hospital
    • Contact: Contact Person; Phone Number: 44-1733-874-000
  • Shoreham-by-Sea, United Kingdom, BN43 6TQ
    • Recruiting
    • Southlands Hospital
    • Contact: Contact Person; Phone Number: 44-1903-205-111
  • Southampton, United Kingdom, SO16 5YA
    • Recruiting
    • Princess Anne Hospital
    • Contact: Contact Person; Phone Number: 44-23-8077-7222
  • England
    • Ashford-Kent, England, United Kingdom, TN24 0LZ
      • Recruiting
      • William Harvey Hospital
      • Contact: Contact Person; Phone Number: 44-1233-633-331
    • Ashton-Under-Lyne, England, United Kingdom, OL6 9RW
      • Recruiting
      • Tameside General Hospital
      • Contact: Contact Person; Phone Number: 44-161-331-6000
    • Aylesbury-Buckinghamshire, England, United Kingdom, HP21 8AL
      • Recruiting
      • Stoke Mandeville Hospital
      • Contact: Contact Person; Phone Number: 44-1296-315-000
    • Barnstaple, England, United Kingdom, EX31 4JB
      • Recruiting
      • North Devon District Hospital
      • Contact: Contact Person; Phone Number: 44-1271-322-577
    • Barrow in Furness, England, United Kingdom, LA14 4LF
      • Recruiting
      • Furness General Hospital
      • Contact: Contact Person; Phone Number: 44-1229-870-870
    • Basildon, England, United Kingdom, SS16 5NL
      • Recruiting
      • Basildon University Hospital
      • Contact: Contact Person; Phone Number: 44-1268-533-911
    • Basingstoke, England, United Kingdom, RG24 9NA
      • Recruiting
      • Basingstoke and North Hampshire NHS Foundation Trust
      • Contact: Contact Person; Phone Number: 44-125-631-4793
    • Bath, England, United Kingdom, BA1 3NG
      • Recruiting
      • Royal United Hospital
      • Contact: Contact Person; Phone Number: 44-1-225-824-042
    • Bedford, England, United Kingdom, MK42 9DJ
      • Recruiting
      • Primrose Centre at Bedford Hospitals NHS Trust
      • Contact: Contact Person; Phone Number: 44-123-435-5122
    • Birmingham, England, United Kingdom, B9 5SS
      • Recruiting
      • Birmingham Heartlands Hospital
      • Contact: Contact Person; Phone Number: 44-121-424-2000
    • Birmingham, England, United Kingdom, B15 2TH
      • Recruiting
      • Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust
      • Contact: Contact Person; Phone Number: 44-121-472-1311
    • Birmingham, England, United Kingdom, B18 7QH
      • Recruiting
      • City Hospital - Birmingham
      • Contact: Contact Person; Phone Number: 44-121-554-3801
    • Birmingham, England, United Kingdom, B75 7RR
      • Recruiting
      • Good Hope Hospital
      • Contact: Contact Person; Phone Number: 44-121-424-2000
    • Blackburn, England, United Kingdom, BB2 3 HH
      • Recruiting
      • Royal Blackburn Hospital
      • Contact: Contact Person; Phone Number: 44-1254-263-555
    • Blackpool, England, United Kingdom, FY3 8NR
      • Recruiting
      • Blackpool Victoria Hospital
      • Contact: Contact Person; Phone Number: 44-20-7210-4850
    • Boston, England, United Kingdom, PE21 9QT
      • Recruiting
      • Pilgrim Hospital
      • Contact: Contact Person; Phone Number: 44-1205-364-801
    • Bournemouth, England, United Kingdom, BH7 7DW
      • Recruiting
      • Royal Bournemouth Hospital
      • Contact: Contact Person; Phone Number: 44-202-303-626
    • Brighton, England, United Kingdom, BN2 5BE
      • Recruiting
      • Sussex Cancer Centre at Royal Sussex County Hospital
      • Contact: Contact Person; Phone Number: 44-12-7369-6955
    • Bristol, England, United Kingdom, BS10 5NB
      • Recruiting
      • Southmead Hospital
      • Contact: Contact Person; Phone Number: 44-117-950-5050
    • Bristol, England, United Kingdom, BS2 8HW
