Effectiveness and Tolerability of Tarka® in the Treatment of Hypertensive Patients With High Risk of Developing Diabetes Mellitus (TARDIA)

April 15, 2011 updated by: Abbott

Effectiveness and Tolerability of Tarka in the Treatment of Hypertensive Patients With High Risk of Developing Diabetes Mellitus, Not Controlled on Single-drug Therapy: A Multicountry, Multicenter, Post-marketing Observational Study in the Routine Clinical Use

The aim of this post-marketing observational study (PMOS) is to provide data on the effectiveness and tolerability of Tarka in patients with a high risk of developing diabetes mellitus, as prescribed by the physicians in a community setting and in accordance with the terms of the local marketing authorization. The following specific questions will be addressed:

Effectiveness of Tarka in lowering the blood pressure in hypertensive patients being at high risk of developing diabetes, not controlled on single-drug therapy.
Tolerability of Tarka as assessed by withdrawal rates.

Study Overview

Status

Completed

Conditions

Hypertension

Detailed Description

This is a non-interventional, observational, open-label, multicountry, multicenter post-marketing study in which Tarka is prescribed in the usual manner in accordance with the terms of the local market authorization with regards to dose, population and indication. Patients with a high risk of developing diabetes mellitus treated by secondary care specialists (such as internal medicine specialists, nephrologists, endocrinologists, etc.), whose hypertension is not controlled on single-drug therapy will be included.

The assignment of the patient to the treatment with Tarka is not decided in advance by this protocol but falls within current practice. The prescription of Tarka is clearly separated from the decision to include the patient in this study. No additional procedures (other than standard of care) shall be applied to the patients.

Each patient will be treated at the physician's discretion. Dosing schedule should be in the accordance with the locally approved Summary of Product Characteristics (SmPC). Physicians will be provided with a study kit that includes a protocol, Tarka's locally approved SmPC, and case reports forms for each patient to be enrolled.

The patient's demographic data, height, weight and waist circumference will be reported in the Inclusion visit. The previous antihypertensive therapy should be noted (generic name of the drug and total daily dose). All other drugs the patient currently receives for cardiovascular disease treatment should be recorded as well.

The patient will then be followed via regular office visits as determined by the physician. As this study is observational in nature, patient follow-up is not interventional and is left to the judgment of each physician within the 6-month period, which defines the survey for each patient. For indicative purposes, follow-up of participant should enable 3 patient visits during this period. For these reasons, the most likely visits are defined as "Inclusion visit" at which treatment with Tarka is to be commenced, and then "Follow-up visit Month 3 " and "Follow-up visit Month 6", although dates will depend only on the decision of the physician. As a result, failure to meet these suggested dates will not constitute a breach of the protocol.

Study Type

Observational

Enrollment (Actual)

