Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Signaling Pathways
February 22, 2013 updated by: Humberto Nicastro, University of Sao Paulo
Effects of Leucine, Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Remodelling Signaling Pathways: a Randomized, Double-blind, and Placebo-controlled Study
This study aims to evaluate the effects of leucine and branched-chain amino acids supplementation on skeletal muscle remodeling signaling pathways induced by resistance exercise.
Study Overview
Status
Completed
Conditions
Study Type
Interventional
Enrollment (Actual)
18
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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-
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São Paulo, Brazil, 05508-030
- University of São Paulo - School of Physical Education and Sports
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 30 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- Sedentaries
- Must be able to exercise
- Must be able to swallow tablets
Exclusion Criteria:
- Use of nutritional supplements
- Use of anti-inflammatory drugs
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Placebo Comparator: Placebo
|
1 bout of resistance exercise and supplementation of 9.6 g of alanine
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Experimental: Leucine
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1 bout of resistance exercise and supplementation of 4.0 g of leucine + 5.6 g of alanine
|
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Experimental: BCAA
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1 bout of resistance exercise and supplementation of 4.0 g of leucine + 2.8 g of isoleucine + 2.8 g of valine
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Protein synthesis
Time Frame: 1 hour
|
Phosphorylation of proteins involved in protein synthesis
|
1 hour
|
|
Protein degradation
Time Frame: 1 hour
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Expression of protein involved in proteolytic pathway
|
1 hour
|
|
Inflammation
Time Frame: 1 hour
|
Expression of systemic and muscular cytokines
|
1 hour
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Claudia R da Luz, Master Student, University of Sao Paulo
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
August 1, 2011
Primary Completion (Actual)
February 1, 2013
Study Completion (Actual)
February 1, 2013
Study Registration Dates
First Submitted
May 2, 2011
First Submitted That Met QC Criteria
May 6, 2011
First Posted (Estimate)
May 9, 2011
Study Record Updates
Last Update Posted (Estimate)
February 25, 2013
Last Update Submitted That Met QC Criteria
February 22, 2013
Last Verified
February 1, 2013
More Information
Terms related to this study
Other Study ID Numbers
- 2011/04690-6
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.