United Coronary Biobanks (UNICORN)

United CORoNary Biobanks

The UNICORN consists of two collaborating biobanks, one in Utrecht and one in Singapore. From these two sites we include all patients who undergo a coronary catheterization for any reason.

At the moment of catheterization we draw blood, which will be stored in a biobank and we collect clinical characteristics. Patients are followed-up for 5 years for the occurrence of major cardiovascular events.

By including from two sites in the world we include 4 major ethnic groups: Caucasians, Chinese, Indians and Malays. We aim at including at least 2000 patients per ethnic group.

Our hypothesis is that there are differences in the risk factor burden, clinical presentation of CAD, and biochemical patterns in the blood among the ethnic groups.

Furthermore, this biobank offers a platform for multi-ethnic biomarker discovery.

Study Overview

• Status: Completed
• Conditions: Myocardial Infarction; Coronary Artery Disease; Acute Coronary Syndrome; Stable Angina

• Study Type: Observational
• Enrollment (Actual): 2000

Contacts and Locations

Study Locations

• Singapore
  • Singapore, Singapore, 119074
    • National University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 21 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

All patients that undergo coronary catheterization for any reason are eligible to enroll in the study.

Description

Inclusion Criteria:

• Patients undergoing coronary angiography

Exclusion Criteria:

• < 21 years of age
• Hemoglobin levels <7 g/dL in women, or hemoglobin levels <8 g/dL in men

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Ethnicity

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
All-cause death	5 years

Secondary Outcome Measures

Outcome Measure	Time Frame
Major cardiovascular events	5 years

Collaborators and Investigators

• Sponsor: UMC Utrecht
• Collaborators: National University Hospital, Singapore

Study record dates

Study Major Dates

• Study Start: September 1, 2010
• Primary Completion (Actual): December 1, 2015
• Study Completion (Actual): December 1, 2015

Study Registration Dates

• First Submitted: April 24, 2014
• First Submitted That Met QC Criteria: April 28, 2014
• First Posted (Estimate): April 29, 2014

Study Record Updates

• Last Update Posted (Estimate): December 8, 2015
• Last Update Submitted That Met QC Criteria: December 7, 2015
• Last Verified: December 1, 2015

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Ischemia; Pathologic Processes; Necrosis; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Pain; Neurologic Manifestations; Coronary Disease; Chest Pain; Angina Pectoris; Myocardial Infarction; Infarction; Coronary Artery Disease; Acute Coronary Syndrome; Angina, Stable
• Other Study ID Numbers: 11-183