15436

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Bulgaria
- - Haskovo, Bulgaria, 6300
    - Site Reference ID/Investigator# 29197
  - Pleven, Bulgaria, 5800
    - Site Reference ID/Investigator# 29685
  - Plovdiv, Bulgaria, 4000
    - Site Reference ID/Investigator# 29682
  - Plovdiv, Bulgaria, 4000
    - Site Reference ID/Investigator# 29686
  - Sofia, Bulgaria, 1233
    - Site Reference ID/Investigator# 29097
  - Sofia, Bulgaria, 1309
    - Site Reference ID/Investigator# 28954
  - Sofia, Bulgaria, 1431
    - Site Reference ID/Investigator# 29681
  - Sofia, Bulgaria, 1431
    - Site Reference ID/Investigator# 29683
  - Sofia, Bulgaria, 1632
    - Site Reference ID/Investigator# 29079
  - Sofia, Bulgaria, 1756
    - Site Reference ID/Investigator# 29651
  - Stara Zagora, Bulgaria, 6003
    - Site Reference ID/Investigator# 29484
  - Stara Zagora, Bulgaria, 6003
    - Site Reference ID/Investigator# 29485
  - Varna, Bulgaria, 9000
    - Site Reference ID/Investigator# 29480
  - Varna, Bulgaria, 9000
    - Site Reference ID/Investigator# 7568
  - Veliko Turnovo, Bulgaria, 5000
    - Site Reference ID/Investigator# 29196
Czech Republic
- - Adamov, Czech Republic, 679 04
    - Site Reference ID/Investigator# 28887
  - As, Czech Republic, 352 01
    - Site Reference ID/Investigator# 28660
  - As, Czech Republic, 35201
    - Site Reference ID/Investigator# 28705
  - Bilina, Czech Republic, 418 01
    - Site Reference ID/Investigator# 28726
  - Bilina, Czech Republic, 418 01
    - Site Reference ID/Investigator# 29013
  - Bilina, Czech Republic, 418 01
    - Site Reference ID/Investigator# 29146
  - Bohumin, Czech Republic, 735 31
    - Site Reference ID/Investigator# 29070
  - Bolatice, Czech Republic, 746 23
    - Site Reference ID/Investigator# 28891
  - Borsov nad Vltavou, Czech Republic, 373 82
    - Site Reference ID/Investigator# 28803
  - Boskovice, Czech Republic, 680 01
    - Site Reference ID/Investigator# 29047
  - Brandysek, Czech Republic, 273 41
    - Site Reference ID/Investigator# 29108
  - Brasy-Stupno, Czech Republic, 338 24
    - Site Reference ID/Investigator# 28843
  - Breclav, Czech Republic, 69002
    - Site Reference ID/Investigator# 28646
  - Brno, Czech Republic, 602 00
    - Site Reference ID/Investigator# 28578
  - Brno, Czech Republic, 602 00
    - Site Reference ID/Investigator# 28737
  - Brno, Czech Republic, 602 00
    - Site Reference ID/Investigator# 29043
  - Brno, Czech Republic, 612 00
    - Site Reference ID/Investigator# 28706
  - Brno, Czech Republic, 612 00
    - Site Reference ID/Investigator# 28973
  - Brno, Czech Republic, 612 00
    - Site Reference ID/Investigator# 29173
  - Brno, Czech Republic, 612 00
    - Site Reference ID/Investigator# 29175
  - Brno, Czech Republic, 614 00
    - Site Reference ID/Investigator# 28908
  - Brno, Czech Republic, 615 00
    - Site Reference ID/Investigator# 29123
  - Brno, Czech Republic, 619 00
    - Site Reference ID/Investigator# 28759
  - Brno, Czech Republic, 619 00
    - Site Reference ID/Investigator# 28914
  - Brno, Czech Republic, 619 00
    - Site Reference ID/Investigator# 29117
  - Brno, Czech Republic, 619 00
    - Site Reference ID/Investigator# 29124
  - Brno, Czech Republic, 619 00
    - Site Reference ID/Investigator# 29134
  - Brno, Czech Republic, 625 00
    - Site Reference ID/Investigator# 28971
  - Brno, Czech Republic, 625 00
    - Site Reference ID/Investigator# 28972
  - Brno, Czech Republic, 625 00
    - Site Reference ID/Investigator# 29036
  - Brno, Czech Republic
    - Site Reference ID/Investigator# 29044
  - Broumov, Czech Republic, 550 01
    - Site Reference ID/Investigator# 29693
  - Broumov, Czech Republic, 550 01
    - Site Reference ID/Investigator# 29694
  - Bustehrad, Czech Republic, 273 43
    - Site Reference ID/Investigator# 28874
  - Celakovice, Czech Republic, 250 88
    - Site Reference ID/Investigator# 29136
  - Cernosin, Czech Republic, 34958
    - Site Reference ID/Investigator# 28814
  - Cervena Voda, Czech Republic, 56161
    - Site Reference ID/Investigator# 29069
  - Ceska Trebova, Czech Republic, 560 02
    - Site Reference ID/Investigator# 28900
  - Ceske Budejovice, Czech Republic, 370 01
    - Site Reference ID/Investigator# 28634
  - Ceske Budejovice, Czech Republic, 370 04
    - Site Reference ID/Investigator# 28651
  - Ceske Budejovice, Czech Republic, 370 06
    - Site Reference ID/Investigator# 28798
  - Ceske Budejovice, Czech Republic, 371 27
    - Site Reference ID/Investigator# 28877
  - Cesky Tesin, Czech Republic, 737 01
    - Site Reference ID/Investigator# 29118
  - Cheb, Czech Republic, 35002
    - Site Reference ID/Investigator# 28684
  - Cheb, Czech Republic, 35002
    - Site Reference ID/Investigator# 28751
  - Cheb, Czech Republic, 35002
    - Site Reference ID/Investigator# 28847
  - Cheb, Czech Republic, 35002
    - Site Reference ID/Investigator# 29132
  - Cheb, Czech Republic, 35002
    - Site Reference ID/Investigator# 29142
  - Chomutov, Czech Republic, 43001
    - Site Reference ID/Investigator# 28669
  - Chrudim, Czech Republic, 537 01
    - Site Reference ID/Investigator# 28732
  - Chrudim, Czech Republic, 537 01
    - Site Reference ID/Investigator# 28792
  - Chrudim, Czech Republic, 537 01
    - Site Reference ID/Investigator# 29017
  - Cista, Czech Republic, 27034
    - Site Reference ID/Investigator# 28854
  - Decin, Czech Republic, 405 01
    - Site Reference ID/Investigator# 28696
  - Decin, Czech Republic, 405 02
    - Site Reference ID/Investigator# 28748
  - Decin, Czech Republic, 405 02
    - Site Reference ID/Investigator# 28852
  - Dolni Kalna, Czech Republic, 543 74
    - Site Reference ID/Investigator# 28936
  - Domazlice, Czech Republic, 344 01
    - Site Reference ID/Investigator# 28786
  - Domazlice, Czech Republic, 344 01
    - Site Reference ID/Investigator# 28821
  - Domazlice, Czech Republic, 344 01
    - Site Reference ID/Investigator# 29021
  - Duchcov, Czech Republic, 419 01
    - Site Reference ID/Investigator# 28855
  - Frenstat pod Radhostem, Czech Republic, 74401
    - Site Reference ID/Investigator# 29139
  - Frydek-Mistek, Czech Republic, 73818
    - Site Reference ID/Investigator# 29158
  - Frydlant nad Ostravici, Czech Republic, 73911
    - Site Reference ID/Investigator# 28682
  - Havirov, Czech Republic, 736 01
    - Site Reference ID/Investigator# 28817
  - Havlickuv Brod, Czech Republic, 580 01
    - Site Reference ID/Investigator# 28657
  - Havlickuv Brod, Czech Republic, 580 01
    - Site Reference ID/Investigator# 28733
  - Hnevotin, Czech Republic, 78347
    - Site Reference ID/Investigator# 28858
  - Horsovsky Tyn, Czech Republic, 34601
    - Site Reference ID/Investigator# 28904
  - Hostinne, Czech Republic, 54371
    - Site Reference ID/Investigator# 28894
  - Hranice, Czech Republic, 75301
    - Site Reference ID/Investigator# 28665
  - Hranice, Czech Republic, 75301
    - Site Reference ID/Investigator# 28700
  - Hranice, Czech Republic, 75301
    - Site Reference ID/Investigator# 28809
  - Hranice, Czech Republic, 75301
    - Site Reference ID/Investigator# 28933
  - Jablonec nad Nisou, Czech Republic, 466 02
    - Site Reference ID/Investigator# 29155
  - Jablonec nad Nisou, Czech Republic, 466 04
    - Site Reference ID/Investigator# 28861
  - Javornik, Czech Republic, 790 70
    - Site Reference ID/Investigator# 28630
  - Jihlava, Czech Republic, 586 01
    - Site Reference ID/Investigator# 28648
  - Jihlava, Czech Republic, 586 01
    - Site Reference ID/Investigator# 28756
  - Jihlava, Czech Republic, 586 01
    - Site Reference ID/Investigator# 28836
  - Jindrichuv Hradec, Czech Republic, 377 01
    - Site Reference ID/Investigator# 28643
  - Jindrichuv Hradec, Czech Republic, 377 01
    - Site Reference ID/Investigator# 28788
  - Karlovy Vary, Czech Republic, 360 01
    - Site Reference ID/Investigator# 28678
  - Karlovy Vary, Czech Republic, 360 01
    - Site Reference ID/Investigator# 28741
  - Karlovy Vary, Czech Republic, 360 01
    - Site Reference ID/Investigator# 28893
  - Kdyne, Czech Republic, 34 506
    - Site Reference ID/Investigator# 28652
  - Kladeruby, Czech Republic, 258 01
    - Site Reference ID/Investigator# 28796
  - Kladno, Czech Republic, 272 01
    - Site Reference ID/Investigator# 28645
  - Kladno, Czech Republic, 272 01
    - Site Reference ID/Investigator# 28916
  - Klatovy, Czech Republic, 339 01
    - Site Reference ID/Investigator# 28647
  - Klatovy, Czech Republic, 339 01
    - Site Reference ID/Investigator# 28659
  - Kolin, Czech Republic, 280 02
    - Site Reference ID/Investigator# 28773
  - Kolin, Czech Republic, 280 02
    - Site Reference ID/Investigator# 29156
  - Krnov, Czech Republic, 794 01
    - Site Reference ID/Investigator# 29393
  - Kromeriz, Czech Republic, 76701
    - Site Reference ID/Investigator# 28872
  - Kunovice, Czech Republic, 68604
    - Site Reference ID/Investigator# 28760
  - Kutna Hora, Czech Republic, 284 01
    - Site Reference ID/Investigator# 28857
  - Kutna Hora, Czech Republic, 284 01
    - Site Reference ID/Investigator# 28886
  - Lazne Belohrad, Czech Republic, 507 81
    - Site Reference ID/Investigator# 28655
  - Lednice, Czech Republic, 69144
    - Site Reference ID/Investigator# 28898
  - Liberec, Czech Republic, 460 01
    - Site Reference ID/Investigator# 29019
  - Libice nad Cidlinou, Czech Republic, 289 07
    - Site Reference ID/Investigator# 29141
  - Libusin, Czech Republic, 486
    - Site Reference ID/Investigator# 28723
  - Lipnik nad Becvou, Czech Republic, 75131
    - Site Reference ID/Investigator# 29153
  - Litomerice, Czech Republic, 412 01
    - Czech Republic Site Reference ID/Investigator# 28769
  - Litomerice, Czech Republic, 412 01
    - Site Reference ID/Investigator# 28815
  - Litomysl, Czech Republic, 570 01
    - Site Reference ID/Investigator# 29116
  - Lovosice, Czech Republic, 41002
    - Site Reference ID/Investigator# 29020
  - Marianske Lazne, Czech Republic, 353 01
    - Site Reference ID/Investigator# 28650
  - Melnik, Czech Republic, 276 01
    - Site Reference ID/Investigator# 28878
  - Mestec Kralove, Czech Republic, 289 03
    - Site Reference ID/Investigator# 29149
  - Mikulov, Czech Republic, 69201
    - Site Reference ID/Investigator# 28820
  - Mimon, Czech Republic, 47124
    - Site Reference ID/Investigator# 28824
  - Mnichovo Hradiste, Czech Republic, 295 01
    - Site Reference ID/Investigator# 28853
  - Mohelnice, Czech Republic, 789 85
    - Site Reference ID/Investigator# 28867
  - Mohelnice, Czech Republic, 78985
    - Site Reference ID/Investigator# 29361
  - Nachod, Czech Republic, 547 01
    - Site Reference ID/Investigator# 28662
  - Neratovice, Czech Republic, 277 11
    - Site Reference ID/Investigator# 29128
  - Nove Mesto nad Metuji, Czech Republic, 549 01
    - Site Reference ID/Investigator# 29057
  - Novy Bor, Czech Republic, 473 01
    - Site Reference ID/Investigator# 28888
  - Novy bydzov, Czech Republic, 504 01
    - Site Reference ID/Investigator# 28875
  - Nymburk, Czech Republic, 288 02
    - Site Reference ID/Investigator# 28740
  - Olomouc, Czech Republic, 775 20
    - Site Reference ID/Investigator# 29695
  - Olomouc, Czech Republic, 77520
    - Site Reference ID/Investigator# 29689
  - Olomouc, Czech Republic, 77520
    - Site Reference ID/Investigator# 29692
  - Opava, Czech Republic, 74795
    - Site Reference ID/Investigator# 29121
  - Opocno, Czech Republic, 517 73
    - Site Reference ID/Investigator# 29688