      • Recruiting
      • Bristol Royal Infirmary
      • Contact: Contact Person; Phone Number: 44-117-923-0000
    • Bristol, England, United Kingdom, BS16 1LE
      • Recruiting
      • Frenchay Hospital
      • Contact: Contact Person; Phone Number: 44-117-970-1212
    • Broomfield, England, United Kingdom, CM1 7ET
      • Recruiting
      • Broomfield Hospital
      • Contact: Contact Person; Phone Number: 44-124-551-6339
    • Burnley, England, United Kingdom, BB10 2PQ
      • Recruiting
      • Burnley General Hospital
      • Contact: Contact Person; Phone Number: 44-128-242-5071
    • Burton-upon-Trent, England, United Kingdom, DE13 0RB
      • Recruiting
      • Queen's Hospital
      • Contact: Contact Person; Phone Number: 44-1283-566-333
    • Cambridge, England, United Kingdom, CB2 2QQ
      • Recruiting
      • Addenbrooke's Hospital
      • Contact: Contact Person; Phone Number: 44-1223-245-151
    • Canterbury, England, United Kingdom, CT1 3NG
      • Recruiting
      • Kent and Canterbury Hospital
      • Contact: Contact Person; Phone Number: 44-1227-766-877
    • Carshalton, England, United Kingdom, SM5 1AA
      • Recruiting
      • St. Helier Hospital
      • Contact: Contact Person; Phone Number: 44-20-8296-2000
    • Chester, England, United Kingdom, CH2 1UL
      • Recruiting
      • Countess of Chester Hospital
      • Contact: Contact Person; Phone Number: 44-1244-365-000
    • Colchester, England, United Kingdom, CO4 5JL
      • Recruiting
      • Colchester General Hospital
      • Contact: Contact Person; Phone Number: 44-1206-747-474
    • Cottingham, England, United Kingdom, HU16 5JQ
      • Recruiting
      • Castle Hill Hospital
      • Contact: Contact Person; Phone Number: 44-1482-659-331
    • Coventry, England, United Kingdom, CV2 2DX
      • Recruiting
      • Walsgrave Hospital
      • Contact: Contact Person; Phone Number: 44-24-7660-2020
    • Crewe, England, United Kingdom, CW1 4QJ
      • Recruiting
      • Mid Cheshire Hospitals Trust- Leighton Hopsital
      • Contact: Contact Person; Phone Number: 44-1270-255-141
    • Croydon, England, United Kingdom
      • Recruiting
      • Mayday University Hospital
      • Contact: Contact Person; Phone Number: 44-20-8401-3000
    • Dartford Kent, England, United Kingdom, DA2 8DA
      • Recruiting
      • Darent Valley Hospital
      • Contact: Contact Person; Phone Number: 44-1322-428-500
    • Derby, England, United Kingdom, DE1 2QY
      • Recruiting
      • Derbyshire Royal Infirmary
      • Contact: Contact Person; Phone Number: 44-1332-347-141 ext. 2407
    • Derby, England, United Kingdom, DE22 3NE
      • Recruiting
      • Royal Derby Hospital
      • Contact: Contact Person; Phone Number: 44-1332-340-131
    • Dorchester, England, United Kingdom, DT1 2JY
      • Recruiting
      • Dorset County Hospital
      • Contact: Contact Person; Phone Number: 44-1305-251-150
    • Dudley, England, United Kingdom, DY1 2HQ
      • Recruiting
      • Russells Hall Hospital
      • Contact: Contact Person; Phone Number: 44-1384-456-111
    • Eastbourne, England, United Kingdom, BN21 2UD
      • Recruiting
      • Eastbourne District General Hospital
      • Contact: Contact Person; Phone Number: 44-1323-417-400
    • Edgbaston, England, United Kingdom, B15 2TG
      • Recruiting
      • Birmingham Women's Hospital
      • Contact: Contact Person; Phone Number: 44-121-472-1377
    • Epsom, Surrey, England, United Kingdom, KT18 7EG
      • Recruiting
      • Epsom General Hospital
      • Contact: Contact Person; Phone Number: 44-1372-735-735
    • Exeter, England, United Kingdom, Ex2 5DW
      • Recruiting
      • Royal Devon and Exeter Hospital
