Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer (TAILOR RT)

May 11, 2026 updated by: Canadian Cancer Trials Group

TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming back.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

Women with node positive breast cancer normally will receive endocrine therapy and some may receive chemotherapy to help prevent the cancer from coming back. Many women will also receive radiotherapy to the whole breast/chest area and the surrounding lymph glands (called regional radiotherapy). No one really knows whether patients with low risk breast cancer need to receive regional radiotherapy. Some women may be getting regional radiotherapy who do not need it. These women may be exposed to the side effects of their treatment without benefit.

Study Type

Interventional

Enrollment (Estimated)

2140

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Canada
    • Alberta
      • Calgary, Alberta, Canada, T2N 5G2
        • Recruiting
        • Arthur J E Child Comprehensive Cancer Centre
        • Principal Investigator:
          • Jeffrey Q. Cao
        • Contact:
      • Edmonton, Alberta, Canada, T6G 1Z2
        • Recruiting
        • Cross Cancer Institute
        • Principal Investigator:
          • Susan M. Chafe
        • Contact:
          • Site Public Contact
          • Phone Number: 780-432-8500
    • British Columbia
      • Abbotsford British Columbia, British Columbia, Canada, V2S 1K2
        • Recruiting
        • BCCA-Abbotsford Cancer Centre
        • Contact:
          • Site Public Contact
          • Phone Number: 604-851-4710
        • Principal Investigator:
          • Maha Almahmudi
      • Kelowna, British Columbia, Canada, V1Y 5L3
        • Recruiting
        • BCCA-Cancer Centre for the Southern Interior
        • Principal Investigator:
          • Angela Lin
        • Contact:
          • Site Public Contact
          • Phone Number: 250-712-3900
      • Prince George, British Columbia, Canada, V2M 7E9
        • Recruiting
        • BCCA-Cancer Centre for the North
        • Contact:
          • Site Public Contact
          • Phone Number: 855-775-7300
        • Principal Investigator:
          • Robert A. Olson
      • Surrey, British Columbia, Canada, V3V 1Z2
        • Recruiting
        • BCCA-Fraser Valley Cancer Centre
        • Contact:
          • Site Public Contact
          • Phone Number: 604-930-2098
        • Principal Investigator:
          • Dylan Narinesingh
      • Vancouver, British Columbia, Canada, V5Z 4E6
        • Recruiting
        • BCCA-Vancouver Cancer Centre
        • Principal Investigator:
          • Alan M. Nichol
        • Contact:
          • Site Public Contact
          • Phone Number: 888-939-3333
      • Victoria, British Columbia, Canada, V8R 6V5
        • Recruiting
        • BCCA-Vancouver Island Cancer Centre
        • Contact:
          • Site Public Contact
          • Phone Number: 604-877-6010
        • Principal Investigator:
          • Tanya S. Berrang
    • Manitoba
      • Winnipeg, Manitoba, Canada, R3E 0V9
        • Recruiting
        • CancerCare Manitoba
        • Principal Investigator:
          • Bashir M. Bashir
        • Contact:
    • New Brunswick
      • Saint John, New Brunswick, Canada, E2L 4L2
        • Recruiting
        • Atlantic Health Sciences Corporation-Saint John Regional Hospital
        • Principal Investigator:
          • Farah Naz
        • Contact:
          • Site Public Contact
          • Phone Number: 506-648-6890
    • Newfoundland and Labrador
      • St. John's, Newfoundland and Labrador, Canada, A1B 3V6
        • Recruiting
        • Doctor H. Bliss Murphy Cancer Centre
        • Contact:
          • Site Public Contact
          • Phone Number: 709-777-7589
        • Principal Investigator:
          • Craig M. Pochini
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 2Y9
        • Recruiting
        • QEII Health Sciences Centre/Nova Scotia Health Authority
        • Contact:
          • Site Public Contact
          • Phone Number: 902-473-6000
        • Principal Investigator:
          • Wladyslawa Cwajna
    • Ontario
      • Barrie, Ontario, Canada, L4M 6M2
        • Suspended
        • Royal Victoria Regional Health Centre
      • Greater Sudbury, Ontario, Canada, P3E 5J1
        • Suspended
        • Health Sciences North
      • Hamilton, Ontario, Canada, L8V 5C2
        • Suspended
        • Juravinski Cancer Centre at Hamilton Health Sciences
      • Kingston, Ontario, Canada, K7L 2V7
        • Suspended
        • Kingston Health Sciences Centre
      • Kitchener, Ontario, Canada, N2G 1G3
        • Suspended
        • Waterloo Regional Health Network
      • London, Ontario, Canada, N6A 4L6
        • Suspended
        • London Regional Cancer Program
      • Mississauga, Ontario, Canada, L5M 2N1
        • Suspended
        • Trillium Health Partners - Credit Valley Hospital
      • Ottawa, Ontario, Canada, K1H 8L6
        • Suspended
        • Ottawa Hospital and Cancer Center-General Campus
      • Saint Catharines, Ontario, Canada, L2S 0A9
        • Suspended
        • Niagara Health System-Saint Catharines General
      • Sault Ste. Marie, Ontario, Canada, P6B 0A8
        • Recruiting
        • Algoma District Cancer Program Sault Area Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 705-759-3434
        • Principal Investigator:
          • Silvana Spadafora
      • Toronto, Ontario, Canada, M4N 3M5
        • Suspended
        • Odette Cancer Centre- Sunnybrook Health Sciences Centre
      • Toronto, Ontario, Canada, M5G 2M9
        • Suspended
        • University Health Network-Princess Margaret Hospital
    • Quebec
      • Greenfield Park, Quebec, Canada, J4V 2H1
        • Recruiting
        • CSSS Champlain-Charles Le Moyne
        • Contact:
          • Site Public Contact
          • Phone Number: 450-466-5065
        • Principal Investigator:
          • Timothy D. Lymberiou
      • Laval, Quebec, Canada, H7M 3L9
        • Recruiting
        • Hopital de la Cite-de-la-Sante
        • Contact:
          • Site Public Contact
          • Phone Number: 450-975-5359
        • Principal Investigator:
          • Isabelle Roy
      • Montreal, Quebec, Canada, H3T 1E2
        • Recruiting
        • Jewish General Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 8248 514-340-8222
        • Principal Investigator:
          • Thierry M. Muanza
      • Montreal, Quebec, Canada, H2X 3E4
        • Recruiting
        • CHUM - Centre Hospitalier de l'Universite de Montreal
        • Contact:
        • Principal Investigator:
          • Pierre Rousseau
      • Montreal, Quebec, Canada, H3H 2R9
        • Recruiting
        • The Research Institute of the McGill University Health Centre (MUHC)
        • Contact:
        • Principal Investigator:
          • Tarek Hijal
      • Montreal, Quebec, Canada, H1T 2M4
        • Recruiting
        • CIUSSSEMTL-Hopital Maisonneuve-Rosemont
        • Contact:
          • Site Public Contact
          • Phone Number: 3329 514-252-3400
        • Principal Investigator:
          • Michael Yassa
      • Québec, Quebec, Canada, G1R 2J6
        • Recruiting
        • CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
        • Contact:
        • Principal Investigator:
          • Valerie Theberge
      • Sherbrooke, Quebec, Canada, J1H 5N4
        • Recruiting
        • Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
        • Principal Investigator:
          • Sawyna Provencher
        • Contact:
    • Saskatchewan
      • Regina, Saskatchewan, Canada, S4T 7T1
        • Recruiting
        • Allan Blair Cancer Centre
        • Principal Investigator:
          • Derek Suderman
        • Contact:
          • Site Public Contact
          • Phone Number: 306-766-2213
      • Saskatoon, Saskatchewan, Canada, S7N 4H4
        • Recruiting
        • Saskatoon Cancer Centre
        • Principal Investigator:
          • Moftah M. Younis
        • Contact:
          • Site Public Contact
          • Phone Number: 306-655-2914
  • United States
    • Alaska
      • Fairbanks, Alaska, United States, 99701
    • Arizona
      • Gilbert, Arizona, United States, 85234
        • Recruiting
        • Banner MD Anderson Cancer Center
        • Contact:
          • Site Public Contact
          • Phone Number: 602-747-9738
        • Principal Investigator:
          • Arti Sangave
      • Phoenix, Arizona, United States, 85006
        • Suspended
        • Banner-University Medical Center Phoenix
      • Tucson, Arizona, United States, 85719
        • Recruiting
        • University of Arizona Cancer Center-North Campus
        • Principal Investigator:
          • Christopher M. Morrison
        • Contact:
      • Tucson, Arizona, United States, 85704
        • Recruiting
        • University of Arizona Cancer Center-Orange Grove Campus
        • Principal Investigator:
          • Christopher M. Morrison
        • Contact:
          • Site Public Contact
          • Phone Number: 520-694-8900
    • Arkansas
      • Little Rock, Arkansas, United States, 72205
        • Active, not recruiting
        • University of Arkansas for Medical Sciences
    • California
      • Anaheim, California, United States, 92806
        • Recruiting
        • Kaiser Permanente-Anaheim
        • Contact:
        • Principal Investigator:
          • Aakash Batra
      • Bellflower, California, United States, 90706
        • Recruiting
        • Kaiser Permanente-Bellflower
        • Contact:
        • Principal Investigator:
          • Aakash Batra
      • Berkeley, California, United States, 94704
        • Active, not recruiting
        • Alta Bates Summit Medical Center-Herrick Campus
      • Corona, California, United States, 92882
        • Recruiting
        • City of Hope Corona
        • Principal Investigator:
          • Ji H. Kim
        • Contact:
      • Duarte, California, United States, 91010
        • Recruiting
        • City of Hope Comprehensive Cancer Center
        • Contact:
        • Principal Investigator:
          • Ji H. Kim
      • Dublin, California, United States, 94568
        • Recruiting
        • Kaiser Permanente Dublin
        • Contact:
          • Site Public Contact
          • Phone Number: 877-642-4691
        • Principal Investigator:
          • Samantha A. Seaward
      • Encinitas, California, United States, 92024
        • Recruiting
        • UC San Diego Health System - Encinitas
        • Contact:
          • Site Public Contact
          • Phone Number: 760-536-7700
        • Principal Investigator:
          • Dominique L. Rash
      • Fresno, California, United States, 93720
        • Recruiting
        • Fresno Cancer Center
        • Contact:
          • Site Public Contact
          • Phone Number: 877-642-4691
          • Email: Kpoct@kp.org
        • Principal Investigator:
          • Samantha A. Seaward
      • Irvine, California, United States, 92618
        • Recruiting
        • City of Hope at Irvine Lennar
        • Contact:
          • Site Public Contact
          • Phone Number: 877-467-3411
        • Principal Investigator:
          • Ji H. Kim
      • La Jolla, California, United States, 92093
        • Recruiting
        • UC San Diego Moores Cancer Center
        • Contact:
        • Principal Investigator:
          • Dominique L. Rash
      • Lancaster, California, United States, 93534
        • Recruiting
        • City of Hope Antelope Valley
        • Contact:
        • Principal Investigator:
          • Ji H. Kim
      • Los Angeles, California, United States, 90027
        • Recruiting
        • Kaiser Permanente Los Angeles Medical Center
        • Contact:
        • Principal Investigator:
          • Aakash Batra
      • Los Angeles, California, United States, 90033
        • Recruiting
        • USC / Norris Comprehensive Cancer Center
        • Contact:
          • Site Public Contact
          • Phone Number: 323-865-0451
        • Principal Investigator:
          • Jason C. Ye
      • Los Angeles, California, United States, 90033
        • Recruiting
        • Los Angeles General Medical Center
        • Principal Investigator:
          • Jason C. Ye
        • Contact:
      • Napa, California, United States, 94558
        • Recruiting
        • Providence Queen of The Valley
        • Principal Investigator:
          • Charles W. Drescher
        • Contact:
          • Site Public Contact
          • Phone Number: 707-521-3830
      • Oakland, California, United States, 94611
        • Recruiting
        • Kaiser Permanente Oakland-Broadway
        • Contact:
          • Site Public Contact
          • Phone Number: 877-642-4691
          • Email: Kpoct@kp.org
        • Principal Investigator:
          • Samantha A. Seaward
      • Ontario, California, United States, 91761
        • Recruiting
        • Kaiser Permanente-Ontario
        • Contact:
        • Principal Investigator:
          • Aakash Batra
      • Orange, California, United States, 92868
        • Recruiting
        • Saint Joseph Hospital - Orange
        • Principal Investigator:
          • Robert B. Ash
        • Contact:
          • Site Public Contact
          • Phone Number: 714-734-6220
      • Orange, California, United States, 92868
        • Active, not recruiting
        • UC Irvine Health/Chao Family Comprehensive Cancer Center
      • Palm Springs, California, United States, 92262
        • Recruiting
        • Desert Regional Medical Center
        • Contact:
          • Site Public Contact
          • Phone Number: 760-416-4730
        • Principal Investigator:
          • Amir Lavaf
      • Rancho Cordova, California, United States, 95670
        • Recruiting
        • Kaiser Permanente-Rancho Cordova Cancer Center
        • Contact:
          • Site Public Contact
          • Phone Number: 877-642-4691
          • Email: Kpoct@kp.org
        • Principal Investigator:
          • Samantha A. Seaward
      • Rohnert Park, California, United States, 94928
        • Recruiting
        • Rohnert Park Cancer Center
        • Contact:
          • Site Public Contact
          • Phone Number: 877-642-4691
          • Email: Kpoct@kp.org
        • Principal Investigator:
          • Samantha A. Seaward
      • Roseville, California, United States, 95678
        • Recruiting
        • The Permanente Medical Group-Roseville Radiation Oncology
        • Contact:
          • Site Public Contact
          • Phone Number: 877-642-4691
          • Email: Kpoct@kp.org
        • Principal Investigator:
          • Samantha A. Seaward
      • Sacramento, California, United States, 95816
      • Santa Clara, California, United States, 95051
        • Recruiting
        • Kaiser Permanente Medical Center - Santa Clara
        • Contact:
          • Site Public Contact
          • Phone Number: 877-642-4691
          • Email: Kpoct@kp.org
        • Principal Investigator:
          • Samantha A. Seaward
      • Santa Monica, California, United States, 90404
        • Recruiting
        • Saint John's Cancer Institute
        • Contact:
          • Site Public Contact
          • Phone Number: 310-582-7448
        • Principal Investigator:
          • Janie G. Weng Grumley
      • South Pasadena, California, United States, 91030
        • Recruiting
        • City of Hope South Pasadena
        • Contact:
        • Principal Investigator:
          • Ji H. Kim
      • South San Francisco, California, United States, 94080
        • Recruiting
        • Kaiser Permanente Cancer Treatment Center
        • Contact:
          • Site Public Contact
          • Phone Number: 877-642-4691
          • Email: Kpoct@kp.org
        • Principal Investigator:
          • Samantha A. Seaward
      • St. Helena, California, United States, 94574
        • Recruiting
        • Saint Helena Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 707-967-3698
        • Principal Investigator:
          • Ethan D. Schram
      • Torrance, California, United States, 90503
        • Recruiting
        • City of Hope South Bay
        • Contact:
          • Site Public Contact
          • Phone Number: 877-467-3411
        • Principal Investigator:
          • Ji H. Kim
      • Upland, California, United States, 91786
        • Recruiting
        • City of Hope Upland
        • Contact:
        • Principal Investigator:
          • Ji H. Kim
      • Vallejo, California, United States, 94589
        • Active, not recruiting
        • Sutter Solano Medical Center/Cancer Center
      • Walnut Creek, California, United States, 94598
        • Recruiting
        • BASS Medical Group - Lennon
        • Contact:
        • Principal Investigator:
          • Nicholas J. DiBella
    • Colorado
      • Aurora, Colorado, United States, 80045
        • Recruiting
        • UCHealth University of Colorado Hospital
        • Principal Investigator:
          • Rachel A. Rabinovitch
        • Contact:
          • Site Public Contact
          • Phone Number: 720-848-0650
      • Boulder, Colorado, United States, 80304
        • Recruiting
        • Rocky Mountain Cancer Centers-Boulder
        • Contact:
        • Principal Investigator:
          • Nicholas J. DiBella
      • Colorado Springs, Colorado, United States, 80907
      • Colorado Springs, Colorado, United States, 80909
        • Recruiting
        • UCHealth Memorial Hospital Central
        • Principal Investigator:
          • Rachel A. Rabinovitch
        • Contact:
          • Site Public Contact
          • Phone Number: 719-365-2406
      • Colorado Springs, Colorado, United States, 80920
        • Recruiting
        • Memorial Hospital North
        • Principal Investigator:
          • Rachel A. Rabinovitch
        • Contact:
          • Site Public Contact
          • Phone Number: 719-364-6700
      • Colorado Springs, Colorado, United States, 80923
      • Denver, Colorado, United States, 80206
        • Recruiting
        • UCHealth - Cherry Creek
        • Principal Investigator:
          • Rachel A. Rabinovitch
        • Contact:
      • Denver, Colorado, United States, 80210
        • Suspended
        • AdventHealth Porter
      • Fort Collins, Colorado, United States, 80524
        • Recruiting
        • Poudre Valley Hospital
        • Principal Investigator:
          • Rachel A. Rabinovitch
        • Contact:
          • Site Public Contact
          • Phone Number: 970-297-6150
      • Golden, Colorado, United States, 80401
        • Suspended
        • Lutheran Hospital - Cancer Centers of Colorado
      • Greeley, Colorado, United States, 80631
        • Recruiting
        • UCHealth Greeley Hospital
        • Principal Investigator:
          • Rachel A. Rabinovitch
        • Contact:
      • Greeley, Colorado, United States, 80631
      • Highlands Ranch, Colorado, United States, 80129
        • Recruiting
        • UCHealth Highlands Ranch Hospital
        • Principal Investigator:
          • Rachel A. Rabinovitch
        • Contact:
          • Site Public Contact
          • Phone Number: 720-848-0650
      • Littleton, Colorado, United States, 80122
        • Suspended
        • AdventHealth Littleton
      • Loveland, Colorado, United States, 80539
        • Recruiting
        • Banner North Colorado Medical Center - Loveland Campus
        • Contact:
        • Principal Investigator:
          • Supriya Jain
      • Westminster, Colorado, United States, 80023
      • Wheat Ridge, Colorado, United States, 80401
        • Suspended
        • Intermountain Health Lutheran Hospital
    • Connecticut
      • Danbury, Connecticut, United States, 06810
        • Recruiting
        • Danbury Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 203-739-8074
        • Principal Investigator:
          • Seema C. Sanghavi
      • Guilford, Connecticut, United States, 06437
        • Active, not recruiting
        • Smilow Cancer Hospital Care Center - Guilford
      • Hamden, Connecticut, United States, 06518
        • Active, not recruiting
        • Smilow Cancer Hospital-Hamden Care Center
      • New Haven, Connecticut, United States, 06520
        • Active, not recruiting
        • Yale University
      • Norwalk, Connecticut, United States, 06856
        • Recruiting
        • Norwalk Hospital
        • Contact:
        • Principal Investigator:
          • Christine Chin
      • Trumbull, Connecticut, United States, 06611
        • Active, not recruiting
        • Smilow Cancer Hospital Care Center-Trumbull
      • Waterford, Connecticut, United States, 06385
        • Active, not recruiting
        • Smilow Cancer Hospital Care Center - Waterford
    • Delaware
      • Newark, Delaware, United States, 19713
        • Active, not recruiting
        • Helen F Graham Cancer Center
      • Newark, Delaware, United States, 19718
        • Active, not recruiting
        • Christiana Care Health System-Christiana Hospital
    • District of Columbia
      • Washington D.C., District of Columbia, United States, 20007
        • Active, not recruiting
        • MedStar Georgetown University Hospital
      • Washington D.C., District of Columbia, United States, 20016
        • Recruiting
        • Sibley Memorial Hospital
        • Contact:
        • Principal Investigator:
          • Anna W. LaVigne
      • Washington D.C., District of Columbia, United States, 20010
        • Active, not recruiting
        • Medstar Washington Hospital Center
    • Florida
      • Boca Raton, Florida, United States, 33486
        • Recruiting
        • Boca Raton Regional Hospital
        • Principal Investigator:
          • Samuel M. Richter
        • Contact:
          • Site Public Contact
          • Phone Number: 561-955-4800
      • Clearwater, Florida, United States, 33756
        • Recruiting
        • Morton Plant Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 855-314-8646
        • Principal Investigator:
          • Ronica H. Nanda
      • Coral Gables, Florida, United States, 33146
        • Recruiting
        • UM Sylvester Comprehensive Cancer Center at Coral Gables
        • Principal Investigator:
          • Cristiane Takita
        • Contact:
          • Site Public Contact
          • Phone Number: 305-243-2647
      • Deerfield Beach, Florida, United States, 33442
        • Recruiting
        • UM Sylvester Comprehensive Cancer Center at Deerfield Beach
        • Principal Investigator:
          • Cristiane Takita
        • Contact:
          • Site Public Contact
          • Phone Number: 305-243-2647
      • Fort Lauderdale, Florida, United States, 33316
        • Active, not recruiting
        • Broward Health Medical Center
      • Gainesville, Florida, United States, 32610
        • Recruiting
        • UF Health Cancer Institute - Gainesville
        • Principal Investigator:
          • Tithi Biswas
        • Contact:
      • Hollywood, Florida, United States, 33021
        • Recruiting
        • Memorial Regional Hospital/Joe DiMaggio Children's Hospital
        • Principal Investigator:
          • Ignacio Castellon
        • Contact:
          • Site Public Contact
          • Phone Number: 954-265-1847
          • Email: OHR@mhs.net
      • Jacksonville, Florida, United States, 32224-9980
        • Recruiting
        • Mayo Clinic in Florida
        • Principal Investigator:
          • Laura A. Vallow
        • Contact:
          • Site Public Contact
          • Phone Number: 855-776-0015
      • Miami, Florida, United States, 33136
        • Recruiting
        • University of Miami Miller School of Medicine-Sylvester Cancer Center
        • Principal Investigator:
          • Cristiane Takita
        • Contact:
          • Site Public Contact
          • Phone Number: 305-243-2647
      • Miami, Florida, United States, 33176
        • Recruiting
        • Miami Cancer Institute
        • Principal Investigator:
          • Joseph E. Panoff
        • Contact:
          • Site Public Contact
          • Phone Number: 786-596-2000
      • Orlando, Florida, United States, 32806
        • Active, not recruiting
        • Orlando Health Cancer Institute
      • Pembroke Pines, Florida, United States, 33028
        • Recruiting
        • Memorial Hospital West
        • Principal Investigator:
          • Ignacio Castellon
        • Contact:
          • Site Public Contact
          • Phone Number: 954-265-4325
      • Plantation, Florida, United States, 33324
        • Recruiting
        • UM Sylvester Comprehensive Cancer Center at Plantation
        • Principal Investigator:
          • Cristiane Takita
        • Contact:
          • Site Public Contact
          • Phone Number: 305-243-2647
      • Plantation, Florida, United States, 33324
        • Recruiting
        • Miami Cancer Institute at Plantation
        • Principal Investigator:
          • Joseph E. Panoff
        • Contact:
          • Site Public Contact
          • Phone Number: 954-837-1490
      • St. Petersburg, Florida, United States, 33705
        • Recruiting
        • Saint Anthony's Hospital Cancer Care Center
        • Principal Investigator:
          • Ronica H. Nanda
        • Contact:
      • Tampa, Florida, United States, 33607
        • Recruiting
        • Saint Joseph's Hospital/Children's Hospital-Tampa
        • Principal Investigator:
          • Ronica H. Nanda
        • Contact:
      • Tampa, Florida, United States, 33612
        • Recruiting
        • Moffitt Cancer Center
        • Principal Investigator:
          • Iman R. Washington
        • Contact:
      • Weston, Florida, United States, 33331
        • Recruiting
        • Cleveland Clinic-Weston
        • Principal Investigator:
          • Eva M. Suarez
        • Contact:
    • Georgia
      • Atlanta, Georgia, United States, 30322
        • Recruiting
        • Emory University Hospital/Winship Cancer Institute
        • Contact:
          • Site Public Contact
          • Phone Number: 404-778-1868
        • Principal Investigator:
          • Rohini Bhatia
      • Atlanta, Georgia, United States, 30303
        • Recruiting
        • Grady Health System
        • Contact:
          • Site Public Contact
          • Phone Number: 404-778-1868
        • Principal Investigator:
          • Rohini Bhatia
      • Atlanta, Georgia, United States, 30308
        • Recruiting
        • Emory University Hospital Midtown
        • Contact:
          • Site Public Contact
          • Phone Number: 888-946-7447
        • Principal Investigator:
          • Rohini Bhatia
      • Atlanta, Georgia, United States, 30342
        • Recruiting
        • Emory Saint Joseph's Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 404-851-7115
        • Principal Investigator:
          • Rohini Bhatia
      • Decatur, Georgia, United States, 30033
      • Savannah, Georgia, United States, 31405
        • Recruiting
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
        • Contact:
        • Principal Investigator:
          • John A. Pablo
    • Idaho
      • Boise, Idaho, United States, 83706
        • Recruiting
        • Saint Alphonsus Cancer Care Center-Boise
        • Contact:
        • Principal Investigator:
          • Samir Narayan
      • Coeur d'Alene, Idaho, United States, 83814
        • Recruiting
        • Kootenai Health - Coeur d'Alene
        • Principal Investigator:
          • John M. Schallenkamp
        • Contact:
      • Post Falls, Idaho, United States, 83854
        • Recruiting
        • Kootenai Clinic Cancer Services - Post Falls
        • Principal Investigator:
          • John M. Schallenkamp
        • Contact:
    • Illinois
      • Chicago, Illinois, United States, 60612
        • Active, not recruiting
        • University of Illinois
      • Chicago, Illinois, United States, 60637
        • Recruiting
        • University of Chicago Comprehensive Cancer Center
        • Principal Investigator:
          • Steven J. Chmura
        • Contact:
      • Chicago, Illinois, United States, 60611
        • Recruiting
        • Northwestern University
        • Contact:
        • Principal Investigator:
          • Eric D. Donnelly
      • Chicago, Illinois, United States, 60657
        • Recruiting
        • Advocate Illinois Masonic Medical Center
        • Principal Investigator:
          • Ellen L. Ziaja
        • Contact:
          • Site Public Contact
          • Phone Number: 773-296-5360
      • Chicago, Illinois, United States, 60625
        • Recruiting
        • Swedish Covenant Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 773-878-8200
        • Principal Investigator:
          • Elyse A. Lambiase
      • Chicago, Illinois, United States, 60612
        • Recruiting
        • Rush MD Anderson Cancer Center
        • Principal Investigator:
          • Thomas Kim
        • Contact:
      • DeKalb, Illinois, United States, 60115
        • Recruiting
        • Northwestern Medicine Cancer Center Kishwaukee
        • Principal Investigator:
          • Arpi Thukral
        • Contact:
      • Decatur, Illinois, United States, 62526
        • Recruiting
        • Decatur Memorial Hospital
        • Principal Investigator:
          • Bryan A. Faller
        • Contact:
      • Effingham, Illinois, United States, 62401
        • Recruiting
        • Crossroads Cancer Center
        • Principal Investigator:
          • Bryan A. Faller
        • Contact:
      • Evanston, Illinois, United States, 60201
        • Recruiting
        • NorthShore University HealthSystem-Evanston Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 847-570-2109
        • Principal Investigator:
          • Poornima Saha
      • Geneva, Illinois, United States, 60134
        • Recruiting
        • Northwestern Medicine Cancer Center Delnor
        • Principal Investigator:
          • Arpi Thukral
        • Contact:
      • Glenview, Illinois, United States, 60026
        • Recruiting
        • NorthShore University HealthSystem-Glenbrook Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 847-570-2109
        • Principal Investigator:
          • Poornima Saha
      • Harvey, Illinois, United States, 60426
        • Recruiting
        • Ingalls Memorial Hospital
        • Contact:
        • Principal Investigator:
          • Ivy Abraham
      • Highland Park, Illinois, United States, 60035
        • Recruiting
        • NorthShore University HealthSystem-Highland Park Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 847-570-2109
        • Principal Investigator:
          • Poornima Saha
      • Lake Forest, Illinois, United States, 60045
        • Recruiting
        • Northwestern Medicine Lake Forest Hospital
        • Contact:
        • Principal Investigator:
          • Eric D. Donnelly
      • Maywood, Illinois, United States, 60153
        • Recruiting
        • Loyola University Medical Center
        • Principal Investigator:
          • William Small
        • Contact:
          • Site Public Contact
          • Phone Number: 708-226-4357
      • New Lenox, Illinois, United States, 60451
        • Recruiting
        • UC Comprehensive Cancer Center at Silver Cross
        • Principal Investigator:
          • Steven J. Chmura
        • Contact:
      • O'Fallon, Illinois, United States, 62269
        • Recruiting
        • HSHS Saint Elizabeth's Hospital
        • Principal Investigator:
          • Bryan A. Faller
        • Contact:
      • Orland Park, Illinois, United States, 60462
        • Recruiting
        • University of Chicago Medicine-Orland Park
        • Principal Investigator:
          • Steven J. Chmura
        • Contact:
      • Park Ridge, Illinois, United States, 60068
        • Recruiting
        • Advocate Lutheran General Hospital
        • Principal Investigator:
          • Arica Hirsch
        • Contact:
          • Site Public Contact
          • Phone Number: 847-384-3621
      • Peoria, Illinois, United States, 61637
        • Recruiting
        • OSF Saint Francis Medical Center
        • Contact:
        • Principal Investigator:
          • Bryan A. Faller
      • Rockford, Illinois, United States, 61114
        • Recruiting
        • UW Health Carbone Cancer Center Rockford
        • Contact:
        • Principal Investigator:
          • Fahrettin Covut
      • Springfield, Illinois, United States, 62781
        • Recruiting
        • Springfield Memorial Hospital
        • Principal Investigator:
          • Bryan A. Faller
        • Contact:
      • Urbana, Illinois, United States, 61801
        • Recruiting
        • Carle Cancer Center
        • Contact:
        • Principal Investigator:
          • Sinisa Stanic
      • Warrenville, Illinois, United States, 60555
        • Recruiting
        • Northwestern Medicine Cancer Center Warrenville
        • Principal Investigator:
          • Arpi Thukral
        • Contact:
    • Indiana
      • Avon, Indiana, United States, 46123
        • Recruiting
        • IU Health West Hospital
        • Contact:
        • Principal Investigator:
          • Richard C. Zellars
      • Carmel, Indiana, United States, 46032
        • Recruiting
        • IU Health North Hospital
        • Contact:
        • Principal Investigator:
          • Richard C. Zellars
      • Crown Point, Indiana, United States, 46307
        • Recruiting
        • UChicago Medicine Northwest Indiana
        • Principal Investigator:
          • Steven J. Chmura
        • Contact:
      • Fishers, Indiana, United States, 46037
        • Recruiting
        • IU Health Central Indiana Cancer Centers-Fishers
        • Principal Investigator:
          • Richard C. Zellars
        • Contact:
          • Site Public Contact
          • Phone Number: 317-356-2422
      • Indianapolis, Indiana, United States, 46202
        • Recruiting
        • Indiana University/Melvin and Bren Simon Cancer Center
        • Contact:
        • Principal Investigator:
          • Richard C. Zellars
      • Indianapolis, Indiana, United States, 46219
        • Recruiting
        • Community Cancer Center East
        • Contact:
        • Principal Investigator:
          • Daniel W. Weed
      • Indianapolis, Indiana, United States, 46227
        • Recruiting
        • Community Cancer Center South
        • Contact:
        • Principal Investigator:
          • Daniel W. Weed
      • Indianapolis, Indiana, United States, 46256
        • Recruiting
        • Community Cancer Center North
        • Contact:
        • Principal Investigator:
          • Daniel W. Weed
      • Indianapolis, Indiana, United States, 46202
        • Recruiting
        • IU Health Methodist Hospital
        • Contact:
        • Principal Investigator:
          • Richard C. Zellars
      • Muncie, Indiana, United States, 47303
        • Recruiting
        • IU Health Ball Memorial Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 765-751-5850
        • Principal Investigator:
          • Yunjie X. Lin
    • Iowa
      • Cedar Rapids, Iowa, United States, 52402
        • Recruiting
        • Saint Luke's Hospital
        • Contact:
        • Principal Investigator:
          • Candace R. Correa
      • Clive, Iowa, United States, 50325
        • Recruiting
        • Mercy Cancer Center-West Lakes
        • Contact:
          • Site Public Contact
          • Phone Number: 515-241-3305
        • Principal Investigator:
          • Richard L. Deming
      • Creston, Iowa, United States, 50801
        • Recruiting
        • Greater Regional Medical Center
        • Contact:
          • Site Public Contact
          • Phone Number: 515-241-3305
        • Principal Investigator:
          • Richard L. Deming
      • Des Moines, Iowa, United States, 50314
        • Recruiting
        • Mercy Medical Center - Des Moines
        • Contact:
          • Site Public Contact
          • Phone Number: 515-241-3305
        • Principal Investigator:
          • Richard L. Deming
      • Des Moines, Iowa, United States, 50309
        • Recruiting
        • Iowa Methodist Medical Center
        • Contact:
          • Site Public Contact
          • Phone Number: 515-241-6727
        • Principal Investigator:
          • Seema Harichand-Herdt
    • Kansas
      • Kansas City, Kansas, United States, 66160
        • Recruiting
        • University of Kansas Cancer Center
        • Contact:
        • Principal Investigator:
          • Julia R. White
      • Olathe, Kansas, United States, 66061
        • Recruiting
        • The University of Kansas Cancer Center - Olathe
        • Contact:
        • Principal Investigator:
          • Julia R. White
      • Overland Park, Kansas, United States, 66210
        • Recruiting
        • University of Kansas Cancer Center-Overland Park
        • Contact:
        • Principal Investigator:
          • Julia R. White
      • Topeka, Kansas, United States, 66606
        • Recruiting
        • University of Kansas Health System Saint Francis Campus
        • Contact:
          • Site Public Contact
          • Phone Number: 785-295-8000
        • Principal Investigator:
          • Julia R. White
      • Wichita, Kansas, United States, 67214
        • Recruiting
        • Ascension Via Christi Hospitals Wichita
        • Contact:
        • Principal Investigator:
          • Dennis F. Moore
    • Kentucky
      • Edgewood, Kentucky, United States, 41017
        • Recruiting
        • Saint Elizabeth Healthcare Edgewood
        • Principal Investigator:
          • Bradley J. Huth
        • Contact:
      • Fort Thomas, Kentucky, United States, 41075
        • Suspended
        • Saint Elizabeth Healthcare Fort Thomas
      • Lexington, Kentucky, United States, 40509
        • Suspended
        • Saint Joseph Hospital East
      • Lexington, Kentucky, United States, 40504
      • Lexington, Kentucky, United States, 40536
        • Terminated
        • University of Kentucky/Markey Cancer Center
      • Louisville, Kentucky, United States, 40202
        • Recruiting
        • The James Graham Brown Cancer Center at University of Louisville
        • Contact:
          • Site Public Contact
          • Phone Number: 502-562-3429
        • Principal Investigator:
          • Neal E. Dunlap
      • Louisville, Kentucky, United States, 40245
        • Recruiting
        • UofL Health Medical Center Northeast
        • Principal Investigator:
          • Neal E. Dunlap
        • Contact:
      • Owensboro, Kentucky, United States, 42303
        • Active, not recruiting
        • Owensboro Health Mitchell Memorial Cancer Center
    • Louisiana
      • Shreveport, Louisiana, United States, 71103
        • Active, not recruiting
        • LSU Health Sciences Center at Shreveport
    • Maine
      • Bath, Maine, United States, 04530
        • Recruiting
        • MaineHealth Coastal Cancer Treatment Center
        • Contact:
        • Principal Investigator:
          • Matthew D. Cheney
      • Brewer, Maine, United States, 04412
        • Recruiting
        • Lafayette Family Cancer Center-EMMC
        • Principal Investigator:
          • Sarah J. Sinclair
        • Contact:
          • Site Public Contact
          • Phone Number: 800-987-3005
      • Portland, Maine, United States, 04102
        • Recruiting
        • MaineHealth Maine Medical Center - Portland
        • Principal Investigator:
          • Matthew D. Cheney
        • Contact:
      • Sanford, Maine, United States, 04073
        • Recruiting
        • MaineHealth Cancer Care Center of York County
        • Principal Investigator:
          • Matthew D. Cheney
        • Contact:
          • Site Public Contact
          • Phone Number: 207-459-1600
      • Scarborough, Maine, United States, 04074
        • Recruiting
        • MaineHealth Maine Medical Center- Scarborough
        • Principal Investigator:
          • Matthew D. Cheney
        • Contact:
    • Maryland
      • Annapolis, Maryland, United States, 21401
        • Recruiting
        • Luminis Health Anne Arundel Medical Center
        • Contact:
        • Principal Investigator:
          • Barry R. Meisenberg
      • Baltimore, Maryland, United States, 21287
        • Recruiting
        • Johns Hopkins University/Sidney Kimmel Cancer Center
        • Contact:
        • Principal Investigator:
          • Anna W. LaVigne
      • Baltimore, Maryland, United States, 21204
        • Recruiting
        • Greater Baltimore Medical Center
        • Contact:
          • Site Public Contact
          • Phone Number: 443-849-3706
        • Principal Investigator:
          • Kruti Patel
      • Baltimore, Maryland, United States, 21229
        • Recruiting
        • Saint Agnes Hospital
        • Principal Investigator:
          • Richard S. Hudes
        • Contact:
          • Site Public Contact
          • Phone Number: 410-368-2910
      • Baltimore, Maryland, United States, 21237
        • Recruiting
        • MedStar Franklin Square Medical Center/Weinberg Cancer Institute
        • Principal Investigator:
          • Sonali Rudra
        • Contact:
          • Site Public Contact
          • Phone Number: 443-777-7364
      • Baltimore, Maryland, United States, 21201
        • Recruiting
        • University of Maryland/Greenebaum Cancer Center
        • Principal Investigator:
          • Sarah A. Mcavoy
        • Contact:
          • Site Public Contact
          • Phone Number: 800-888-8823
      • Baltimore, Maryland, United States, 21239
        • Recruiting
        • MedStar Good Samaritan Hospital
        • Contact:
        • Principal Investigator:
          • Sonali Rudra
      • Bel Air, Maryland, United States, 21014
        • Recruiting
        • UM Upper Chesapeake Medical Center
        • Principal Investigator:
          • Kamila Nowak Choi
        • Contact:
          • Site Public Contact
          • Phone Number: 443-643-3010
      • Bethesda, Maryland, United States, 20814
        • Recruiting
        • Suburban Hospital
        • Contact:
        • Principal Investigator:
          • Anna W. LaVigne
      • Easton, Maryland, United States, 21601
        • Recruiting
        • University of Maryland Shore Medical Center at Easton
        • Principal Investigator:
          • Sarah A. Mcavoy
        • Contact:
      • Glen Burnie, Maryland, United States, 21061
        • Recruiting
        • UM Baltimore Washington Medical Center/Tate Cancer Center
        • Principal Investigator:
          • Sarah A. Mcavoy
        • Contact:
          • Site Public Contact
          • Phone Number: 410-553-8100
      • Largo, Maryland, United States, 20774
        • Recruiting
        • UM Capital Region Medical Center
        • Principal Investigator:
          • Sarah A. Mcavoy
        • Contact:
      • Towson, Maryland, United States, 21204
        • Recruiting
        • UM Saint Joseph Medical Center
        • Contact:
        • Principal Investigator:
          • Jason R. Citron
    • Massachusetts
      • Boston, Massachusetts, United States, 02111
      • Boston, Massachusetts, United States, 02215
        • Active, not recruiting
        • Beth Israel Deaconess Medical Center
      • Boston, Massachusetts, United States, 02114
        • Active, not recruiting
        • Massachusetts General Hospital Cancer Center
      • Burlington, Massachusetts, United States, 01805
        • Active, not recruiting
        • Lahey Hospital and Medical Center
      • Lowell, Massachusetts, United States, 01854
      • Springfield, Massachusetts, United States, 01199
        • Recruiting
        • Baystate Medical Center
        • Principal Investigator:
          • Seth A. Kaufman
        • Contact:
    • Michigan
      • Ann Arbor, Michigan, United States, 48109
        • Recruiting
        • University of Michigan Rogel Cancer Center
        • Principal Investigator:
          • Lori J. Pierce
        • Contact:
      • Bay City, Michigan, United States, 48706
        • Recruiting
        • McLaren Cancer Institute-Bay City
        • Principal Investigator:
          • Brian K. Yeh
        • Contact:
      • Clarkston, Michigan, United States, 48346
        • Recruiting
        • McLaren Cancer Institute-Clarkston
        • Principal Investigator:
          • Brian K. Yeh
        • Contact:
      • Dearborn, Michigan, United States, 48124
        • Recruiting
        • Corewell Health Dearborn Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 248-551-7695
        • Principal Investigator:
          • Joshua T. Dilworth
      • Farmington Hills, Michigan, United States, 48336
        • Recruiting
        • Corewell Health Farmington Hills Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 248-551-7695
        • Principal Investigator:
          • Joshua T. Dilworth
      • Flint, Michigan, United States, 48532
        • Recruiting
        • McLaren Cancer Institute-Flint
        • Principal Investigator:
          • Brian K. Yeh
        • Contact:
      • Grand Rapids, Michigan, United States, 49503
        • Recruiting
        • Trinity Health Grand Rapids Hospital
        • Contact:
        • Principal Investigator:
          • Kathleen Y. Butler
      • Grand Rapids, Michigan, United States, 49503
        • Recruiting
        • Corewell Health Grand Rapids Hospitals - Butterworth Hospital
        • Contact:
        • Principal Investigator:
          • Kathleen Y. Butler
      • Kalamazoo, Michigan, United States, 49007
        • Recruiting
        • West Michigan Cancer Center
        • Contact:
        • Principal Investigator:
          • Kathleen Y. Butler
      • Lansing, Michigan, United States, 48910
        • Recruiting
        • Karmanos Cancer Institute at McLaren Greater Lansing
        • Principal Investigator:
          • Brian K. Yeh
        • Contact:
      • Mount Clemens, Michigan, United States, 48043
        • Recruiting
        • McLaren Cancer Institute-Macomb
        • Principal Investigator:
          • Brian K. Yeh
        • Contact:
      • Mount Pleasant, Michigan, United States, 48858
        • Recruiting
        • McLaren Cancer Institute-Central Michigan
        • Principal Investigator:
          • Brian K. Yeh
        • Contact:
      • Muskegon, Michigan, United States, 49444
        • Recruiting
        • Trinity Health Muskegon Hospital
        • Contact:
        • Principal Investigator:
          • Kathleen Y. Butler
      • Novi, Michigan, United States, 48374
        • Recruiting
        • Henry Ford Health Providence Novi Hospital
        • Principal Investigator:
          • Cynthia M. Vakhariya
        • Contact:
      • Petoskey, Michigan, United States, 49770
        • Recruiting
        • McLaren Cancer Institute-Northern Michigan
        • Principal Investigator:
          • Brian K. Yeh
        • Contact:
      • Port Huron, Michigan, United States, 48060
        • Recruiting
        • McLaren-Port Huron
        • Principal Investigator:
          • Brian K. Yeh
        • Contact:
      • Royal Oak, Michigan, United States, 48073
        • Recruiting
        • Corewell Health William Beaumont University Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 248-551-7695
        • Principal Investigator:
          • Joshua T. Dilworth
      • Southfield, Michigan, United States, 48075
        • Recruiting
        • Henry Ford Health Providence Southfield Hospital
        • Principal Investigator:
          • Cynthia M. Vakhariya
        • Contact:
      • Traverse City, Michigan, United States, 49684
        • Recruiting
        • Munson Medical Center
        • Contact:
        • Principal Investigator:
          • Kathleen Y. Butler
      • Troy, Michigan, United States, 48085
        • Recruiting
        • Corewell Health Beaumont Troy Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 248-551-7695
        • Principal Investigator:
          • Joshua T. Dilworth
      • Wyoming, Michigan, United States, 49519
        • Recruiting
        • University of Michigan Health - West
        • Contact:
        • Principal Investigator:
          • Kathleen Y. Butler
    • Minnesota
      • Bemidji, Minnesota, United States, 56601
      • Duluth, Minnesota, United States, 55805
        • Recruiting
        • Miller-Dwan Hospital
        • Contact:
        • Principal Investigator:
          • Bret E. Friday
      • Minneapolis, Minnesota, United States, 55407
        • Recruiting
        • Abbott-Northwestern Hospital
        • Contact:
        • Principal Investigator:
          • David M. King
      • Minneapolis, Minnesota, United States, 55415
        • Recruiting
        • Hennepin County Medical Center
        • Contact:
        • Principal Investigator:
          • David M. King
    • Mississippi
      • Southhaven, Mississippi, United States, 38671
        • Recruiting
        • Baptist Memorial Hospital and Cancer Center-Desoto
        • Principal Investigator:
          • Michael Tomblyn
        • Contact:
    • Missouri
      • Cape Girardeau, Missouri, United States, 63703
        • Recruiting
        • Saint Francis Medical Center
        • Principal Investigator:
          • Bryan A. Faller
        • Contact:
          • Site Public Contact
          • Phone Number: 573-334-2230
          • Email: sfmc@sfmc.net
      • Columbia, Missouri, United States, 65212
        • Recruiting
        • MU Health - University Hospital/Ellis Fischel Cancer Center
        • Contact:
          • Site Public Contact
          • Phone Number: 573-882-7440
        • Principal Investigator:
          • Andrew Leiker
      • Jefferson City, Missouri, United States, 65109
        • Active, not recruiting
        • MU Health Care Goldschmidt Cancer Center
      • Kansas City, Missouri, United States, 64154
        • Recruiting
        • University of Kansas Cancer Center - North
        • Contact:
        • Principal Investigator:
          • Julia R. White
      • Lee's Summit, Missouri, United States, 64064
        • Recruiting
        • University of Kansas Cancer Center - Lee's Summit
        • Contact:
        • Principal Investigator:
          • Julia R. White
      • St Louis, Missouri, United States, 63131
        • Recruiting
        • Missouri Baptist Medical Center
        • Principal Investigator:
          • Bryan A. Faller
        • Contact:
          • Site Public Contact
          • Phone Number: 314-996-5569
    • Montana
      • Billings, Montana, United States, 59101
        • Recruiting
        • Billings Clinic Cancer Center
        • Principal Investigator:
          • John M. Schallenkamp
        • Contact:
      • Butte, Montana, United States, 59701
        • Suspended
        • Saint James Community Hospital and Cancer Treatment Center
      • Great Falls, Montana, United States, 59405
        • Recruiting
        • Benefis Sletten Cancer Institute
        • Principal Investigator:
          • John M. Schallenkamp
        • Contact:
      • Havre, Montana, United States, 59501
        • Recruiting
        • Hi-Line Sletten Cancer Center
        • Principal Investigator:
          • John M. Schallenkamp
        • Contact:
      • Missoula, Montana, United States, 59804
        • Recruiting
        • Community Medical Center
        • Principal Investigator:
          • John M. Schallenkamp
        • Contact:
    • Nebraska
      • Omaha, Nebraska, United States, 68124
      • Omaha, Nebraska, United States, 68198
        • Active, not recruiting
        • University of Nebraska Medical Center
    • Nevada
      • Las Vegas, Nevada, United States, 89106
        • Recruiting
        • Radiation Oncology Centers of Nevada Central
        • Contact:
        • Principal Investigator:
          • John A. Ellerton
      • Las Vegas, Nevada, United States, 89119
        • Recruiting
        • Radiation Oncology Centers of Nevada Southeast
        • Contact:
        • Principal Investigator:
          • John A. Ellerton
    • New Hampshire
      • Concord, New Hampshire, United States, 03301
        • Recruiting
        • New Hampshire Oncology Hematology PA-Concord
        • Contact:
          • Site Public Contact
          • Phone Number: 603-224-2556
        • Principal Investigator:
          • Michael S. Buff
      • Dover, New Hampshire, United States, 03820
        • Active, not recruiting
        • Wentworth-Douglass Hospital
      • Exeter, New Hampshire, United States, 03833
        • Active, not recruiting
        • Exeter Hospital
      • Lebanon, New Hampshire, United States, 03756
        • Recruiting
        • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
        • Principal Investigator:
          • Lesley A. Jarvis
        • Contact:
      • Manchester, New Hampshire, United States, 03103
        • Recruiting
        • Solinsky Center for Cancer Care
        • Contact:
          • Site Public Contact
          • Phone Number: 800-339-6484
        • Principal Investigator:
          • Michael S. Buff
    • New Jersey
      • Basking Ridge, New Jersey, United States, 07920
        • Recruiting
        • Memorial Sloan Kettering Basking Ridge
        • Principal Investigator:
          • Lior Z. Braunstein
        • Contact:
          • Site Public Contact
          • Phone Number: 212-639-7592
      • Englewood, New Jersey, United States, 07631
        • Active, not recruiting
        • Englewood Hospital and Medical Center
      • Freehold, New Jersey, United States, 07728
        • Recruiting
        • CentraState Medical Center
        • Contact:
          • Site Public Contact
          • Phone Number: 732-303-5047
        • Principal Investigator:
          • Neesha Rodrigues
      • Hamilton, New Jersey, United States, 08690
        • Active, not recruiting
        • The Cancer Institute of New Jersey Hamilton
      • Middletown, New Jersey, United States, 07748
        • Recruiting
        • Memorial Sloan Kettering Monmouth
        • Principal Investigator:
          • Lior Z. Braunstein
        • Contact:
          • Site Public Contact
          • Phone Number: 212-639-7592
      • Montvale, New Jersey, United States, 07645
        • Recruiting
        • Memorial Sloan Kettering Bergen
        • Principal Investigator:
          • Lior Z. Braunstein
        • Contact:
          • Site Public Contact
          • Phone Number: 212-639-7592
      • New Brunswick, New Jersey, United States, 08901
        • Recruiting
        • Saint Peter's University Hospital
        • Contact:
        • Principal Investigator:
          • Payal D. Soni
      • New Brunswick, New Jersey, United States, 08903
        • Active, not recruiting
        • Rutgers Cancer Institute of New Jersey
      • Sewell, New Jersey, United States, 08080
        • Active, not recruiting
        • Sidney Kimmel Cancer Center Washington Township
      • Somerville, New Jersey, United States, 08876
        • Active, not recruiting
        • Robert Wood Johnson University Hospital Somerset
      • Toms River, New Jersey, United States, 08755
        • Active, not recruiting
        • Community Medical Center
    • New Mexico
      • Albuquerque, New Mexico, United States, 87109
        • Active, not recruiting
        • New Mexico Oncology Hematology Consultants
      • Albuquerque, New Mexico, United States, 87109
        • Recruiting
        • Lovelace Radiation Oncology
        • Contact:
        • Principal Investigator:
          • David Y. Lee
      • Albuquerque, New Mexico, United States, 87106
        • Recruiting
        • University of New Mexico Cancer Center
        • Contact:
        • Principal Investigator:
          • David Y. Lee
      • Las Cruces, New Mexico, United States, 88011
        • Recruiting
        • Memorial Medical Center-Las Cruces
        • Principal Investigator:
          • David Y. Lee
        • Contact:
    • New York
      • Astoria, New York, United States, 11102
        • Active, not recruiting
        • Mount Sinai Queens
      • Brooklyn, New York, United States, 11215
        • Suspended
        • New York-Presbyterian/Brooklyn Methodist Hospital
      • Brooklyn, New York, United States, 11219
        • Active, not recruiting
        • Maimonides Medical Center
      • Brooklyn, New York, United States, 11220
        • Recruiting
        • NYU Langone Hospital - Brooklyn
        • Principal Investigator:
          • Naamit K. Gerber
        • Contact:
      • Canandaigua, New York, United States, 14424
        • Recruiting
        • Sands Cancer Center
        • Contact:
          • Site Public Contact
          • Phone Number: 585-396-6161
        • Principal Investigator:
          • Kimberly Gergelis
      • Commack, New York, United States, 11725
        • Recruiting
        • Memorial Sloan Kettering Commack
        • Principal Investigator:
          • Lior Z. Braunstein
        • Contact:
          • Site Public Contact
          • Phone Number: 212-639-7592
      • Cooperstown, New York, United States, 13326
        • Recruiting
        • Mary Imogene Bassett Hospital
        • Principal Investigator:
          • Timothy P. Korytko
        • Contact:
      • Dansville, New York, United States, 14437
        • Recruiting
        • Noyes Memorial Hospital/Myers Cancer Center
        • Contact:
        • Principal Investigator:
          • Kimberly Gergelis
      • Harrison, New York, United States, 10604
        • Recruiting
        • Memorial Sloan Kettering Westchester
        • Principal Investigator:
          • Lior Z. Braunstein
        • Contact:
          • Site Public Contact
          • Phone Number: 212-639-7592
      • Mineola, New York, United States, 11501
        • Recruiting
        • NYU Langone Hospital - Long Island
        • Principal Investigator:
          • Naamit K. Gerber
        • Contact:
      • New York, New York, United States, 10032
        • Recruiting
        • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
        • Principal Investigator:
          • Eileen P. Connolly
        • Contact:
      • New York, New York, United States, 10065
        • Recruiting
        • Memorial Sloan Kettering Cancer Center
        • Principal Investigator:
          • Lior Z. Braunstein
        • Contact:
          • Site Public Contact
          • Phone Number: 212-639-7592
      • New York, New York, United States, 10016
        • Recruiting
        • Laura and Isaac Perlmutter Cancer Center at NYU Langone
        • Principal Investigator:
          • Naamit K. Gerber
        • Contact:
      • New York, New York, United States, 10029
        • Active, not recruiting
        • Mount Sinai Hospital
      • New York, New York, United States, 10019
        • Active, not recruiting
        • Mount Sinai West
      • New York, New York, United States, 10011
        • Active, not recruiting
        • Mount Sinai Chelsea
      • New York, New York, United States, 10003
        • Active, not recruiting
        • Mount Sinai Union Square
      • Nyack, New York, United States, 10960
        • Recruiting
        • Nyack Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 845-348-8507
        • Principal Investigator:
          • Sung Ho B. Lee
      • Rochester, New York, United States, 14642
        • Recruiting
        • University of Rochester
        • Contact:
          • Site Public Contact
          • Phone Number: 585-275-5830
        • Principal Investigator:
          • Kimberly Gergelis
      • Rochester, New York, United States, 14620
        • Recruiting
        • Highland Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 585-341-8113
        • Principal Investigator:
          • Kimberly Gergelis
      • Rochester, New York, United States, 14621
        • Recruiting
        • Rochester General Hospital
        • Principal Investigator:
          • Sheema Chawla
        • Contact:
      • Rochester, New York, United States, 14606
        • Recruiting
        • Wilmot Cancer Institute Radiation Oncology at Greece
        • Contact:
          • Site Public Contact
          • Phone Number: 585-758-7877
        • Principal Investigator:
          • Kimberly Gergelis
      • Rochester, New York, United States, 14623
        • Recruiting
        • Pluta Cancer Center
        • Contact:
        • Principal Investigator:
          • Kimberly Gergelis
      • Stony Brook, New York, United States, 11794
        • Recruiting
        • Stony Brook University Medical Center
        • Principal Investigator:
          • Alexander M. Stessin
        • Contact:
          • Site Public Contact
          • Phone Number: 800-862-2215
      • Syracuse, New York, United States, 13210
        • Recruiting
        • State University of New York Upstate Medical University
        • Principal Investigator:
          • Anna Shapiro
        • Contact:
          • Site Public Contact
          • Phone Number: 315-464-5476
      • The Bronx, New York, United States, 10461
        • Recruiting
        • Montefiore Medical Center-Einstein Campus
        • Principal Investigator:
          • Jana L. Fox
        • Contact:
      • The Bronx, New York, United States, 10467
        • Recruiting
        • Montefiore Medical Center - Moses Campus
        • Principal Investigator:
          • Jana L. Fox
        • Contact:
      • Uniondale, New York, United States, 11553
        • Recruiting
        • Memorial Sloan Kettering Nassau
        • Principal Investigator:
          • Lior Z. Braunstein
        • Contact:
          • Site Public Contact
          • Phone Number: 212-639-7592
      • Valley Stream, New York, United States, 11580
        • Recruiting
        • Mount Sinai South Nassau
        • Contact:
        • Principal Investigator:
          • Leester D. Wu
      • Webster, New York, United States, 14580
    • North Carolina
      • Asheville, North Carolina, United States, 28801
      • Asheville, North Carolina, United States, 28816
      • Cary, North Carolina, United States, 27518
        • Recruiting
        • Duke Cancer Center Cary
        • Contact:
        • Principal Investigator:
          • Sarah Westergaard
      • Chapel Hill, North Carolina, United States, 27599
        • Recruiting
        • UNC Lineberger Comprehensive Cancer Center
        • Contact:
        • Principal Investigator:
          • Dana L. Casey
      • Durham, North Carolina, United States, 27710
        • Recruiting
        • Duke University Medical Center
        • Contact:
          • Site Public Contact
          • Phone Number: 888-275-3853
        • Principal Investigator:
          • Sarah Westergaard
      • Gastonia, North Carolina, United States, 28054
        • Active, not recruiting
        • CaroMont Regional Medical Center
      • Hendersonville, North Carolina, United States, 28791
        • Active, not recruiting
        • Margaret R Pardee Memorial Hospital
      • Raleigh, North Carolina, United States, 27607
        • Recruiting
        • Duke Women's Cancer Care Raleigh
        • Contact:
          • Site Public Contact
          • Phone Number: 919-785-4878
        • Principal Investigator:
          • Sarah Westergaard
    • North Dakota
      • Bismarck, North Dakota, United States, 58501
      • Grand Forks, North Dakota, United States, 58201
        • Recruiting
        • Altru Cancer Center
        • Contact:
          • Site Public Contact
          • Phone Number: 701-780-6520
        • Principal Investigator:
          • Grant R. Seeger
    • Ohio
      • Akron, Ohio, United States, 44307
        • Recruiting
        • Cleveland Clinic Akron General
        • Principal Investigator:
          • Ashok Ramalingam
        • Contact:
      • Avon, Ohio, United States, 44011
        • Recruiting
        • UH Seidman Cancer Center at UH Avon Health Center
        • Contact:
          • Site Public Contact
          • Phone Number: 800-641-2422
        • Principal Investigator:
          • Janice Lyons
      • Beachwood, Ohio, United States, 44122
        • Recruiting
        • UHHS-Chagrin Highlands Medical Center
        • Contact:
        • Principal Investigator:
          • Janice Lyons
      • Canton, Ohio, United States, 44710
        • Recruiting
        • Aultman Health Foundation
        • Contact:
        • Principal Investigator:
          • Sunitha Vemulapalli
      • Canton, Ohio, United States, 44708
        • Active, not recruiting
        • Cleveland Clinic Mercy Hospital
      • Chardon, Ohio, United States, 44024
        • Recruiting
        • Geauga Hospital
        • Contact:
        • Principal Investigator:
          • Janice Lyons
      • Cleveland, Ohio, United States, 44106
        • Recruiting
        • Case Western Reserve University
        • Contact:
        • Principal Investigator:
          • Janice Lyons
      • Cleveland, Ohio, United States, 44109
        • Recruiting
        • MetroHealth Medical Center
        • Contact:
        • Principal Investigator:
          • Suzanne M. Russo
      • Columbus, Ohio, United States, 43214
        • Recruiting
        • Riverside Methodist Hospital
        • Principal Investigator:
          • Virginia M. Diavolitsis
        • Contact:
      • Columbus, Ohio, United States, 43215
        • Recruiting
        • Grant Medical Center
        • Principal Investigator:
          • Virginia M. Diavolitsis
        • Contact:
      • Columbus, Ohio, United States, 43219
        • Recruiting
        • The Mark H Zangmeister Center
        • Contact:
        • Principal Investigator:
          • Aruna C. Gowda
      • Columbus, Ohio, United States, 43210
        • Recruiting
        • Ohio State University Comprehensive Cancer Center
        • Contact:
        • Principal Investigator:
          • Sachin R. Jhawar
      • Delaware, Ohio, United States, 43015
        • Recruiting
        • Delaware Health Center-Grady Cancer Center
        • Principal Investigator:
          • Virginia M. Diavolitsis
        • Contact:
      • Dublin, Ohio, United States, 43016
        • Recruiting
        • Dublin Methodist Hospital
        • Principal Investigator:
          • Virginia M. Diavolitsis
        • Contact:
      • Elyria, Ohio, United States, 44035
        • Suspended
        • Mercy Cancer Center-Elyria
      • Grove City, Ohio, United States, 43123
        • Recruiting
        • Mount Carmel Grove City Hospital
        • Contact:
        • Principal Investigator:
          • Aruna C. Gowda
      • Mansfield, Ohio, United States, 44903
        • Recruiting
        • OhioHealth Mansfield Hospital
        • Principal Investigator:
          • Virginia M. Diavolitsis
        • Contact:
      • Mentor, Ohio, United States, 44060
        • Recruiting
        • UH Seidman Cancer Center at Lake Health Mentor Campus
        • Contact:
        • Principal Investigator:
          • Janice Lyons
      • Middleburg Heights, Ohio, United States, 44130
        • Recruiting
        • UH Seidman Cancer Center at Southwest General Hospital
        • Contact:
        • Principal Investigator:
          • Janice Lyons
      • Parma, Ohio, United States, 44129
        • Recruiting
        • University Hospitals Parma Medical Center
        • Contact:
        • Principal Investigator:
          • Janice Lyons
      • Perrysburg, Ohio, United States, 43551
        • Recruiting
        • Mercy Health - Perrysburg Hospital
        • Contact:
        • Principal Investigator:
          • Aruna C. Gowda
      • Ravenna, Ohio, United States, 44266
        • Recruiting
        • University Hospitals Portage Medical Center
        • Contact:
        • Principal Investigator:
          • Janice Lyons
      • Sandusky, Ohio, United States, 44870
        • Recruiting
        • UH Seidman Cancer Center at Firelands Regional Medical Center
        • Contact:
        • Principal Investigator:
          • Janice Lyons
      • Sylvania, Ohio, United States, 43560
        • Recruiting
        • ProMedica Flower Hospital
        • Principal Investigator:
          • Jeffrey A. Forquer
        • Contact:
      • Wadsworth, Ohio, United States, 44281
        • Recruiting
        • University Hospitals Sharon Health Center
        • Contact:
        • Principal Investigator:
          • Janice Lyons
      • Westerville, Ohio, United States, 43081
        • Recruiting
        • Saint Ann's Hospital
        • Contact:
        • Principal Investigator:
          • Aruna C. Gowda
      • Westlake, Ohio, United States, 44145
        • Recruiting
        • UH Seidman Cancer Center at Saint John Medical Center
        • Contact:
        • Principal Investigator:
          • Janice Lyons
      • Westlake, Ohio, United States, 44145
        • Recruiting
        • UHHS-Westlake Medical Center
        • Contact:
        • Principal Investigator:
          • Janice Lyons
    • Oklahoma
      • Oklahoma City, Oklahoma, United States, 73104
        • Recruiting
        • University of Oklahoma Health Sciences Center
        • Contact:
        • Principal Investigator:
          • Christina Henson
    • Oregon
      • Bend, Oregon, United States, 97701
        • Recruiting
        • Saint Charles Health System
        • Contact:
        • Principal Investigator:
          • Charles W. Drescher
      • Corvallis, Oregon, United States, 97330
        • Active, not recruiting
        • Good Samaritan Hospital
      • Portland, Oregon, United States, 97239
        • Recruiting
        • Oregon Health and Science University
        • Contact:
        • Principal Investigator:
          • Arthur Y. Hung
    • Pennsylvania
      • Bryn Mawr, Pennsylvania, United States, 19010
        • Recruiting
        • Bryn Mawr Hospital
        • Contact:
        • Principal Investigator:
          • Arezoo Ghaneie
      • Carlisle, Pennsylvania, United States, 17015
        • Recruiting
        • Carlisle Regional Cancer Center
        • Contact:
        • Principal Investigator:
          • Parul N. Barry
      • Chadds Ford, Pennsylvania, United States, 19317
        • Active, not recruiting
        • Christiana Care Health System-Concord Health Center
      • Chambersburg, Pennsylvania, United States, 17201
        • Recruiting
        • Chambersburg Hospital
        • Principal Investigator:
          • Amit B. Shah
        • Contact:
      • Ephrata, Pennsylvania, United States, 17522
        • Recruiting
        • Ephrata Cancer Center
        • Principal Investigator:
          • Amit B. Shah
        • Contact:
          • Site Public Contact
          • Phone Number: 717-721-4840
      • Erie, Pennsylvania, United States, 16505
        • Recruiting
        • UPMC Hillman Cancer Center Erie
        • Principal Investigator:
          • Parul N. Barry
        • Contact:
      • Erie, Pennsylvania, United States, 16544
        • Recruiting
        • Saint Vincent Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 814-452-5000
        • Principal Investigator:
          • Chirag S. Shah
      • Farrell, Pennsylvania, United States, 16121
        • Recruiting
        • UPMC Cancer Center at UPMC Horizon
        • Contact:
        • Principal Investigator:
          • Parul N. Barry
      • Gettysburg, Pennsylvania, United States, 17325
        • Recruiting
        • Adams Cancer Center
        • Principal Investigator:
          • Amit B. Shah
        • Contact:
          • Site Public Contact
          • Phone Number: 877-441-7957
      • Greensburg, Pennsylvania, United States, 15601
        • Recruiting
        • UPMC Cancer Centers - Arnold Palmer Pavilion
        • Contact:
          • Site Public Contact
          • Phone Number: 724-838-1900
        • Principal Investigator:
          • Parul N. Barry
      • Harrisburg, Pennsylvania, United States, 17109
        • Recruiting
        • UPMC Pinnacle Cancer Center/Community Osteopathic Campus
        • Contact:
        • Principal Investigator:
          • Parul N. Barry
      • Hershey, Pennsylvania, United States, 17033-0850
        • Recruiting
        • Penn State Milton S Hershey Medical Center
        • Contact:
        • Principal Investigator:
          • Aruna Turaka
      • Indiana, Pennsylvania, United States, 15701
        • Recruiting
        • IRMC Cancer Center
        • Contact:
        • Principal Investigator:
          • Parul N. Barry
      • Jefferson Hills, Pennsylvania, United States, 15025
        • Recruiting
        • Jefferson Hospital
        • Contact:
        • Principal Investigator:
          • Chirag S. Shah
      • Johnstown, Pennsylvania, United States, 15901
        • Recruiting
        • UPMC-Johnstown/John P. Murtha Regional Cancer Center
        • Contact:
          • Site Public Contact
          • Phone Number: 814-534-4724
        • Principal Investigator:
          • Parul N. Barry
      • Lancaster, Pennsylvania, United States, 17601
        • Recruiting
        • Lancaster General Ann B Barshinger Cancer Institute
        • Principal Investigator:
          • Pamela Boimel
        • Contact:
      • Lancaster, Pennsylvania, United States, 17602
        • Active, not recruiting
        • Lancaster General Hospital
      • Mechanicsburg, Pennsylvania, United States, 17050
        • Recruiting
        • UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
        • Contact:
        • Principal Investigator:
          • Parul N. Barry
      • Media, Pennsylvania, United States, 19063
