Glypican4 and CTRP5 in Metabolic Syndrome and the Effect of Exercise on These Adipokines

September 20, 2012 updated by: K. M. Choi, Korea University

Effects of Exercise on Glypican4,CTRP3,5 and RBP4 Levels and Circulating Levels of These Adipokines in the Subjects With or Without Metabolic Syndrome

Glypican4, CTRP3, CTRP5 are emerging novel adipokines mediating obesity and inflammation related disorders. RBP4 and adiponectin are well known important adipokines. Therefore, we examine the circulating levels of theses adipokines in the subjects with or without metabolic syndrome. Furthermore, we tried to clarify the effect of exercise on the circulating these adipokines.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

90

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 80 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Women between 30 and 60 years of age who had a body mass index (BMI) more than 25 kg/m2
  • The subjects of metabolic syndrome and age, gender matched non metabolic syndrome among the participants of Korean SO Study (KSOS) study, which is an ongoing epidemiologic study supported by the Korea Science and Engineering Foundation

Exclusion Criteria:

  • participants had a history of cardiovascular disease
  • any type of diabetes
  • stage 2 hypertension
  • malignant disease, severe renal, or hepatic disease
  • Subjects taking medications that might affect body weight or body composition

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: Exercise
obese women who are volunteers for the 3 months exercise programs
Behavioral: 3months Exercise
training session consisting of a brief warm-up, followed by an approximately 45-min session of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (approximately 300 kcal/day) and a 20-min muscle strength train- ing programme (approximately 100 kcal/day), followed by a brief cool-down period.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
The changes of circulating glypican4 levels after 3 months exercise
Time Frame: baseline and 12weeks
baseline and 12weeks
The changes of circulating CTRP3 levels after 3 months exercise
Time Frame: baseline and 12weeks
baseline and 12weeks
The changes of circulating CTRP5 levels after 3 months exercise
Time Frame: baseline and 12weeks
baseline and 12weeks
The changes of circulating RBP4 levels after 3 months exercise
Time Frame: baseline and 12weeks
baseline and 12weeks
The changes of circulating adiponectin levels after 3 months exercise
Time Frame: baseline and 12weeks
baseline and 12weeks

Secondary Outcome Measures

Outcome Measure
Time Frame
Circulating glypican4 levels in the subjects with or without metabolic syndrome
Time Frame: baseline
baseline
Circulating CTRP3 levels in the subjects with or without metabolic syndrome
Time Frame: baseline
baseline
Circulating CTRP5 levels in the subjects with or without metabolic syndrome
Time Frame: baseline
baseline
Circulating RBP4 levels in the subjects with or without metabolic syndrome
Time Frame: baseline
baseline
Circulating adiponectin levels in the subjects with or without metabolic syndrome
Time Frame: baseline
baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Korea University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

July 1, 2012

Primary Completion (Actual)

September 1, 2012

Study Completion (Actual)

September 1, 2012

Study Registration Dates

First Submitted

September 13, 2012

First Submitted That Met QC Criteria

September 19, 2012

First Posted (Estimate)

September 20, 2012

Study Record Updates

Last Update Posted (Estimate)

September 21, 2012

Last Update Submitted That Met QC Criteria

September 20, 2012

Last Verified

September 1, 2012

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • KoreaSO_Exercise

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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