A Prospective Cohort Study on Drug-induced Liver Injury in China（DILI-P） (DILI-P)

A Multi-center, Prospective, Non-interventional Cohort Study on Drug Induced Liver Injury in Mainland China

This is a multi-center, prospective, non-interventional cohort study .

Its primary objectives are:

1. assess DILI patients' clinical characteristics, disease progression and influencing factors in clinical practice;
2. learn about suspected drug caused DILI,rechallenging, liver biochemical abnormalities mode, etc.

Study Overview

• Status: Unknown
• Conditions: Drug-induced Liver Injury

Detailed Description

The main purpose of this study is to understand patients with DILI clinical outcome and influencing factors in China's second and tertiary general hospitals (including Western medicine hospital, Chinese medicine hospital andIntegrated traditional Chinese and Western Medicine Hospital) and vulnerabilities of drug-induced liver injury specialist hospital (tuberculosis hospital, Pulmonary, etc.) in mainland.

The main purpose

1. assess the DILI patients' clinical outcomes and influencing factors in the real world;
2. learn about suspected drug caused DILI,rechallenging, liver biochemical abnormalities mode, etc.

Secondary objectives

1. assess the compliance of the DILI practice to the 2015 vision of the DILI guidelines in china.;
2. evaluate the histological features of DILI patients;
3. assessment DILI characteristics, prognosis and influencing factors in specific populations(such as the elderly, children with underlying liver disease background, etc.)

• Study Type: Observational
• Enrollment (Anticipated): 10000

Contacts and Locations

• Study Contact: Name: Chunxia Zhang; Email: chunxia.zhang@unimedsci.com

Study Locations

• China
  • Shanghai, China
    • Recruiting
    • RenJi Hospital
    • Contact: Yimin Mao

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: ADULT; OLDER_ADULT; CHILD
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

all patients with drug-induced liver injury

Description

Inclusion Criteria:

• Diagnosis of DILI patients with various types and severity according to the 2015 version of the Chinese DILI treatment guidelines
• RUCAM ≥6, or RUCAM between 3-5 is required by the three experts determined that the drug-induced liver injury
• patient can provide informed consent form

Exclusion Criteria:

• non-drug-induced liver injury

Study Plan

How is the study designed?

Number of groups / cohorts

6

Cohorts and Interventions

Group / Cohort
cohort 1; Compound glycyrrhizin tablets / injection
cohort 2; Isoglycyrrhizinate magnesium injection / diammonium glycyrrhizinate enteric-coated capsules
cohort 3; Bicyclol
cohort 4; Silibinin capsules
cohort 5; Ursodeoxycholic acid capsules
cohort 6; N- acetylcysteine

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Disease progression of DILI (drug-induced liver injury ), i.e. death, liver failure, chronic DILI, recover	6 months