  - Orlova, Czech Republic, 735 14
    - Site Reference ID/Investigator# 29071
  - Ostrava, Czech Republic, 700 30
    - Site Reference ID/Investigator# 29014
  - Ostrava, Czech Republic, 70030
    - Site Reference ID/Investigator# 28708
  - Ostrava, Czech Republic, 70030
    - Site Reference ID/Investigator# 28746
  - Ostrava, Czech Republic, 70030
    - Site Reference ID/Investigator# 28755
  - Ostrava, Czech Republic, 70030
    - Site Reference ID/Investigator# 28863
  - Ostrava, Czech Republic, 70030
    - Site Reference ID/Investigator# 29046
  - Ostrava, Czech Republic, 702 00
    - Site Reference ID/Investigator# 29691
  - Ostrava, Czech Republic, 70200
    - Site Reference ID/Investigator# 28807
  - Ostrava, Czech Republic, 70700
    - Site Reference ID/Investigator# 28868
  - Ostrava, Czech Republic, 70800
    - Site Reference ID/Investigator# 29113
  - Ostrava, Czech Republic, 70800
    - Site Reference ID/Investigator# 29690
  - Ostrava, Czech Republic, 70900
    - Site Reference ID/Investigator# 28679
  - Ostrava, Czech Republic, 71500
    - Site Reference ID/Investigator# 28664
  - Ostrava, Czech Republic, 71500
    - Site Reference ID/Investigator# 28681
  - Ostrava, Czech Republic, 71500
    - Site Reference ID/Investigator# 29152
  - Ostrava, Czech Republic, 719 00
    - Site Reference ID/Investigator# 28816
  - Ostrava, Czech Republic, 72100
    - Site Reference ID/Investigator# 28711
  - Ostrava, Czech Republic, 72100
    - Site Reference ID/Investigator# 28787
  - Ostrava-Hostalkovice, Czech Republic, 725 28
    - Site Reference ID/Investigator# 28905
  - Ostrava-Krasne Pole, Czech Republic, 72526
    - Site Reference ID/Investigator# 28780
  - Ostrava-Poruba, Czech Republic, 708 00
    - Site Reference ID/Investigator# 28663
  - Ostrov, Czech Republic, 363 01
    - Site Reference ID/Investigator# 28902
  - Otrokovice, Czech Republic, 765 02
    - Site Reference ID/Investigator# 28728
  - Pardubice, Czech Republic, 530 03
    - Site Reference ID/Investigator# 28661
  - Pardubice, Czech Republic, 530 03
    - Site Reference ID/Investigator# 28668
  - Pardubice, Czech Republic, 530 03
    - Site Reference ID/Investigator# 28735
  - Pardubice, Czech Republic, 530 03
    - Site Reference ID/Investigator# 28742
  - Pardubice, Czech Republic, 530 03
    - Site Reference ID/Investigator# 28770
  - Pardubice, Czech Republic, 530 03
    - Site Reference ID/Investigator# 28776
  - Pardubice, Czech Republic, 530 03
    - Site Reference ID/Investigator# 28789
  - Pardubice, Czech Republic, 530 03
    - Site Reference ID/Investigator# 28845
  - Pardubice, Czech Republic, 530 03
    - Site Reference ID/Investigator# 28873
  - Pardubice, Czech Republic, 530 03
    - Site Reference ID/Investigator# 28964
  - Pardubice, Czech Republic, 530 03
    - Site Reference ID/Investigator# 29120
  - Paseka, Czech Republic, 783 97
    - Site Reference ID/Investigator# 28777
  - Pelhrimov, Czech Republic, 393 01
    - Site Reference ID/Investigator# 28615
  - Pelhrimov, Czech Republic, 393 01
    - Site Reference ID/Investigator# 28675
  - Pisek, Czech Republic, 397 01
    - Site Reference ID/Investigator# 28844
  - Pisek, Czech Republic, 397 01
    - Site Reference ID/Investigator# 29143
  - Plana nad Luznici, Czech Republic, 39111
    - Site Reference ID/Investigator# 29115
  - Plzen, Czech Republic, 301 00
    - Site Reference ID/Investigator# 28670
  - Plzen, Czech Republic, 301 00
    - Site Reference ID/Investigator# 28931
  - Plzen, Czech Republic, 30100
    - Site Reference ID/Investigator# 28685
  - Plzen, Czech Republic, 30446
    - Site Reference ID/Investigator# 29145
  - Plzen, Czech Republic, 320 000
    - Site Reference ID/Investigator# 28683
  - Plzen, Czech Republic, 320 00
    - Site Reference ID/Investigator# 28680
  - Plzen, Czech Republic, 323 00
    - Site Reference ID/Investigator# 28827
  - Plzen, Czech Republic, 323 18
    - Site Reference ID/Investigator# 28752
  - Plzen, Czech Republic, 326 00
    - Site Reference ID/Investigator# 28785
  - Policka, Czech Republic, 572 01
    - Site Reference ID/Investigator# 28676
  - Postoloprty, Czech Republic, 439 42
    - Site Reference ID/Investigator# 28658
  - Prachatice, Czech Republic, 383 01
    - Site Reference ID/Investigator# 28833
  - Prague, Czech Republic, 190 00
    - Site Reference ID/Investigator# 29131
  - Prague, Czech Republic, 74781
    - Site Reference ID/Investigator# 28774
  - Prague 1, Czech Republic, 110 00
    - Site Reference ID/Investigator# 28802
  - Prague 10, Czech Republic, 100 00
    - Site Reference ID/Investigator# 28703
  - Prague 10, Czech Republic, 100 00
    - Site Reference ID/Investigator# 28801
  - Prague 10, Czech Republic, 100 34
    - Site Reference ID/Investigator# 29060
  - Prague 10, Czech Republic, 102 00
    - Site Reference ID/Investigator# 28656
  - Prague 10, Czech Republic, 106 00
    - Site Reference ID/Investigator# 28623
  - Prague 10, Czech Republic, 108 00
    - Site Reference ID/Investigator# 28633
  - Prague 10, Czech Republic, 108 00
    - Site Reference ID/Investigator# 28698
  - Prague 10, Czech Republic, 108 00
    - Site Reference ID/Investigator# 28842
  - Prague 10, Czech Republic
    - Site Reference ID/Investigator# 28692
  - Prague 2, Czech Republic, 128 08
    - Site Reference ID/Investigator# 29696
  - Prague 3, Czech Republic, 130 00
    - Site Reference ID/Investigator# 28790
  - Prague 3, Czech Republic, 130 00
    - Site Reference ID/Investigator# 28876
  - Prague 4, Czech Republic, 140 00
    - Site Reference ID/Investigator# 28687
  - Prague 4, Czech Republic, 140 00
    - Site Reference ID/Investigator# 28794
  - Prague 4, Czech Republic, 142 00
    - Site Reference ID/Investigator# 28631
  - Prague 4, Czech Republic, 142 00
    - Site Reference ID/Investigator# 28635
  - Prague 4, Czech Republic, 142 00
    - Site Reference ID/Investigator# 28797
  - Prague 4, Czech Republic, 142 00
    - Site Reference ID/Investigator# 28926
  - Prague 4, Czech Republic, 143 00
    - Site Reference ID/Investigator# 28767
  - Prague 4, Czech Republic, 149 00
    - Site Reference ID/Investigator# 28826
  - Prague 4, Czech Republic, 149 00
    - Site Reference ID/Investigator# 28831
  - Prague 4, Czech Republic, 149 00
    - Site Reference ID/Investigator# 28864
  - Prague 4, Czech Republic, 149 00
    - Site Reference ID/Investigator# 29376
  - Prague 4, Czech Republic, 149 00
    - Site Reference ID/Investigator# 29377
  - Prague 5, Czech Republic, 158 00
    - Site Reference ID/Investigator# 28617
  - Prague 5, Czech Republic, 160 00
    - Site Reference ID/Investigator# 28627
  - Prague 5, Czech Republic, 160 00
    - Site Reference ID/Investigator# 28649
  - Prague 5, Czech Republic, 160 00
    - Site Reference ID/Investigator# 28813
  - Prague 5, Czech Republic, 160 00
    - Site Reference ID/Investigator# 28840
  - Prague 5, Czech Republic, 160 00
    - Site Reference ID/Investigator# 29127
  - Prague 5, Czech Republic, 160 00
    - Site Reference ID/Investigator# 29396
  - Prague 5, Czech Republic, 160 00
    - Site Reference ID/Investigator# 29687
  - Prague 6, Czech Republic, 162 00
    - Site Reference ID/Investigator# 28913
  - Prague 7, Czech Republic, 170 00
    - Site Reference ID/Investigator# 28765
  - Prague 7, Czech Republic, 170 00
    - Site Reference ID/Investigator# 28928
  - Prague 8, Czech Republic, 181 00
    - Site Reference ID/Investigator# 28653
  - Prague 8, Czech Republic, 182 00
    - Site Reference ID/Investigator# 28823
  - Prague 8, Czech Republic, 186 00
    - Site Reference ID/Investigator# 28724
  - Prague 9, Czech Republic, 180 49
    - Site Reference ID/Investigator# 28673
  - Prague 9, Czech Republic, 180 49
    - Site Reference ID/Investigator# 28795
  - Prague 9, Czech Republic, 180 49
    - Site Reference ID/Investigator# 28882
  - Prague 9, Czech Republic, 180 49
    - Site Reference ID/Investigator# 28911
  - Prague 9, Czech Republic, 180 49
    - Site Reference ID/Investigator# 28935
  - Prague 9, Czech Republic, 180 49
    - Site Reference ID/Investigator# 29150
  - Prelouc, Czech Republic, 535 01
    - Site Reference ID/Investigator# 28701
  - Prelouc, Czech Republic, 535 01
    - Site Reference ID/Investigator# 28822
  - Prerov, Czech Republic, 75011
    - Site Reference ID/Investigator# 28719
  - Pribram, Czech Republic, 261 01
    - Site Reference ID/Investigator# 28783
  - Pribram V-Zdabor, Czech Republic, 261 01
    - Site Reference ID/Investigator# 29022
  - Primda, Czech Republic, 348 06
    - Site Reference ID/Investigator# 28750
  - Prostejov, Czech Republic, 796 01
    - Site Reference ID/Investigator# 29111
  - Prostejov, Czech Republic, 796 04
    - Site Reference ID/Investigator# 29418
  - Prostejov, Czech Republic, 796 04
    - Site Reference ID/Investigator# 29420
  - Rakovnik, Czech Republic, 269 01
    - Site Reference ID/Investigator# 28707
  - Rakovnik, Czech Republic, 269 01
    - Site Reference ID/Investigator# 28768
  - Rakovnik, Czech Republic, 269 01
    - Site Reference ID/Investigator# 29024
  - Revnice, Czech Republic, 252 30
    - Site Reference ID/Investigator# 28846
  - Revnice, Czech Republic, 252 30
    - Site Reference ID/Investigator# 29300
  - Rosice, Czech Republic, 538 63
    - Site Reference ID/Investigator# 28714
  - Rosice, Czech Republic, 664 83
    - Site Reference ID/Investigator# 7575
  - Roznov pod Radhostem, Czech Republic, 75661
    - Site Reference ID/Investigator# 28772
  - Roznov pod Radhostem, Czech Republic, 75661
    - Site Reference ID/Investigator# 29137
  - Rybitvi, Czech Republic, 533 54
    - Site Reference ID/Investigator# 28674
  - Sezimovo Usti, Czech Republic, 391 01
    - Site Reference ID/Investigator# 28848
  - Sezimovo Usti, Czech Republic, 391 02
    - Site Reference ID/Investigator# 28866
  - Slany, Czech Republic, 274 01
    - Site Reference ID/Investigator# 29122
  - Slavicin, Czech Republic, 76321
    - Site Reference ID/Investigator# 28712
  - Sokolov, Czech Republic, 356 01
    - Site Reference ID/Investigator# 28628
  - Sokolov, Czech Republic, 356 01
    - Site Reference ID/Investigator# 28860
  - Stepankovice, Czech Republic, 74795
    - Site Reference ID/Investigator# 28791
  - Sumperk, Czech Republic, 787 01
    - Site Reference ID/Investigator# 28890
  - Sumperk, Czech Republic, 787 52
    - Site Reference ID/Investigator# 29066
  - Svitavy, Czech Republic, 568 02
    - Site Reference ID/Investigator# 29067
  - Tabor, Czech Republic, 390 05
    - Site Reference ID/Investigator# 28677
  - Tabor, Czech Republic, 390 05
    - Site Reference ID/Investigator# 28710
  - Telc, Czech Republic, 588 56
    - Site Reference ID/Investigator# 28672
  - Teplice, Czech Republic, 415 01
    - Site Reference ID/Investigator# 28704
  - Teplice, Czech Republic, 415 01
    - Site Reference ID/Investigator# 28811
  - Teplice, Czech Republic, 415 01
    - Site Reference ID/Investigator# 28862
  - Trebic, Czech Republic, 674 01
    - Site Reference ID/Investigator# 28912
  - Trebic, Czech Republic, 674 01
    - Site Reference ID/Investigator# 29126
  - Trebic, Czech Republic
    - Site Reference ID/Investigator# 28616
  - Trhove Sviny, Czech Republic, 374 01
    - Site Reference ID/Investigator# 28758
  - Trinec-Kanada, Czech Republic, 73961
    - Site Reference ID/Investigator# 29157
  - Trutnov, Czech Republic, 541 01
    - Site Reference ID/Investigator# 28899
  - Trutnov, Czech Republic, 541 01
    - Site Reference ID/Investigator# 29110
  - Turnov, Czech Republic, 511 01