      • Contact: Contact Person; Phone Number: 44-1392-411-611
    • Farnworth, England, United Kingdom, BL4 0JR
      • Recruiting
      • Royal Bolton Hospital
      • Contact: Contact Person; Phone Number: 44-120-439-0390
    • Frimley, England, United Kingdom, GU16 7UJ
      • Recruiting
      • Frimley Park Hospital
      • Contact: Contact Person; Phone Number: 44-1276-604-604
    • Grantham, Lincolnshire, England, United Kingdom, NG31 8DG
      • Recruiting
      • Grantham and District Hospital
      • Contact: Contact Person; Phone Number: 44-1476-565-232
    • Grimsby, England, United Kingdom, DN33 2BA
      • Recruiting
      • Diana Princess of Wales Hospital
      • Contact: Contact Person; Phone Number: 44-147-287-4111
    • Harrogate, England, United Kingdom, HG2 7SX
      • Recruiting
      • Harrogate District Hospital
      • Contact: Contact Person; Phone Number: 44-1423-885-959
    • High Wycombe, England, United Kingdom
      • Recruiting
      • Wycombe General Hospital
      • Contact: Contact Person; Phone Number: 44-1494-526-161
    • Hull, England, United Kingdom, HU8 9HE
      • Recruiting
      • Princess Royal Hospital at Hull and East Yorkshire NHS Trust
      • Contact: Contact Person; Phone Number: 44-1482-701-151
    • Ipswich, England, United Kingdom, IP4 5PD
      • Recruiting
      • Ipswich Hospital
      • Contact: Contact Person; Phone Number: 44-1473-712-233
    • Kidderminster Worcestershire, England, United Kingdom, DY11 6RJ
      • Recruiting
      • Kidderminster Hospital
      • Contact: Contact Person; Phone Number: 44-190-576-0635
    • Lancanshire, England, United Kingdom, WN1 2NN
      • Recruiting
      • Royal Albert Edward Infirmary
      • Contact: Contact Person; Phone Number: 44-1942-244-000
    • Lancaster, England, United Kingdom, LA1 4RP
      • Recruiting
      • Royal Lancaster Infirmary
      • Contact: Contact Person; Phone Number: 44-1524-659-44
    • Leeds, England, United Kingdom, LS9 7TF
      • Recruiting
      • Leeds Cancer Centre at St. James's University Hospital
    • Leeds, England, United Kingdom, LS1 3EX
      • Recruiting
      • Leeds General Infirmary
      • Contact: Contact Person; Phone Number: 44-113-243-2799
    • Leeds, England, United Kingdom, LS16 6QB
      • Recruiting
      • Cookridge Hospital
      • Contact: Contact Person; Phone Number: 44-113-267-3411
    • Leicester, England, United Kingdom, LE1 5WW
      • Recruiting
      • Leicester Royal Infirmary
      • Contact: Contact Person; Phone Number: 44-116-254-1414
    • Leicester, England, United Kingdom, LE5 4PW
      • Recruiting
      • Leicester General Hospital
      • Contact: Contact Person; Phone Number: 44-116-249-0490
    • Lincoln, England, United Kingdom, LN2 5QY
      • Recruiting
      • Lincoln County Hospital
      • Contact: Contact Person; Phone Number: 44-1522-573-965
    • Liverpool, England, United Kingdom, L7 8XP
      • Recruiting
      • Royal Liverpool University Hospital
      • Contact: Contact Person; Phone Number: 44-151-706-2000
    • London, England, United Kingdom, EC1A 7BE
      • Recruiting
      • Saint Bartholomew's Hospital
      • Contact: Contact Person; Phone Number: 44-20-7601-8391
    • London, England, United Kingdom, E11 1NR
      • Recruiting
      • Whipps Cross Hospital
      • Contact: Contact Person; Phone Number: 44-20-8539-5522
    • London, England, United Kingdom, W1T 3AA
      • Recruiting
      • Middlesex Hospital
      • Contact: Contact Person; Phone Number: 44-845-1555-000
    • London, England, United Kingdom, SE1 9RT
      • Recruiting
      • Guy's Hospital
      • Contact: Contact Person; Phone Number: 44-20-7188-7188
