Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease (FIGARO-DKD)

April 13, 2022 updated by: Bayer

A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter, Event-driven Phase 3 Study to Investigate Efficacy and Safety of Finerenone on the Reduction of Cardiovascular Morbidity and Mortality in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease in Addition to Standard of Care.

The purpose of this study was to evaluate whether oral finerenone (study drug), in addition to standard daily therapy, is effective and safe in treating patients with type 2 diabetes mellitus and diabetic kidney disease, when compared to a placebo.

Study Overview

Status

Completed

Conditions

Diabetic Kidney Disease

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

7352

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - Córdoba, Argentina, X5000JHQ
  - Córdoba, Argentina, X5000AAW Córdoba
  - San Luis, Argentina, D5702AAx
- Buenos Aires
  - Caba, Buenos Aires, Argentina, C1120AAC
  - Junín, Buenos Aires, Argentina, B6000GMA
  - Lanús, Buenos Aires, Argentina, B1824KAJ
  - Mar del Plata, Buenos Aires, Argentina, B7602CBM
  - Sarandí, Buenos Aires, Argentina, 1872
- Ciudad Auton. De Buenos Aires
  - Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina, C1056ABJ
  - Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina, C1426ABP
  - Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina, C1428ART
  - Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina, C1429BWN
  - Caba, Ciudad Auton. De Buenos Aires, Argentina, C1018DES
  - Ciudad Autón. de Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina, C1425AGC
Australia
- - Elizabeth Vale, Australia, 5112
- Australian Capital Territory
  - Garran, Australian Capital Territory, Australia, 2605
- New South Wales
  - Gosford, New South Wales, Australia, 2250
  - Kanwal, New South Wales, Australia, 2259
  - Liverpool, New South Wales, Australia, 2170
  - New Lambton Heights, New South Wales, Australia, 2305
  - Wollongong, New South Wales, Australia, 2500
- Queensland
  - Brisbane, Queensland, Australia, 4064
- South Australia
  - Adelaide, South Australia, Australia, 5000
- Victoria
  - Fitzroy, Victoria, Australia, 3065
  - Heidelberg, Victoria, Australia, 3081
  - Melbourne, Victoria, Australia, 3052
  - Prahran, Victoria, Australia, 3181
  - Reservoir, Victoria, Australia, 3073
  - Richmond, Victoria, Australia, 3121
  - St. Albans, Victoria, Australia, 3021
Austria
- - Innsbruck, Austria, 6020
  - Salzburg, Austria, 5020
  - Wels, Austria, 4600
  - Wien, Austria, 1030
  - Wien, Austria, 1130
  - Wien, Austria, 1090
  - Wien, Austria, 1060
- Oberösterreich
  - Linz, Oberösterreich, Austria, 4020
  - Linz, Oberösterreich, Austria, 4021
- Steiermark
  - Graz, Steiermark, Austria, 8036
  - Saint Stefan, Steiermark, Austria, 8511
- Tirol
  - Zams, Tirol, Austria, 6511
- Vorarlberg
  - Feldkirch, Vorarlberg, Austria, 6807
Belgium
- - Bruxelles - Brussel, Belgium, 1070
  - Edegem, Belgium, 2650
  - Gent, Belgium, 9000
  - Ieper, Belgium, 8900
  - Kortrijk, Belgium, 8500
  - Leuven, Belgium, 3000
  - Liege, Belgium, 4000
  - Roeselare, Belgium, 8800
Brazil
- - Rio de Janeiro, Brazil, 20241-180
  - Rio de Janeiro, Brazil, 21941-913
  - Sao Paulo, Brazil, 01223-001
  - Sao Paulo, Brazil, 01228-200
  - Sao Paulo, Brazil, 04039-000
- Ceará
  - Fortaleza, Ceará, Brazil, 60115-282
  - Fortaleza, Ceará, Brazil, 60430-140
  - Fortaleza, Ceará, Brazil
- Distrito Federal
  - Brasilia, Distrito Federal, Brazil, 70.200-730
- Goiás
  - Aparecida de Goiania, Goiás, Brazil, 74935-530
  - Goiania, Goiás, Brazil, 74605-020
- Minas Gerais
  - Juiz de Fora, Minas Gerais, Brazil, 36036-330
  - Uberlândia, Minas Gerais, Brazil, 38411-186
- Parana
  - Campina Grande do Sul, Parana, Brazil, 83430 000
  - Curitiba, Parana, Brazil, 80030-110
  - Curitiba, Parana, Brazil, 80230-130
  - Curitiba, Parana, Brazil, 80440-020
- Rio Grande Do Sul
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90430-001
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90610-000
- Sao Paulo
  - São Bernardo do Campo, Sao Paulo, Brazil, 09715-090
  - São José do Rio Preto, Sao Paulo, Brazil, 15090-000
  - São José dos Campos, Sao Paulo, Brazil, 12243-280
  - São Paulo, Sao Paulo, Brazil, 04029-000
  - São Paulo, Sao Paulo, Brazil
Bulgaria
- - Blagoevgrad, Bulgaria, 2700
  - Botevgrad, Bulgaria, 2140
  - Dimitrovgrad, Bulgaria, 6400
  - Gorna Oryahovitsa, Bulgaria, 5100
  - Kazanlak, Bulgaria, 6102
  - Kozloduy, Bulgaria, 3320
  - Lukovit, Bulgaria, 5770
  - Plovdiv, Bulgaria, 4004
  - Plovdiv, Bulgaria, 4002
  - Razgrad, Bulgaria, 7200
  - Sliven, Bulgaria, 8800
  - Sofia, Bulgaria, 1233
  - Sofia, Bulgaria, 1606
  - Sofia, Bulgaria, 1407
  - Sofia, Bulgaria, 1680
  - Stara Zagora, Bulgaria, 6000
  - Varna, Bulgaria, 9000
  - Yambol, Bulgaria, 8600
Canada
- - Quebec, Canada, G1V 4W2
- Alberta
  - Edmonton, Alberta, Canada, T5A 4L8
- British Columbia
  - Burnaby, British Columbia, Canada, V3J 1N4
  - Coquitlam, British Columbia, Canada, V3K 3P4
  - New Westminster, British Columbia, Canada, V3L 0A6
- Newfoundland and Labrador
  - Mount Pearl, Newfoundland and Labrador, Canada, A1N 1W7
  - St. John's, Newfoundland and Labrador, Canada, A1A 3R5
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 1V8
- Ontario
  - Cambridge, Ontario, Canada, N1R 7L6
  - Hamilton, Ontario, Canada, L8N 4A6
  - Hamilton, Ontario, Canada, L8M 1K7
  - Kitchener, Ontario, Canada, N2G 4V5
  - Newmarket, Ontario, Canada, L3Y 5G8
  - Oshawa, Ontario, Canada, L1G 2B9
  - Ottawa, Ontario, Canada, K1K 4L2
  - Sarnia, Ontario, Canada, N7T 4X3
  - Smith Falls, Ontario, Canada, K7A 4W8
