Associations Between Air Pollutants Exposures and Respiratory System Study

November 10, 2016 updated by: Bei He, Peking University Third Hospital

Epidemiological investigations has suggested exposure to air pollution linked with respiratory disease, especially chronic obstructive pulmonary disease. However, the potential mechanisms of adverse effects remains scare. The present study will assess the association between air pollutants and respiratory related parameters to elucidate possible mechanisms.

Study Overview

Status

Completed

Conditions

Chronic Obstructive Pulmonary Disease

Study Type

Observational

Enrollment (Actual)

106

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

23 years to 82 years (Adult, Older Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Subjects including health volunteers and COPD patients,both of them without severe cardiopulmonary diseases and long-term residents in Beijing

Description

Inclusion Criteria:

Long-term residents, aged >23 and <82 years

Exclusion Criteria:

Severe cardiopulmonary diseases, active inflammatory diseases, cancer

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Observational Models: Cohort
Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Lung Function indices were performed in peking university third hospital Time Frame: Repeated-measure study was conducted from November,2014 to January,2016,lung function was measured by every four months	Lung Function indices including FEV1(ml), FVC(ml),the ratio of FEV1/FVC et, al.. When we perform data analysis,these parameters will be expressed as the percentage of the predicted values based on the subject-specific sex, age,height and weight.	Repeated-measure study was conducted from November,2014 to January,2016,lung function was measured by every four months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Inflammation related biomarkers were measured by flow cytometry Time Frame: Repeated-measure study was conducted from November,2014 to January,2016,biomarkers were measured by every four months	Inflammation related factors including IL,TNFa et, al. all biomarkers units are pg/ml.	Repeated-measure study was conducted from November,2014 to January,2016,biomarkers were measured by every four months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Peking University Third Hospital

Collaborators

Peking University

Investigators

Study Director: Bei He, MD/Ph.D, Peking University Third Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2014

Primary Completion (Actual)

January 1, 2016

Study Completion (Actual)

January 1, 2016

Study Registration Dates

First Submitted

October 31, 2016

First Submitted That Met QC Criteria

November 10, 2016

First Posted (Estimate)

November 15, 2016

Study Record Updates

Last Update Posted (Estimate)