    - Site Reference ID/Investigator# 28739
  - Turnov, Czech Republic, 511 01
    - Site Reference ID/Investigator# 28747
  - Tyn nad Vltavou, Czech Republic, 375 01
    - Site Reference ID/Investigator# 28925
  - Tyn nad Vltavou, Czech Republic, 375 01
    - Site Reference ID/Investigator# 28927
  - Uherske Hradiste, Czech Republic, 67601
    - Site Reference ID/Investigator# 29151
  - Ujezd u Brna, Czech Republic, 664 53
    - Site Reference ID/Investigator# 28636
  - Ujezd u Brna, Czech Republic, 664 53
    - Site Reference ID/Investigator# 29135
  - Usti nad Labem, Czech Republic, 400 01
    - Site Reference ID/Investigator# 28699
  - Usti nad Labem, Czech Republic, 40007
    - Site Reference ID/Investigator# 28869
  - Usti nad Orlici, Czech Republic, 562 01
    - Site Reference ID/Investigator# 29114
  - Valasske Klobouky, Czech Republic, 76601
    - Site Reference ID/Investigator# 28709
  - Valasske Mezirici, Czech Republic, 575 01
    - Site Reference ID/Investigator# 28865
  - Valasske Mezirici, Czech Republic, 757 01
    - Site Reference ID/Investigator# 28654
  - Valasske Mezirici, Czech Republic, 757 01
    - Site Reference ID/Investigator# 29112
  - Valasske Mezirici, Czech Republic, 757 01
    - Site Reference ID/Investigator# 29144
  - Vamberk, Czech Republic, 51754
    - Site Reference ID/Investigator# 28818
  - Velke Hamry, Czech Republic, 468 45
    - Site Reference ID/Investigator# 28895
  - Vintirov, Czech Republic, 395 01
    - Site Reference ID/Investigator# 29390
  - Visnova, Czech Republic, 262 61
    - Site Reference ID/Investigator# 28713
  - Vlasim, Czech Republic, 258 01
    - Site Reference ID/Investigator# 28624
  - Vodnany, Czech Republic, 38901
    - Site Reference ID/Investigator# 29025
  - Votice-Otradovice, Czech Republic, 765 02
    - Site Reference ID/Investigator# 29018
  - Vratimov, Czech Republic, 739 32
    - Site Reference ID/Investigator# 29148
  - Vsetin, Czech Republic, 755 01
    - Site Reference ID/Investigator# 28666
  - Vsetin, Czech Republic, 75501
    - Site Reference ID/Investigator# 28856
  - Vsetin, Czech Republic, 75501
    - Site Reference ID/Investigator# 29109
  - Vysoke Myto, Czech Republic, 566 01
    - Site Reference ID/Investigator# 29049
  - Zabreh na Morave, Czech Republic, 789 01
    - Site Reference ID/Investigator# 28837
  - Zahradky, Czech Republic, 47101
    - Site Reference ID/Investigator# 28697
  - Zamberk, Czech Republic, 56421
    - Site Reference ID/Investigator# 28962
  - Zd'ar, Czech Republic, 270 33
    - Site Reference ID/Investigator# 28906
  - Zirovnice, Czech Republic, 394 68
    - Site Reference ID/Investigator# 29048
  - Znojmo, Czech Republic, 66902
    - Site Reference ID/Investigator# 28781
  - Znojmo, Czech Republic, 66902
    - Site Reference ID/Investigator# 28924
  - Znojmo, Czech Republic, 67181
    - Site Reference ID/Investigator# 28804
Romania
- - Alba-Iulia, Romania, 510077
    - Site Reference ID/Investigator# 28575
  - Bacau, Romania, 600015
    - Site Reference ID/Investigator# 28581
  - Bacau, Romania, 600114
    - Site Reference ID/Investigator# 28580
  - Baia Mare, Romania, 430031
    - Site Reference ID/Investigator# 29749
  - Brasov, Romania, 500365
    - Site Reference ID/Investigator# 29077
  - Bucharest, Romania, 20125
    - Site Reference ID/Investigator# 28605
  - Bucuresti, Romania, 10825
    - Site Reference ID/Investigator# 32095
  - Bucuresti, Romania, 10825
    - Site Reference ID/Investigator# 32096
  - Bucuresti, Romania, 11171
    - Site Reference ID/Investigator# 28577
  - Bucuresti, Romania, 21711
    - Site Reference ID/Investigator# 29072
  - Bucuresti, Romania, 22104
    - Site Reference ID/Investigator# 29073
  - Bucuresti, Romania, 22328
    - Site Reference ID/Investigator# 28982
  - Bucuresti, Romania, 50659
    - Site Reference ID/Investigator# 28955
  - Buzau, Romania, 120140
    - Site Reference ID/Investigator# 28583
  - Cluj Napoca, Romania, 400001
    - Site Reference ID/Investigator# 32109
  - Cluj Napoca, Romania, 400001
    - Site Reference ID/Investigator# 32110
  - Cluj Napoca, Romania, 400001
    - Site Reference ID/Investigator# 32111
  - Constanta, Romania, 900553
    - Site Reference ID/Investigator# 29099
  - Constanta, Romania, 900615
    - Site Reference ID/Investigator# 28579
  - Constanta, Romania, 900705
    - Site Reference ID/Investigator# 28584
  - Covasna, Romania, 520050
    - Site Reference ID/Investigator# 28992
  - Giurgiu, Romania, 80641
    - Site Reference ID/Investigator# 28613
  - Iasi, Romania, 700536
    - Site Reference ID/Investigator# 29074
  - Iasi, Romania, 700661
    - Site Reference ID/Investigator# 28602
  - Iasi, Romania, 700703
    - Site Reference ID/Investigator# 28967
  - Odorheiu Secuiesc, Romania, 535600
    - Site Reference ID/Investigator# 28961
  - Oradea, Romania, 410159
    - Site Reference ID/Investigator# 28963
  - Oradea, Romania, 410469
    - Site Reference ID/Investigator# 29752
  - Pitesti, Romania, 110084
    - Site Reference ID/Investigator# 28995
  - Pitesti, Romania, 110084
    - Site Reference ID/Investigator# 29628
  - Pitesti, Romania, 110084
    - Site Reference ID/Investigator# 29629
  - Ploiesti, Romania, 100018
    - Site Reference ID/Investigator# 29031
  - Resita, Romania, 320076
    - Site Reference ID/Investigator# 29191
  - Sibiu, Romania, 550245
    - Site Reference ID/Investigator# 6369
  - Suceava, Romania, 720019
    - Site Reference ID/Investigator# 29006
  - Targoviste, Romania, 130048
    - Site Reference ID/Investigator# 29088
  - Targu Mures, Romania, 546136
    - Site Reference ID/Investigator# 29089
  - Targu Mures, Romania, 546136
    - Site Reference ID/Investigator# 29330
  - Targu Mures, Romania, 546136
    - Site Reference ID/Investigator# 29331
  - Tg. Mures, Romania, 540042
    - Site Reference ID/Investigator# 29032
  - Timisoara, Romania, 300024
    - Site Reference ID/Investigator# 29087
  - Timisoara, Romania, 300310
    - Site Reference ID/Investigator# 29086
Russian Federation
- - Chelyabinsk, Russian Federation, 454000
    - Site Reference ID/Investigator# 28596
  - Chelyabinsk, Russian Federation, 454000
    - Site Reference ID/Investigator# 28986
  - Chelyabinsk, Russian Federation, 454000
    - Site Reference ID/Investigator# 29248
  - Chelyabinsk, Russian Federation, 454000
    - Site Reference ID/Investigator# 29332
  - Chelyabinsk, Russian Federation, 454000
    - Site Reference ID/Investigator# 29546
  - Chelyabinsk, Russian Federation, 454000
    - Site Reference ID/Investigator# 29547
  - Dmitrov, Russian Federation, 141800
    - Site Reference ID/Investigator# 29491
  - Dmitrov, Russian Federation, 141800
    - Site Reference ID/Investigator# 29492
  - Ekaterinburg, Russian Federation, 620000
    - Site Reference ID/Investigator# 29404
  - Ekaterinburg, Russian Federation, 620000
    - Site Reference ID/Investigator# 29405
  - Ekaterinburg, Russian Federation, 620000
    - Site Reference ID/Investigator# 29406
  - Ekaterinburg, Russian Federation, 620000
    - Site Reference ID/Investigator# 29411
  - Ekaterinburg, Russian Federation, 620000
    - Site Reference ID/Investigator# 29412
  - Ekaterinburg, Russian Federation, 620000
    - Site Reference ID/Investigator# 29414
  - Ivanteyevka, Russian Federation, 141280
    - Site Reference ID/Investigator# 29496
  - Kazan, Russian Federation, 420000
    - Site Reference ID/Investigator# 29221
  - Kazan, Russian Federation, 420000
    - Site Reference ID/Investigator# 29256
  - Kazan, Russian Federation, 420000
    - Site Reference ID/Investigator# 29423
  - Kazan, Russian Federation, 420000
    - Site Reference ID/Investigator# 29427
  - Kazan, Russian Federation, 420000
    - Site Reference ID/Investigator# 29562
  - Kazan, Russian Federation, 420000
    - Site Reference ID/Investigator# 29649
  - Kazan, Russian Federation, 420000
    - Site Reference ID/Investigator# 29650
  - Kemerovo, Russian Federation, 650000
    - Site Reference ID/Investigator# 28597
  - Kemerovo, Russian Federation, 650000
    - Site Reference ID/Investigator# 29162
  - Kemerovo, Russian Federation, 650000
    - Site Reference ID/Investigator# 29189
  - Kemerovo, Russian Federation, 650000
    - Site Reference ID/Investigator# 29326
  - Kemerovo, Russian Federation, 650000
    - Site Reference ID/Investigator# 29343
  - Kemerovo, Russian Federation, 650000
    - Site Reference ID/Investigator# 29429
  - Kemerovo, Russian Federation, 650000
    - Site Reference ID/Investigator# 29431
  - Khimki, Russian Federation, 141410
    - Site Reference ID/Investigator# 29498
  - Korolev, Russian Federation, 141060
    - Site Reference ID/Investigator# 28598
  - Krasnodar, Russian Federation, 350000
    - Site Reference ID/Investigator# 29499
  - Krasnodar, Russian Federation, 350000
    - Site Reference ID/Investigator# 29500
  - Krasnodar, Russian Federation, 350000
    - Site Reference ID/Investigator# 29501
  - Krasnodar, Russian Federation, 350000
    - Site Reference ID/Investigator# 29502
  - Krasnodar, Russian Federation, 350000
    - Site Reference ID/Investigator# 29503
  - Krasnodar, Russian Federation, 350000
    - Site Reference ID/Investigator# 29504
  - Krasnogorsk, Russian Federation, 143400
    - Site Reference ID/Investigator# 29527
  - Krasnogorsk, Russian Federation, 143400
    - Site Reference ID/Investigator# 29530
  - Krasnoyarsk, Russian Federation, 660000
    - Site Reference ID/Investigator# 28979
  - Krasnoyarsk, Russian Federation, 660000
    - Site Reference ID/Investigator# 28981
  - Krasnoyarsk, Russian Federation, 660000
    - Site Reference ID/Investigator# 29174
  - Krasnoyarsk, Russian Federation, 660000
    - Site Reference ID/Investigator# 29209
  - Krasnoyarsk, Russian Federation, 660000
    - Site Reference ID/Investigator# 29444
  - Krasnoyarsk, Russian Federation, 660000
    - Site Reference ID/Investigator# 29446
  - Krasnoyarsk, Russian Federation, 660000
    - Site Reference ID/Investigator# 29448
  - Krasnoyarsk, Russian Federation, 660000
    - Site Reference ID/Investigator# 29449
  - Krasnoyarsk, Russian Federation, 660000
    - Site Reference ID/Investigator# 29451
  - Lipetsk, Russian Federation, 398000
    - Site Reference ID/Investigator# 29169
  - Lipetsk, Russian Federation, 398000
    - Site Reference ID/Investigator# 29231
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 28593
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 28940
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 28941
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 28949
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 28980
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 29078
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 29181
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 29185
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 29194
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 29205
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 29216
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 29220
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 29223
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 29227
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 29237
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 29561
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 29602
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 29603
  - Moscow, Russian Federation, 125009
    - Site Reference ID/Investigator# 29621
  - Mytischi, Russian Federation, 141000