  - Sudbury, Ontario, Canada, P3A 1W8
  - Thornhill, Ontario, Canada, L4J 1W3
  - Toronto, Ontario, Canada, M3J 1N2
  - Toronto, Ontario, Canada, M4G 3E8
  - Toronto, Ontario, Canada, M5C 2T2
  - Waterloo, Ontario, Canada, N2J 1C4
- Quebec
  - Greenfield Park, Quebec, Canada, J4V 2H1
  - Laval, Quebec, Canada, H7T 2P5
  - Mirabel, Quebec, Canada, J7J 2K8
  - Montreal, Quebec, Canada, H4A 3J1
  - Montreal, Quebec, Canada, H4J 1C5
  - Montreal, Quebec, Canada, H1M 1B1
  - Montreal, Quebec, Canada, H2K 1H2
  - Montreal, Quebec, Canada, H4A 3T2
Chile
- - Santiago, Chile, 7500710
  - Santiago, Chile, 8331143
  - Santiago, Chile, 8380456
- Los Lagos
  - Osorno, Los Lagos, Chile, 5311092
- Santiago
  - Las Condes, Santiago, Chile, 7591047
  - Providencia, Santiago, Chile, 7500520
  - Providencia, Santiago, Chile, 7500922
  - San Bernardo, Santiago, Chile, 8053095
  - San Miguel, Santiago, Chile, 8910108
China
- - Beijing, China, 100050
  - Beijing, China, 100730
  - Beijing, China, 100071
  - Beijing, China, 100028
  - Chongqing, China, 400010
  - Shanghai, China, 200025
  - Shanghai, China, 200040
  - Shanghai, China, 200092
  - Shanghai, China, 200062
  - Shanghai, China, 200072
  - Shanghai, China, 200240
  - Shanghai, China, 201199
  - Tianjin, China, 300121
  - Tianjin, China, 300142
- Fujian
  - Xiamen, Fujian, China, 361003
  - Xiamen, Fujian, China, 361004
- Gansu
  - Lanzhou, Gansu, China, 730030
- Guangdong
  - Guangzhou, Guangdong, China, 510080
  - Guangzhou, Guangdong, China, 510120
  - Guangzhou, Guangdong, China, 510405
  - Guangzhou, Guangdong, China, 510150
  - Guangzhou, Guangdong, China, 510630
  - Zhuhai, Guangdong, China, 519000
- Guangxi
  - Nanning, Guangxi, China, 530021
  - Nanning, Guangxi, China, 530031
- Hainan
  - Haikou, Hainan, China, 570311
  - Haikou, Hainan, China, 570102
- Hubei
  - Wuhan, Hubei, China, 430022
  - Wuhan, Hubei, China, 430034
- Hunan
  - Changsha, Hunan, China, 410011
  - Changsha, Hunan, China, 410013
  - Changsha, Hunan, China, 410008
- Inner Mongolia
  - Hohhot, Inner Mongolia, China, 010017
- Jiangsu
  - Changzhou, Jiangsu, China, 213004
  - Huai'An, Jiangsu, China, 223300
  - Lianyungang, Jiangsu, China, 222002
  - Nanjing, Jiangsu, China, 210006
  - Nanjing, Jiangsu, China, 210008
  - Nanjing, Jiangsu, China, 210029
  - Nanjing, Jiangsu, China, 210002
  - Nanjing, Jiangsu, China, 210011
  - Suzhou, Jiangsu, China, 215006
  - Wuxi, Jiangsu, China, 214023
  - Yancheng, Jiangsu, China, 224000
- Jiangxi
  - Nanchang, Jiangxi, China, 330006
  - Nanchang, Jiangxi, China, 330008
- Jilin
  - Changchun, Jilin, China, 130000
  - Changchun, Jilin, China, 130021
- Liaoning
  - Shenyang, Liaoning, China, 110016
  - Shenyang, Liaoning, China, 110022
- Ningxia
  - Yinchuan, Ningxia, China, 750004
- Shaanxi
  - Xi'an, Shaanxi, China, 710061
- Shandong
  - Qingdao, Shandong, China, 266071
- Shanxi
  - Taiyuan, Shanxi, China, 030001
- Sichuan
  - Chengdu, Sichuan, China, 610041
  - Chengdu, Sichuan, China, 610072
- Xinjiang
  - Urumqi, Xinjiang, China, 830054
- Zhejiang
  - Hangzhou, Zhejiang, China, 310013
  - Taizhou, Zhejiang, China, 317000
  - Wenzhou, Zhejiang, China, 325000
Colombia
- - Barranquilla, Colombia
  - Bogota, Colombia
  - Floridablanca, Colombia
  - Medellín, Colombia
- Antioquia
  - Medellin, Antioquia, Colombia, 050034
  - Medellín, Antioquia, Colombia
  - Medellín, Antioquia, Colombia
- Atlántico
  - Barranquilla, Atlántico, Colombia
  - Barranquilla, Atlántico, Colombia
- Caldas
  - Manizales, Caldas, Colombia
- Cundinamarca
  - Zipaquirá, Cundinamarca, Colombia
- Distrito Capital De Bogotá
  - Bogotá, Distrito Capital De Bogotá, Colombia
  - Bogotá, Distrito Capital De Bogotá, Colombia
  - Cundinamarca, Distrito Capital De Bogotá, Colombia
- Nariño
  - Pasto, Nariño, Colombia
- Quindío
  - Armenia, Quindío, Colombia
- Risaralda
  - Pereira, Risaralda, Colombia
- Valle Del Cauca
  - Cali, Valle Del Cauca, Colombia, 760032
  - Cali, Valle Del Cauca, Colombia
Czechia
- - Beroun, Czechia, 266 01
  - Brandys nad Labem, Czechia, 250 01
  - Breclav, Czechia, 690 02
  - Ceska Lipa, Czechia, 470 01
  - Cesky Krumlov, Czechia, 381 01
  - Cesky Krumlov, Czechia, 381 27
  - Frydek-Mistek, Czechia, 738 01
  - Hodonin, Czechia, 695 01
  - Holesov, Czechia, 769 01
  - Hranice, Czechia, 753 001
  - Koprivnice, Czechia, 742 21
  - Krnov, Czechia, 794 01
  - Mlada Boleslav, Czechia, 293 50
  - Olomouc, Czechia, 775 20
  - Olomouc, Czechia, 779 00
  - Ostrava, Czechia, 702 00
  - Plzen, Czechia, 301 66
  - Prague 6, Czechia, 169 00
  - Praha 2, Czechia, 12808
  - Praha 4, Czechia, 140 00
  - Praha 4, Czechia, 140 46
  - Praha 5, Czechia, 150 00
  - Vlasim, Czechia, 258 01
Denmark
- - Aalborg, Denmark, 9000
  - Aarhus N, Denmark, 8200
  - Esbjerg, Denmark, 6700
  - Gentofte, Denmark, 2730
  - Hellerup, Denmark, 2900
  - Herlev, Denmark, 2730
  - Hillerød, Denmark, DK-3400
  - Holbæk, Denmark, 4300
  - Holstebro, Denmark, DK-7500
  - Hvidovre, Denmark, 2650
  - Kolding, Denmark, 6000
  - København NV, Denmark, 2400
  - Odense C, Denmark, DK-5000
  - Svendborg, Denmark, 5700
  - Viborg, Denmark, 8800
Finland
- - Jyväskylä, Finland, 40620
  - Kajaani, Finland, 87140
  - Kerava, Finland, 04200
  - Klaukkala, Finland, 01800
  - Kuopio, Finland, 70100
  - Nurmijärvi, Finland, 01900
  - Oulu, Finland, 90100
  - Rauma, Finland, 26100
  - Seinäjoki, Finland, 60100
  - Tampere, Finland, 33520
  - Turku, Finland, 20521
  - Vantaa, Finland, 01600
France
- - Bois-guillaume, France, 76230
  - Boulogne Sur Mer, France, 62321
  - Brest, France, 29200
  - COLMAR Cedex, France, 68024
  - Dijon, France, 21000