    • London, England, United Kingdom, W2 1NY
      • Recruiting
      • St. Mary's Hospital
      • Contact: Contact Person; Phone Number: 44-20-7886- 6666
    • London, England, United Kingdom, W6 8RF
      • Recruiting
      • Charing Cross Hospital
      • Contact: Contact Person; Phone Number: 44-20-8846-1234
    • London, England, United Kingdom, W12 OHS
      • Recruiting
      • Hammersmith Hospital
      • Contact: Contact Person; Phone Number: 44-20-8383-1000
    • London, England, United Kingdom, E1 1BB
      • Recruiting
      • Royal London Hospital
      • Contact: Contact Person; Phone Number: 44-20-7377-7000
    • Macclesfield, England, United Kingdom, SK10 3BL
      • Recruiting
      • Macclesfield District General Hospital
      • Contact: Contact Person; Phone Number: 44-1625-421-000
    • Maidstone, England, United Kingdom, ME16 9QQ
      • Recruiting
      • Maidstone Hospital
    • Manchester, England, United Kingdom, M20 4BX
      • Recruiting
      • Christie Hospital
      • Contact: Contact Person; Phone Number: 44-845-226-3000
    • Merseyside, England, United Kingdom, CH63 4JY
      • Recruiting
      • Clatterbridge Centre for Oncology
      • Contact: Contact Person; Phone Number: 44-151-334-1155
    • Middlesbrough, England, United Kingdom, TS4 3BW
      • Recruiting
      • James Cook University Hospital
      • Contact: Contact Person; Phone Number: 44-1642-850-850
    • Milton Keynes, England, United Kingdom, MK6 5LD
      • Recruiting
      • Milton Keynes General Hospital
      • Contact: Contact Person; Phone Number: 44-1908-660-033
    • Newcastle-Upon-Tyne, England, United Kingdom, NE7 7DN
      • Recruiting
      • Newcastle Upon Tyne Hospitals NHS Trust
      • Contact: Contact Person; Phone Number: 44-191-232-5131
    • Northwood, England, United Kingdom, HA6 2RN
      • Recruiting
      • Mount Vernon Cancer Centre at Mount Vernon Hospital
      • Contact: Contact Person; Phone Number: 44-1923-826-111
    • Norwich, England, United Kingdom, NR4 7UY
      • Recruiting
      • Norfolk and Norwich University Hospital
      • Contact: Contact Person; Phone Number: 44-603-286-286
    • Nottingham, England, United Kingdom, NG5 1PB
      • Recruiting
      • Nottingham City Hospital
      • Contact: Contact Person; Phone Number: 44-115-969-1169
    • Nottinghamshire, England, United Kingdom, NG17 4JL
      • Recruiting
      • Kings Mill Hospital
      • Contact: Contact Person; Phone Number: 44-162-362-2515
    • Nuneaton, England, United Kingdom, CV10 7DJ
      • Recruiting
      • George Eliot Hospital
      • Contact: Contact Person; Phone Number: 44-24-7635-1351
    • Oxford, England, United Kingdom, OX3 7LJ
      • Recruiting
      • Churchill Hospital
      • Contact: Contact Person; Phone Number: 44-186-574-1841
    • Peterborough, England, United Kingdom, PE3 6DA
      • Recruiting
      • Peterborough Hospitals Trust
      • Contact: Contact Person; Phone Number: 44-1733-874-510
    • Plymouth, England, United Kingdom, PL6 8DH
      • Recruiting
      • Derriford Hospital
      • Contact: Contact Person; Phone Number: 44-175-277-7111
    • Poole Dorset, England, United Kingdom, BH15 2JB
      • Recruiting
      • Dorset Cancer Centre
      • Contact: Contact Person; Phone Number: 44-1202-448-263
    • Preston, England, United Kingdom, PR2 9HT
      • Recruiting
      • Rosemere Cancer Centre at Royal Preston Hospital
      • Contact: Contact Person; Phone Number: 44-1772-710-089
    • Reading, England, United Kingdom, RG1 5AN
      • Recruiting
      • Berkshire Cancer Centre at Royal Berkshire Hospital
      • Contact: Contact Person; Phone Number: 44-118-322-7878
    • Redditch, Worcestershire, England, United Kingdom, B98 7UB
