Circadian Rhythm of Blood Lactate

Circadian Rhythm of Blood Lactate, Lipid Transferproteins and Genetic Markers (PPARs, CLOCK, Bmal1)

To elucidate whether blood lactate, lipid transfer proteins and PPARs/CLOCK/Bal1 have a circadian rhythm

Study Overview

• Status: Completed
• Conditions: Healthy
• Intervention / Treatment: Other: Blood Sampling

Detailed Description

Blood will be drawn fasting and then every hour over a period of 24 hours in 30 healthy probands.

• Study Type: Observational
• Enrollment (Actual): 30

Contacts and Locations

Study Locations

• Germany
  • Halle (Saale), Germany, 06120
    • University Clinic Halle, Martin Luther-University Halle-Wittenberg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

30 healthy probands

Description

Inclusion Criteria:

• Age between 18 and 40 years old

Exclusion Criteria:

• Inability/unwilling to give written informed consent
• Chronic disease

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Healthy probands; Healthy probands, age between 18 and 40 years	Other: Blood Sampling; Blood Sampling over 24 hours

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Circadian rhythm of blood lactate	Blood samples	5 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Circadian rhythm of Lipid transfer proteins	Blood	5 months
Circadian rhythm of PPARs, CLOCK and Bal1	Blood	5 months

Collaborators and Investigators

• Sponsor: Martin-Luther-Universität Halle-Wittenberg
• Collaborators: State University of New York - Downstate Medical Center
• Investigators: Principal Investigator: Axel Schlitt, MD, Department of Medicine III, University Clinic Halle, Martin Luther-University Halle-Wittenberg

Study record dates

Study Major Dates

• Study Start: February 1, 2011
• Primary Completion (Actual): December 1, 2011
• Study Completion (Actual): May 1, 2012

Study Registration Dates

• First Submitted: February 24, 2011
• First Submitted That Met QC Criteria: February 24, 2011
• First Posted (Estimate): February 25, 2011

Study Record Updates

• Last Update Posted (Estimate): May 2, 2012
• Last Update Submitted That Met QC Criteria: May 1, 2012
• Last Verified: May 1, 2012

More Information

Terms related to this study

• Keywords: Blood lactate; Lactate; PLTP; CETP; PPARs; Lipid transfer proteins; CLOCk; Bal1
• Other Study ID Numbers: UKH2011Sport1