  - Grenoble Cedex 9, France, 38043
  - Le Coudray, France, 28630
  - Le Creusot, France, 71200
  - Lyon Cedex, France, 69437
  - Mulhouse, France, 68051
  - NIMES cedex 9, France, 30029
  - Paris, France, 75018
  - Saint Herblain, France, 44093
  - Tourcoing, France, 59280
  - Vandoeuvre-les-nancy, France, 54500
  - Venissieux, France, 69200
Germany
- - Berlin, Germany, 13347
  - Berlin, Germany, 12203
  - Berlin, Germany, 10437
  - Berlin, Germany, 13187
  - Hamburg, Germany, 22041
- Baden-Württemberg
  - Heidelberg, Baden-Württemberg, Germany, 69115
  - Ludwigsburg, Baden-Württemberg, Germany, 71640
  - Sinzheim, Baden-Württemberg, Germany, 76547
- Bayern
  - Nürnberg, Bayern, Germany, 90443
  - Schweinfurt, Bayern, Germany, 97421
  - Würzburg, Bayern, Germany, 97080
- Brandenburg
  - Elsterwerda, Brandenburg, Germany, 04910
- Hessen
  - Bad Homburg, Hessen, Germany, 61348
  - Bad König, Hessen, Germany, 64732
  - Frankfurt, Hessen, Germany, 60313
  - Frankfurt, Hessen, Germany, 60596
- Niedersachsen
  - Göttingen, Niedersachsen, Germany, 37075
  - Hannover, Niedersachsen, Germany, 30625
- Nordrhein-Westfalen
  - Bad Oeynhausen, Nordrhein-Westfalen, Germany, 32545
  - Dortmund, Nordrhein-Westfalen, Germany, 44137
  - Düsseldorf, Nordrhein-Westfalen, Germany, 40225
  - Düsseldorf, Nordrhein-Westfalen, Germany, 40210
  - Essen, Nordrhein-Westfalen, Germany, 45136
  - Münster, Nordrhein-Westfalen, Germany, 48145
  - Nettetal, Nordrhein-Westfalen, Germany, 41334
  - Witten, Nordrhein-Westfalen, Germany, 58455
- Rheinland-Pfalz
  - Ludwigshafen, Rheinland-Pfalz, Germany, 67059
  - Mainz, Rheinland-Pfalz, Germany, 55128
- Sachsen
  - Dresden, Sachsen, Germany, 01307
  - Dresden, Sachsen, Germany, 01277
  - Leipzig, Sachsen, Germany, 04103
  - Leipzig, Sachsen, Germany, 04249
  - Leipzig, Sachsen, Germany, 04315
- Sachsen-Anhalt
  - Magdeburg, Sachsen-Anhalt, Germany, 39120
- Thüringen
  - Jena, Thüringen, Germany, 07747
Greece
- - Alexandroupolis, Greece, 68100
  - Athens, Greece, 11527
  - Athens, Greece, 14455
  - Chaidari, Greece, 12462
  - Larissa, Greece, 41100
  - Nea Ionia, Greece, 14233
  - Thessaloniki, Greece, 56403
  - Thessaloniki, Greece, 54642
Hong Kong
- - Hong Kong, Hong Kong
  - Shatin, Hong Kong
  - Sheung Wan, Hong Kong
  - Wong Tai Sin, Hong Kong
Hungary
- - Baja, Hungary, 6500
  - Balatonfured, Hungary, 8230
  - Budapest, Hungary, 1083
  - Budapest, Hungary, 1134
  - Budapest, Hungary, 1135
  - Budapest, Hungary, 1088
  - Budapest, Hungary, 1036
  - Budapest, Hungary, 1042
  - Budapest, Hungary, 1089
  - Debrecen, Hungary, 4031
  - Eger, Hungary, 3300
  - Kistarcsa, Hungary, H-2143
  - Nyiregyhaza, Hungary, 4400
  - Nyiregyhaza, Hungary, 4405
  - Papa, Hungary, 8500
  - Siofok, Hungary, 8600
  - Szeged, Hungary, 6725
  - Szekesfehervar, Hungary, 8000
  - Szentes, Hungary, 6600
  - Szombathely, Hungary, 9700
Ireland
- - Cork, Ireland
  - Dublin, Ireland, DUBLIN 4
  - Galway, Ireland
Israel
- - Afula, Israel, 1834111
  - Ashkelon, Israel, 7830604
  - Beer Sheva, Israel, 8410101
  - Haifa, Israel, 3109601
  - Holon, Israel, 5822012
  - Jerusalem, Israel, 9112001
  - Kfar Saba, Israel, 4428164
  - Nahariya, Israel, 2210001
  - Nahariya, Israel, 22100
  - Nazareth, Israel, 16100
  - Ramat Gan, Israel, 5262000
  - Rehovot, Israel, 7610001
  - Sakhnin, Israel, 3081000
  - Tel Aviv, Israel, 6423906
  - Tel Aviv, Israel, 6203854
  - Tel Aviv, Israel, 6905234
  - Tel Aviv, Israel, 6937947
  - Tiberias, Israel, 1528001
  - Zefat, Israel, 1311001
  - Zerifin, Israel, 7030000
Italy
- Campania
  - Napoli, Campania, Italy, 80131
- Emilia-Romagna
  - Bologna, Emilia-Romagna, Italy, 40138
  - Parma, Emilia-Romagna, Italy, 43126
  - Reggio Emilia, Emilia-Romagna, Italy, 42123
- Liguria
  - Genova, Liguria, Italy, 16132
  - Genova, Liguria, Italy, 16011
- Lombardia
  - Bergamo, Lombardia, Italy, 24127
  - Bergamo, Lombardia, Italy, 24020
  - Bergamo, Lombardia, Italy, 24047
  - Milano, Lombardia, Italy, 20132
  - Milano, Lombardia, Italy, 20157
  - Milano, Lombardia, Italy, 20142
  - Milano, Lombardia, Italy, 20024
  - Monza Brianza, Lombardia, Italy, 20832
- Piemonte
  - Torino, Piemonte, Italy, 10024
  - Torino, Piemonte, Italy, 10043
- Sardegna
  - Cagliari, Sardegna, Italy, 09134
  - Sassari, Sardegna, Italy, 07026
- Sicilia
  - Catania, Sicilia, Italy, 95124
  - Messina, Sicilia, Italy, 98125
- Toscana
  - Pisa, Toscana, Italy, 56124
- Veneto
  - Verona, Veneto, Italy, 37126
Japan
- - Fukui, Japan, 910-8526
  - Fukui, Japan, 918-8503
  - Fukuoka, Japan, 811-0213
  - Fukuoka, Japan, 814-0180
  - Fukuoka, Japan, 815-8555
  - Kagoshima, Japan, 890-8760
  - Kumamoto, Japan, 861-4193
  - Kumamoto, Japan, 861-8520
  - Kumamoto, Japan, 862-0976
  - Nagasaki, Japan, 852-8511
  - Osaka, Japan, 530-0001
  - Osaka, Japan, 530-8480
  - Osaka, Japan, 558-8558
  - Osaka, Japan, 543-0035
  - Osaka, Japan, 553-0003
  - Saitama, Japan, 331-8577
- Aichi
  - Nagoya, Aichi, Japan, 457-8510
  - Nagoya, Aichi, Japan, 460-0001
  - Nagoya, Aichi, Japan, 451-8511
  - Nagoya, Aichi, Japan, 456-0058
  - Nagoya, Aichi, Japan, 466-8650
  - Toyota, Aichi, Japan, 471-8513
- Chiba
  - Funabashi, Chiba, Japan, 273-8588
  - Ichikawa, Chiba, Japan, 272-8516
- Ehime
  - Matsuyama, Ehime, Japan, 790-0024
  - Matsuyama, Ehime, Japan, 791-8026
- Fukuoka
  - Chikushino, Fukuoka, Japan, 818-8502
  - Kasuga, Fukuoka, Japan, 816-0864
  - Kitakyushu, Fukuoka, Japan, 802-8555
  - Kitakyushu, Fukuoka, Japan, 800-0296
  - Kitakyushu, Fukuoka, Japan, 805-8508
  - Kitakyushu, Fukuoka, Japan, 807-0857
- Fukushima
  - Shirakawa, Fukushima, Japan, 961-0005
- Gifu
  - Ogaki, Gifu, Japan, 503-8502
