The Effects of Pistacia Mutica on De Novo Dental Plaque Formation, Gingival Inflammation and Oral Microorganisms

September 8, 2009 updated by: Tabriz University
Dental plaque is a well known etiologic factor for gingivitis. Recently, herbal extracts are a matter of scientific interest to inhibit plaque accumulation on teeth. The purpose of this study was to evaluate the effects of pistacia Mutica (PM) mouth wash on de novo dental plaque plaque formation, gingival inflammation indices and oral microorganisms.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

25

Phase

  • Phase 2

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Iran, Islamic Republic of
    • East azarbaijan
      • Tabriz, East azarbaijan, Iran, Islamic Republic of
        • Drug Applied Science Center, tabriz Univ. of Medical Sciences

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 65 years (Adult, Older Adult)

Accepts Healthy Volunteers

N/A

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • had merely gingivitis (pocket depth≤3 mm, no attachment loss)
  • without any fixed or removable oral appliances

Exclusion Criteria:

  • Individuals who had a history of any relevant systemic diseases
  • Individuals who had a history of any drug usage

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: pistacia Mutica
The subjects were asked to use a mouthwash containing pistacia Mutica extract twice a day for 4 days.
Drug: pistacia Mutica extract
The subjects were asked to use a mouthwash containing pistacia Mutica extract twice a day for 4 days.
Placebo Comparator: placebo
The subjects were asked to use a mouthwash containing Placebo twice a day for 4 days.
Drug: Placebo
The subjects were asked to use a placebo mouthwash twice a day for 4 days.
Active Comparator: Chlorhexidine
The subjects were asked to use a mouthwash containing Chlorhexidine twice a day for 4 days.
Drug: Chlorhexidine
The subjects were asked to use a mouthwash containing Chlorhexidine twice a day for 4 days.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
The effects of pistacia Mutica extract (PM) on de novo plaque formation.
Time Frame: In a 4 days experimental periods followed by a 10 days wash-out periods.
In a 4 days experimental periods followed by a 10 days wash-out periods.

Secondary Outcome Measures

Outcome Measure
Time Frame
staining effects of pistacia Mutica extract in comparison to placebo or Chlorhexidine
Time Frame: In a 4 days experimental periods followed by a 10 days wash-out periods
In a 4 days experimental periods followed by a 10 days wash-out periods

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Tabriz University

Investigators

  • Principal Investigator: Reza Pourabbas, DDS,MSD, Tabriz University of Medical Sciences

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2008

Study Completion (Actual)

May 1, 2009

Study Registration Dates

First Submitted

September 8, 2009

First Submitted That Met QC Criteria

September 8, 2009

First Posted (Estimate)

September 9, 2009

Study Record Updates

Last Update Posted (Estimate)

September 9, 2009

Last Update Submitted That Met QC Criteria

September 8, 2009

Last Verified

February 1, 2007

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 8660

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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