    - Site Reference ID/Investigator# 29625
  - N.Novgorod, Russian Federation, 603051
    - Site Reference ID/Investigator# 29532
  - N.Novgorod, Russian Federation, 603051
    - Site Reference ID/Investigator# 29533
  - N.Novgorod, Russian Federation, 603051
    - Site Reference ID/Investigator# 29534
  - N.Novgorod, Russian Federation, 603051
    - Site Reference ID/Investigator# 29535
  - N.Novgorod, Russian Federation, 603051
    - Site Reference ID/Investigator# 29634
  - Novokuibyshevsk, Russian Federation, 446200
    - Site Reference ID/Investigator# 29182
  - Novosibirsk, Russian Federation, 630000
    - Site Reference ID/Investigator# 29226
  - Novosibirsk, Russian Federation, 630000
    - Site Reference ID/Investigator# 29536
  - Novosibirsk, Russian Federation, 630000
    - Site Reference ID/Investigator# 29568
  - Novosibirsk, Russian Federation, 630000
    - Site Reference ID/Investigator# 29619
  - Novosibirsk, Russian Federation, 630000
    - Site Reference ID/Investigator# 29627
  - Novosibirsk, Russian Federation, 630000
    - Site Reference ID/Investigator# 29647
  - Novosibirsk, Russian Federation, 630000
    - Site Reference ID/Investigator# 29648
  - Omsk, Russian Federation, 644000
    - Site Reference ID/Investigator# 28592
  - Omsk, Russian Federation, 644000
    - Site Reference ID/Investigator# 28976
  - Omsk, Russian Federation, 644000
    - Site Reference ID/Investigator# 28977
  - Omsk, Russian Federation, 644000
    - Site Reference ID/Investigator# 29335
  - Omsk, Russian Federation, 644000
    - Site Reference ID/Investigator# 29337
  - Omsk, Russian Federation, 644000
    - Site Reference ID/Investigator# 29338
  - Omsk, Russian Federation, 644000
    - Site Reference ID/Investigator# 29339
  - Omsk, Russian Federation, 644000
    - Site Reference ID/Investigator# 29537
  - Omsk, Russian Federation, 644000
    - Site Reference ID/Investigator# 29622
  - Rostov-na-Donu, Russian Federation, 344000
    - Site Reference ID/Investigator# 29511
  - Rostov-na-Donu, Russian Federation, 344000
    - Site Reference ID/Investigator# 29512
  - Rostov-na-Donu, Russian Federation, 344000
    - Site Reference ID/Investigator# 29513
  - Rostov-na-Donu, Russian Federation, 344000
    - Site Reference ID/Investigator# 29514
  - Rostov-na-Donu, Russian Federation, 344000
    - Site Reference ID/Investigator# 29515
  - Rostov-na-Donu, Russian Federation, 344000
    - Site Reference ID/Investigator# 29516
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 28604
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 28987
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29183
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29187
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29201
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29202
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29203
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29222
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29253
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29276
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29277
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29474
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29475
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29476
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29523
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29524
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29539
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29540
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29541
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29543
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29616
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29617
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29641
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29643
  - Samara, Russian Federation, 443028
    - Site Reference ID/Investigator# 29644
  - Shchelkovo, Russian Federation, 141113
    - Site Reference ID/Investigator# 29544
  - St. Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29487
  - St. Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 33322
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 28594
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 28603
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 28942
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29178
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29200
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29210
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29213
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29217
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29246
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29341
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29342
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29349
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29457
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29471
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29472
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29473
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29486
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29488
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29549
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29553
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29554
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29575
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29576
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29584
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29589
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29590
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29592
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29594
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29595
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29611
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29614
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 29615
  - St.Petersburg, Russian Federation, 190000
    - Site Reference ID/Investigator# 6368
  - Stavropol, Russian Federation, 355000
    - Site Reference ID/Investigator# 28599
  - Stavropol, Russian Federation, 355000
    - Site Reference ID/Investigator# 29005
  - Stavropol, Russian Federation, 355000
    - Site Reference ID/Investigator# 29242
  - Stavropol, Russian Federation, 355000
    - Site Reference ID/Investigator# 29347
  - Stavropol, Russian Federation, 355000
    - Site Reference ID/Investigator# 29348
  - Stavropol, Russian Federation, 355000
    - Site Reference ID/Investigator# 29654
  - Tolyatti, Russian Federation, 445000
    - Site Reference ID/Investigator# 28975
  - Tolyatti, Russian Federation, 445000
    - Site Reference ID/Investigator# 29463
  - Tolyatti, Russian Federation, 445000
    - Site Reference ID/Investigator# 29572
  - Tolyatti, Russian Federation, 445000
    - Site Reference ID/Investigator# 29632
  - Tolyatti, Russian Federation, 445000
    - Site Reference ID/Investigator# 29633
  - Tyumen, Russian Federation, 625000
    - Site Reference ID/Investigator# 29094
  - Tyumen, Russian Federation, 625000
    - Site Reference ID/Investigator# 29464
  - Tyumen, Russian Federation, 625000
    - Site Reference ID/Investigator# 29466
  - Tyumen, Russian Federation, 625000
    - Site Reference ID/Investigator# 29656
  - Tyumen, Russian Federation, 625000
    - Site Reference ID/Investigator# 29657
  - Tyumen, Russian Federation, 625000
    - Site Reference ID/Investigator# 29659
  - Tyumen, Russian Federation, 625000
    - Site Reference ID/Investigator# 29661
  - Tyumen, Russian Federation, 625000
    - Site Reference ID/Investigator# 29665
  - Tyumen, Russian Federation, 625000
    - Site Reference ID/Investigator# 29672
  - Tyumen, Russian Federation, 625000
    - Site Reference ID/Investigator# 29677
  - Tyumen, Russian Federation, 625000
    - Site Reference ID/Investigator# 33324
  - Volgograd, Russian Federation, 400127
    - Site Reference ID/Investigator# 28978
  - Volgograd, Russian Federation, 400127
    - Site Reference ID/Investigator# 29250
  - Volgograd, Russian Federation, 400127
    - Site Reference ID/Investigator# 29605
  - Volgograd, Russian Federation, 400127
    - Site Reference ID/Investigator# 29606
  - Volgograd, Russian Federation, 400127
    - Site Reference ID/Investigator# 29607
  - Voronezh, Russian Federation, 394000
    - Site Reference ID/Investigator# 29251
  - Voronezh, Russian Federation, 394000
    - Site Reference ID/Investigator# 29519
  - Voronezh, Russian Federation, 394000
    - Site Reference ID/Investigator# 29521
  - Voronezh, Russian Federation, 394000
    - Site Reference ID/Investigator# 29522
Slovakia
- - Banska Bystrica, Slovakia, 974 01
    - Site Reference ID/Investigator# 28754
  - Banska Bystrica, Slovakia, 974 01
    - Site Reference ID/Investigator# 28896
  - Banska Bystrica, Slovakia, 974 01
    - Site Reference ID/Investigator# 29366
  - Banska Bystrica, Slovakia, 974 01
    - Site Reference ID/Investigator# 29367
  - Banska Bystrica, Slovakia, 974 05
    - Site Reference ID/Investigator# 28808
  - Bardejov, Slovakia, 08 501
    - Site Reference ID/Investigator# 28918
  - Bardejov, Slovakia, 08 501
    - Site Reference ID/Investigator# 29129
  - Bardejov, Slovakia, 08 501
    - Site Reference ID/Investigator# 29324
  - Bardejov, Slovakia, 08 501
    - Site Reference ID/Investigator# 29350
  - Bratislava, Slovakia, 81107
    - Site Reference ID/Investigator# 28932
  - Bratislava, Slovakia, 81108
    - Site Reference ID/Investigator# 28693
  - Bratislava, Slovakia, 81369
    - Site Reference ID/Investigator# 29415
  - Bratislava, Slovakia, 81369
    - Site Reference ID/Investigator# 29417
  - Bratislava, Slovakia, 82104
    - Site Reference ID/Investigator# 28717
  - Bratislava, Slovakia, 82107
    - Site Reference ID/Investigator# 28749
  - Bratislava, Slovakia, 82109
    - Site Reference ID/Investigator# 28614
  - Bratislava, Slovakia, 83305
    - Site Reference ID/Investigator# 29416
  - Bratislava, Slovakia, 83309
    - Site Reference ID/Investigator# 40734
  - Bratislava, Slovakia, 84108
    - Site Reference ID/Investigator# 28849
  - Bratislava, Slovakia, 84231
    - Site Reference ID/Investigator# 28889
  - Bratislava, Slovakia, 85101
    - Site Reference ID/Investigator# 28694
  - Bratislava, Slovakia, 85101
    - Site Reference ID/Investigator# 28745
  - Bratislava, Slovakia, 85107
    - Site Reference ID/Investigator# 28757
  - Cierne, Slovakia, 2313
    - Site Reference ID/Investigator# 28879
  - Detva, Slovakia, 962 12
    - Site Reference ID/Investigator# 29388
  - Detva, Slovakia, 962 12
    - Site Reference ID/Investigator# 29389
  - Dudince, Slovakia, 962 71
    - Site Reference ID/Investigator# 29357
  - Dudince, Slovakia, 962 71
    - Site Reference ID/Investigator# 29358
  - Dunajska Streda, Slovakia, 929 01
    - Site Reference ID/Investigator# 28880
  - Dunajska Streda, Slovakia, 929 01
    - Site Reference ID/Investigator# 29364
  - Dunajska Streda, Slovakia, 929 01
    - Site Reference ID/Investigator# 29365
  - Galanta, Slovakia, 924 22
    - Site Reference ID/Investigator# 29312
  - Galanta, Slovakia, 924 22
    - Site Reference ID/Investigator# 29313
  - Galanta, Slovakia, 924 22
    - Site Reference ID/Investigator# 29380
  - Galanta, Slovakia, 924 22
    - Site Reference ID/Investigator# 29381