- Gunma
  - Maebashi, Gunma, Japan, 371-0821
- Hiroshima
  - Higashihiroshima, Hiroshima, Japan, 739-0041
- Hokkaido
  - Asahikawa, Hokkaido, Japan, 078-8234
  - Hakodate, Hokkaido, Japan, 041-8680
  - Obihiro, Hokkaido, Japan, 080-0848
  - Sapporo, Hokkaido, Japan, 007-0841
- Hyogo
  - Kobe, Hyogo, Japan, 650-0047
- Ibaraki
  - Naka, Ibaraki, Japan, 311-0113
  - Ushiku, Ibaraki, Japan, 300-1207
- Ishikawa
  - Komatsu, Ishikawa, Japan, 923-8560
- Kagawa
  - Sanuki, Kagawa, Japan, 769-2393
  - Takamatsu, Kagawa, Japan, 760-0018
  - Takamatsu, Kagawa, Japan, 760-0017
- Kanagawa
  - Atsugi, Kanagawa, Japan, 243-0035
  - Fujisawa, Kanagawa, Japan, 251-0041
  - Kamakura, Kanagawa, Japan, 247-8533
  - Yokohama, Kanagawa, Japan, 235-0045
  - Yokohama, Kanagawa, Japan, 245-8575
  - Yokohama, Kanagawa, Japan, 247-8581
- Kumamoto
  - Tamana, Kumamoto, Japan, 865-0016
  - Yatsushiro, Kumamoto, Japan, 866-0824
- Nagasaki
  - Sasebo, Nagasaki, Japan, 857-1195
- Oita
  - Beppu, Oita, Japan, 874-0011
  - Yufu, Oita, Japan, 879-5593
- Okinawa
  - Nakagami-gun, Okinawa, Japan, 901-2393
  - Shimajiri, Okinawa, Japan, 901-0493
- Osaka
  - Matsubara, Osaka, Japan, 580-0032
  - Suita, Osaka, Japan, 565-0862
- Saitama
  - Kawaguchi, Saitama, Japan, 332-0012
  - Sayama, Saitama, Japan, 350-1305
- Shiga
  - Otsu, Shiga, Japan, 520-0804
- Shizuoka
  - Iwata, Shizuoka, Japan, 438-8550
- Tochigi
  - Oyama, Tochigi, Japan, 323-0022
- Tokyo
  - Minato, Tokyo, Japan, 108-0073
  - Musashino, Tokyo, Japan, 180-8610
  - Shibuya-ku, Tokyo, Japan, 150-0002
  - Tacchikawa, Tokyo, Japan, 190-8531
Korea, Republic of
- - Busan, Korea, Republic of, 49241
  - Daegu, Korea, Republic of, 42601
  - Seoul, Korea, Republic of, 05278
  - Seoul, Korea, Republic of, 05505
  - Seoul, Korea, Republic of, 06351
  - Seoul, Korea, Republic of, 02841
  - Seoul, Korea, Republic of, 03722
  - Seoul, Korea, Republic of, 07441
  - Seoul, Korea, Republic of, 110-746
- Gang''weondo
  - Wonju, Gang''weondo, Korea, Republic of, 26426
- Gyeonggido
  - Anyang-si, Gyeonggido, Korea, Republic of, 14068
  - Seongnam-si, Gyeonggido, Korea, Republic of, 13620
- Seoul Teugbyeolsi
  - Seoul, Seoul Teugbyeolsi, Korea, Republic of, 03080
Lithuania
- - Kaunas, Lithuania, LT-45217
  - Kaunas, Lithuania, LT-48259
  - Kaunas, Lithuania, LT-49449
  - Kaunas, Lithuania, LT-51270
  - Klaipeda, Lithuania, LT-92304
  - Utena, Lithuania, LT-28142
  - Vilnius, Lithuania, LT-08661
Malaysia
- - Johor Bahru, Malaysia, 80100
  - Kelantan, Malaysia, 15200
  - Kelantan, Malaysia
  - Kuala Lumpur, Malaysia, 59100
  - Pahang, Malaysia, 25100
  - Perak, Malaysia, 30450
  - Perak, Malaysia, 32040
  - Pulau Pinang, Malaysia, 10450
  - Putrajaya, Malaysia, 62250
  - Selangor, Malaysia, 47000
Mexico
- - Aguascalientes, Mexico, 20219
  - Chihuahua, Mexico, 31238
  - Durango, Mexico, 34000
- Distrito Federal
  - Ciudad de México, Distrito Federal, Mexico, 06729
  - Ciudad de México, Distrito Federal, Mexico, 11650
  - Ciudad de México, Distrito Federal, Mexico, 6700
  - México D.F., Distrito Federal, Mexico, 14080
  - México, D. F., Distrito Federal, Mexico, 11850
  - México, D. F., Distrito Federal, Mexico, 3100
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44600
  - Guadalajara, Jalisco, Mexico, 44657
- Morelos
  - Cuernavaca, Morelos, Mexico, 62250
- Nuevo Leon
  - Monterrey, Nuevo Leon, Mexico, 64460
- Querétaro
  - Queretaro, Querétaro, Mexico, 76000
  - San Juan del Río, Querétaro, Mexico, 76800
- Sinaloa
  - Culiacán, Sinaloa, Mexico, 80200
  - Culiacán, Sinaloa, Mexico, 80230
  - Mazatlán, Sinaloa, Mexico, 82110
- Veracruz
  - Puerto de Veracruz, Veracruz, Mexico, 91900
  - Xalapa, Veracruz, Mexico, 91193
Netherlands
- - Alkmaar, Netherlands, 1815 JD
  - Almere, Netherlands, 1315 RA
  - Amersfoort, Netherlands, 3818 TZ
  - Amsterdam, Netherlands, 1105 AZ
  - Amsterdam, Netherlands, 1091 AC
  - Apeldoorn, Netherlands, 7334 DZ
  - Breda, Netherlands, 4818 CK
  - Den Haag, Netherlands, 2545 CH
  - Eindhoven, Netherlands, 5600 PD
  - Geleen, Netherlands, 6162 BG
  - Groningen, Netherlands, 9713 GZ
  - Hoogeveen, Netherlands, 7909 AA
  - Zwijndrecht, Netherlands, 3331 LZ
New Zealand
- - Auckland, New Zealand, 2025
  - Auckland, New Zealand
  - Christchurch, New Zealand, 8011
  - Hamilton, New Zealand, 3204
  - Hawkes Bay, New Zealand, 4130
  - Palmerston North, New Zealand, 4414
  - Tauranga, New Zealand, 3110
  - Wellington, New Zealand
Norway
- - Hamar, Norway, 2317
  - Hamar, Norway
  - Kløfta, Norway, 2040
  - Kongsvinger, Norway
  - Kristiansand, Norway, 4604
  - Levanger, Norway, 7601
  - Lierskogen, Norway, 3420
  - Oslo, Norway, 0176
  - Oslo, Norway, 0586
  - Skedsmokorset, Norway, 2020
  - Ålesund, Norway, 6017
Philippines
- - Iloilo City, Philippines, 5000
  - Marikina City, Philippines
  - Pasig City, Philippines, 1600
  - Quezon City, Philippines, 1102
  - Quezon City, Philippines, 1110
  - Quezon City, Philippines, 1112
Poland
- - Bialystok, Poland, 15-351
  - Bydgoszcz, Poland, 85-079
  - Chojnice, Poland, 89-600
  - Gdansk, Poland, 80-952
  - Gdynia, Poland, 81-537
  - Katowice, Poland, 40-040
  - Krakow, Poland, 30-510
  - Krakow, Poland, 31-156
  - Krakow, Poland, 31-261
  - Krakow, Poland, 31-559
  - Lodz, Poland, 90-153
  - Lodz, Poland, 92-213
  - Lodz, Poland, 94-060
  - Lublin, Poland, 20-538
  - Poznan, Poland, 60-834
  - Rzeszow, Poland, 35-055
  - Skorzewo, Poland, 60-185
  - Szczecin, Poland, 70-111
  - Torun, Poland, 87-100
  - Warszawa, Poland
  - Warszawa, Poland, 01-868
  - Wroclaw, Poland, 51-162
  - Wroclaw, Poland, 51-685
  - Zabrze, Poland, 41-800
Portugal
- - Almada, Portugal, 2801-951
  - Amadora, Portugal, 2720-276
  - Braga, Portugal, 4710-243
  - Faro, Portugal, 8000-386
  - Leiria, Portugal, 2410-197
  - Lisboa, Portugal, 1069-166
  - Lisboa, Portugal, 1250-189
  - Lisboa, Portugal, 1449-005
  - Lisboa, Portugal, 1500-650
  - Porto, Portugal, 4200-319
  - Porto, Portugal, 4099-001
  - Viana do Castelo, Portugal, 4901-858
- Castelo Branco
  - Covilha, Castelo Branco, Portugal, 6200-251
- Lisboa
  - Loures, Lisboa, Portugal, 2674-514
- Porto
  - Matosinhos, Porto, Portugal, 4464-513
- Região Autónoma Da Madeira
  - Funchal, Região Autónoma Da Madeira, Portugal, 9004-514
- Santarém
  - Torres Novas, Santarém, Portugal, 2350-754
- Setúbal
  - Setubal, Setúbal, Portugal, 2900-446
Puerto Rico
- - Cidra, Puerto Rico, 00739
  - San Juan, Puerto Rico, 00909-3004
  - San Juan, Puerto Rico, 00917
Romania
- - Brasov, Romania, 500269
  - Bucuresti, Romania, 010825
  - Bucuresti, Romania, 010507
  - Bucuresti, Romania, 010627
  - Bucuresti, Romania, 014142
  - Bucuresti, Romania, 020614
  - Bucuresti, Romania, 031818
  - Bucuresti, Romania, 050538
  - Cluj-Napoca, Romania, 400006
  - Galati, Romania, 800001
  - Iasi, Romania, 700547
  - Oradea, Romania, 410159
  - Satu Mare, Romania, 440055
  - Timisoara, Romania, 300736
- Alba
  - Alba-Iulia, Alba, Romania, 510053
- Bihor
  - Oradea, Bihor, Romania, 410519
- Maramures
  - Baia Mare, Maramures, Romania, 430222
- Prahova
  - Ploiesti, Prahova, Romania, 100179
- Timis
  - Timisoara, Timis, Romania, 300456
Russian Federation
- - Arkhangelsk, Russian Federation, 163001
  - Barnaul, Russian Federation, 656024
  - Chelyabinsk, Russian Federation, 454021
  - Irkutsk, Russian Federation, 664079
  - Izhevsk, Russian Federation, 426063
  - Kazan, Russian Federation, 420012
  - Kazan, Russian Federation, 420101
  - Kemerovo, Russian Federation, 650002
  - Kemerovo, Russian Federation, 650055
  - Kemerovo, Russian Federation, 650066
  - Kirov, Russian Federation, 610014
  - Krasnodar, Russian Federation, 350086
  - Krasnoyarsk, Russian Federation, 660062
  - Kursk, Russian Federation, 305004
  - Moscow, Russian Federation, 111539
  - Moscow, Russian Federation, 119991
  - Moscow, Russian Federation, 123182
  - Moscow, Russian Federation, 125101
  - Moscow, Russian Federation, 129110
  - Moscow, Russian Federation, 117292
  - Moscow, Russian Federation, 119034
  - Moscow, Russian Federation, 119192
  - Moscow, Russian Federation, 123423
  - Moscow, Russian Federation, 125315
  - Nizhny Novgorod, Russian Federation, 603126
  - Nizhny Novgorod, Russian Federation, 603018
  - Novosibirsk, Russian Federation, 630068
  - Novosibirsk, Russian Federation, 630089
  - Novosibirsk, Russian Federation, 630117
  - Novosibirsk, Russian Federation, 630047
  - Novosibirsk, Russian Federation, 630005
  - Omsk, Russian Federation, 644112
  - Omsk, Russian Federation, 644024
  - Omsk, Russian Federation, 644033
  - Orenburg, Russian Federation, 460040
  - Perm, Russian Federation, 614097
  - Saratov, Russian Federation, 410030
  - St. Petersburg, Russian Federation, 194354
  - St. Petersburg, Russian Federation, 194044
  - St. Petersburg, Russian Federation, 193312
  - St. Petersburg, Russian Federation, 194223
  - St. Petersburg, Russian Federation, 195067
  - St. Petersburg, Russian Federation, 195112
  - St. Petersburg, Russian Federation, 195257
  - St. Petersburg, Russian Federation, 197762
  - St. Petersburg, Russian Federation, 199226
  - Stavropol, Russian Federation, 355030
  - Syktyvkar, Russian Federation, 167981
  - Voronezh, Russian Federation, 394018
  - Voronezh, Russian Federation, 394077
  - Yaroslavl, Russian Federation, 150062
  - Yaroslavl, Russian Federation, 150003
  - Yekaterinburg, Russian Federation, 620102
Singapore
- - Singapore, Singapore, 169608
  - Singapore, Singapore, 169609
  - Singapore, Singapore, 768828
Slovakia
- - Banska Bystrica, Slovakia, 974 01
  - Bardejov, Slovakia, 085 01
  - Nitra, Slovakia, 949 11
  - Rimavska Sobota, Slovakia, 979 01
  - Roznava, Slovakia, 048 01
  - Zilina, Slovakia, 01001
South Africa
- Eastern Cape
  - Port Elizabeth, Eastern Cape, South Africa, 6045
- Gauteng
  - Benoni, Gauteng, South Africa, 1501
  - Johannesburg, Gauteng, South Africa, 2198
  - Lenasia South, Gauteng, South Africa, 1835
  - Newtown, Gauteng, South Africa, 2113
  - Pretoria, Gauteng, South Africa, 0181
  - Pretoria, Gauteng, South Africa, 0002
  - Soweto, Gauteng, South Africa, 1818
- Kwazulu-Natal
  - Durban, Kwazulu-Natal, South Africa, 4030
  - Isipingo Rail, Kwazulu-Natal, South Africa, 4110
  - Tongaat, Kwazulu-Natal, South Africa, 4400
- Mpumalanga
  - Middelburg, Mpumalanga, South Africa, 1055
  - Witbank, Mpumalanga, South Africa, 1035
- Western Cape
  - Cape Town, Western Cape, South Africa, 7570
  - Cape Town, Western Cape, South Africa, 7925
  - Somerset West, Western Cape, South Africa, 7130
  - Worcester, Western Cape, South Africa, 6850
Spain
- - A Coruña, Spain, 15006
  - Barcelona, Spain, 08036
  - Barcelona, Spain, 08003
  - Barcelona, Spain, 08035
  - Barcelona, Spain, 08025
  - Barcelona, Spain, 08023
  - Córdoba, Spain, 14004
  - Granada, Spain, 18012
  - Jaén, Spain, 23007
  - Madrid, Spain, 28041
  - Madrid, Spain, 28007
  - Málaga, Spain, 29010
  - Valencia, Spain, 46017
  - Valencia, Spain, 46014
  - Valencia, Spain, 46026
  - Valencia, Spain, 46010
- A Coruña
  - Ferrol, A Coruña, Spain, 15405
- Barcelona
  - Badalona, Barcelona, Spain, 08916
  - L'Hospitalet de Llobregat, Barcelona, Spain, 08907
  - Manresa, Barcelona, Spain, 08243
  - Sant Joan Despi, Barcelona, Spain, 08970
- Cádiz
  - Jerez de la Frontera, Cádiz, Spain, 11407
- Lugo