Collaborators and Investigators

• Sponsor: Drug Induced Liver Disease Study Group
• Investigators: Principal Investigator: Yongguo Li, First Affiliated Hospital of Harbin Medical University; Principal Investigator: Jinjun Chen, Nanfang Hospital of Southern Medical University; Principal Investigator: Xingfang Li, Pulmonary Hospital of Lanzhou; Principal Investigator: Yiling Li, First Hospital of China Medical University; Principal Investigator: Dongliang Li, Fuzhou General Hospital; Principal Investigator: Suocai Zhang, Changzhou Third People 's Hospital; Principal Investigator: Rongxia Sang, First Hospital of Shijiazhuang City; Principal Investigator: Zhihui Li, Hebei Chest Hospital; Principal Investigator: Feng Sun, First Affiliated Hospital of Heilongjiang Chinese Medicine University; Principal Investigator: Wushu Yan, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine; Principal Investigator: Yanqin Wu, Bazhou People 's Hospital; Principal Investigator: Xu Lian, Mudanjiang Red Flag Hospital; Principal Investigator: Mingfang Wang, Pingdingshan People's Hospital No.1; Principal Investigator: Yanrong Shi, General Hospital of Pingdingshan Coal Industry Company; Principal Investigator: Hongwei Chen, Luoyang Central Hospital; Principal Investigator: Ximei Wang, Third Hospital Affiliated to Henan University of Science and Technology; Principal Investigator: Hongling Liu, The First People's Hospital of Luoyang; Principal Investigator: Renping Li, The Second Hospital Affiliated to Henan University of Science and Technology; Principal Investigator: Zhengsheng Zou, Beijing 302 Hospital; Principal Investigator: Jiguang Ding, Ruian People's Hospital; Principal Investigator: Yanjun Guo, Daqing oilfield general hospital; Principal Investigator: Weixin He, The No.123 Hospital of Chinese People's Liberation Army; Principal Investigator: Wufang Qi, Tianjin First Central Hospital; Principal Investigator: Yuqin Xu, The No.211 Hospital of Chinese People's Liberation Army; Principal Investigator: Jing Zhang, Beijin Youan Hospital,Capital Medical University; Principal Investigator: Peilan Zong, Jiangxi Chest Hospital; Principal Investigator: Yuefei Shen, The First People's Hospital of Hangzhou Xiaoshan District; Principal Investigator: Chunyan Zhou, Infectious Diseases Hospital of Shangqiu; Principal Investigator: Baijing Ding, The second People's Hospital of Wuhu; Principal Investigator: Liyun Chen, Wuhu Third People's Hospital; Principal Investigator: Yongze Guo, Affiliated Hospital of Hebei University of Engineering; Principal Investigator: Haibin Wang, Fifth Hospital of Shijiazhuang City; Principal Investigator: Hui Guo, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine; Principal Investigator: Hongling Liu, Beijing 302 Hospital; Principal Investigator: Yingjian Zhang, The First Affiliated Hospital of Henan University of Science and Technology; Principal Investigator: Qing Mao, Southwest Hospital, China; Principal Investigator: Jiawei Gen, First People's Hospital of Yunnan Province; Principal Investigator: Weize Zuo, The First Affiliated Hospital of Medical College,Shihezi University; Principal Investigator: Xia Zhang, Nanjing Chest Hospital; Principal Investigator: Xuan Zhu, The First Affiliated Hospital of NanChang University; Principal Investigator: Feng Shuai, Linyi People's Hospital; Principal Investigator: Kunyun Yang, Hunan Chest Hospital; Principal Investigator: Chuanwu Zhu, The Fifth People,Hospital of Suzhou; Principal Investigator: Wei Ge, Renmin Hospital of Wuhan University; Principal Investigator: Xiaojin Wang, 85 Hospital of People's Liberation Army; Principal Investigator: Jiajun Liu, The First Affiliated Hospital of Xiamen University; Principal Investigator: Fangping He, First Affiliated Hospital of Xinjiang Medical University; Principal Investigator: Xinmin Zhou, Xijing Hospital; Principal Investigator: Aiqing Lin, The First Affiliated Hospital of Inner Mongolia University of Science and Technology; Principal Investigator: Xiaojing Jiang, Wuhan General Hospital of Guangzhou Military; Principal Investigator: Qing Xie, Ruijin Hospital; Principal Investigator: Qingge Zhang, Xingtai People's Hospital; Principal Investigator: Yanyan Yu, Peking University first hospital; Principal Investigator: Jing Yuan, Shenzhen Third People's Hospital; Principal