A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)

October 30, 2023 updated by: AbbVie

A Phase 3 Multicenter, Long-Term Extension Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) in Subjects With Ulcerative Colitis

This study is designed to evaluate the long-term safety and efficacy of Upadacitinib in participants with ulcerative colitis (UC) who have not responded at the end of the induction period in Study M14-234 Substudy 1, who have had loss of response during the maintenance period of Study M14-234 Substudy 3, or who have successfully completed Study M14-234 Substudy 3.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

950

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Argentina
      • Cordoba, Argentina, 5016
        • Hospital Privado Univesitario /ID# 164186
    • Buenos Aires
      • San Isidro, Buenos Aires, Argentina, 1642
        • Cardio Alem /ID# 211281
    • Ciudad Autonoma De Buenos Aires
      • Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina, 1115
        • Gedyt /ID# 210016
      • Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina, 1128
        • Mautalen Salud e Investigacion /ID# 171174
      • Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina, 1280
        • Hospital Britanico de Buenos Aires /ID# 209496
    • Tucuman
      • San Miguel de Tucuman, Tucuman, Argentina, 4000
        • Sanatorio 9 de Julio /ID# 150215
  • Australia
    • New South Wales
      • Macquarie University, New South Wales, Australia, 2109
        • Macquarie University Hospital /ID# 211953
    • Queensland
      • South Brisbane, Queensland, Australia, 4101
        • Mater Misericordiae Limited /ID# 212686
      • Southport, Queensland, Australia, 4222
        • Griffith University /ID# 211954
    • Victoria
      • Clayton, Victoria, Australia, 3168
        • Monash Medical Centre /ID# 150218
      • Fitzroy Melbourne, Victoria, Australia, 3065
        • St Vincent's Hospital Melbourne /ID# 152503
    • Western Australia
      • Murdoch, Western Australia, Australia, 6150
        • Fiona Stanley Hospital /ID# 211641
  • Austria
      • Salzburg, Austria, 5020
        • Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 150463
    • Oberoesterreich
      • Linz, Oberoesterreich, Austria, 4010
        • Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 150462
    • Wien
      • Vienna, Wien, Austria, 1030
        • Klinik Landstrasse /ID# 162867
      • Vienna, Wien, Austria, 1090
        • Medizinische Universitaet Wien /ID# 150616
  • Belarus
      • Витебск, Belarus, 210001
        • Vitebsk Regional Advanced Clin /ID# 169592
  • Belgium
      • Gent, Belgium, 9000
        • AZ Maria Middelares /ID# 150466
    • Vlaams-Brabant
      • Leuven, Vlaams-Brabant, Belgium, 3000
        • Universitair Ziekenhuis Leuven /ID# 150468
    • West-Vlaanderen
      • Roeselare, West-Vlaanderen, Belgium, 8800
        • AZ-Delta /ID# 150467
  • Bosnia and Herzegovina
      • Mostar, Bosnia and Herzegovina, 88000
        • University Clinical Hospital Mostar /ID# 150711
      • Sarajevo, Bosnia and Herzegovina, 71000
        • Clinical Center University of Sarajevo /ID# 150222
    • Republika Srpska
      • Banja Luka, Republika Srpska, Bosnia and Herzegovina, 78000
        • University Clinical Centre of the Republic of Srpska /ID# 150223
      • Banja Luka, Republika Srpska, Bosnia and Herzegovina, 78000
        • University Clinical Centre of the Republic of Srpska /ID# 150712
    • Tuzlanski
      • Tuzla, Tuzlanski, Bosnia and Herzegovina, 75000
        • University Clinical Center Tuzla /ID# 150224
  • Brazil
    • Goias
      • Goiânia, Goias, Brazil, 74535-170
        • Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 153744
    • Parana
      • Curitiba, Parana, Brazil, 80810-040
        • Hospital Nossa Senhora das Graças /ID# 152488
    • Rio Grande Do Sul
      • Porto Alegre, Rio Grande Do Sul, Brazil, 90035-903
        • Hospital de Clinicas de Porto Alegre /ID# 153745
    • Sao Paulo
      • Botucatu, Sao Paulo, Brazil, 18618-686
        • Upeclin Fmb - Unesp /Id# 152493
      • Ribeirão Preto, Sao Paulo, Brazil, 14051-140
        • Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 152492
      • Santo André, Sao Paulo, Brazil, 09060-870
        • Faculdade de Medicina do ABC /ID# 152489
      • Sao Jose Do Rio Preto, Sao Paulo, Brazil, 15015-110
        • Kaiser Clinica e Hospital Dia /ID# 152491
  • Canada
    • Alberta
      • Calgary, Alberta, Canada, T2N 4Z6
        • University of Calgary /ID# 151818
      • Edmonton, Alberta, Canada, T5R 1W2
        • Allen Whey Khye Lim Professional Corporation /ID# 211169
      • Edmonton, Alberta, Canada, T6G 2X8
        • University of Alberta - Zeidler Ledcor Centre /ID# 151824
      • Edmonton, Alberta, Canada, T6K 4B2
        • Covenant Health /ID# 158931
    • British Columbia
      • Kelowna, British Columbia, Canada, V1Y 1Z9
        • OCT Research ULC /ID# 153179
      • Victoria, British Columbia, Canada, V8V 3M9
        • Percuro Clinical Research, Ltd /ID# 150479
    • Ontario
      • Hamilton, Ontario, Canada, L8S 4K1
        • Hamilton Health Sciences - McMaster University Medical Centre /ID# 150477
      • Ottawa, Ontario, Canada, K1H 8L6
        • Ottawa Hospital Research Institute /ID# 151817
      • Sudbury, Ontario, Canada, P3A 1W8
        • Medicor Research Inc /ID# 151825
      • Vaughan, Ontario, Canada, L4L 4Y7
        • Toronto Digestive Disease Associates, Inc. /ID# 150475
    • Quebec
      • Greenfield Park, Quebec, Canada, J4V 2H1
        • CISSS de la Monteregie /ID# 159271
      • Levis, Quebec, Canada, G6V 3Z1
        • Duplicate_CISSS de Chaudière-Appalaches, Hôpital Hotel-Dieu de Lévis /ID# 150473
      • Montreal, Quebec, Canada, H1M 1B1
        • Recherche GCP Research /ID# 151819
      • Montreal, Quebec, Canada, H2X 0A9
        • Centre Hospitalier de l'Universite de Montreal - CRCHUM /ID# 167170
      • Montréal, Quebec, Canada, H3G 1A4
        • Montreal General Hospital - McGill University Health Centre /ID# 170013
      • Sherbrooke, Quebec, Canada, J1G 2E8
        • CIUSSS de l'Estrie - CHUS /ID# 150478
  • Chile
      • Concepción, Chile, 4070038
        • Hospital Guillermo Grant Benavente de Concepción /ID# 212425
      • Providencia, Chile, 7500571
        • CTR Estudios Clinicos /ID# 200111
      • Santiago, Chile, 7501504
        • Hospital Clinico Universidad De Los Andes /ID# 207427
    • Region Metropolitana De Santiago
      • Santiago, Region Metropolitana De Santiago, Chile, 2540364
        • Research Group /ID# 203177
    • Region Metropolitana Santiago
      • Santiago, Region Metropolitana Santiago, Chile, 7750495
        • M y F Estudios Clínicos /ID# 200112
    • Valparaíso
      • Viña del Mar, Valparaíso, Chile, 2540488
        • Centro de Investigaciones Clínicas Viña del Mar /ID# 150226
  • China
      • Shenyang, China, 110022
        • Shengjing Hospital of China Medical University /ID# 166921
      • Tianjin, China, 300052
        • Tianjin Medical University General Hospital /ID# 170605
    • Guangdong
      • Guangzhou, Guangdong, China, 510080
        • The First Affiliated Hospital, Sun Yat-sen University /ID# 150517
      • Guangzhou, Guangdong, China, 510655
        • The Sixth Affiliated Hosp Sun /ID# 150518
    • Hubei
      • Shiyan, Hubei, China, 442700
        • Affiliated Taihe Hospital of Hubei University of Medicine /ID# 216407
      • Wuhan, Hubei, China, 430022
        • Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 167089
      • Wuhan, Hubei, China, 430022
        • Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 167079
    • Hunan
      • Changsha, Hunan, China, 410008
        • Xiangya Hospital Central South University /ID# 167230