  - Burela, Lugo, Spain, 27880
- Madrid
  - Alcalá de Henares, Madrid, Spain, 28805
  - Getafe, Madrid, Spain, 28905
- Valencia
  - Sagunto, Valencia, Spain, 46520
Sweden
- - Göteborg, Sweden, 413 45
  - Göteborg, Sweden, 413 46
  - Lund, Sweden, 221 85
  - Lund, Sweden, 222 21
  - Rättvik, Sweden, 795 30
  - Skövde, Sweden, 541 50
  - Stockholm, Sweden, 113 24
  - Stockholm, Sweden, 114 46
  - Stockholm, Sweden, 182 88
  - Uppsala, Sweden, 751 85
  - Uppsala, Sweden, 752 37
  - Örebro, Sweden, 701 85
  - Örebro, Sweden, 703 62
Switzerland
- - Bern, Switzerland, 3010
  - Genève, Switzerland, 1205
- Sankt Gallen
  - St. Gallen, Sankt Gallen, Switzerland, 9007
  - St. Gallen, Sankt Gallen, Switzerland, 9016
- Solothurn
  - Olten, Solothurn, Switzerland, 4600
- Vaud
  - Lausanne, Vaud, Switzerland, 1011
Taiwan
- - Changhua, Taiwan, 50006
  - Kaohsiung, Taiwan, 833
  - New Taipei City, Taiwan, 220
  - Taichung, Taiwan, 40447
  - Taichung, Taiwan, 40705
  - Taipei, Taiwan, 100
  - Taipei, Taiwan, 11217
  - Taipei, Taiwan, 110
  - Taoyuan, Taiwan, 33305
Thailand
- - Bangkok, Thailand
  - Bangkok, Thailand, 10400
  - Chiangmai, Thailand, 50200
  - Khon Kaen, Thailand, 40002
Turkey
- - Ankara, Turkey
  - Antalya, Turkey, 07059
  - Antalya, Turkey, 07003
  - Aydin, Turkey, 09100
  - Istanbul, Turkey, 34303
  - Istanbul, Turkey, 34722
  - Istanbul, Turkey, 34899
  - Izmir, Turkey, 35100
  - Izmir, Turkey, 35180
  - Izmir, Turkey, 35540
  - Kayseri, Turkey, 38039
  - Kocaeli, Turkey, 41380
  - Malatya, Turkey, 44280
  - Sivas, Turkey, 58140
Ukraine
- - Cherkasy, Ukraine, 18009
  - Chernivtsi, Ukraine, 58002
  - Dnipro, Ukraine, 49023
  - Dnipro, Ukraine, 49000
  - Ivano-Frankivsk, Ukraine, 76008
  - Kharkiv, Ukraine, 61039
  - Kharkiv, Ukraine, 61037
  - Kharkiv, Ukraine, 61058
  - Kharkiv, Ukraine, 61070
  - Kiev, Ukraine, 01021
  - Kiev, Ukraine, 04050
  - Kiev, Ukraine, 04114
  - Kiev, Ukraine, 1601
  - Kyiv, Ukraine, 03037
  - Kyiv, Ukraine, 03049
  - Lviv, Ukraine, 79010
  - Mykolayiv, Ukraine, 54003
  - Ternopil, Ukraine, 46002
  - Vinnytsia, Ukraine, 21001
  - Zaporizhzhya, Ukraine, 69001
  - Zaporozhye, Ukraine, 69000
United Kingdom
- - Bristol, United Kingdom, BS10 5NB
  - Glasgow, United Kingdom, G20 OSP
  - London, United Kingdom, SE5 9RS
  - London, United Kingdom, E1 1BB
  - Manchester, United Kingdom, M8 5RB
  - Middlesborough, United Kingdom, TS4 3BW
- Carmarthenshire
  - Llanelli, Carmarthenshire, United Kingdom, SA14 8QF
- Merseyside
  - Liverpool, Merseyside, United Kingdom, L7 8XP
- Northamptonshire
  - Northampton, Northamptonshire, United Kingdom, NN1 5BD
- Surrey
  - Carshalton, Surrey, United Kingdom, SM5 1AA
- West Midlands
  - Birmingham, West Midlands, United Kingdom, B15 2SQ
- West Sussex
  - Chichester, West Sussex, United Kingdom, PO19 6SE
United States
- Alabama
  - Birmingham, Alabama, United States, 35294-2041
  - Fort Payne, Alabama, United States, 35967
  - Huntsville, Alabama, United States, 35801-4317
- Arizona
  - Mesa, Arizona, United States, 85210
  - Phoenix, Arizona, United States, 85032
  - Phoenix, Arizona, United States, 85016
  - Prescott, Arizona, United States, 86301
  - Tucson, Arizona, United States, 85724
  - Tucson, Arizona, United States, 85723
- California
  - Bakersfield, California, United States, 93309
  - Chula Vista, California, United States, 91910
  - Dublin, California, United States, 94568
  - El Centro, California, United States, 92243
  - Fresno, California, United States, 93720
  - Fresno, California, United States, 93721
  - La Mesa, California, United States, 91942
  - Loma Linda, California, United States, 92357
  - Los Angeles, California, United States, 90025
  - Los Angeles, California, United States, 90073
  - Los Angeles, California, United States, 90017
  - Los Angeles, California, United States, 90022
  - Northridge, California, United States, 91325
  - Port Hueneme, California, United States, 93041
  - Poway, California, United States, 92064
  - Rancho Cucamonga, California, United States, 91730
  - Rialto, California, United States, 92377
  - Roseville, California, United States, 95661
  - San Diego, California, United States, 92117
  - Santa Rosa, California, United States, 95405
  - Torrance, California, United States, 90502
  - Vista, California, United States, 92083
- Connecticut
  - New Haven, Connecticut, United States, 06520
  - Waterbury, Connecticut, United States, 06708
- Florida
  - Fort Lauderdale, Florida, United States, 33308
  - Fort Lauderdale, Florida, United States, 33312
  - Fort Lauderdale, Florida, United States, 33316-1958
  - Hialeah, Florida, United States, 33016
  - Hialeah, Florida, United States, 33012
  - Hollywood, Florida, United States, 33024
  - Jacksonville, Florida, United States, 32204
  - Miami, Florida, United States, 33186
  - Miami, Florida, United States, 33173
  - Miami, Florida, United States, 33126
  - Miami, Florida, United States, 33144
  - Miami, Florida, United States, 33165
  - Miami, Florida, United States, 33155
  - Miami, Florida, United States, 33175
  - Miami, Florida, United States, 33145
  - Miami, Florida, United States, 33032
  - Miami, Florida, United States, 33130
  - Miami, Florida, United States, 33156
  - Miami Beach, Florida, United States, 33140
  - Miami Gardens, Florida, United States, 33014
  - Miami Lakes, Florida, United States, 33016
  - Miami Lakes, Florida, United States, 33014
  - New Port Richey, Florida, United States, 34652
  - Ocala, Florida, United States, 34471
  - Orlando, Florida, United States, 32825
  - Palm Harbor, Florida, United States, 34684
  - Sarasota, Florida, United States, 34239