Investigator: Shiwu Ma, Kunming General Hospital of Chengdu Military Area Command; Principal Investigator: Jun Chen, Central South University; Principal Investigator: Qinghua Yao, Zhejiang Cancer Hospital; Principal Investigator: Yihong Zhang, The No.457 Hospital of Chinese People's Liberation Army; Principal Investigator: Qi Wang, Second Hospital of Shanxi Medical University; Principal Investigator: Xiaozhong Wang, Xinjiang Autonomous Region Hospital of TCM; Principal Investigator: Yongwen Ma, Daqing Longnan Hopital; Principal Investigator: Fangfang Lv, Sir Run Run Shaw Hospital; Principal Investigator: Xiaojun Zhang, Ankang City Central Hospital; Principal Investigator: Riwang Hu, The Fouth People's Hospital of Datong; Principal Investigator: Yi Song, Chongqing Traditional Chinese Medicine Hospital; Principal Investigator: Peng Hu, The Second Affiliated Hospital of Chongqing Medical University; Principal Investigator: Wen Xie, Beijing Ditan Hospital; Principal Investigator: Haiyan Jin, Yanbian University Hospital; Principal Investigator: Zheng Li, The First People's Hospital of Qinzhou; Principal Investigator: Shuixiang He, First Affiliated Hospital Xi'an Jiaotong University; Principal Investigator: Junqi Niu, The First Affiliated Hospital of Jilin University; Principal Investigator: Bin Jiang, The Second People's Hospital of Liaoyuan; Principal Investigator: Jing You, The First Affiliated Hospital of Kunming Medical College; Principal Investigator: Youqin Yan, WUHAN NO.7 HOSPITAL; Principal Investigator: Lvye Xv, General Hospital of The Yangtze River Shipping; Principal Investigator: Changyong Zhang, Wuhan Mental Health Centre; Principal Investigator: Guanghua Xv, Ya'nan University Affiliated Hospital; Principal Investigator: Hongbin Li, The First Affiliated Hospital of Anhui Medical University; Principal Investigator: Xilian Dong, Yuncheng Central Hospital; Principal Investigator: Xuefeng Su, Linfen People's Hospital; Principal Investigator: Mudan Yang, Shanxi Provincial Cancer Hospital; Principal Investigator: Zhen Ma, The Affiliated Hospital of Inner Mongolia Medical University; Principal Investigator: Hong Tang, West China Hospital; Principal Investigator: Chenghai Liu, Shanghai Shuguang Hospital; Principal Investigator: Zhenyu Yan, South China University of Science And Technology Affiliated Hospital; Principal Investigator: Fei Qiao, Jiangsu Province Hospital of TCM; Principal Investigator: Xingxiang Yang, Sichuan province hospital; Principal Investigator: Weihong Sha, Guangdong Provincial People's Hospital; Principal Investigator: Jie Jin, First People's Hospital of Hangzhou; Principal Investigator: Feng Lin, Hainan General Hospital; Principal Investigator: Guoqi Zheng, Cangzhou Central Hospital; Principal Investigator: Jiyao Wang, Zhong Shan Hospital; Principal Investigator: Lin Chen, LanZhou University; Principal Investigator: Dongliang Yang, Tongji Medical College of Huazhong University of Science and Technology; Principal Investigator: Li Chen, The Center Hospital Of Maanshan; Principal Investigator: Yong Wang, Fuyang First People's Hospital; Principal Investigator: Lianqing Lou, Yiwu Central Hospital; Principal Investigator: Huaming Li, Hangzhou Third People's Hospital; Principal Investigator: Shifang Chen, Huizhou Municipal Central Hospital; Principal Investigator: Zhifen Pan, First Affiliated Hospital of Jiaxing University; Principal Investigator: Wenlong Zheng, Hangzhou hospital of traditional Chinese medicine; Principal Investigator: Jingbo Pei, Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine; Principal Investigator: Feng Guo, Hangzhou Xiaoshan First People's Hospital; Principal Investigator: Feng Qian, Dongyang People's Hospital; Principal Investigator: Jianzheng Mao, Zhejiang Quhua Hospital; Principal Investigator: Ahuo Ma, Shaoxing People's Hospital; Principal Investigator: Qinhong Zheng, People's Hospital of Quzhou; Principal Investigator: Jufen Xu, Tongxiang First People's Hospital; Principal Investigator: Jiemin Hong, Ningbo Yinzhou No.2 Hospital; Principal Investigator: Jianwei Shen, Ningbo Medical Center Lihuili Eastern Hospital; Principal Investigator: Yunsong Qian, Ningbo No.2 Hospital; Principal Investigator: Weihong Du, Jinhua Central Hospital; Principal Investigator: Jiaxin Liu, Huzhou Hospital of Traditional Chinese