    • Jiangxi
      • Nanchang, Jiangxi, China, 330006
        • The First Affiliated Hospital of Nanchang University /ID# 212185
    • Jilin
      • Changchun, Jilin, China, 130021
        • The First Hospital of Jilin University /ID# 210087
    • Shanghai
      • Shanghai, Shanghai, China, 200065
        • Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 150523
      • Shanghai, Shanghai, China, 200127
        • Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 165826
      • Shanghai, Shanghai, China, 200072
        • Shanghai Tenth People's Hospital /ID# 150522
    • Sichuan
      • Chengdu, Sichuan, China, 610041
        • West China Hospital, Sichuan University /ID# 167041
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310009
        • The second Affiliated hospital of Zhejiang University school of Medicine /ID# 165813
      • Hangzhou, Zhejiang, China, 310018
        • Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 150516
  • Colombia
      • Medellin, Colombia
        • Hospital Universitario de San /ID# 155388
    • Cordoba
      • Monteria, Cordoba, Colombia, 230003
        • Oncomedica SAS /ID# 207052
    • Cundinamarca
      • Bogota DC, Cundinamarca, Colombia, 111221
        • Coorp Hosp Juan Ciudad Sede Hospital Universitario Mayor Mederi /ID# 152811
  • Croatia
      • Grad Zagreb, Croatia, 10000
        • Poliklinika Solmed /ID# 211567
      • Zadar, Croatia, 23000
        • Zadar General Hospital /ID# 150261
    • Grad Zagreb
      • Zagreb, Grad Zagreb, Croatia, 10000
        • Klinicki bolnicki centar Zagreb /ID# 150262
      • Zagreb, Grad Zagreb, Croatia, 10000
        • Klinicki bolnicki centar Zagreb /ID# 150715
      • Zagreb, Grad Zagreb, Croatia, 10000
        • Klinicka bolnica Dubrava Zagreb /ID# 150228
    • Osjecko-baranjska Zupanija
      • Osijek, Osjecko-baranjska Zupanija, Croatia, 31000
        • Duplicate_Klinicki bolnicki centar Osijek /ID# 150229
    • Primorsko-goranska Zupanija
      • Rijeka, Primorsko-goranska Zupanija, Croatia, 51000
        • Klinicki bolnicki centar Rijeka /ID# 150714
    • Splitsko-dalmatinska Zupanija
      • Split, Splitsko-dalmatinska Zupanija, Croatia, 21000
        • Klinicki bolnicki centar Split /ID# 213989
  • Czechia
      • Hradec Kralove, Czechia, 500 12
        • Hepato-Gastroenterologie HK, s.r.o. /ID# 150946
      • Olomouc, Czechia, 779 00
        • CTCenter MaVe s.r.o. /ID# 150903
      • Ostrava, Czechia, 722 00
        • ARTROSCAN s.r.o. /ID# 150502
      • Pardubice, Czechia, 530 03
        • Nemocnice Pardubickeho kraje, a.s. /ID# 213541
      • Praha, Czechia, 118 33
        • Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 216224
      • Praha, Czechia, 140 00
        • Axon Clinical, s.r.o. /ID# 152477
      • Praha, Czechia, 190 00
        • ISCARE a.s. /ID# 209279
  • Estonia
      • Tallinn, Estonia, 10617
        • West Tallinn Central Hospital /ID# 150490
    • Harjumaa
      • Mustamäe Linnaosa, Harjumaa, Estonia, 13419
        • North Estonia Medical Centre /ID# 160871
      • Tallinn, Harjumaa, Estonia, 11312
        • East Tallinn Central Hospital /ID# 150488
    • Tartumaa
      • Tartu Linn, Tartumaa, Estonia, 50406
        • Tartu University Hospital /ID# 150489
  • Finland
      • Helsinki, Finland, 00290
        • Duplicate_Helsinki Univ Central Hospital /ID# 154283
      • Jyvaskyla, Finland, 40620
        • Keski-Suomen Sairaala Nova /ID# 155665
      • Mikkeli, Finland, 50100
        • Laakarikeskus Ikioma /ID# 150377
      • Turku, Finland, 20520
        • Turku University Hospital /ID# 169895
    • Pirkanmaa
      • Tampere, Pirkanmaa, Finland, 33520
        • Tampere University Hospital /ID# 150376
  • France
      • La Roche Sur Yon, France, 85000
        • CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 165749
      • SAINT-ETIENNE Cedex 1, France, 42270
        • CHU de Saint-Etienne, Hopital Nord /ID# 165756
    • Alpes-Maritimes
      • Nice, Alpes-Maritimes, France, 06200
        • Chu de Nice-Hopital L'Archet Ii /Id# 152608
    • Auvergne-Rhone-Alpes
      • Pierre Benite CEDEX, Auvergne-Rhone-Alpes, France, 69495
        • HCL - Hopital Lyon Sud /ID# 152540
    • Hauts-de-France
      • Lille, Hauts-de-France, France, 59037
        • CHRU Lille - Hopital Claude Huriez /ID# 152609
    • Herault
      • Montpellier Cedex 5, Herault, France, 34295
        • CHU Montpellier - Hôpital Saint Eloi /ID# 200088
  • Germany
      • Berlin, Germany, 10825
        • MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 151697
      • Frankfurt am Main, Germany, 60431
        • Agaplesion Markus Krankenhaus /ID# 161870
      • Muenster, Germany, 48155
        • Medizinisches Versorgungszentrum Portal 10 /ID# 207136
      • Tübingen, Germany, 72076
        • Universitätsklinikum Tübingen /ID# 151698
      • Wiesbaden, Germany, 65189
        • Praxis medicum /ID# 150404
    • Baden-Wuerttemberg
      • Mannheim, Baden-Wuerttemberg, Germany, 68167
        • Universitatsklinikum Mannheim /ID# 150405
    • Niedersachsen
      • Munster, Niedersachsen, Germany, 48149
        • Universitaetsklinikum Muenster /ID# 150402
    • Nordrhein-Westfalen
      • Herne, Nordrhein-Westfalen, Germany, 44623
        • Gastroenterologische Gemeinschaftspraxis Herne /ID# 214575
    • Saarland
      • Saarbrücken, Saarland, Germany, 66111
        • Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 215812
    • Schleswig-Holstein
      • Kiel, Schleswig-Holstein, Germany, 24105
        • Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 161871
  • Greece
      • Athens, Greece, 10676
        • General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 150406
      • Ioannina, Greece, 45500
        • University General Hospital of Ioannina /ID# 164247
      • Thessaloniki, Greece, 54639
        • Theageneio Anticancer Hospital /ID# 164187
      • Thessaloniki, Greece, 54642
        • General Hospital of Thessaloniki Hippokrateio /ID# 209522
    • Attiki
      • Athens, Attiki, Greece, 11527
        • General Hospital of Athens Laiko /ID# 208672
      • Athens, Attiki, Greece, 11527
        • General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202101
    • Kriti
      • Heraklion, Kriti, Greece, 71500
        • University General Hospital of Heraklion PA.G.N.I /ID# 150236
  • Hungary
      • Bekescsaba, Hungary, 5600
        • Bekes Megyei Kozponti Korhaz /ID# 151601
      • Budapest, Hungary, 1085
        • Semmelweis Egyetem /ID# 150409
      • Kecskemet, Hungary, 6000
        • Meditres Kft. /ID# 151597
      • Sopron, Hungary, 9400
        • Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet /ID# 151599
      • Szekesfehervar, Hungary, 8000
        • Mentahaz Maganorvosi Kozpont /ID# 206977
    • Vas
      • Szombathely, Vas, Hungary, 9700
        • Markusovszky Egyetemi Oktatokorhaz /ID# 150410
  • Ireland
      • Cork, Ireland, T12 WE28
        • Mercy University Hospital /ID# 153794
      • Galway, Ireland, H91 YR71
        • University Hospital Galway /ID# 150412
    • Dublin
      • Beaumont, Dublin, Ireland, D09 XR63
        • Beaumont Hospital /ID# 150414
      • Dublin 8, Dublin, Ireland, D08 NHY1
        • St James Hospital /ID# 150413
      • Elm Park, Dublin, Ireland, D04 T6F4
        • St Vincent's University Hospital /ID# 150411
  • Israel
    • H_efa
      • Haifa, H_efa, Israel, 3109601
        • Rambam Health Care Campus /ID# 150416
    • HaDarom
      • Be'er Sheva, HaDarom, Israel, 8410101
        • Soroka University Medical Center /ID# 156562
    • Yerushalayim
      • Jerusalem, Yerushalayim, Israel, 91120
        • Hadassah Medical Center-Hebrew University /ID# 165119
      • Jerusalem, Yerushalayim, Israel, 91031
        • Shaare Zedek Medical Center /ID# 163139