  - Hlohovec, Slovakia, 92001
    - Site Reference ID/Investigator# 29056
  - Hlohovec, Slovakia, 92001
    - Site Reference ID/Investigator# 33325
  - Hnusta, Slovakia, 981 01
    - Site Reference ID/Investigator# 29386
  - Hnusta, Slovakia, 981 01
    - Site Reference ID/Investigator# 29387
  - Humenne, Slovakia, 6601
    - Site Reference ID/Investigator# 28923
  - Humenne, Slovakia, 6601
    - Site Reference ID/Investigator# 29159
  - Kezmarok, Slovakia, 060 01
    - Site Reference ID/Investigator# 29370
  - Kezmarok, Slovakia, 060 01
    - Site Reference ID/Investigator# 29371
  - Kezmarok, Slovakia, 6001
    - Site Reference ID/Investigator# 29355
  - Kezmarok, Slovakia, 6001
    - Site Reference ID/Investigator# 29356
  - Kezmarok, Slovakia, 6601
    - Site Reference ID/Investigator# 28907
  - Kolarovo, Slovakia, 946 03
    - Site Reference ID/Investigator# 28793
  - Komarno, Slovakia, 945 01
    - Site Reference ID/Investigator# 29016
  - Kosice, Slovakia, 4001
    - Site Reference ID/Investigator# 28620
  - Kosice, Slovakia, 4001
    - Site Reference ID/Investigator# 28621
  - Kosice, Slovakia, 4001
    - Site Reference ID/Investigator# 28718
  - Kosice, Slovakia, 4001
    - Site Reference ID/Investigator# 28841
  - Kosice, Slovakia, 4001
    - Site Reference ID/Investigator# 28909
  - Kosice, Slovakia, 4001
    - Site Reference ID/Investigator# 29160
  - Kosice, Slovakia, 4001
    - Site Reference ID/Investigator# 29286
  - Kosice, Slovakia, 4001
    - Site Reference ID/Investigator# 29287
  - Kosice, Slovakia, 4001
    - Site Reference ID/Investigator# 29316
  - Kosice, Slovakia, 4001
    - Site Reference ID/Investigator# 29317
  - Kosice, Slovakia, 4016
    - Site Reference ID/Investigator# 28762
  - Kosice, Slovakia, 4061
    - Site Reference ID/Investigator# 29037
  - Kralovsky Chlmec, Slovakia, 7701
    - Site Reference ID/Investigator# 28917
  - Levice, Slovakia, 934 01
    - Site Reference ID/Investigator# 29310
  - Levice, Slovakia, 934 01
    - Site Reference ID/Investigator# 29311
  - Levice, Slovakia, 934 05
    - Site Reference ID/Investigator# 29292
  - Levice, Slovakia, 934 05
    - Site Reference ID/Investigator# 29293
  - Liptovsky Hradok, Slovakia, 033 01
    - Site Reference ID/Investigator# 28671
  - Martin, Slovakia, 036 01
    - Site Reference ID/Investigator# 29382
  - Martin, Slovakia, 036 01
    - Site Reference ID/Investigator# 29383
  - Medzilaborce, Slovakia, 6801
    - Site Reference ID/Investigator# 29130
  - Michalovce, Slovakia, 7101
    - Site Reference ID/Investigator# 28828
  - Modra, Slovakia, 90001
    - Site Reference ID/Investigator# 29284
  - Modra, Slovakia, 90001
    - Site Reference ID/Investigator# 29285
  - Moldava nad Bodvou, Slovakia, 4501
    - Site Reference ID/Investigator# 28622
  - Nitra, Slovakia, 94901
    - Site Reference ID/Investigator# 29028
  - Nitra, Slovakia, 950 01
    - Site Reference ID/Investigator# 28835
  - Nitra, Slovakia, 950 01
    - Site Reference ID/Investigator# 29302
  - Nova Dubnica, Slovakia, 1851
    - Site Reference ID/Investigator# 29351
  - Nova Dubnica, Slovakia, 1851
    - Site Reference ID/Investigator# 29352
  - Nove Mesto nad Vahom, Slovakia, 915 01
    - Site Reference ID/Investigator# 29398
  - Nove Mesto nad Vahom, Slovakia, 915 01
    - Site Reference ID/Investigator# 29399
  - Nove Zamke, Slovakia, 940 52
    - Site Reference ID/Investigator# 29294
  - Nove Zamke, Slovakia, 940 52
    - Site Reference ID/Investigator# 29295
  - Nove Zamke, Slovakia, 940 63
    - Site Reference ID/Investigator# 29363
  - Nove Zamky, Slovakia, 940 53
    - Site Reference ID/Investigator# 29304
  - Nove Zamky, Slovakia, 940 53
    - Site Reference ID/Investigator# 29305
  - Nove Zamky, Slovakia, 940 63
    - Site Reference ID/Investigator# 29362
  - Novy Smokovec, Slovakia, 6201
    - Site Reference ID/Investigator# 28695
  - Partizanske, Slovakia, 95814
    - Site Reference ID/Investigator# 28743
  - Pezinok, Slovakia, 90201
    - Site Reference ID/Investigator# 28744
  - Piestany, Slovakia, 92101
    - Site Reference ID/Investigator# 28734
  - Poprad, Slovakia, 5801
    - Site Reference ID/Investigator# 29378
  - Poprad, Slovakia, 5801
    - Site Reference ID/Investigator# 29379
  - Presov, Slovakia, 08 001
    - Site Reference ID/Investigator# 28637
  - Presov, Slovakia, 08 001
    - Site Reference ID/Investigator# 29353
  - Presov, Slovakia, 08 001
    - Site Reference ID/Investigator# 29354
  - Presov, Slovakia, 08 001
    - Site Reference ID/Investigator# 29397
  - Prievidza, Slovakia, 971 01
    - Site Reference ID/Investigator# 28881
  - Prievidza, Slovakia, 971 01
    - Site Reference ID/Investigator# 29314
  - Prievidza, Slovakia, 971 01
    - Site Reference ID/Investigator# 29315
  - Prievidza, Slovakia, 971 01
    - Site Reference ID/Investigator# 29374
  - Prievidza, Slovakia, 971 01
    - Site Reference ID/Investigator# 29375
  - Rimavska Sobota, Slovakia, 979 01
    - Site Reference ID/Investigator# 29320
  - Rimavska Sobota, Slovakia, 979 01
    - Site Reference ID/Investigator# 29321
  - Roznava, Slovakia, 4801
    - Site Reference ID/Investigator# 28838
  - Ruzomberok, Slovakia, 034 01
    - Site Reference ID/Investigator# 28761
  - Ruzomberok, Slovakia, 034 01
    - Site Reference ID/Investigator# 29306
  - Ruzomberok, Slovakia, 034 01
    - Site Reference ID/Investigator# 29307
  - Ruzomberok, Slovakia, 034 01
    - Site Reference ID/Investigator# 29372
  - Ruzomberok, Slovakia, 034 01
    - Site Reference ID/Investigator# 29373
  - Sahy, Slovakia, 936 01
    - Site Reference ID/Investigator# 29308
  - Sahy, Slovakia, 936 01
    - Site Reference ID/Investigator# 29309
  - Sala, Slovakia, 927 03
    - Site Reference ID/Investigator# 28638
  - Senec, Slovakia, 903 01
    - Site Reference ID/Investigator# 28832
  - Senec, Slovakia, 903 01
    - Site Reference ID/Investigator# 28897
  - Senica, Slovakia, 905 01
    - Site Reference ID/Investigator# 28812
  - Sirk, Slovakia, 049 64
    - Site Reference ID/Investigator# 28691
  - Snina, Slovakia, 6901
    - Site Reference ID/Investigator# 28920
  - Snina, Slovakia, 6901
    - Site Reference ID/Investigator# 29083
  - Snina, Slovakia, 6901
    - Site Reference ID/Investigator# 6367
  - Sobrance, Slovakia, 7301
    - Site Reference ID/Investigator# 28629
  - Spisska Nova Ves, Slovakia, 5201
    - Site Reference ID/Investigator# 29394
  - Spisska Nova Ves, Slovakia, 5201
    - Site Reference ID/Investigator# 29395
  - Stara Lubovna, Slovakia, 6401
    - Site Reference ID/Investigator# 29296
  - Stara Lubovna, Slovakia, 6401
    - Site Reference ID/Investigator# 29297
  - Stara Tura, Slovakia, 916 01
    - Site Reference ID/Investigator# 28771
  - Svidnik, Slovakia, 08 901
    - Site Reference ID/Investigator# 29298
  - Svidnik, Slovakia, 08 901
    - Site Reference ID/Investigator# 29299
  - Svit 14, Slovakia, 5921
    - Site Reference ID/Investigator# 28763
  - Topolcany, Slovakia, 95501
    - Site Reference ID/Investigator# 28903
  - Topolcany, Slovakia, 95501
    - Site Reference ID/Investigator# 29282
  - Topolcany, Slovakia, 95501
    - Site Reference ID/Investigator# 29283
  - Tornala, Slovakia, 982 01
    - Site Reference ID/Investigator# 29391
  - Trebisov, Slovakia, 7501
    - Site Reference ID/Investigator# 28919
  - Trencianske Teplice, Slovakia, 91451
    - Site Reference ID/Investigator# 28764
  - Trencin, Slovakia, 91101
    - Site Reference ID/Investigator# 29119
  - Trencin, Slovakia, 91105
    - Site Reference ID/Investigator# 28806
  - Trencin, Slovakia, 91105
    - Site Reference ID/Investigator# 29133
  - Trnava, Slovakia, 917 01
    - Site Reference ID/Investigator# 28667
  - Trnava, Slovakia, 917 01
    - Site Reference ID/Investigator# 28805
  - Trnava, Slovakia, 917 01
    - Site Reference ID/Investigator# 28892
  - Trnava, Slovakia, 917 01
    - Site Reference ID/Investigator# 28910
  - Trnava, Slovakia, 917 01
    - Site Reference ID/Investigator# 28929
  - Trnava, Slovakia, 917 01
    - Site Reference ID/Investigator# 29359
  - Trnava, Slovakia, 917 01
    - Site Reference ID/Investigator# 29360
  - Trnava, Slovakia, 917 01
    - Site Reference ID/Investigator# 29384
  - Trnava, Slovakia, 917 01
    - Site Reference ID/Investigator# 29385
  - Turcianske Teplice, Slovakia, 039 01
    - Site Reference ID/Investigator# 29288
  - Turcianske Teplice, Slovakia, 039 01
    - Site Reference ID/Investigator# 29289
  - Turzovka, Slovakia, 2354
    - Site Reference ID/Investigator# 28690
  - Velke Kapusany, Slovakia, 7901
    - Site Reference ID/Investigator# 28716
  - Velke Zaluzie, Slovakia, 951 35
    - Site Reference ID/Investigator# 28921
  - Velky Biel, Slovakia, 900 24
    - Site Reference ID/Investigator# 28819
  - Velky Krtis, Slovakia, 990 01
    - Site Reference ID/Investigator# 28883
  - Vrable, Slovakia, 95201
    - Site Reference ID/Investigator# 29303
  - Vranov nad Topl'ou, Slovakia, 930
    - Site Reference ID/Investigator# 29368
  - Vranov nad Topl'ou, Slovakia, 930
    - Site Reference ID/Investigator# 29369
  - Vrutky, Slovakia, 038 61
    - Site Reference ID/Investigator# 29023
  - Zavar, Slovakia, 916 26
    - Site Reference ID/Investigator# 28688
  - Ziar nad Hronom, Slovakia, 965 01
    - Site Reference ID/Investigator# 28736
  - Zilina, Slovakia, 1001
    - Site Reference ID/Investigator# 28686
  - Zilina, Slovakia, 1001
    - Site Reference ID/Investigator# 28829
  - Zilina, Slovakia, 1001
    - Site Reference ID/Investigator# 29290
  - Zilina, Slovakia, 1001
    - Site Reference ID/Investigator# 29291
  - Zilina, Slovakia, 1008
    - Site Reference ID/Investigator# 29322
  - Zilina, Slovakia, 1008
    - Site Reference ID/Investigator# 29323
  - Zlate Moravce, Slovakia, 95301
    - Site Reference ID/Investigator# 29318
  - Zlate Moravce, Slovakia, 95301
    - Site Reference ID/Investigator# 29319
Slovenia
- - Adjovscina, Slovenia, 5270
    - Site Reference ID/Investigator# 30484
  - Adjovscina, Slovenia, 5270
    - Site Reference ID/Investigator# 30485
  - Adjovscina, Slovenia, 5270
    - Site Reference ID/Investigator# 6366
  - Bled, Slovenia, 4260
    - Site Reference ID/Investigator# 33326
  - Bled, Slovenia, 4260
    - Site Reference ID/Investigator# 33327
  - Celje, Slovenia, 3000
    - Site Reference ID/Investigator# 28625
  - Celje, Slovenia, 3000
    - Site Reference ID/Investigator# 29033
  - Celje, Slovenia, 3000
    - Site Reference ID/Investigator# 29837
  - Celje, Slovenia, 3000
    - Site Reference ID/Investigator# 30486
  - Celje, Slovenia, 3000
    - Site Reference ID/Investigator# 30487
  - Cerknica, Slovenia, 1380
    - Site Reference ID/Investigator# 28587
  - Cerknica, Slovenia, 1380
    - Site Reference ID/Investigator# 33328
  - Deskle, Slovenia, 5210
    - Site Reference ID/Investigator# 30088
  - Dol pri Hrastniku, Slovenia, 1431
    - Site Reference ID/Investigator# 30145
  - Dolenjske toplice, Slovenia, 8350
    - Site Reference ID/Investigator#28729
  - Domzale, Slovenia, 1230
    - Site Reference ID/Investigator# 28775
  - Fram, Slovenia, 2313
    - Site Reference ID/Investigator# 30186
  - Golnik, Slovenia, 4204
    - Site Reference ID/Investigator# 29918
  - Golnik, Slovenia, 4204
    - Site Reference ID/Investigator# 33331
  - Grosuplje, Slovenia, 1290
    - Site Reference ID/Investigator# 29040
  - Grosuplje, Slovenia, 1290
    - Site Reference ID/Investigator# 30488
  - Ilirska Bistrica, Slovenia, 6250
    - Site Reference ID/Investigator# 29955
  - Jesenice, Slovenia, 4270