Medicine; Principal Investigator: Qingjing Ru, Zhejiang Construction Hospital; Principal Investigator: Chunsheng Zhao, The No.98 Hospital of Chinese People's Liberation Army; Principal Investigator: Yinxia Hao, Baoding First Central Hospital; Principal Investigator: Li Sun, Xi'an No.3 Hospital; Principal Investigator: Wenlei Hu, Le Qin People's Hospital; Principal Investigator: Shuangsuo Dang, Second Affiliated Hospital of Xi'an JiaoTong University; Principal Investigator: Yu Chen, Zhengzhou No.6 People's Hospital; Principal Investigator: Zhaoxia Liu, First Affiliated Hospital of Heilongjiang Chinese Medicine University; Principal Investigator: Yang Pan, Heilongjiang Provincial Hospital of Traditional Chinese Medicine; Principal Investigator: Yi Shen, Dandong City Infectious Disease Hospital; Principal Investigator: Xia Li, Baoding City Infectious Disease Hospital; Principal Investigator: Qian Zhong, Anshan Central Hospita; Principal Investigator: Zhixiong Fang, Xiangtan Central Hospita; Principal Investigator: Xiaoping Xu, Xiangxi Autonomous Prefecture People's Hospital; Principal Investigator: Sihai Li, The First People's Hospital of Yueyang; Principal Investigator: Hui Tian, The People's Hospital Of Xuancheng City; Principal Investigator: Shiquan Ka, The First People's Hospital of Lanzhou City; Principal Investigator: Dongfang Li, Anhui Province Chest Hospital; Principal Investigator: Yuqiang Nie, Guangzhou First People's Hospital; Principal Investigator: Yan Song, Heilongjiang Mudanjiang Nanshan Hospital; Principal Investigator: Xiaoyan Guo, Second Affiliated Hospital of Xi'an JiaoTong University; Principal Investigator: Caiyan Zhao, Hebei Medical University Third Hospital; Principal Investigator: Yuemin Nan, Hebei Medical University Third Hospital; Principal Investigator: Dingguo Wang, People 's Hospital of Kaizhou District, Chongqing City; Principal Investigator: Li Wang, Public health clinical center of chengdu; Principal Investigator: Lixin Tong, First Hospital of Hebei Medical University; Principal Investigator: Hao Wu, West China Hospital,Huaxi University; Principal Investigator: Shurui Piao, Jinshan Hospital Fudan University; Principal Investigator: Lvfeng Yao, Meng Chao Liver and Gallbladder Hospital of Fujian Medical University; Principal Investigator: Yanqing Tian, Affiliated Hospital of Hebei University; Principal Investigator: Zhenbin Hu, The First Affiliated Hospital of Guangxi University of Chinese Medicine; Principal Investigator: Caisheng Wang, No.2 Hospital Of Huhhot; Principal Investigator: Xiaoyan Wang, The Third Xiangya Hospital of Central South University; Principal Investigator: Feng Jin, Shandong Provincial Chest Hospital; Principal Investigator: Yanbo Jiang, Donggang Center Hospital; Principal Investigator: Zhiqiang Wang, The 3Th People's Hospital Of Hengshui; Principal Investigator: Yu Xiong, Shandong Provincial Chest Hospital; Principal Investigator: Xinmei Guo, Shandong Provincial Chest Hospital; Principal Investigator: Yan Zhuang, People's Hospital Of Nongan county; Principal Investigator: Chaoren Zhao, Shandong Provincial Chest Hospital; Principal Investigator: Zhonghua Zhao, Tuberculosis Department, Shandong Provincialchest Hospital; Principal Investigator: Meiying Lin, Tuberculosis Department, Shandong Provincialchest Hospital; Principal Investigator: Jihong Yang, Affiliated Hospital of Hebei University; Principal Investigator: Jingyi Zhang, The Center Hospital Of Maanshan; Principal Investigator: Sangen Chen, People's Hospital Of Jinxian county; Principal Investigator: Yongping Pan, The Fourth Affiliated Hospital of Nanchang University; Principal Investigator: Ruipu Li, Second Central Hospital of Baoding; Principal Investigator: Xueshan Tao, Lushan Tuberculosis Prevention and Control Hospital; Principal Investigator: Shilin Qu, Ganzhou People's Hospital; Principal Investigator: Jie Liu, Jingzhou Chest Hospital; Principal Investigator: Diefeng Yin, People's Hospital Of Luxi county; Principal Investigator: Jianfeng Wu, Chinese Medicine Hospital of Gao'an City; Principal Investigator: Xueqiang Jiang, Sinopharm Dongfeng General Hospital; Principal Investigator: Yong Yang, The 94th Hospital of the People's Liberation Army; Principal Investigator: Chengyun Yang, People's Hospital Of Nanchang county; Principal Investigator: Shengjun