Chemotherapy With DNA Damaging Agents In Colorectal Cancer

Phase 1 Study Of The Efficacy Of Chemotherapy With DNA Damaging Agents Versus Surgery In Colorectal Cancer

Chemotherapy Treatment alone with DNA damaging drugs might be as effective as chemotherapy combined with surgery in colorectal cancer (CRC) avoiding surgery complications.

Study Overview

• Status: Completed
• Conditions: Colorectal Cancer
• Intervention / Treatment: Procedure: surgery; Other: Treatment with chemotherapy; Other: Only chemotherapy treatment for study cohort

• Study Type: Interventional
• Phase: Phase 1

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 40 years to 90 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

- patients that did not underwent surgery

Exclusion Criteria:

- patients that underwent surgery

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Control (chemotherapy and surgery); Patients treated with chemotherapy + surgery	Procedure: surgery; Other: Treatment with chemotherapy
Active Comparator: Study; Patients treated only with chemotherapy	Other: Only chemotherapy treatment for study cohort; Control patients were treated both with surgery and chemotherapy. Study patients were treated only with chemotherapy

Collaborators and Investigators

• Sponsor: Centro Hospitalar Nordeste

Study record dates

Study Registration Dates

• First Submitted: October 18, 2011
• First Submitted That Met QC Criteria: October 20, 2011
• First Posted (Estimate): October 21, 2011

Study Record Updates

• Last Update Posted (Estimate): October 21, 2011
• Last Update Submitted That Met QC Criteria: October 20, 2011
• Last Verified: September 1, 2008

More Information

Terms related to this study

• Keywords: DNA damaging agents
• Additional Relevant MeSH Terms: Digestive System Diseases; Neoplasms; Neoplasms by Site; Gastrointestinal Neoplasms; Digestive System Neoplasms; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Intestinal Neoplasms; Rectal Diseases; Colorectal Neoplasms
• Other Study ID Numbers: ACCRC10