    - Site Reference ID/Investigator# 30490
  - Jesenice, Slovenia, 4270
    - Site Reference ID/Investigator# 30491
  - Jesenice, Slovenia, 4270
    - Site Reference ID/Investigator# 30492
  - Koper, Slovenia, 6000
    - Site Reference ID/Investigator# 28689
  - Kostanjevica na Krki, Slovenia, 8311
    - Site Reference ID/Investigator# 30164
  - Kranj, Slovenia, 4000
    - Site Reference ID/Investigator# 29438
  - Kranj, Slovenia, 4000
    - Site Reference ID/Investigator# 29439
  - Kranj, Slovenia, 4000
    - Site Reference ID/Investigator# 30204
  - Kranj, Slovenia, 4000
    - Site Reference ID/Investigator# 30494
  - Kranj, Slovenia, 4000
    - Site Reference ID/Investigator# 30495
  - Kranj, Slovenia, 4000
    - Site Reference ID/Investigator# 30496
  - Kropa, Slovenia, 4245
    - Site Reference ID/Investigator# 30000
  - Krsko, Slovenia, 8270
    - Site Reference ID/Investigator# 29168
  - Krsko, Slovenia, 8270
    - Site Reference ID/Investigator# 29821
  - Limbus, Slovenia, 2341
    - Site Reference ID/Investigator# 30117
  - Litija, Slovenia, 1270
    - Site Reference ID/Investigator# 28720
  - Litija, Slovenia, 1270
    - Site Reference ID/Investigator# 28884
  - Ljubljana, Slovenia, 1000
    - Site Reference ID/Investigator# 28727
  - Ljubljana, Slovenia, 1000
    - Site Reference ID/Investigator# 28779
  - Ljubljana, Slovenia, 1000
    - Site Reference ID/Investigator# 29015
  - Ljubljana, Slovenia, 1000
    - Site Reference ID/Investigator# 29171
  - Ljubljana, Slovenia, 1000
    - Site Reference ID/Investigator# 29751
  - Ljubljana, Slovenia, 1000
    - Site Reference ID/Investigator# 29996
  - Ljubljana, Slovenia, 1000
    - Site Reference ID/Investigator# 30012
  - Ljubljana, Slovenia, 1000
    - Site Reference ID/Investigator# 30199
  - Ljubljana, Slovenia, 1000
    - Site Reference ID/Investigator# 30498
  - Ljubljana, Slovenia, 1000
    - Site Reference ID/Investigator# 30499
  - Ljubljana, Slovenia, 1000
    - Site Reference ID/Investigator# 30500
  - Ljubljana, Slovenia, 1000
    - Site Reference ID/Investigator# 30501
  - Ljubljana, Slovenia, 1000
    - Site Reference ID/Investigator# 30502
  - Ljubljana, Slovenia, 1000
    - Site Reference ID/Investigator# 30503
  - Ljutomer, Slovenia, 9240
    - Site Reference ID/Investigator# 28715
  - Ljutomer, Slovenia, 9240
    - Site Reference ID/Investigator# 30120
  - Logatec, Slovenia, 1370
    - Site Reference ID/Investigator# 30505
  - Maribor, Slovenia, 2000
    - Site Reference ID/Investigator# 28930
  - Maribor, Slovenia, 2000
    - Site Reference ID/Investigator# 29460
  - Maribor, Slovenia, 2000
    - Site Reference ID/Investigator# 29461
  - Maribor, Slovenia, 2000
    - Site Reference ID/Investigator# 29679
  - Maribor, Slovenia, 2000
    - Site Reference ID/Investigator# 30017
  - Maribor, Slovenia, 2000
    - Site Reference ID/Investigator# 30018
  - Maribor, Slovenia, 2000
    - Site Reference ID/Investigator# 30128
  - Maribor, Slovenia, 2000
    - Site Reference ID/Investigator# 30221
  - Maribor, Slovenia, 2000
    - Site Reference ID/Investigator# 30507
  - Maribor, Slovenia, 2000
    - Site Reference ID/Investigator# 30508
  - Markovci, Slovenia, 2281
    - Site Reference ID/Investigator# 28640
  - Mezica, Slovenia, 2392
    - Site Reference ID/Investigator# 2392
  - Miklavz na Dravskem polju, Slovenia, 2204
    - Site Reference ID/Investigator# 28642
  - Murska Sobota, Slovenia, 9000
    - Site Reference ID/Investigator# 28951
  - Murska Sobota, Slovenia, 9000
    - Site Reference ID/Investigator# 30005
  - Murska Sobota, Slovenia, 9000
    - Site Reference ID/Investigator# 30081
  - Muta, Slovenia, 2366
    - Site Reference ID/Investigator# 30196
  - Naklo, Slovenia, 4202
    - Site Reference ID/Investigator# 28952
  - Nazarje, Slovenia, 3331
    - Site Reference ID/Investigator# 30087
  - Nova Gorica, Slovenia, 5000
    - Site Reference ID/Investigator# 28958
  - Novo mesto, Slovenia, 2000
    - Site Reference ID/Investigator# 28959
  - Novo mesto, Slovenia, 2000
    - Site Reference ID/Investigator# 30142
  - Oplotnica, Slovenia, 2317
    - Site Reference ID/Investigator# 30125
  - Ormoz, Slovenia, 2270
    - Site Reference ID/Investigator# 30509
  - Ormoz, Slovenia, 2270
    - Site Reference ID/Investigator# 30510
  - Polzela, Slovenia, 3310
    - Site Reference ID/Investigator# 30131
  - Postojna, Slovenia, 6230
    - Site Reference ID/Investigator# 29920
  - Postojna, Slovenia, 6230
    - Site Reference ID/Investigator# 30119
  - Prevalje, Slovenia, 2391
    - Site Reference ID/Investigator# 30511
  - Prevalje, Slovenia, 2391
    - Site Reference ID/Investigator# 30512
  - Ptuj, Slovenia, 2250
    - Site Reference ID/Investigator# 28810
  - Ptuj, Slovenia, 2250
    - Site Reference ID/Investigator# 28850
  - Ptuj, Slovenia, 2250
    - Site Reference ID/Investigator# 28983
  - Ptuj, Slovenia, 2250
    - Site Reference ID/Investigator# 30147
  - Puconci, Slovenia, 9201
    - Site Reference ID/Investigator# 30123
  - Radece, Slovenia, 1433
    - Site Reference ID/Investigator# 33329
  - Radenci, Slovenia, 9252
    - Site Reference ID/Investigator# 29906
  - Radovljica, Slovenia, 4240
    - Site Reference ID/Investigator# 28985
  - Radovljica, Slovenia, 4240
    - Site Reference ID/Investigator# 30124
  - Ravne na Koroskem, Slovenia, 2390
    - Site Reference ID/Investigator# 30095
  - Ravne na Koroskem, Slovenia, 2390
    - Site Reference ID/Investigator# 30513
  - Ravne na Koroskem, Slovenia, 2390
    - Site Reference ID/Investigator# 30514
  - Ribnica, Slovenia, 1310
    - Site Reference ID/Investigator# 30135
  - Rogaska Slatina, Slovenia, 3250
    - Site Reference ID/Investigator# 33330
  - Ruse, Slovenia, 2342
    - Site Reference ID/Investigator# 28885
  - Senovo, Slovenia, 8281
    - Site Reference ID/Investigator# 30162
  - Sentilj v Slovenskih goricah, Slovenia, 2212
    - Site Reference ID/Investigator# 28738
  - Sentjur pri Celju, Slovenia, 3230
    - Site Reference ID/Investigator# 28609
  - Sentjur pri Celju, Slovenia, 3230
    - Site Reference ID/Investigator# 30163
  - Sevnica, Slovenia, 8290
    - Site Reference ID/Investigator# 30015
  - Sevnica, Slovenia, 8290
    - Site Reference ID/Investigator# 30113
  - Sevnica, Slovenia, 8290
    - Site Reference ID/Investigator# 30168
  - Sevnica, Slovenia, 8290
    - Site Reference ID/Investigator# 30517
  - Sevnica, Slovenia, 8290
    - Site Reference ID/Investigator# 30518
  - Sezana, Slovenia, 6210
    - Site Reference ID/Investigator# 30130
  - Skofljica, Slovenia, 1291
    - Site Reference ID/Investigator# 28851
  - Sladki vrh, Slovenia, 2214
    - Site Reference ID/Investigator# 29125
  - Slovenska Bistrica, Slovenia, 2310
    - Site Reference ID/Investigator# 28825
  - Slovenske Konjice, Slovenia, 3219
    - Site Reference ID/Investigator# 28994
  - Sostanj, Slovenia, 3325
    - Site Reference ID/Investigator# 29917
  - Straza, Slovenia, 8351
    - Site Reference ID/Investigator# 28641
  - Tolmin, Slovenia, 5220
    - Site Reference ID/Investigator# 29090
  - Trebnje, Slovenia, 8210
    - Site Reference ID/Investigator# 30519
  - Trebnje, Slovenia, 8210
    - Site Reference ID/Investigator# 30520
  - Turnisce, Slovenia, 9224
    - Site Reference ID/Investigator# 29093
  - Velenje, Slovenia, 3320
    - Site Reference ID/Investigator# 29098
  - Vojnik, Slovenia, 3212
    - Site Reference ID/Investigator# 29045
  - Vrhnika, Slovenia, 1360
    - Site Reference ID/Investigator# 30121
  - Zagorje, Slovenia, 1410
    - Site Reference ID/Investigator# 28618
  - Zagorje, Slovenia, 1410
    - Site Reference ID/Investigator# 30144
  - Zalec, Slovenia, 3310
    - Site Reference ID/Investigator# 28639
  - Zalec, Slovenia, 3310
    - Site Reference ID/Investigator# 30187
  - Zrece, Slovenia, 3214
    - Site Reference ID/Investigator# 29106
  - Zrece, Slovenia, 3214
    - Site Reference ID/Investigator# 30195
Ukraine
- - Dnipropetrovsk, Ukraine, 49000
    - Site Reference ID/Investigator# 10476
  - Dnipropetrovsk, Ukraine, 49000
    - Site Reference ID/Investigator# 30523
  - Dnipropetrovsk, Ukraine, 49000
    - Site Reference ID/Investigator# 30524
  - Dnipropetrovsk, Ukraine, 49000
    - Site Reference ID/Investigator# 30525
  - Dnipropetrovsk, Ukraine, 49000
    - Site Reference ID/Investigator# 30526
  - Donetsk, Ukraine, 83096
    - Site Reference ID/Investigator# 30527
  - Donetsk, Ukraine, 83096
    - Site Reference ID/Investigator# 30528
  - Donetsk, Ukraine, 83096
    - Site Reference ID/Investigator# 30529
  - Donetsk, Ukraine, 83096
    - Site Reference ID/Investigator# 30530
  - Kharkov, Ukraine, 61000
    - Site Reference ID/Investigator# 30541
  - Kharkov, Ukraine, 61000
    - Site Reference ID/Investigator# 30542
  - Kharkov, Ukraine, 61000
    - Site Reference ID/Investigator# 30543
  - Kharkov, Ukraine, 61000
    - Site Reference ID/Investigator# 30544
  - Kiev, Ukraine, 3151
    - Site Reference ID/Investigator# 30636
  - Kiev, Ukraine, 3151
    - Site Reference ID/Investigator# 30637
  - Kiev, Ukraine, 3151
    - Site Reference ID/Investigator# 30638
  - Kiev, Ukraine, 3151
    - Site Reference ID/Investigator# 30639
  - Kiev, Ukraine, 3151
    - Site Reference ID/Investigator# 30640
  - Kiev, Ukraine, 3151
    - Site Reference ID/Investigator# 30641
  - Kiev, Ukraine, 3151
    - Site Reference ID/Investigator# 30642
  - Kiev, Ukraine, 3151
    - Site Reference ID/Investigator# 30643
  - Kiev, Ukraine, 3151
    - Site Reference ID/Investigator# 30644
  - Kiev, Ukraine, 3151
    - Site Reference ID/Investigator# 30645
  - Kiev, Ukraine, 3151
    - Site Reference ID/Investigator# 30646
  - Kiev, Ukraine, 3151
    - Site Reference ID/Investigator# 30647
  - Lugansk, Ukraine, 91000
    - Site Reference ID/Investigator# 30546
  - Lugansk, Ukraine, 91000
    - Site Reference ID/Investigator# 30547
  - Lugansk, Ukraine, 91000
    - Site Reference ID/Investigator# 30548
  - Lugansk 91000, Ukraine
    - Site Reference ID/Investigator# 30545
  - Lviv, Ukraine, 79000
    - Site Reference ID/Investigator# 30549
  - Lviv, Ukraine, 79000
    - Site Reference ID/Investigator# 30550
  - Lviv, Ukraine, 79000
    - Site Reference ID/Investigator# 30551
  - Lviv, Ukraine, 79000
    - Site Reference ID/Investigator# 30552
  - Odessa, Ukraine, 65000
    - Site Reference ID/Investigator# 30610
  - Odessa, Ukraine, 65000
    - Site Reference ID/Investigator# 30611
  - Odessa, Ukraine, 65000
    - Site Reference ID/Investigator# 30612
  - Odessa, Ukraine, 65000
    - Site Reference ID/Investigator# 30613
  - Sevastopol, Ukraine, 99000
    - Site Reference ID/Investigator# 30634
  - Sevastopol, Ukraine, 99000
    - Site Reference ID/Investigator# 30635
  - Simferopol', Ukraine, 95000
    - Site Reference ID/Investigator# 30607
  - Simferopol', Ukraine, 95000
    - Site Reference ID/Investigator# 30608
  - Simferopol', Ukraine, 95000
    - Site Reference ID/Investigator# 30609
  - Vinnitsa, Ukraine, 21000
    - Site Reference ID/Investigator# 30648
  - Vinnitsa, Ukraine, 21000
    - Site Reference ID/Investigator# 30649
  - Vinnitsa, Ukraine, 21000
    - Site Reference ID/Investigator# 30650
  - Vinnitsa, Ukraine, 21000
    - Site Reference ID/Investigator# 30651
  - Zaporizhzhya, Ukraine, 69000
    - Site Reference ID/Investigator# 30596
  - Zaporizhzhya, Ukraine, 69000
    - Site Reference ID/Investigator# 30597
  - Zaporizhzhya, Ukraine, 69000
    - Site Reference ID/Investigator# 30598
  - Zaporizhzhya, Ukraine, 69000
    - Site Reference ID/Investigator# 30599