Li, People's Hospital Of Xunyang; Principal Investigator: Jizhu Zhang, The Third People's Hospital Of Weifang; Principal Investigator: Jianjun Zhao, The Third People's Hospital Of Weifang; Principal Investigator: Gang Wu, The Third People's Hospital Of Jiujiang City; Principal Investigator: Yong Li, Fengyang County People's Hospital; Principal Investigator: Yansheng Sun, Infectious Disease Hospital Of Heilongjiang Province; Principal Investigator: Xiong Tang, Third People's Hospital Of Jiujiang City; Principal Investigator: Shousong Zhao, First Affiliated Hospital Bengbu Medical College; Principal Investigator: Jiandao Zhang, Lingbi County People's Hospital; Principal Investigator: Long Yu, Liu'an People's Hospital; Principal Investigator: Weihua Xun, Shexian People's Hospital; Principal Investigator: Yong Jia, Anhui Provincial Hospital; Principal Investigator: Yi Li, Anhui Provincial Hospital Infectious Hospital; Principal Investigator: Zhengmao Yang, The Second People's Hospital Of Lanzhou City; Principal Investigator: Jianmin Liu, Zhuzhou No.2 Hospital; Principal Investigator: Huafa Yin, The First Affiliated Hospital of Anhui Medical University; Principal Investigator: Meilong Ding, Anhui Province Xuancheng City Central Hospital; Principal Investigator: Shanlou Hu, People's Hospital Of Dongzhi county; Principal Investigator: Yi Ding, Xiaoxian People's Hospital; Principal Investigator: Weidong Fang, Huangshan City People's Hospital; Principal Investigator: Liu Hong, Anhui Wuhu County Hospital; Principal Investigator: Xiaorong Xu, Bozhou Hospital of Traditional Chinese Medicine; Principal Investigator: Delian Wu, Suzhou Hospital Affiliated To Anhui Medical University; Principal Investigator: Yong Huang, The Second People's Hospital of Hefei; Principal Investigator: Qiliang Tan, Dazhou Central Hospital; Principal Investigator: Songqing Liao, Huainanchaoyang Hospital; Principal Investigator: Bin Yao, The People's Hospital Huaibei; Principal Investigator: Shuiqing Jiang, Huainan First People's Hospital; Principal Investigator: Yanmin Wang, Infectious Disease Hospital Of Baishan; Principal Investigator: Lei Zhang, Anhui Chest Hospital; Principal Investigator: Wenhong Lin, Anhui Chest Hospital; Principal Investigator: Wengang Zhang, Tonghua Central Hospital; Principal Investigator: Chongfeng Gu, The Ninth People's Hospital Of Jilin; Principal Investigator: Zhe Zhang, Jilin Tuberculosis Prevention and Control Institute; Principal Investigator: Junfeng Wang, Jixijikuang Hospital; Principal Investigator: Jie Zhou, Tianjin Tuberculosis Prevention and Control Center; Principal Investigator: Guomin Tang, Renmin Hospital Of Shayang; Principal Investigator: Zhuo Li, Baiyupao Hospital; Principal Investigator: Guohui Zhu, The Third People's Hospital Of Weifang; Principal Investigator: Xingping Liu, The Third People's Hospital Of Weifang; Principal Investigator: Jingen Wang, Zhangshu People's Hospital; Principal Investigator: Xinyan Zhao, Beijing Friendship Hospital; Principal Investigator: Hongliang Liang, Avic 363 Hospital; Principal Investigator: Lijun Liu, Yiyang Central Hospital; Principal Investigator: Fangchun Li, Fengcheng People's Hospital; Principal Investigator: Jianwei Zhou, Xiangdong Hospital Hunan Normal University; Principal Investigator: Zhongrui Su, Zhangjiajie City People's Hospital; Principal Investigator: Wei Xiao, The Third Xiangya Hospital of Central South University; Principal Investigator: Bohui Yuan, Qitaihe Coal Mine Hospital; Principal Investigator: Chun Yang, Beilun People's Hospital; Principal Investigator: Gaizhi Zhang, Luohe Psychiatric Hospital; Principal Investigator: Zhixue Zhang, Qiqihar Tuberculosis Prevention and Control Center; Principal Investigator: Wei Yue, The First People's Hospital of Yunnan; Principal Investigator: Li Zhou, Ningbo Medical Center Lihuili Eastern Hospital; Principal Investigator: Xiaoqing Li, Anqing Municipal Hospitalis; Principal Investigator: Chunge Tian, Dengzhou Central Hospital; Principal Investigator: Tianming Wang, No.1 People's Hospital Of Zhumadian; Principal Investigator: Ji'ao Han, People's Hospital of Zhengzhou University; Principal Investigator: Jingxia Ma, People's Hospital Of Xinye; Principal Investigator: Jie Bao, The First People's Hospital of Xinmi; Principal Investigator: Jianhui Sun, Weihui People's