      • Recruiting
      • Alexandra Healthcare NHS
      • Contact: Contact Person; Phone Number: 44-015-2750-3030
    • Romford, England, United Kingdom, RM3 0BE
      • Recruiting
      • Queens Hospital
      • Contact: Contact Person; Phone Number: 44-170-834-5533
    • Saint Leonards-on-Sea, England, United Kingdom, TN37 7RD
      • Recruiting
      • Conquest Hospital
      • Contact: Contact Person; Phone Number: 44-1424-755-255
    • Salford, England, United Kingdom, M6 8HD
      • Recruiting
      • Hope Hospital
      • Contact: Contact Person; Phone Number: 44-161-789-7373
    • Salisbury, England, United Kingdom, SP2 8BJ
      • Recruiting
      • Salisbury District Hospital
      • Contact: Contact Person; Phone Number: 44-1722-336-262
    • Scarborough, England, United Kingdom, YO12 6QL
      • Recruiting
      • Scarborough General Hospital
      • Contact: Contact Person; Phone Number: 44-1723-368-111
    • Scunthorpe, England, United Kingdom, DN15 7BH
      • Recruiting
      • Scunthorpe General Hospital
      • Contact: Contact Person; Phone Number: 44-172-428-2282
    • Shrewsbury, England, United Kingdom, SY3 8XQ
      • Recruiting
      • Royal Shrewsbury Hospital
      • Contact: Contact Person; Phone Number: 44-1743-261-000
    • Slough, Berkshire, England, United Kingdom, SL2 4HL
      • Recruiting
      • Wexham Park Hospital
      • Contact: Contact Person; Phone Number: 44-1753-633-000
    • Solihull, England, United Kingdom, B91 2JL
      • Recruiting
      • Solihull Hospital
      • Contact: Contact Person; Phone Number: 44-121-424-2000
    • Southampton, England, United Kingdom, SO16 6YD
      • Recruiting
      • Southampton General Hospital
    • Southport, England, United Kingdom, PR8 6PN
      • Recruiting
      • Southport and Formby District General Hospital
      • Contact: Contact Person; Phone Number: 44-1704-547-471
    • Stafford, England, United Kingdom, ST16 3SA
      • Recruiting
      • Staffordshire General Hospital
      • Contact: Contact Person; Phone Number: 44-178-525-7731
    • Stevenage, England, United Kingdom, SG1 4AB
      • Recruiting
      • Lister Hospital
      • Contact: Contact Person; Phone Number: 44-1438-314-333
    • Stirling, England, United Kingdom, FK8 2AU
      • Recruiting
      • Stirling Royal Infirmary
      • Contact: Contact Person; Phone Number: 44-1786-434-000
    • Stockport, England, United Kingdom, SK2 7JE
      • Recruiting
      • Stepping Hill Hospital
      • Contact: Contact Person; Phone Number: 44-161-483-1010
    • Surrey, England, United Kingdom, KT2 7QB
      • Recruiting
      • Kingston Hospital
      • Contact: Contact Person; Phone Number: 44-20-8546-7711
    • Surrey, England, United Kingdom, RH1 5RH
      • Recruiting
      • East Surrey Hospital
      • Contact: Contact Person; Phone Number: 44-1737-768-511
    • Sutton, England, United Kingdom, SM2 5PT
      • Recruiting
      • Royal Marsden - Surrey
      • Contact: Contact Person; Phone Number: 44-20-8642-6011
    • Swindon, England, United Kingdom, SN3 6BB
      • Recruiting
      • Great Western Hospital
      • Contact: Contact Person; Phone Number: 44-1793-604-020
    • Taunton, England, United Kingdom, TA1 5DA
      • Recruiting
      • Taunton and Somerset Hospital
      • Contact: Contact Person; Phone Number: 44-1823-333-444
    • Torquay, England, United Kingdom, TQ2 7AA
      • Recruiting
      • Torbay Hospital
      • Contact: Contact Person; Phone Number: 44-1803-614-567
    • Uxbridge, England, United Kingdom, UB8 3NN
      • Recruiting
      • Hillingdon Hospital
      • Contact: Contact Person; Phone Number: 44-1895-238-282
    • Warwick, England, United Kingdom, CV34 5BW
      • Recruiting
      • Warwick Hospital
      • Contact: Contact Person; Phone Number: 44-1926-495-321
    • West Bromwich, England, United Kingdom, B71 4HJ
      • Recruiting
      • Sandwell General Hospital
      • Contact: Contact Person; Phone Number: 44-21-553-1831 ext. 3817
    • Westcliff-On-Sea, England, United Kingdom, SS0 0RY
      • Recruiting
      • Southend University Hospital NHS Foundation Trust
      • Contact: Contact Person; Phone Number: 44-1702-435-555
    • Wolverhampton, England, United Kingdom, WV10 0QP
      • Recruiting
      • New Cross Hospital
      • Contact: Contact Person; Phone Number: 44-190-230-7999
    • Worthing, England, United Kingdom, BN11 2DH
      • Recruiting
      • Worthing Hospital
      • Contact: Contact Person; Phone Number: 44-1903-205-111
    • Yeovil, England, United Kingdom, BA21 4AT
      • Recruiting
      • Yeovil District Hospital
      • Contact: Contact Person; Phone Number: 44-1935-475-122
    • York, England, United Kingdom, Y031 8HE
      • Recruiting
      • Cancer Care Centre at York Hospital
      • Contact: Contact Person; Phone Number: 44-1904-726-931
  • Northern Ireland
    • Belfast, Northern Ireland, United Kingdom, BT8 8JR
      • Recruiting
      • Belfast City Hospital Trust Incorporating Belvoir Park Hospital
      • Contact: Contact Person; Phone Number: 44-2890-699-069
    • Downpatrick, Northern Ireland, United Kingdom, BT30 6JA
      • Recruiting
      • Downe Hospital
      • Contact: Contact Person; Phone Number: 44-28-4461-3311
    • Londonderry, Northern Ireland, United Kingdom, BT47 1SB
      • Recruiting
      • Altnagelvin Area Hospital
      • Contact: Contact Person; Phone Number: 44-1504-45-171
    • Portadown, Craigavon, Northern Ireland, United Kingdom, BT63 5QQ
      • Recruiting
      • Craigavon Area Hospital
      • Contact: Contact Person; Phone Number: 44-28-3833-4444
  • Scotland
    • Aberdeen, Scotland, United Kingdom, AB25 2ZN
      • Recruiting
      • Aberdeen Royal Infirmary
      • Contact: Contact Person; Phone Number: 44-84-5456-6000
    • Ayr, Scotland, United Kingdom, KA6 6DX
      • Recruiting
      • Ayr Hospital
      • Contact: Contact Person; Phone Number: 44-1292-610-555
    • Falkirk, Scotland, United Kingdom, FK1 5QE
      • Recruiting
      • Falkirk and District Royal Infirmary
      • Contact: Contact Person; Phone Number: 44-1324-624-000
    • Glasgow, Scotland, United Kingdom, G11 6NT
      • Recruiting
      • Western Infirmary
      • Contact: Contact Person; Phone Number: 44-141-211-2000
    • Wakefield, Scotland, United Kingdom, WF1 4DG
      • Recruiting
      • Pinderfields General Hospital
      • Contact: Contact Person; Phone Number: 44-84-4811-8110
  • Wales
    • Bridgend, Wales, United Kingdom, CF31 1JP
      • Recruiting
      • Princess of Wales Hospital
      • Contact: Contact Person; Phone Number: 44-1656-752-752
    • Cardiff, Wales, United Kingdom, CF14 2TL
      • Recruiting
      • Velindre Cancer Center at Velindre Hospital
      • Contact: Contact Person; Phone Number: 44-29-2031-6292
    • Cardiff, Wales, United Kingdom, CF14 4XW
      • Recruiting
      • University Hospital of Wales
      • Contact: Contact Person; Phone Number: 44-29-2074-7747
    • Newport Gwent, Wales, United Kingdom, NP9 2UB
      • Recruiting
      • Royal Gwent Hospital
      • Contact: Contact Person; Phone Number: 44-1633-234-234
    • Rhyl, Denbighshire, Wales, United Kingdom, LL 18 5UJ
      • Recruiting
      • Glan Clwyd Hospital
    • Swansea, Wales, United Kingdom, SA2 8QA
      • Recruiting
      • Singleton Hospital
      • Contact: Contact Person; Phone Number: 44-1792-285-501