  • Italy
      • Bologna, Italy, 40138
        • IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 150424
      • Milan, Italy, 20122
        • Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 150421
      • Milano, Italy, 20121
        • ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 150605
      • Palermo, Italy, 90146
        • A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 150263
    • Lazio
      • Rome, Lazio, Italy, 00152
        • Azienda Ospedaliera San Camillo Forlanini /ID# 151362
    • Milano
      • Rho, Milano, Italy, 20017
        • ASST Rhodense/Presidio Ospedaliero di Rho /ID# 216673
      • Rozzano, Milano, Italy, 20089
        • Istituto Clinico Humanitas /ID# 151363
    • Roma
      • Rome, Roma, Italy, 00168
        • Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 150420
      • Rome, Roma, Italy, 00133
        • Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 150425
    • Verona
      • Negrar, Verona, Italy, 37024
        • IRCCS Ospedale Sacro Cuore Don Calabria /ID# 201726
  • Japan
      • Takatsuki-shi, Japan, 569-0086
        • Shoyukai Fujita Gastroenterological Hospital /ID# 216494
    • Aichi
      • Nagakute-shi, Aichi, Japan, 480-1195
        • Aichi Medical University Hospital /ID# 151994
      • Nagoya shi, Aichi, Japan, 467-8602
        • Nagoya City University Hospital /ID# 151949
      • Nagoya-shi, Aichi, Japan, 4668560
        • Nagoya University Hospital /ID# 152728
      • Toyohashi-shi, Aichi, Japan, 441-8570
        • Toyohashi Municipal Hospital /ID# 171470
      • Toyota-shi, Aichi, Japan, 470-1219
        • Ieda Hospital /ID# 157782
    • Aomori
      • Hirosaki-shi, Aomori, Japan, 036-8545
        • National Hospital Organization Hirosaki General Medical Center /ID# 152761
    • Chiba
      • Abiko-shi, Chiba, Japan, 270-1168
        • Tokatsu Tsujinaka Hospital /ID# 214964
      • Kashiwa-shi, Chiba, Japan, 277-0871
        • Tsujinaka Hospital Kashiwanoha /ID# 209572
      • Sakura-shi, Chiba, Japan, 285-8741
        • Toho University Sakura Medical Center /ID# 151935
      • Urayasu-shi, Chiba, Japan, 279-0021
        • Juntendo University Urayasu Hospital /ID# 208783
    • Fukui
      • Fukui-shi, Fukui, Japan, 910-8526
        • Fukui Prefectural Hospital /ID# 210450
    • Fukuoka
      • Chikushino-shi, Fukuoka, Japan, 818-8502
        • Fukuoka University Chikushi Hospital /ID# 152627
      • Fukuoka-shi, Fukuoka, Japan, 810-0001
        • Saiseikai Fukuoka Genaral Hospital /ID# 209481
      • Fukuoka-shi, Fukuoka, Japan, 812-8582
        • Kyushu University Hospital /ID# 152525
      • Kitakyushu, Fukuoka, Japan, 8020077
        • Kitakyushu Municipal Medical Center /ID# 152589
      • Kurume-shi, Fukuoka, Japan, 830-0011
        • Kurume University Hospital /ID# 151977
    • Gifu
      • Ogaki-shi, Gifu, Japan, 503-8502
        • Ogaki Municipal Hospital /ID# 208226
    • Hiroshima
      • Fukuyama-shi, Hiroshima, Japan, 720-8520
        • NHO Fukuyama Medical Center /ID# 206294
      • Hiroshima-shi, Hiroshima, Japan, 734-8551
        • Hiroshima University Hospital /ID# 151952
    • Hokkaido
      • Asahikawa-shi, Hokkaido, Japan, 078-8510
        • Asahikawa Medical University Hospital /ID# 170281
      • Obihiro-shi, Hokkaido, Japan, 080-0024
        • Obihiro kosei Hospital /ID# 210425
      • Sapporo-shi, Hokkaido, Japan, 004-0041
        • Sapporo Tokushukai Hospital /ID# 209449
      • Sapporo-shi, Hokkaido, Japan, 060-0033
        • Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 151705
      • Sapporo-shi, Hokkaido, Japan, 060-8543
        • Sapporo Medical University Hospital /ID# 206493
      • Sapporo-shi, Hokkaido, Japan, 065-0033
        • Sapporo Higashi Tokushukai Hospital /ID# 208495
    • Hyogo
      • Kobe-shi, Hyogo, Japan, 650-0015
        • Aoyama Clinic /ID# 152048
      • Nishinomiya-shi, Hyogo, Japan, 663-8501
        • Hyogo Medical University Hospital /ID# 152433
    • Ibaraki
      • Higashi Ibaraki-gun, Ibaraki, Japan, 311-3193
        • National Hospital Organization Mito Medical Center /ID# 152626
    • Ishikawa
      • Kanazawa-shi, Ishikawa, Japan, 920-8641
        • Kanazawa University Hospital /ID# 207810
    • Iwate
      • Morioka-shi, Iwate, Japan, 020-8505
        • Iwate Medical University Uchimaru Medical Center /ID# 203412
    • Kagoshima
      • Kagoshima-shi, Kagoshima, Japan, 890-0064
        • Imamura General Hospital /ID# 227138
      • Kagoshima-shi, Kagoshima, Japan, 892-0824
        • Idzuro Imamura Hospital /ID# 207640
      • Kagoshima-shi, Kagoshima, Japan, 892-0846
        • Sameshima Hospital /ID# 206673
      • Kagoshima-shi, Kagoshima, Japan, 8920804
        • Kagoshima IBD Gastroenterology Clinic /ID# 245222
    • Kanagawa
      • Kawasaki-shi, Kanagawa, Japan, 216-8511
        • St. Marianna University Hospital /ID# 209452
      • Yokohama shi, Kanagawa, Japan, 232-0024
        • Yokohama City University Medical Center /ID# 169900
      • Yokohama-shi, Kanagawa, Japan, 227-8501
        • Showa University Fujigaoka Hospital /ID# 208223
    • Kyoto
      • Kyoto-shi, Kyoto, Japan, 605-0981
        • Japanese Red Cross Kyoto Daiichi Hosital /ID# 152358
      • Kyoto-shi, Kyoto, Japan, 606-8507
        • Kyoto University Hospital /ID# 211808
    • Mie
      • Tsu-shi, Mie, Japan, 514-8507
        • Mie University Hospital /ID# 207253
      • Yokkaichi-shi, Mie, Japan, 510-0016
        • Yokkaichi Hazu Medical Center /ID# 214349
    • Miyagi
      • Sendai-shi, Miyagi, Japan, 983-8520
        • National Hospital Organization Sendai Medical Center /ID# 209529
    • Nagasaki
      • Omura-shi, Nagasaki, Japan, 856-8562
        • NHO Nagasaki Medical Center /ID# 210821
    • Nara
      • Yamatotakada-shi, Nara, Japan, 635-0022
        • Kenseikai Dongo Hospital /ID# 208102
    • Niigata
      • Niigata-shi, Niigata, Japan, 950-1104
        • Saiseikai Niigata Hospital /ID# 209923
      • Niigata-shi, Niigata, Japan, 951-8520
        • Niigata University Medical & Dental Hospital /ID# 218050
    • Oita
      • Oita-shi, Oita, Japan, 870-0823
        • Ishida Clinic of IBD and Gastroenterology /ID# 210118
    • Okayama
      • Kurashiki-shi, Okayama, Japan, 710-0142
        • Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 157820
      • Okayama-shi, Okayama, Japan, 700-8558
        • Okayama University Hospital /ID# 217924
    • Osaka
      • Osaka-shi, Osaka, Japan, 530-0011
        • Kinshukai Infusion Clinic /ID# 207866
      • Osaka-shi, Osaka, Japan, 534-0021
        • Osaka City General Hospital /ID# 152703
      • Osaka-shi, Osaka, Japan, 543-8555
        • Japanese Red Cross Osaka Hospital /ID# 209477
      • Osaka-shi, Osaka, Japan, 530-8480
        • Kitano Hospital, Tazuke Kofukai Medical Research Institute /ID# 210396
      • Osaka-shi, Osaka, Japan, 545-8586
        • Osaka Metropolitan University Hospital /ID# 152681
      • Toyonaka-shi, Osaka, Japan, 560-0055
        • Toyonaka Municipal Hospital /ID# 217083
    • Saga
      • Saga-shi, Saga, Japan, 849-8501
        • Saga University Hospital /ID# 209272
    • Saitama
      • Kawagoe-shi, Saitama, Japan, 350-8550
        • Saitama Medical Center /ID# 152019
      • Saitama-shi, Saitama, Japan, 336-0963
        • Tokitokai Tokito clinic /ID# 152676
    • Shiga
      • Higashi-ohmi-shi, Shiga, Japan, 527-8505
        • National Hospital Organization Higashi-Ohmi General Medical Center /ID# 210711
    • Shimane
      • Izumo-shi, Shimane, Japan, 693-8501
        • Shimane University Hospital /ID# 208906
    • Shizuoka
      • Hamamatsu-shi, Shizuoka, Japan, 431-3192
        • Hamamatsu University Hospital /ID# 205709
      • Sunto-gun, Shizuoka, Japan, 411-8611
        • NHO Shizuoka Medical Center /ID# 163571
    • Tokyo
      • Bunkyo-ku, Tokyo, Japan, 113-8519
        • Tokyo Medical And Dental University Hospital /ID# 152017
      • Chuo-ku, Tokyo, Japan, 104-8560
        • St.Luke's International Hospital /ID# 208075
      • Hachioji-shi, Tokyo, Japan, 192-0032
        • Tokai University Hachioji Hospital /ID# 152584
      • Itabashi-ku, Tokyo, Japan, 173-8606
        • Teikyo University Hospital /ID# 209865
      • Minato-ku, Tokyo, Japan, 108-8642
        • Kitasato University Kitasato Institute Hospital /ID# 152687
      • Mitaka-shi, Tokyo, Japan, 181-8611
        • Kyorin University Hospital /ID# 153195
      • Shinjuku-ku, Tokyo, Japan, 162-8655
        • Center Hospital of the National Center for Global Health and Medicine /ID# 209533
      • Shinjuku-ku, Tokyo, Japan, 162-8666
        • Tokyo Women's Medical University Hospital /ID# 205978
    • Yamagata
      • Yamagata-shi, Yamagata, Japan, 990-9585
        • Yamagata University Hospital /ID# 171468
    • Yamaguchi
      • Shunan-shi, Yamaguchi, Japan, 745-8522
        • Tokuyama Central Hospital /ID# 216995
    • Yamanashi
      • Kofu-shi, Yamanashi, Japan, 400-8506
        • Yamanashi Prefectural Central Hospital /ID# 151909
  • Korea, Republic of
      • Busan, Korea, Republic of, 49201
        • Dong-A University Hospital /ID# 161568
      • Busan, Korea, Republic of, 49241
        • Pusan National University Hospital /ID# 161569
      • Daegu, Korea, Republic of, 42415
        • Yeungnam University Medical Center /ID# 150432
      • Seoul, Korea, Republic of, 05505
        • Asan Medical Center /ID# 159155
      • Seoul, Korea, Republic of, 06351
        • Samsung Medical Center /ID# 150433
    • Gyeonggido
      • Guri, Gyeonggido, Korea, Republic of, 11923
        • Hanyang University Gurihospital /ID# 150431
      • Seongnam, Gyeonggido, Korea, Republic of, 13496
        • CHA University Bundang Medical Center /ID# 161567
      • Suwon, Gyeonggido, Korea, Republic of, 16247
        • The Catholic University of Korea, ST. Vincent's Hospital /ID# 150434
    • Seoul Teugbyeolsi
      • Seoul, Seoul Teugbyeolsi, Korea, Republic of, 03181
        • Kangbuk Samsung Hospital /ID# 150435
      • Seoul, Seoul Teugbyeolsi, Korea, Republic of, 03722
        • Yonsei University Health System Severance Hospital /ID# 161566
  • Latvia
      • Riga, Latvia, 1035
        • VCA Polyclinic Aura /ID# 150436
      • Riga, Latvia, LV- 1002
        • Pauls Stradins Clinical University Hospital /ID# 153183
  • Lithuania
      • Kaunas, Lithuania, 50161
        • Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 150439
      • Klaipeda, Lithuania, 92288
        • Klaipeda University Hospital /ID# 163719
      • Klaipeda, Lithuania, 92288
        • Klaipeda university hospital /ID# 163501
      • Vilnius, Lithuania, LT-08661
        • Vilnius University Hospital /ID# 164172
  • Malaysia
      • Ampang, Malaysia, 68000
        • Hospital Ampang /ID# 152311
      • Kuala Lumpur, Malaysia, 59100
        • Uni Malaya MC /ID# 150440
    • Kedah
      • Alor Setar, Kedah, Malaysia, 05460
        • Hospital Sultanah Bahiyah /ID# 152310
    • Selangor
      • Kuala Lumpur, Selangor, Malaysia, 56000
        • Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 152313
  • Mexico
    • Guanajuato
      • Leon, Guanajuato, Mexico, 37000
        • Morales Vargas Centro de Investigacion S.C. /ID# 211327
    • Jalisco
      • Guadalajara, Jalisco, Mexico, 44650
        • Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 202334
    • Nuevo Leon
      • Monterrey, Nuevo Leon, Mexico, 64610
        • Centro Regiomontano de Estudios Clínicos ROMA S.C /ID# 150265
  • Netherlands
      • Amsterdam, Netherlands, 1105 AZ
        • Academisch Medisch Centrum /ID# 150617
      • Leiden, Netherlands, 2333 ZA
        • Leids Universitair Medisch Centrum /ID# 152625
      • Utrecht, Netherlands, 3584 CX
        • Universitair Medisch Centrum Utrecht /ID# 152776
    • Gelderland
      • Nijmegen, Gelderland, Netherlands, 6525 GA
        • Radboud Universitair Medisch Centrum /ID# 151701
    • Zuid-Holland
      • Rotterdam, Zuid-Holland, Netherlands, 3015 GD
        • Erasmus Medisch Centrum /ID# 150619
  • Norway
    • Akershus
      • Lorenskog, Akershus, Norway, 1478
        • Akershus Universitetssykehus_MAIN /ID# 150622
    • Troms
      • Tromsø, Troms, Norway, 9019
        • Universitetssykehuset Nord-Norge /ID# 152836
  • Poland
    • Kujawsko-pomorskie
      • Torun, Kujawsko-pomorskie, Poland, 87-100
        • Gastromed Sp. z o.o /ID# 216198
    • Mazowieckie
      • Warszawa, Mazowieckie, Poland, 00-635
        • Centrum Zdrowia MDM /ID# 150626
      • Warszawa, Mazowieckie, Poland, 04-730
        • Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 215733
      • Warszawa, Mazowieckie, Poland, 02-665
        • Centrum Medyczne Reuma Park /ID# 150624
      • Warszawa, Mazowieckie, Poland, 03-580
        • NZOZ Vivamed Jadwiga Miecz /ID# 216743
      • Warszawa, Mazowieckie, Poland, 02-507
        • Panstwowy Instytut Medyczny MSWiA w Warszawie /ID# 150627
    • Pomorskie
      • Sopot, Pomorskie, Poland, 81-756
        • Endoskopia Sp. z o.o. /ID# 152940
  • Portugal
      • Almada, Portugal, 2805-267
        • Hospital Garcia de Orta, EPE /ID# 151622
      • Braga, Portugal, 4710-243
        • CCA Braga - Hospital de Braga /ID# 151617
      • Lisboa, Portugal, 1169-050
        • Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 151620
      • Lisboa, Portugal, 1649-035
        • Centro Hospitalar Universitario de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 151615
      • Porto, Portugal, 4200-319
        • Centro Hospitalar Universitario de Sao Joao, EPE /ID# 151619
    • Braga
      • Guimaraes, Braga, Portugal, 4835-044
        • Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 151616
    • Porto
      • Santa Maria Da Feira, Porto, Portugal, 4520-211
        • Centro Hospitalar de Entre Douro e Vouga /ID# 152336
    • Viana Do Castelo
      • Ponte de Lima, Viana Do Castelo, Portugal, 4990-041
        • Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 151618
  • Puerto Rico
      • San Juan, Puerto Rico, 00935
        • School of Medicine University of Puerto Rico-Medical Science Campus /ID# 150629
  • Russian Federation
      • Moscow, Russian Federation, 105554
        • Olla-Med Clinic /ID# 215334
      • Petrozavodsk, Russian Federation, 185019
        • Republican hospital named after V.A. Baranov /ID# 206508
      • Pushkin, Russian Federation, 196603
        • Euromedservice /ID# 208968
      • Stavropol, Russian Federation, 355017
        • Duplicate_Stavropol State Medical Univ /ID# 150635
    • Kaliningradskaya Oblast
      • Kaliningrad, Kaliningradskaya Oblast, Russian Federation, 236016
        • Immanuel Kant Baltic Federal University /ID# 202129
    • Leningradskaya Oblast
      • St. Petersburg, Leningradskaya Oblast, Russian Federation, 191015
        • NW State Medical Univ na Mechn /ID# 169332
    • Permskiy Kray
      • Perm, Permskiy Kray, Russian Federation, 614109
        • Perm Clinical Center of the Federal Medical and Biological Agency /ID# 150634
    • Samarskaya Oblast
      • Samara, Samarskaya Oblast, Russian Federation, 443063
        • Medical Company Hepatolog /ID# 200208
    • Stavropol Skiy Kray
      • Pyatigorsk, Stavropol Skiy Kray, Russian Federation, 357500
        • LLC Novaya Klinika /ID# 208106
    • Tatarstan, Respublika
      • Kazan, Tatarstan, Respublika, Russian Federation, 420012
        • Kazan State Medical University /ID# 166040
  • Serbia
      • Leskovac, Serbia, 16000
        • General Hospital Leskovac /ID# 217882
    • Beograd
      • Belgrade, Beograd, Serbia, 11000
        • Clinical Hosp Center Zvezdara /ID# 150641
      • Belgrade, Beograd, Serbia, 11000
        • Military Medical Academy /ID# 150643
      • Belgrade, Beograd, Serbia, 11000
        • University Clinical Center Serbia /ID# 150642
      • Belgrade, Beograd, Serbia, 11080
        • Clin Hosp Ctr Bezanijska Kosa /ID# 150640
    • Nisavski Okrug
      • NIS, Nisavski Okrug, Serbia, 18000
        • University Clinical Center of Nis /ID# 151902
    • Sumadijski Okrug
      • Kragujevac, Sumadijski Okrug, Serbia, 34000
        • University Clinical Center Kragujevac /ID# 150644
    • Vojvodina
      • Novi Sad, Vojvodina, Serbia, 21000
        • Clinical Center Vojvodina /ID# 150759
  • Singapore
      • Singapore, Singapore, 119074
        • National University Hospital /ID# 150583
      • Singapore, Singapore, 258499
        • Gleneagles Medical Centre /ID# 206020
      • Singapore, Singapore, 308433
        • Tan Tock Seng Hospital /ID# 150646
  • Slovakia
      • Banska Bystrica, Slovakia, 975 17
        • Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 150869
      • Bratislava, Slovakia, 851 01
        • Medak s.r.o. /ID# 150550
      • Ilava, Slovakia, 019 01
        • Slovak Research Center Team Me /ID# 150240
      • Kosice, Slovakia, 040 01
        • B+B MED, s.r.o. /ID# 150584
      • Nove Zamky, Slovakia, 940 34
        • Fakultna nemocnica s poliklinikou Nove Zamky /ID# 211371
      • Presov, Slovakia, 080 01
        • GASTRO I., s.r.o. /ID# 150585
  • South Africa
    • Gauteng
      • Boksburg North, Gauteng, South Africa, 1460
        • MD Search /ID# 157524
      • Johannesburg, Gauteng, South Africa, 1619
        • Clinresco Centers /ID# 163625
      • Johannesburg, Gauteng, South Africa, 1820
        • Lenasia Clinical Trial Centre /ID# 214361
      • Johannesburg, Gauteng, South Africa, 2193
        • Wits Clinical Research , Wits Health Consortium (PTY) Ltd /ID# 157730
      • Johannesburg, Gauteng, South Africa, 2193
        • Wits Clinical Research Site /ID# 150586
    • Western Cape
      • CAPE TOWN Milnerton, Western Cape, South Africa, 7441
        • Spoke Research Inc /ID# 162203
      • Cape Town, Western Cape, South Africa, 7708
        • Kingsbury Hospital /ID# 150587
      • Cape Town, Western Cape, South Africa, 7800
        • Private Practice Dr MN Rajabally /ID# 155145
  • Spain
      • A Coruna, Spain, 15006
        • Hospital Universitario A Coruna - CHUAC /ID# 203912
      • Barcelona, Spain, 08036
        • Hospital Clinic de Barcelona /ID# 150598
      • Cordoba, Spain, 14004
        • Hospital Universitario Reina Sofia /ID# 154031
      • Madrid, Spain, 28034
        • Hospital Universitario Ramon y Cajal /ID# 171491
      • Madrid, Spain, 28046
        • Hospital Universitario La Paz /ID# 214541
      • Salamanca, Spain, 37711
        • Hospital Universitario de Salamanca /ID# 150590
      • Valencia, Spain, 46026
        • Hospital Universitario y Politecnico La Fe /ID# 150591
    • A Coruna
      • Santiago de Compostela, A Coruna, Spain, 15706
        • Hospital Clínico Universitario de Santiago-CHUS /ID# 171492
    • Cantabria
      • Santander, Cantabria, Spain, 39008
        • Hospital Unversitario Marques de Valdecilla /ID# 216621
    • Las Palmas
      • Las Palmas de Gran Canaria, Las Palmas, Spain, 35019
        • Hospital Universitario Dr. Negrin /ID# 203965
  • Sweden
    • Vastra Gotalands Lan
      • Gothenburg, Vastra Gotalands Lan, Sweden, 413 45
        • Sahlgrenska University Hospital /ID# 152326
  • Switzerland
      • Bern, Switzerland, 3010
        • Inselspital, Universitätsspital Bern /ID# 152602
    • Basel-Stadt
      • Basel, Basel-Stadt, Switzerland, 4031
        • Universitätsspital Basel /ID# 161732
    • Sankt Gallen
      • St. Gallen, Sankt Gallen, Switzerland, 9007
        • Kantonsspital St. Gallen /ID# 152601
    • Zuerich
      • Zurich, Zuerich, Switzerland, 8091
        • Universitatsspital Zurich /ID# 152603
  • Taiwan
      • Kaohsiung, Taiwan, 807
        • Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 150606
      • Taichung, Taiwan, 40201
        • Chung Shan Medical University Hospital /ID# 150603
      • Taichung, Taiwan, 40447
        • China Medical University Hospital /ID# 150600
      • Tainan, Taiwan, 704
        • National Cheng Kung University Hospital /ID# 151751
      • Taipei, Taiwan, 11217
        • Taipei Veterans General Hosp /ID# 151750
      • Taipei City, Taiwan, 100
        • National Taiwan University Hospital /ID# 150604
  • Turkey
      • Cerrahpasa, Turkey, 34098
        • Istanbul University Cerrahpasa Faculty of Medicine /ID# 150491
      • Istanbul, Turkey, 34764
        • Umraniye Training and Res Hosp /ID# 163136
      • Istanbul, Turkey, 34899
        • Marmara University Medical Fac /ID# 214573
      • Mersin, Turkey, 33343
        • Mersin University Medical /ID# 163135
    • Ankara
      • Yenimahalle, Ankara, Turkey, 06560
        • Gazi Universitesi Tip Fakultes /ID# 150493
    • Kayseri
      • Melikgazi, Kayseri, Turkey, 38030
        • Erciyes University Medical Fac /ID# 150495
  • Ukraine
      • Dnipro, Ukraine, 49005
        • Municipal Enterprise "I.I. Mechnikov Dnipropetrovsk Regional Clinical Hospital" /ID# 207731
      • Kharkiv, Ukraine, 61058
        • CNCE of Kharkiv Regional Council Regional Clinical Hospital /ID# 206941
      • Kropyvnytskyi, Ukraine, 25006
        • PE PMC Acinus, Medical and Diagnostic Center /ID# 217219
      • Kyiv, Ukraine, 04050
        • Medical Center CONSILIUM MEDICAL /ID# 217448
      • Kyiv, Ukraine, 04073
        • CNPE of Kyiv Regional Council Kyiv Regional Hospital /ID# 217374
      • Kyiv, Ukraine, 01030
        • Kyiv City Clinical Hospital No.18 /ID# 150505
      • Lviv, Ukraine, 79010
        • Lviv Regional Clinical Hospital /ID# 150508
      • Odesa, Ukraine, 65025
        • Municipal Non-Commercial Enterprise Odesa Regional Clinical Hospital of the Od /ID# 162502
      • Vinnytsia, Ukraine, 21028
        • CNE Vinnytsya Regional Clinical Hospital named after N.I.Pirogov /ID# 216302
    • Vinnytska Oblast
      • Vinnytsya, Vinnytska Oblast, Ukraine, 21009
        • Medical Center of the "Health /ID# 162501
  • United Kingdom
      • Bath, United Kingdom, BA1 3NG
        • Royal United Hospitals Bath /ID# 154211
      • Birmingham, United Kingdom, B15 2TH
        • University Hospitals Birmingham NHS Foundation Trust /ID# 150513
      • Huddersfield, United Kingdom, HX3 0PW
        • Calderdale and Huddersfield NHS Foundation Trust /ID# 217659
      • Tooting, United Kingdom, SW17 0QT
        • St George's University Hospitals NHS Foundation Trust /ID# 208376
    • Devon
      • Exeter, Devon, United Kingdom, EX2 5DW
        • Royal Devon University Healthcare NHS Foundation Trust /ID# 150510
    • Essex
      • Basingstoke, Essex, United Kingdom, RG24 9NA
        • Hampshire Hospitals NHS Foundation Trust /ID# 150511
    • London, City Of
      • London, London, City Of, United Kingdom, E1 2ES
        • Barts Health NHS Trust /ID# 150515
    • Scotland
      • Glasgow, Scotland, United Kingdom, G12 0XH
        • NHS Greater Glasgow and Clyde /ID# 163788
  • United States
    • Alabama
      • Mobile, Alabama, United States, 36606
        • East View Medical Research, LLC /ID# 171184
      • Mobile, Alabama, United States, 36608
        • CB Flock Research Corporation /ID# 165986
    • Arizona
      • Chandler, Arizona, United States, 85224
        • Delsol Research Management, Ll /Id# 170130
      • Mesa, Arizona, United States, 85206
        • Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211886
      • Sun City, Arizona, United States, 85306
        • Arizona Arthritis & Rheumatology Research, PLLC /ID# 169823
      • Tucson, Arizona, United States, 85712
        • Adobe Clinical Research LLC /ID# 155249
      • Tucson, Arizona, United States, 85724
        • University of Arizona /ID# 150568
    • California
      • Covina, California, United States, 91722-3797
        • Citrus Valley Gastroenterology /ID# 151915
      • Huntington Beach, California, United States, 92648-5994
        • Newport Huntington Medical Group /ID# 217006
      • La Jolla, California, United States, 92037
        • UC San Diego Health System /ID# 155187
      • Los Alamitos, California, United States, 90720-3309
        • United Medical Doctors /ID# 207467
      • Los Angeles, California, United States, 90048
        • TLC Clinical Research Inc /ID# 216830
      • Los Angeles, California, United States, 90067-2001
        • Gastrointestinal Biosciences Clinical Trials, LLC /ID# 157082
      • Mission Hills, California, United States, 91345
        • Facey Medical Foundation /ID# 203135
      • Murrieta, California, United States, 92563
        • United Medical Doctors - Murrieta /ID# 151213
      • Oxnard, California, United States, 93030
        • InSite Digestive Health Care - Oxnard /ID# 163417
      • Rialto, California, United States, 92377
        • Inland Empire Clinical Trials, LLC /ID# 216163
      • San Diego, California, United States, 92120
        • San Diego Clinical Trials /ID# 212121
      • San Diego, California, United States, 92123
        • Medical Assoc Research Grp /ID# 169149
      • San Francisco, California, United States, 94158
        • Univ of California San Francis /ID# 164583
    • Colorado
      • Colorado Springs, Colorado, United States, 80918
        • Delta Waves, Inc. /ID# 151727
      • Lone Tree, Colorado, United States, 80124
        • South Denver Gastroenterology /ID# 151224
      • Wheat Ridge, Colorado, United States, 80033-2896
        • Western States Clinical Res /ID# 158078
    • Connecticut
      • Danbury, Connecticut, United States, 06810
        • Western Connecticut Medical Group /ID# 169211
      • Hamden, Connecticut, United States, 06518
        • Medical Research Center of CT /ID# 150534
    • Florida
      • Clearwater, Florida, United States, 33762
        • West Central Gastroenterology /ID# 155242
      • Doral, Florida, United States, 33166
        • Moonshine Research Center, Inc /ID# 152534
      • Doral, Florida, United States, 33166
        • Universal Axon Clinical Research /ID# 213463
      • Hialeah, Florida, United States, 33016
        • Palmetto Research, LLC /ID# 151724
      • Inverness, Florida, United States, 34452-4717
        • Nature Coast Clinical Research - Inverness /ID# 154070
      • Jacksonville, Florida, United States, 32256
        • Encore Borland-Groover Clinical Research /Id# 170913
      • Kissimmee, Florida, United States, 34741-4161
        • SIH Research Mumtaz, Inc /ID# 163199
      • Maitland, Florida, United States, 32751-6108
        • Cfagi Llc /Id# 202018
      • Miami, Florida, United States, 33136
        • University of Miami /ID# 215443
      • Miami, Florida, United States, 33165-3372
        • New Horizon Research Center /ID# 152475
      • Miami, Florida, United States, 33165
        • Crystal Pharmacology Research /ID# 151848
      • Miami, Florida, United States, 33186-4643
        • Coral Research Clinic /ID# 150524
      • Miami, Florida, United States, 33147
        • Advanced Pharma CR, LLC /ID# 151723
      • New Port Richey, Florida, United States, 34653
        • Advanced Research Institute, Inc /ID# 163093
      • Orlando, Florida, United States, 32803
        • Endoscopic Research, Inc. /ID# 151725
      • Orlando, Florida, United States, 32808
        • Omega Research Group /ID# 200271
      • Tampa, Florida, United States, 33607
        • Clinical Research Trials of Florida, Inc. /ID# 201791
      • Tampa, Florida, United States, 33612
        • University of South Florida /ID# 214494
      • Tampa, Florida, United States, 33613-4680
        • AdventHealth Tampa /ID# 200274
    • Georgia
      • Macon, Georgia, United States, 31201
        • Gastroenterology Associates of Central Georgia, LLC /ID# 165783
      • Riverdale, Georgia, United States, 30274
        • Infinite Clinical Trials /ID# 215342
      • Suwanee, Georgia, United States, 30024
        • Atlanta Gastroenterology Spec /ID# 150565
    • Illinois
      • Chicago, Illinois, United States, 60605-2168
        • Next Innovative Clinical Research - Chicago /ID# 217323
      • Chicago, Illinois, United States, 60637
        • The University of Chicago DCAM /ID# 150564
      • Evanston, Illinois, United States, 60201
        • NorthShore University HealthSystem /ID# 150570
      • Hoffman Estates, Illinois, United States, 60169
        • Northwest Health Care Associates /ID# 151591
      • Urbana, Illinois, United States, 61801
        • Carle Foundation Hospital /ID# 151155
    • Indiana
      • Evansville, Indiana, United States, 47714-8011
        • MediSphere Medical Research Center /ID# 152080
      • Indianapolis, Indiana, United States, 46237
        • Indianapolis Gastroenterology /ID# 162914
    • Iowa
      • Iowa City, Iowa, United States, 52242
        • University of Iowa Hospitals and Clinics /ID# 157059
    • Kansas
      • Topeka, Kansas, United States, 66606
        • Cotton O'Neil Clinical Research Center, Digestive Health /ID# 167183
    • Kentucky
      • Crestview Hills, Kentucky, United States, 41017
        • Tri-State Gastroenterology /ID# 169812
    • Louisiana
      • Houma, Louisiana, United States, 70360
        • Houma Digestive Health Special /ID# 151851
      • New Orleans, Louisiana, United States, 70115
        • Nola Research Works, LLC /ID# 153365
      • Shreveport, Louisiana, United States, 71105-6800
        • Louisiana Research Center, LLC /ID# 150526
    • Maryland
      • Baltimore, Maryland, United States, 21201
        • University of Maryland Med Ctr /ID# 150529
      • Columbia, Maryland, United States, 21045
        • Gastro Center of Maryland /ID# 200024
    • Massachusetts
      • Boston, Massachusetts, United States, 02114
        • Massachusetts General Hospital /ID# 165678
    • Michigan
      • Ann Arbor, Michigan, United States, 48109
        • University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 151158
      • Ann Arbor, Michigan, United States, 48197
        • Huron Gastroenterology Assoc /ID# 152712
      • Chesterfield, Michigan, United States, 48047
        • Clin Res Inst of Michigan, LLC /ID# 153031
      • Chesterfield, Michigan, United States, 48047
        • Clin Res Inst of Michigan, LLC /ID# 161983
      • Southfield, Michigan, United States, 48034-1659
        • Revival Research Institute, LLC /ID# 207281
      • Wyoming, Michigan, United States, 49519
        • Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 157487
    • Minnesota
      • Rochester, Minnesota, United States, 55905-0001
        • Mayo Clinic - Rochester /ID# 151681
      • Saint Paul, Minnesota, United States, 55114
        • Minnesota Gastroenterology PA /ID# 151682
    • Mississippi
      • Jackson, Mississippi, United States, 39216-4500
        • University of Mississippi Medical Center /ID# 213140
      • Jackson, Mississippi, United States, 39216
        • Southern Therapy and Advanced Research (STAR) LLC /ID# 170713
    • Missouri
      • Saint Louis, Missouri, United States, 63110
        • Washington University-School of Medicine /ID# 150537
    • Nevada
      • Las Vegas, Nevada, United States, 89113
        • Las Vegas Medical Research /ID# 153052
    • New Hampshire
      • Lebanon, New Hampshire, United States, 03756
        • Dartmouth-Hitchcock Medical Center /ID# 150566
    • New Jersey
      • Egg Harbor Township, New Jersey, United States, 08234