Hospital; Principal Investigator: Xiaoju Luo, Yuanyang Central Hospital; Principal Investigator: Weili Niu, The Third People's Hospital Of Hebi; Principal Investigator: Ming Wang, Hepatobiliary Hospital Of Jilin; Principal Investigator: Yiwen Qiao, Dengzhou Hospital of TCM; Principal Investigator: Chuan Zhao, Suining Infectious Diseases Hospital; Principal Investigator: Xiaoqian Zhang, Anhui Mental Health Center; Principal Investigator: Jingchao Guo, Wugang People's Hospital; Principal Investigator: Weihua Liu, General Hospital of Heilongjiang Provincial Agricultural Reclamation Bureau; Principal Investigator: Feng Wu, Baoji People's Hospital; Principal Investigator: Man Chen, Taian Enliang Hospital; Principal Investigator: Hong Wu, Xiuyan Central Hospital; Principal Investigator: Shansong Bai, Anshan Mental Health Center; Principal Investigator: Xiuying Men, General Hospital of Liaohe Oilfield; Principal Investigator: Yanhua Jiang, Tiefa Coal Group General Hospital; Principal Investigator: Junzu Yang, The People's Hospital Of Lingchengqu; Principal Investigator: Haiyan Zhou, Baoshan Hospital Of Chifeng; Principal Investigator: Yu Feng, The Third Affiliated Hospital of Jinzhou Medical University; Principal Investigator: Yihua Song, Liaoyang City Central Hospital; Principal Investigator: Tao Yang, Panshan Mental Rehabilitation Hospital; Principal Investigator: Yueping Li, Wafangdian Central hospital; Principal Investigator: Guosheng Jiang, People's Hospital Of Ningjinxian; Principal Investigator: Bo Zhang, Taian City Central Hospital; Principal Investigator: Shujun Geng, Hebei Chest Hospital; Principal Investigator: Jin Huang, The Second People's Hospital of Changzhou; Principal Investigator: Fengming Yin, The 169th Hospital Of P.L.A.; Principal Investigator: Weiguo He, Public Health Affiliated Hospital,University Of South China; Principal Investigator: Zhefeng Zhong, Affiliated NanHua Hospital,University Of South China; Principal Investigator: Yuan Yang, First Affiliated Hospital Xi'an Jiaotong University; Principal Investigator: Guoping Fang, The Third People's Hospital of Changzhou; Principal Investigator: Qiang Miao, Tonghua Tuberculosis Prevention and Control Center; Principal Investigator: Xin'guang Huang, The Fourth People's Hospital Of Chenzhou; Principal Investigator: Duanbao Tian, The Fourth People's Hospital of Zibo; Principal Investigator: Yaoming Yuan, People's Hospital Of Shishou; Principal Investigator: Yuzi Lin, Yanji Tuberculosis Prevention and Control Center; Principal Investigator: Ligang Chen, Dunhua Tuberculosis Prevention and Control Center; Principal Investigator: Yu Zhang, Huichun Tuberculosis Prevention and Control Center; Principal Investigator: Chunrong Li, Yanji Brain Hospital; Principal Investigator: Aimin Wu, Yanji Brain Hospital; Principal Investigator: Xiangzhu Bai, Antu Tuberculosis Prevention and Control Center; Principal Investigator: Shaorong Deng, People's Hospital Of Zhongxiang; Principal Investigator: Shaoguang Yang, Tianjin Xiqing Hospital; Principal Investigator: Guohong Ge, People's Hospital Of Zhenjiang; Principal Investigator: Xuebing Yan, The Affiliated Hospital of Xuzhou Medical University; Principal Investigator: Sheng Huang, People's Hospital Of Songzi; Principal Investigator: Gongying Chen, Affiliated Hospital of Hangzhou Normal University; Principal Investigator: Jiehua Li, The First Affiliated Hospital of Anhui Medical University; Principal Investigator: Weiwei Kang, Beijing YouAn Hospital

Study record dates

Study Major Dates

• Study Start: April 1, 2016
• Primary Completion (Anticipated): December 1, 2020
• Study Completion (Anticipated): December 1, 2020

Study Registration Dates

• First Submitted: October 24, 2016
• First Submitted That Met QC Criteria: November 10, 2016
• First Posted (Estimate): November 11, 2016

Study Record Updates

• Last Update Posted (Actual): April 28, 2020
• Last Update Submitted That Met QC Criteria: April 26, 2020
• Last Verified: April 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Chemically-Induced Disorders; Digestive System Diseases; Liver Diseases; Drug-Related Side Effects and Adverse Reactions; Poisoning; Wounds and Injuries; Chemical and Drug Induced Liver Injury
• Other Study ID Numbers: 2012ZX09303-002

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO