- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02498938
The Association of SERPINA1 Gene Disturbance in Patients With Lung and Gum Disorders (SA1PLG)
Evaluation of SERPINA1 Gene Polymorphisms in COPD as a Risk Factor for Periodontitis
Study Overview
Status
Intervention / Treatment
Detailed Description
periodontitis is a polymicrobial inflammatory disease caused by various modifiable and non-modifiable risk factors. the non-modifiable risk factors include genetic polymorphisms like the gene coding for alpha-1-antitrypsinase
COPD is a chronic inflammatory disease characterized by deterioration of lung function due to loss of elasticity of the lungs.
SERPINA1 gene product has a protective role on the connective tissue components of both lungs and gums.
Hence, this study tries to determine if the gene polymorphism in COPD serves as a risk factor for developing periodontitis.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
Telangana
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Hyderabad, Telangana, India, 500034
- Dr. Sneha Agarwal PG(periodontics)
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Male and female patients aged between 30-70yrs diagnosed with COPD and chronic periodontitis who are willing to participate in the study.
Exclusion Criteria:
- Pateints with other systemic disorders
- patients not willing to participate in the study
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
SERPINA1 gene in COPD and periodontitis
patients aged between 30-70 yrs with COPD (satisfying Gold's criteria) and chronic periodontitis (>4mm pocket probing depth)
|
2ml blood sample collected from patients to extract DNA for assessment of SERPINA1 gene polymorphism
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
SERPINA1 gene polymorphism
Time Frame: 9 months
|
of blood samples and running samples by PCR
|
9 months
|
Collaborators and Investigators
Investigators
- Principal Investigator: Dr. Sneha Agarwal, PG(perio), Panineeya Mahavidyalaya institute of dental sciences and research centre
Publications and helpful links
General Publications
- Scott DA, von Ahsen N, Palmer RM, Wilson RF. Analysis of two common alpha 1-antitrypsin deficiency alleles (PI*Z and PI*S) in subjects with periodontitis. J Clin Periodontol. 2002 Dec;29(12):1118-21. doi: 10.1034/j.1600-051x.2002.291212.x.
- Travis J, Pike R, Imamura T, Potempa J. The role of proteolytic enzymes in the development of pulmonary emphysema and periodontal disease. Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 2):S143-6. doi: 10.1164/ajrccm/150.6_Pt_2.S143. Erratum In: Am J Respir Crit Care Med 1995 Mar;151(3 Pt 1):926.
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Pathologic Processes
- Respiratory Tract Diseases
- Disease Attributes
- Stomatognathic Diseases
- Periodontal Diseases
- Mouth Diseases
- Lung Diseases, Obstructive
- Lung Diseases
- Pulmonary Disease, Chronic Obstructive
- Periodontitis
- Chronic Disease
- Chronic Periodontitis
- Molecular Mechanisms of Pharmacological Action
- Enzyme Inhibitors
- Protease Inhibitors
Other Study ID Numbers
- D149206031
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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