  - Tampa, Florida, United States, 33614
  - West Palm Beach, Florida, United States, 33401-3430
  - Winter Haven, Florida, United States, 33880
- Georgia
  - Atlanta, Georgia, United States, 30303
  - Atlanta, Georgia, United States, 30342
  - Augusta, Georgia, United States, 30904
  - Lawrenceville, Georgia, United States, 30046
  - Macon, Georgia, United States, 31210
- Hawaii
  - Honolulu, Hawaii, United States, 96814
- Illinois
  - Chicago, Illinois, United States, 60612
  - Elgin, Illinois, United States, 60123
  - Morton, Illinois, United States, 61550
  - Springfield, Illinois, United States, 62702-1311
- Indiana
  - Indianapolis, Indiana, United States, 46202
- Iowa
  - Iowa City, Iowa, United States, 52242
  - West Des Moines, Iowa, United States, 50265
- Kansas
  - Hutchinson, Kansas, United States, 67502-1131
  - Topeka, Kansas, United States, 66606
  - Wichita, Kansas, United States, 67214
- Louisiana
  - Metairie, Louisiana, United States, 70006
  - Monroe, Louisiana, United States, 71201
  - New Orleans, Louisiana, United States, 70112
  - Shreveport, Louisiana, United States, 71101
- Massachusetts
  - Boston, Massachusetts, United States, 02215
- Michigan
  - Ann Arbor, Michigan, United States, 48109
  - Flint, Michigan, United States, 48504
  - Flint, Michigan, United States, 48532
  - Kalamazoo, Michigan, United States, 49009
- Minnesota
  - Minneapolis, Minnesota, United States, 55455
- Missouri
  - Columbia, Missouri, United States, 65212
  - Columbia, Missouri, United States, 65201
  - Jefferson City, Missouri, United States, 65109
  - Kansas City, Missouri, United States, 64111
  - Kansas City, Missouri, United States, 64128
  - Saint Louis, Missouri, United States, 63106
  - Saint Louis, Missouri, United States, 63136
- Nebraska
  - Omaha, Nebraska, United States, 68131
  - Omaha, Nebraska, United States, 68124
- Nevada
  - Las Vegas, Nevada, United States, 89128
  - Las Vegas, Nevada, United States, 89119
  - Las Vegas, Nevada, United States, 89102
  - Las Vegas, Nevada, United States, 89086
  - Las Vegas, Nevada, United States, 89113-2215
  - Reno, Nevada, United States, 89511
- New Jersey
  - Newark, New Jersey, United States, 07103
- New Mexico
  - Albuquerque, New Mexico, United States, 87106
- New York
  - Albany, New York, United States, 12203
  - Brooklyn, New York, United States, 11203
  - Brooklyn, New York, United States, 11229
  - New York, New York, United States, 10029
  - Rosedale, New York, United States, 11422
  - Smithtown, New York, United States, 11787
  - Staten Island, New York, United States, 10301
- North Carolina
  - Asheboro, North Carolina, United States, 27203
  - Chapel Hill, North Carolina, United States, 27312
  - Charlotte, North Carolina, United States, 28207
  - Greenville, North Carolina, United States, 27834
  - New Bern, North Carolina, United States, 28562
  - Winston-Salem, North Carolina, United States, 27157
- Ohio
  - Canton, Ohio, United States, 44718
  - Willoughby Hills, Ohio, United States, 44094
- Pennsylvania
  - Beaver, Pennsylvania, United States, 15009
  - Bethlehem, Pennsylvania, United States, 18017
  - Hershey, Pennsylvania, United States, 17033
  - Jersey Shore, Pennsylvania, United States, 17740
- South Carolina
  - Anderson, South Carolina, United States, 29625
  - Charleston, South Carolina, United States, 29425
  - Greenville, South Carolina, United States, 29607
  - Murrells Inlet, South Carolina, United States, 29576
  - Myrtle Beach, South Carolina, United States, 29588
  - Orangeburg, South Carolina, United States, 29118
- Tennessee
  - Chattanooga, Tennessee, United States, 37404
  - Memphis, Tennessee, United States, 38104
  - Memphis, Tennessee, United States, 38120
  - Memphis, Tennessee, United States, 38163
  - Nashville, Tennessee, United States, 37205
  - Nashville, Tennessee, United States, 37208
  - Nashville, Tennessee, United States, 37232-1371
- Texas
  - Arlington, Texas, United States, 76014
  - Corpus Christi, Texas, United States, 78414
  - Dallas, Texas, United States, 75216
  - Dallas, Texas, United States, 75246
  - Dallas, Texas, United States, 75251
  - El Paso, Texas, United States, 79902-4672
  - Houston, Texas, United States, 77024
  - Houston, Texas, United States, 77008
  - Houston, Texas, United States, 77018
  - Houston, Texas, United States, 77040
  - Houston, Texas, United States, 77061
  - Houston, Texas, United States, 77079
  - Houston, Texas, United States, 77095
  - Kingwood, Texas, United States, 77339
  - McAllen, Texas, United States, 78503
  - McKinney, Texas, United States, 75069
  - Missouri City, Texas, United States, 77459
  - Pearland, Texas, United States, 77584
  - Pflugerville, Texas, United States, 78660
  - San Antonio, Texas, United States, 78215
  - San Antonio, Texas, United States, 78212
  - San Antonio, Texas, United States, 78229-3900
  - Sugar Land, Texas, United States, 77479
  - Sugar Land, Texas, United States, 77478
  - Tomball, Texas, United States, 77375
  - Waco, Texas, United States, 76708
- Utah
  - Salt Lake City, Utah, United States, 84108
- Vermont
  - Burlington, Vermont, United States, 05401
- Virginia
  - Alexandria, Virginia, United States, 22304
  - Charlottesville, Virginia, United States, 22908
  - Manassas, Virginia, United States, 20110
  - Salem, Virginia, United States, 24153
  - Virginia Beach, Virginia, United States, 23462
- Washington
  - Spokane, Washington, United States, 99204
  - Tacoma, Washington, United States, 98405
Vietnam
- - Ha Noi, Vietnam
  - Ha Noi, Vietnam, 10000
  - Ho Chi Minh City, Vietnam, 70000
  - Ho Chi Minh City, Vietnam, 84
  - Ho Chi Minh City, Vietnam

