Nonalcoholic Fatty Liver Disease is Associated With Increased Atrial Fibrillation Risk in an Elderly Chinese Population

Nonalcoholic Fatty Liver Disease is Associated With Increased Atrial Fibrillation Risk in an Elderly Chinese Population: a Cross-sectional Study

Atrial fibrillation and nonalcoholic fatty liver disease are two pathological conditions that are highly prevalent worldwide and share multiple CVD risk factors. There is rare research performed among elderly adults. The investigators are conducting a cross-sectional analysis of elderly adults (≥65 years) to investigate the association between atrial fibrillation and nonalcoholic fatty liver disease in an elderly Chinese population.

Study Overview

• Status: Completed
• Conditions: Atrial Fibrillation; Nonalcoholic Fatty Liver Disease; Cross-sectional Study

Detailed Description

Because of the aging population and improvements in cardiovascular treatments, its prevalence is expected to increase substantially over the next few decades. AF has been reported to be associated with high rates of hospitalization and death. Along with older age, there are many independent risk factors for AF like obesity, hypertension, diabetes, ischemic heart disease, heart failure and valvular heart disease.

Non-alcoholic fatty liver disease is one of the most prevalent liver diseases in the world whose prevalence ranges from 6% to 35%, with a median of 20% in the general population. In recent years, an increasing body of evidence have indicated that NAFLD is linked to cardiovascular disease, myocardial abnormalities, left ventricular diastolic dysfunction, heart failure, aortic valve sclerosis and so on.

NAFLD has also been observed to be significantly associated with AF in patients with type 2 diabetes. Furthermore, a cohort study showed that NAFLD was associated with an increased risk of prevalent AF in a middle-aged population. However, whether the association between NAFLD and AF also holds true in the elderly population remains uncertain. Therefore, the investigators conducted this cross-sectional study to explore the association between NAFLD and AF in an elderly Chinese population.

• Study Type: Observational
• Enrollment (Actual): 2000

Contacts and Locations

Study Locations

• China
  • Zhejiang
    • Ningbo, Zhejiang, China, 315010
      • Ningbo NO.1 hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years to 100 years (Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

The elderly adults (≥65 years old) who had undergone an annual physical examination at Zhenhai Lianhua Hospital, Ningbo, China in 2014

Description

Inclusion Criteria:

• those who undergone an annual physical examination at Zhenhai Lianhua Hospital, Ningbo, China in 2014
• elderly adults (≥65 years old)

Exclusion Criteria:

• unknown alcohol intake or excessive alcohol intake
• unknown BMI or BMI≤18.0kg/m2
• incomplete basic physical data
• missing liver ultrasonic diagnosis
• unknown causes of chronic liver disease

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Association of nonalcoholic fatty liver disease and atrial fibrillation	The association of nonalcoholic fatty liver disease and atrial fibrillation by chi-square test.	the physical examination data in the year of 2014

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Prevalence of AF in an elderly Chinese population stratified by normal or elevated serum liver enzyme concentration	Prevalence of AF in an elderly Chinese population stratified by normal or elevated serum liver enzyme concentration by chi-square test.	the physical examination data in the year of 2014
Prevalence of AF in an elderly Chinese population stratified by NAFLD status on ultrasound combined with normal or elevated serum AST/ALT/GGT concentration	Prevalence of AF in an elderly Chinese population stratified by NAFLD status on ultrasound combined with normal or elevated serum AST/ALT/GGT concentration by chi-square test.	the physical examination data in the year of 2014

Collaborators and Investigators

• Sponsor: Ningbo No. 1 Hospital
• Investigators: Principal Investigator: Lei Xu, Dr., Department of Gastroenterology, Ningbo No. 1 Hospital, Ningbo, China

Study record dates

Study Major Dates

• Study Start (Actual): December 12, 2017
• Primary Completion (Actual): January 18, 2018
• Study Completion (Actual): January 30, 2018

Study Registration Dates

• First Submitted: October 26, 2017
• First Submitted That Met QC Criteria: December 3, 2017
• First Posted (Actual): December 8, 2017

Study Record Updates

• Last Update Posted (Actual): June 21, 2019
• Last Update Submitted That Met QC Criteria: June 20, 2019
• Last Verified: July 1, 2018

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Digestive System Diseases; Pathologic Processes; Heart Diseases; Cardiovascular Diseases; Arrhythmias, Cardiac; Liver Diseases; Fatty Liver; Atrial Fibrillation; Non-alcoholic Fatty Liver Disease
• Other Study ID Numbers: Ningbo2