        • Cooper Gastroenterology at Fire Road /ID# 153048
      • Morristown, New Jersey, United States, 07960
        • Atlantic Digestive Health Inst /ID# 150527
      • New Brunswick, New Jersey, United States, 08901
        • Rutgers Robert Wood Johnson /ID# 155247
    • New Mexico
      • Albuquerque, New Mexico, United States, 87131
        • Duplicate_University of New Mexico Department of Internal Medicine /ID# 214399
    • New York
      • Bronx, New York, United States, 10467
        • Montefiore Medical Center - Moses Campus /ID# 150559
      • Bronx, New York, United States, 10468
        • Advantage Clinical Trials /ID# 163940
      • Brooklyn, New York, United States, 11235
        • NY Scientific /ID# 152708
      • Great Neck, New York, United States, 11021
        • NYU Langone Long Island Clinical Research Association /ID# 155271
      • New York, New York, United States, 10032-3725
        • Columbia Univ Medical Center /ID# 163409
      • North Massapequa, New York, United States, 11758
        • DiGiovanna Institute for Medical Education & Research /ID# 201534
      • Poughkeepsie, New York, United States, 12601
        • Premier Medical Group - GI Division /ID# 153366
      • Rochester, New York, United States, 14618-5703
        • Gastoenterology Group of Rochester /ID# 151080
      • Staten Island, New York, United States, 10310-1664
        • Richmond University Medical Center /ID# 201860
    • North Carolina
      • Asheville, North Carolina, United States, 28801
        • Digestive Health Partners, P.A /ID# 167238
      • Charlotte, North Carolina, United States, 28203
        • Atrium Health Carolinas Medical Center /ID# 157060
      • Charlotte, North Carolina, United States, 28207
        • Charlotte Gastroenterology and Hepatology, PLLC /ID# 150561
      • Greenville, North Carolina, United States, 27834
        • Atlantic Gastroenterology Clinical Research /ID# 151901
      • Winston-Salem, North Carolina, United States, 27103
        • Clinical Trials of America /ID# 153453
      • Winston-Salem, North Carolina, United States, 27157-0001
        • Wake Forest Baptist Medical Center /ID# 150528
    • North Dakota
      • Fargo, North Dakota, United States, 58104-5925
        • Plains Clinical Research Center, LLC /ID# 170291
    • Ohio
      • Cincinnati, Ohio, United States, 45267-0585
        • University of Cincinnati /ID# 164584
      • Cincinnati, Ohio, United States, 45219
        • Gastro Health Research /ID# 151683
      • Columbus, Ohio, United States, 43210
        • The Ohio State University /ID# 169417
      • Columbus, Ohio, United States, 43235
        • Optimed Research, Ltd. /ID# 169697
      • Dayton, Ohio, United States, 45424
        • Hometown Urgent Care and Resea /ID# 200066
      • Englewood, Ohio, United States, 45415
        • Dayton Gastroenterology, Inc. /ID# 167632
      • Mentor, Ohio, United States, 44060
        • Ohio Clinical Research Partner /ID# 154074
      • Mentor, Ohio, United States, 44060-6211
        • Great Lakes Gastroenterology Research, LLC /ID# 201773
    • Oklahoma
      • Oklahoma City, Oklahoma, United States, 73102
        • Hightower Clinical /ID# 216338
      • Oklahoma City, Oklahoma, United States, 73112
        • Digestive Disease Specialists /ID# 201057
      • Tulsa, Oklahoma, United States, 74104
        • Options Health Research, LLC /ID# 150569
      • Tulsa, Oklahoma, United States, 74135
        • Healthcare Research Consultant /ID# 163096
    • Oregon
      • Portland, Oregon, United States, 97210
        • Northwest Gastroenterology Clinic /ID# 152528
    • Pennsylvania
      • Sayre, Pennsylvania, United States, 18840
        • Guthrie Medical Group, PC /ID# 150533
      • State College, Pennsylvania, United States, 16803-2309
        • Penn State Health Colonnade /ID# 150267
    • South Carolina
      • Charleston, South Carolina, United States, 29412
        • Pharmacorp Clinical Trials /ID# 153363
      • Greenville, South Carolina, United States, 29607
        • Gastroenterology Associates, P.A. of Greenville /ID# 150557
    • Tennessee
      • Cordova, Tennessee, United States, 38018
        • Gastro One /ID# 151154
      • Johnson City, Tennessee, United States, 37604
        • East Tennessee Research Institute /ID# 203611
      • Nashville, Tennessee, United States, 37211
        • Quality Medical Research /ID# 203427
      • Nashville, Tennessee, United States, 37232-0011
        • Vanderbilt University Medical Center /ID# 153364
    • Texas
      • Arlington, Texas, United States, 76012
        • TX Clinical Research Institute /ID# 151528
      • Baytown, Texas, United States, 77521-2415
        • Inquest Clinical Research /ID# 164636
      • Cedar Park, Texas, United States, 78613-5028
        • Texas Digestive Disease Consultants /ID# 209949
      • Cedar Park, Texas, United States, 78613
        • GI Alliance /ID# 209806
      • Dallas, Texas, United States, 75246
        • Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 200771
      • Garland, Texas, United States, 75044-2208
        • DHAT Research Institute /ID# 151221
      • Houston, Texas, United States, 77017-2337
        • Vilo Research Group Inc /ID# 212626
      • Houston, Texas, United States, 77027-6812
        • CliniCore International, LLC /ID# 152078
      • Houston, Texas, United States, 77030-3411
        • Baylor College of Medicine - Baylor Medical Center /ID# 150538
      • Houston, Texas, United States, 77058
        • Centex Studies, Inc. - Houston /ID# 201217
      • Houston, Texas, United States, 77070-4347
        • GI Specialists of Houston /ID# 202337
      • Lubbock, Texas, United States, 79424-3017
        • Caprock Gastro Research, LLC /ID# 215116
      • San Antonio, Texas, United States, 78212
        • Clinical Associates in Research Therapeutics of America, LLC /ID# 167954
      • San Antonio, Texas, United States, 78229-5390
        • Southern Star Research Institute, LLC /ID# 169397
      • Sugar Land, Texas, United States, 77478
        • Carl R. Meisner Medical Clinic /ID# 171270
      • Temple, Texas, United States, 76508
        • Baylor Scott & White Center for Diagnostic Medicine /ID# 204777
      • Tyler, Texas, United States, 75701-4464
        • Tyler Research Institute, LLC /ID# 169147
      • Victoria, Texas, United States, 77904
        • Gastro Health & Nutrition - Victoria /ID# 167764
    • Utah
      • Bountiful, Utah, United States, 84010
        • HP Clinical Research /ID# 163941
      • Ogden, Utah, United States, 84403
        • Advanced Research Institute /ID# 162640
      • Salt Lake City, Utah, United States, 84124
        • Utah Gastroenternology - St. Mark's Office /ID# 163097
      • West Jordan, Utah, United States, 84088
        • Velocity Clinical Research - Salt Lake City /ID# 163180
    • Virginia
      • Franklin, Virginia, United States, 23851
        • Ctr for Gastrointestinal Healt /ID# 153369
    • Washington
      • Bellevue, Washington, United States, 98004
        • Texas Digestive Disease Consultants, PLLC dba GI Alliance /ID# 163630
      • Seattle, Washington, United States, 98101
        • Virginia Mason Medical Center /ID# 153030
      • Seattle, Washington, United States, 98122-4201
        • The Polyclinic /ID# 165117
      • Vancouver, Washington, United States, 98664
        • The Vancouver Clinic, INC. PS /ID# 162334
    • Wisconsin
      • Grafton, Wisconsin, United States, 53024
        • Aurora Medical Center - Grafto /ID# 151726
      • Milwaukee, Wisconsin, United States, 53215
        • Wisconsin Center for Advanced Research, a division of GI Associates, LLC /ID# 151845
      • Milwaukee, Wisconsin, United States, 53226-3522
        • Medical College of Wisconsin /ID# 151850