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

DISEASE CHARACTERISTICS:

• Meets 1 of the following criteria:

  • Diagnosis of prostate cancer meeting any of the following criteria:

    • Attending prostate clinics at The Royal Marsden NHS Foundation Trust

      • Any age at diagnosis

    • Not attending prostate clinics at The Royal Marsden NHS Foundation Trust, meeting 1 of the following criteria:

      • No older than 60 years at diagnosis
      • Diagnosis in two relatives where one is ≤ 65 years at diagnosis
      • At any age in a cluster with 3 or more cases
  • Any unaffected male relatives of men who are already taking part in the study

PATIENT CHARACTERISTICS:

• Able to understand the information sheet and give informed consent
• No man who is too ill to take part

PRIOR CONCURRENT THERAPY:

• Not specified

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Prostate cancer (PC) predisposition (PCP) genes

Secondary Outcome Measures

Outcome Measure
Association of PCP genes with disease and treatment parameters
Association of PCP with environmental factors
Family history of PC
Relative risk of developing PC
Increased risk relatives of PC patients are to develop cancers other than PC
Markers of PC that are associated with PCP genes
Specific tumor genetic profile correlated with PCP genes

Collaborators and Investigators

• Sponsor: Institute of Cancer Research, United Kingdom
• Investigators: Principal Investigator: Rosalind Eeles, PhD, FRCR, FRCP, FMed Sci, Royal Marsden NHS Foundation Trust

Study record dates

Study Major Dates

• Study Start: June 1, 1993

Study Registration Dates

• First Submitted: August 13, 2009
• First Submitted That Met QC Criteria: August 13, 2009
• First Posted (Estimate): August 14, 2009

Study Record Updates

• Last Update Posted (Estimate): August 26, 2013
• Last Update Submitted That Met QC Criteria: August 23, 2013
• Last Verified: August 1, 2009

More Information

Terms related to this study

• Keywords: stage III prostate cancer; stage IV prostate cancer; recurrent prostate cancer; stage I prostate cancer; stage IIB prostate cancer; stage IIA prostate cancer
• Additional Relevant MeSH Terms: Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Genital Neoplasms, Male; Prostatic Diseases; Prostatic Neoplasms
• Other Study ID Numbers: CDR0000636371; ICR-UKGPCS; EU-20909