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

All

Description

Inclusion Criteria:

Men or women ≥18 years of age
Subjects with Type Type 2 Diabetes Mellitus as defined by the American Diabetes Association
Diagnosis of Diabetic Kidney Disease with persistent high albuminuria or persistent very high albuminuria at the Run-In and Screening Visit
Pretreated with either angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) at maximal tolerated labeled dose without adjustments
Serum potassium <=4.8 mmol/L

Exclusion Criteria:

Confirmed significant non-diabetic renal disease, including clinically relevant renal artery stenosis
Uncontrolled arterial hypertension (ie, mean sitting systolic blood pressure (SBP) ≥170 mmHg or mean sitting diastolic blood pressure(DBP) ≥110 mmHg at run in visit, or mean sitting SBP ≥160 mmHg or mean sitting DBP ≥100 mmHg at screening)
Clinical diagnosis of chronic heart failure with reduced ejection fraction (HFrEF) and persistent symptoms {New York Heart Association (NYHA) class II - IV} at Run in visit [class 1A recommendation for mineralcorticoid receptor antagonist (MRAs)]
Dialysis for acute renal failure within 12 weeks of Run-in visit
Renal allograft in place or scheduled kidney transplant within next 12 months
Glycated hemoglobin (HbA1c) >12%

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo Matching placebo	Drug: Placebo Matching placebo to be taken orally, once daily.
Experimental: BAY94-8862 Finerenone tablet	Drug: Finerenone (BAY94-8862) 10 mg or 20 mg Finerenone tablet to be given orally, once daily.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The First Occurrence of the Composite Endpoint of Cardiovascular Death, Non-fatal Myocardial Infarction, Non Fatal Stroke, or Hospitalization for Heart Failure. Time Frame: From randomization up until the first occurrence of the CV composite endpoint, or censoring at the end of the study, with an average study duration of 41 months.	Number of participants with the first occurrence of the primary cardiovascular (CV) composite outcome, CV death, non-fatal myocardial infarction (MI), non-fatal stroke, or hospitalization for heart failure were reported as descriptive result.	From randomization up until the first occurrence of the CV composite endpoint, or censoring at the end of the study, with an average study duration of 41 months.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The First Occurrence of the Composite Endpoint of Onset of Kidney Failure, a Sustained Decrease of eGFR ≥40% From Baseline Over at Least 4 Weeks, or Renal Death. Time Frame: From randomization up until the first occurrence of the renal composite endpoint, or censoring at the end of the study, with an average study duration of 41 months.	Number of participants with first occurrence of the composite endpoint of onset of kidney failure, a sustained decrease of eGFR ≥40% from baseline over at least 4 weeks, or renal death were reported as descriptive result.	From randomization up until the first occurrence of the renal composite endpoint, or censoring at the end of the study, with an average study duration of 41 months.
All-cause Hospitalization Time Frame: From randomization up until the first occurrence of the hospitalization due to any cause, or censoring at the end of study, with an average study duration of 41 months	Number of participants with first occurrence of a hospitalization event were reported as descriptive result.	From randomization up until the first occurrence of the hospitalization due to any cause, or censoring at the end of study, with an average study duration of 41 months
All-cause Mortality Time Frame: From randomization up until death due to any cause, or censoring at the end of the study, with an average study duration of 41 months	Number of participants with death due to any cause were reported as descriptive result. Number of participants with outcome death reported here includes deaths occurred after randomization until the end of the study visit. Deaths after end of study visit are not included in this table.	From randomization up until death due to any cause, or censoring at the end of the study, with an average study duration of 41 months
Change in Urinary Albumin-to-creatine Ratio (UCAR) From Baseline to Month 4 Time Frame: From baseline up until Month 4	First morning void urine samples were collected to evaluate the urinary albumin-to-creatinine ratio (UACR). Month 4 was the visit closest to day 120 within a time window of 120 ± 30 days after randomization. If no measurements were available in this time window, the participant was excluded from this analysis. Ratio of UACR at Month 4 to UACR at baseline is reported as the change.	From baseline up until Month 4
The First Occurrence of the Composite Endpoint of Onset of Kidney Failure, a Sustained Decrease in eGFR of ≥57% From Baseline Over at Least 4 Weeks, or Renal Death Time Frame: From randomization up until the first occurrence of the renal composite endpoint, or censoring at the end of the study, with an average study duration of 41 months	Number of participants with first occurrence of the renal composite outcome, onset of kidney failure, a sustained decrease in eGFR of ≥57% from baseline over at least 4 weeks, or renal death were reported as descriptive result.	From randomization up until the first occurrence of the renal composite endpoint, or censoring at the end of the study, with an average study duration of 41 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Bayer

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 17, 2015

Primary Completion (Actual)

February 2, 2021

Study Completion (Actual)

February 2, 2021

Study Registration Dates

First Submitted

September 2, 2015

First Submitted That Met QC Criteria

September 7, 2015

First Posted (Estimate)

September 9, 2015

Study Record Updates

Last Update Posted (Actual)

April 15, 2022

Last Update Submitted That Met QC Criteria

April 13, 2022

Last Verified

April 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

17530
2015-000950-39 (EudraCT Number)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, time point and process of data access. As such, Bayer commits to sharing upon request from qualified researcher's patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014. Interested researchers can use www.clinicalstudydatarequest.com to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the Study sponsors section of the portal.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

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Intervention / Treatment

Study Type

Enrollment (Actual)

Phase

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Study Locations

Participation Criteria

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Ages Eligible for Study

Accepts Healthy Volunteers

Genders Eligible for Study

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Publications and helpful links

General Publications

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Estimate)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Diabetic Kidney Disease

Clinical Trials on Placebo

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