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

16 years to 75 years (Child, Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

Note: Participants aged 16 or 17 may enroll in M14-234 or M14-675 where locally permissible

  • Participant has not achieved clinical response at the end of the induction period (Week 8) in Study M14-234 Substudy 1, has had loss of response during the maintenance period of Study M14-234 Substudy 3, or has successfully completed Study M14-234 Substudy 3. During the COVID-19 pandemic, for participants with missing endoscopy at Week 8, Week 16 or Week 52 due to the COVID-19 pandemic in Studies M14-234 Substudy 2, M14-234 Substudy 3 and M14-675, participants may be enrolled if certain criteria are met.
  • If female, participant must meet the contraception criteria.
  • Women of childbearing potential must have a negative urine pregnancy test at Week 0 visit.
  • Participant is judged to be in otherwise good health as determined by the principal investigator based upon clinical evaluations performed during the preceding study (Study M14-234).
  • Must be able and willing to give written informed consent and to comply with the requirements of this study protocol.

Exclusion Criteria:

  • For any reason participant is considered by the investigator to be an unsuitable candidate.
  • Female participant with a positive pregnancy test at the final visit of Study M14-234 or who is considering becoming pregnant during the study or within 30 days after the last dose of study drug.
  • Known hypersensitivity to upadacitinib or its excipients or had any adverse event (AE) during the preceding studies, that in the investigator's judgment makes the participant unsuitable for this study.
  • Participant with an active or recurrent infection that based on the investigator's clinical assessment makes the participant an unsuitable candidate for the study. Participants with ongoing infections undergoing treatment may be enrolled BUT NOT dosed until the infection has been successfully treated.
  • Current evidence of active tuberculosis (TB); current evidence of latent tuberculosis and for any reason the participant cannot take full course of TB prophylaxis treatment as required per protocol.
  • Participant with a poorly controlled medical condition, such as uncontrolled diabetes, unstable ischemic heart disease, moderate or severe congestive heart failure (New York Heart Association class III or IV), recent cerebrovascular accidents and any other condition which, in the opinion of the investigator or sponsor, would put the subject at risk by participation in this study.
  • Participants have malignancy, high-grade dysplasia, un-removed low-grade dysplasia of the gastrointestinal tract diagnosed at the endoscopy performed at the final visit of Study M14-234.
  • History of any malignancy except for successfully treated nonmelanoma skin cancer (NMSC) or localized carcinoma in situ of the cervix from evaluations performed in Study M14-234.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Participants receiving Upadacitinib (ABT-494) Dose A or Dose B
The participants in this arm will receive Upadacitinib (ABT-494) dose A or dose B.
Drug: Upadacitinib (ABT-494)
Upadacitinib (ABT-494) will be administered orally.
Other Names:
  • RINVOQ
Experimental: Participants receiving Placebo
The participants in this arm will receive placebo until study is unblinded.
Drug: Placebo
Placebo will be administered orally.
Experimental: Participants receiving Upadacitinib (ABT-494) Dose C
The participants in this arm will receive Upadacitinib (ABT-494) dose C.
Drug: Upadacitinib (ABT-494)
Upadacitinib (ABT-494) will be administered orally.
Other Names:
  • RINVOQ
Experimental: Participants receiving Upadacitinib (ABT-494) Dose B
The participants in this arm will receive Upadacitinib (ABT-494) dose B.
Drug: Upadacitinib (ABT-494)
Upadacitinib (ABT-494) will be administered orally.
Other Names:
  • RINVOQ
Experimental: Participants receiving Upadacitinib (ABT-494) Dose A
The participants in this arm will receive Upadacitinib (ABT-494) dose A.
Drug: Upadacitinib (ABT-494)
Upadacitinib (ABT-494) will be administered orally.
Other Names:
  • RINVOQ

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Assessing Treatment-Emergent Adverse Events
Time Frame: Up to 288 Weeks
Treatment-emergent adverse events are defined as events that begin or worsen either on or after the first dose of the study drug and within 30 days after the last dose of the study drug in the analysis period.
Up to 288 Weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

AbbVie

Investigators

  • Study Director: ABBVIE INC., AbbVie

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 31, 2017

Primary Completion (Estimated)

July 21, 2027

Study Completion (Estimated)

July 21, 2027

Study Registration Dates

First Submitted

December 20, 2016

First Submitted That Met QC Criteria

December 27, 2016

First Posted (Estimated)

December 30, 2016

Study Record Updates

Last Update Posted (Actual)

October 31, 2023

Last Update Submitted That Met QC Criteria

October 30, 2023

Last Verified

October 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • M14-533
  • 2016-000674-38 (EudraCT Number)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols, analyses plans, clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.

IPD Sharing Time Frame

For details on when studies are available for sharing visit https://vivli.org/ourmember/abbvie/

IPD Sharing Access Criteria

Access to this clinical trial data can be requested by any qualified researchers who engage in rigorous independent scientific research, and will be provided following review and approval of a research proposal and statistical analysis plan and execution of a data sharing statement. Data requests can be submitted at any time after approval in the US and/or EU and a primary manuscript is accepted for publication. For more information on the process, or to submit a request, visit the following link https://www.abbvieclinicaltrials.com/hcp/data-sharing/

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • ANALYTIC_CODE
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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