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Patients with a high risk of developing diabetes mellitus treated by secondary care specialists (such as internal medicine specialists, nephrologists, endocrinologists, etc.), whose hypertension is not controlled on single-drug therapy will be included.

Description

Inclusion Criteria:

Adult patients of either gender (more than 18 years of age), with established diagnosis of essential hypertension (systolic blood pressure/ diastolic blood pressure greater than 140/90 mmHg)
Patients not controlled on single-drug therapy and decision was made to introduce Tarka
Patients with a high risk of developing diabetes mellitus (defined according British Medical Society guidelines) with at least one of the following symptoms:
- Positive family history of diabetes or
- Obesity defined by a Body Mass Index (BMI) greater than 30 kg/m^2 or a waist circumference greater than 102 cm (males) or greater than 88 cm (females) or
- Impaired fasting plasma glucose (FPG) levels of 6.1 to 7.0 mmol/l (100-126 mg/dl)

Exclusion Criteria:

Patients with known or established Type 2 diabetes mellitus
The use of Tarka is contraindicated in the following patients:
- Hypersensitive to the active substances or to any of the inactive ingredients
- With cardiogenic shock
- With second and third degree atrioventricular block - except in patients with a functioning artificial pacemaker
- With sick sinus syndrome - except in patients with a functioning artificial pacemaker
- With atrial fibrillation/flutter and concomitant Wolff-Parkinson-White syndrome
- With existing history of angioedema associated with administration of an angiotensin-converting enzyme (ACE) inhibitor
- With severe renal or severe liver impairment
- In pregnant women (women of childbearing potential who are unwilling to use contraception should not be included)
- Lactating women

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Number of groups / cohorts

Cohorts and Interventions

Group / Cohort
Single Patient group with Hypertension

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Reduction in Systolic Blood Pressure and Diastolic Blood Pressure From Baseline to Study End Time Frame: Baseline to 6 months/study end	Participants were to be followed for 6 months. Changes in systolic and diastolic blood pressure were assessed by comparing the blood pressure measurements obtained at the end of Tarka treatment (approximately 6 months) to baseline values. For this analysis of effectiveness the last available value was considered the analysis time point "end of study".	Baseline to 6 months/study end

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Percentage of Participants Achieving Target Blood Pressure (Less Than 140/90) at Study End and the Need for Other Antihypertensive Drugs, Clustered by Type(s) of Drugs Added to Tarka. Time Frame: 6 months	The percentages of participants achieving and not achieving the target blood pressure of less than 140/90 mmHg at the end of the study are presented. Percentages of participants taking Tarka only or taking Tarka plus another antihypertensive drug are summarized by type of drug: beta blockers, angiotensin-converting enzyme (ACE) inhibitors, calcium antagonists, diuretics, and angiotensin II (AT-II) receptor antagonists. Participants taking drugs that did not fit any of the above groups (Other), unknown drugs (Unknown), or more than one additional antihypertensive agent are also summarized.	6 months
Evaluation of Adverse Events (AEs) Leading to Discontinuation of Tarka and a Summary of All AEs Possibly or Probably Related to Tarka by Frequency and Severity Time Frame: 6 months	The number of AEs leading to Tarka discontinuation are summarized. AEs that were considered by the investigator to be possibly or probably related to Tarka are summarized by the severity of the AE (classified as mild, moderate, or severe). AEs considered possibly or probably related to Tarka that led to the discontinuation of Tarka are also presented by severity.	6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Abbott

Investigators

Study Director: Cornelia Preda, MD, Abbott International

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2007

Primary Completion (Actual)

March 1, 2010

Study Completion (Actual)

March 1, 2010

Study Registration Dates

First Submitted

March 1, 2010

First Submitted That Met QC Criteria

March 2, 2010

First Posted (Estimate)

March 3, 2010

Study Record Updates

Last Update Posted (Estimate)

May 9, 2011

Last Update Submitted That Met QC Criteria

April 15, 2011

Last Verified

April 1, 2011

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

P10-299

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Detailed Description

Study Type

Enrollment (Actual)

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Genders Eligible for Study

Sampling Method

Study Population

Description

Study Plan

How is the study designed?

Number of groups / cohorts

Cohorts and Interventions

Group / Cohort

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Investigators

Study record dates

Study Major Dates

Study Start

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Estimate)

Study Record Updates

Last Update Posted (Estimate)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Clinical Trials on Hypertension

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Sponsors and Collaborators

Medical Conditions

Drug Interventions

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Conditions

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Drug Interventions

Dietary Supplements

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Locations