The Parkinson's Genetic Research Study (PaGeR)

The Parkinson's Genetic Research Study (PaGeR)

The Parkinson's Genetic Research Study (PaGeR), headed by Dr. Cyrus Zabetian, is searching for genes that increase the risk of developing Parkinson's disease (PD) and related disorders. The study is a joint effort by neurologists and researchers across the United States and is sponsored by the National Institutes of Health. The coordinating center for PaGeR is located at the University of Washington and the VA Puget Sound Health Care System in Seattle.

Study Overview

• Status: Recruiting
• Conditions: Parkinson's Disease

Detailed Description

PaGeR is focusing on families in which two or more people have been diagnosed with PD. Past research suggests that such "multiplex" families might hold the key to the discovery of new PD genes.

To take part in PaGeR, participants will be asked to complete a questionnaire and to undergo an interview, a neurological exam, a short memory test, and a blood draw. Enrollment in the study usually takes between one and two hours. There is no cost to participate, and all study information is kept strictly confidential.

There are a number of designated sites across the country where families can enroll. However, for family members who are unable to travel to one of these sites, other arrangements can be made.

• Study Type: Observational
• Enrollment (Estimated): 5000

Contacts and Locations

• Study Contact: Name: Jennifer Pate; Phone Number: 1-855-646-4221
• Study Contact Backup: Name: Khryss Capawa; Phone Number: (206) 277-3956; Email: kcapawa@uw.edu

Study Locations

• United States
  • Georgia
    • Atlanta, Georgia, United States, 30329
      • Recruiting
      • Emory University/ Wesley Woods Health Center
      • Contact: Barbara Sommerfield, MSN, RN; Phone Number: 404-728-6944; Email: bsommer@emory.edu
  • Ohio
    • Cincinnati, Ohio, United States, 45267
      • Recruiting
      • University of Cincinnati
      • Contact: Jatue Krier; Phone Number: 513-558-0169; Email: katie.krier@uc.edu
  • Oregon
    • Portland, Oregon, United States, 97239
      • Recruiting
      • Portland VA Medical Center
      • Contact: Susan O'Connor; Phone Number: 53262 503-220-8262
  • Washington
    • Seattle, Washington, United States, 98108
      • Recruiting
      • VA Puget Sound Health Care System
      • Contact: Jennifer Pate; Phone Number: 855-646-4221
      • Principal Investigator: Cyrus Zabetian, MD, MS
    • Seattle, Washington, United States, 98118
      • Recruiting
      • University of Washington
      • Contact: Jennifer Pate; Phone Number: 855-646-4221
      • Principal Investigator: Cyrus Zabetian, MD, MS

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Families in which two or more people have been diagnosed with Parkinson's disease.

Description

Inclusion Criteria:

• Over 18 years of age
• Member of a family in which there are two or more living individuals who have been diagnosed with Parkinson's disease

Exclusion Criteria:

• Under 18 years of age

Study Plan

How is the study designed?

Design Details

• Observational Models: Family-Based
• Time Perspectives: Cross-Sectional

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort
Case; Has a diagnosis of Parkinson's disease
Control; No diagnosis of Parkinson's disease
Family Member; Has a family history of Parkinson's disease. Can be affected or unaffected with Parkinson's disease

Collaborators and Investigators

• Sponsor: University of Washington
• Investigators: Principal Investigator: Cyrus Zabetian, MD, MS, University of Washington, VA Puget Sound Health Care System

Publications and helpful links

Helpful Links

• Study Website

Study record dates

Study Major Dates

• Study Start (Actual): September 1, 2009
• Primary Completion (Estimated): October 31, 2026
• Study Completion (Estimated): October 31, 2026

Study Registration Dates

• First Submitted: March 16, 2012
• First Submitted That Met QC Criteria: March 16, 2012
• First Posted (Estimated): March 20, 2012

Study Record Updates

• Last Update Posted (Actual): May 14, 2024
• Last Update Submitted That Met QC Criteria: May 11, 2024
• Last Verified: May 1, 2024

More Information

Terms related to this study

• Keywords: Genetics; Parkinson's Disease; Family Research; Hereditary Neurodegenerative Diseases
• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Parkinsonian Disorders; Basal Ganglia Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Parkinson Disease
• Other Study ID Numbers: 36777

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No