        • Recruiting
        • Riddle Memorial Hospital
        • Contact:
        • Principal Investigator:
          • Arezoo Ghaneie
      • Monroeville, Pennsylvania, United States, 15146
        • Recruiting
        • Forbes Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 412-858-7746
        • Principal Investigator:
          • Chirag S. Shah
      • Monroeville, Pennsylvania, United States, 15146
        • Recruiting
        • UPMC Cancer Center - Monroeville
        • Contact:
        • Principal Investigator:
          • Parul N. Barry
      • Newtown Square, Pennsylvania, United States, 19073
        • Suspended
        • Bryn Mawr Health Center
      • Paoli, Pennsylvania, United States, 19301
        • Recruiting
        • Paoli Memorial Hospital
        • Contact:
        • Principal Investigator:
          • Arezoo Ghaneie
      • Philadelphia, Pennsylvania, United States, 19107
        • Active, not recruiting
        • Thomas Jefferson University Hospital
      • Philadelphia, Pennsylvania, United States, 19114
        • Active, not recruiting
        • Jefferson Torresdale Hospital
      • Pittsburgh, Pennsylvania, United States, 15213
        • Recruiting
        • UPMC-Magee Womens Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 412-647-2811
        • Principal Investigator:
          • Parul N. Barry
      • Pittsburgh, Pennsylvania, United States, 15224
        • Recruiting
        • West Penn Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 412-578-5000
        • Principal Investigator:
          • Chirag S. Shah
      • Pittsburgh, Pennsylvania, United States, 15215
        • Recruiting
        • UPMC-Saint Margaret
        • Contact:
          • Site Public Contact
          • Phone Number: 412-784-4900
        • Principal Investigator:
          • Parul N. Barry
      • Pittsburgh, Pennsylvania, United States, 15237
        • Recruiting
        • UPMC-Passavant Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 412-367-6454
        • Principal Investigator:
          • Parul N. Barry
      • Pittsburgh, Pennsylvania, United States, 15243
        • Recruiting
        • UPMC-Saint Clair Hospital Cancer Center
        • Contact:
          • Site Public Contact
          • Phone Number: 412-502-3920
        • Principal Investigator:
          • Parul N. Barry
      • Pittsburgh, Pennsylvania, United States, 15212
        • Recruiting
        • Allegheny General Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 877-284-2000
        • Principal Investigator:
          • Chirag S. Shah
      • Pittsburgh, Pennsylvania, United States, 15232
        • Recruiting
        • UPMC-Shadyside Hospital
        • Principal Investigator:
          • Parul N. Barry
        • Contact:
          • Site Public Contact
          • Phone Number: 412-621-2334
      • Reading, Pennsylvania, United States, 19605
        • Suspended
        • Penn State Health Saint Joseph Medical Center
      • Washington, Pennsylvania, United States, 15301
        • Recruiting
        • UPMC Washington Hospital Radiation Oncology
        • Contact:
        • Principal Investigator:
          • Parul N. Barry
      • West Reading, Pennsylvania, United States, 19611
        • Recruiting
        • Reading Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 610-988-9323
        • Principal Investigator:
          • Terrence P. Cescon
      • Wexford, Pennsylvania, United States, 15090
        • Recruiting
        • Wexford Health and Wellness Pavilion
        • Contact:
        • Principal Investigator:
          • Chirag S. Shah
      • Willow Grove, Pennsylvania, United States, 19090
        • Active, not recruiting
        • Asplundh Cancer Pavilion
      • Wynnewood, Pennsylvania, United States, 19096
        • Recruiting
        • Lankenau Medical Center
        • Contact:
        • Principal Investigator:
          • Arezoo Ghaneie
      • York, Pennsylvania, United States, 17403
        • Recruiting
        • WellSpan Health-York Cancer Center
        • Principal Investigator:
          • Amit B. Shah
        • Contact:
          • Site Public Contact
          • Phone Number: 877-441-7957
      • York, Pennsylvania, United States, 17408
        • Recruiting
        • UPMC Memorial
        • Contact:
          • Site Public Contact
          • Phone Number: 717-724-6760
        • Principal Investigator:
          • Parul N. Barry
    • Rhode Island
      • Providence, Rhode Island, United States, 02905
        • Recruiting
        • Women and Infants Hospital
        • Principal Investigator:
          • William M. Sikov
        • Contact:
          • Site Public Contact
          • Phone Number: 401-274-1122
      • Warwick, Rhode Island, United States, 02886
        • Suspended
        • Kent Hospital
    • South Carolina
      • Bluffton, South Carolina, United States, 29910
        • Recruiting
        • Saint Joseph's/Candler - Bluffton Campus
        • Contact:
        • Principal Investigator:
          • John A. Pablo
      • Boiling Springs, South Carolina, United States, 29316
        • Active, not recruiting
        • Prisma Health Cancer Institute - Spartanburg
      • Charleston, South Carolina, United States, 29425
        • Recruiting
        • Medical University of South Carolina
        • Contact:
        • Principal Investigator:
          • Jennifer L. Harper
      • Greenville, South Carolina, United States, 29607
        • Recruiting
        • Saint Francis Cancer Center
        • Principal Investigator:
          • Jennifer Vogel
        • Contact:
      • Greenville, South Carolina, United States, 29605
        • Active, not recruiting
        • Prisma Health Cancer Institute - Faris
      • Greenville, South Carolina, United States, 29615
        • Active, not recruiting
        • Prisma Health Cancer Institute - Eastside
      • Greenwood, South Carolina, United States, 29646
        • Recruiting
        • Self Regional Healthcare
        • Contact:
        • Principal Investigator:
          • Jennifer L. Harper
      • Greer, South Carolina, United States, 29651
        • Recruiting
        • Gibbs Cancer Center-Pelham
        • Contact:
        • Principal Investigator:
          • Heather E. Newlin Allen
      • Greer, South Carolina, United States, 29650
        • Active, not recruiting
        • Prisma Health Cancer Institute - Greer
      • Hilton Head Island, South Carolina, United States, 29926
        • Recruiting
        • The Radiation Oncology Center-Hilton Head/Bluffton
        • Contact:
        • Principal Investigator:
          • John A. Pablo
      • Okatie, South Carolina, United States, 29909
        • Recruiting
        • Beaufort Memorial/New River Cancer Center
        • Principal Investigator:
          • Jennifer L. Harper
        • Contact:
          • Site Public Contact
          • Phone Number: 843-273-7980
      • Seneca, South Carolina, United States, 29672
        • Active, not recruiting
        • Prisma Health Cancer Institute - Seneca
      • Spartanburg, South Carolina, United States, 29303
        • Recruiting
        • Spartanburg Medical Center
        • Contact:
        • Principal Investigator:
          • Heather E. Newlin Allen
      • West Columbia, South Carolina, United States, 29169
        • Recruiting
        • Lexington Medical Center
        • Principal Investigator:
          • Steven A. Madden
        • Contact:
    • South Dakota
      • Sioux Falls, South Dakota, United States, 57117-5134
    • Tennessee
      • Memphis, Tennessee, United States, 38120
        • Recruiting
        • Baptist Memorial Hospital and Cancer Center-Memphis
        • Principal Investigator:
          • Michael Tomblyn
        • Contact:
    • Texas
      • Baytown, Texas, United States, 77521
        • Recruiting
        • Houston Methodist San Jacinto Hospital
        • Principal Investigator:
          • Bin S. Teh
        • Contact:
      • Conroe, Texas, United States, 77384
        • Recruiting
        • MD Anderson in The Woodlands
        • Principal Investigator:
          • Kelly K. Hunt
        • Contact:
      • Cypress, Texas, United States, 77429
        • Recruiting
        • Houston Methodist Cypress Hospital
        • Principal Investigator:
          • Bin S. Teh
        • Contact:
      • Dallas, Texas, United States, 75390
        • Recruiting
        • UT Southwestern/Simmons Cancer Center-Dallas
        • Principal Investigator:
          • Ann M. Leitch
        • Contact:
      • Dallas, Texas, United States, 75235
        • Recruiting
        • Parkland Memorial Hospital
        • Principal Investigator:
          • Ann M. Leitch
        • Contact:
      • Galveston, Texas, United States, 77555-0565
        • Recruiting
        • University of Texas Medical Branch
        • Principal Investigator:
          • Avi B. Markowitz
        • Contact:
      • Houston, Texas, United States, 77030
        • Recruiting
        • M D Anderson Cancer Center
        • Principal Investigator:
          • Kelly K. Hunt
        • Contact:
      • Houston, Texas, United States, 77030
        • Recruiting
        • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
        • Contact:
          • Site Public Contact
          • Phone Number: 713-798-1354
          • Email: burton@bcm.edu
        • Principal Investigator:
          • Daniel A. Hamstra
      • Houston, Texas, United States, 77030
        • Recruiting
        • Houston Methodist Hospital
        • Principal Investigator:
          • Bin S. Teh
        • Contact:
          • Site Public Contact
          • Phone Number: 713-790-2700
      • Houston, Texas, United States, 77030
        • Recruiting
        • Ben Taub General Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 713-873-2000
        • Principal Investigator:
          • Daniel A. Hamstra
      • Houston, Texas, United States, 77070
        • Recruiting
        • Methodist Willowbrook Hospital
        • Principal Investigator:
          • Bin S. Teh
        • Contact:
      • Houston, Texas, United States, 77094
        • Recruiting
        • Houston Methodist West Hospital
        • Principal Investigator:
          • Bin S. Teh
        • Contact:
          • Site Public Contact
          • Phone Number: 832-522-2873
      • Houston, Texas, United States, 77079
        • Recruiting
        • MD Anderson West Houston
        • Principal Investigator:
          • Kelly K. Hunt
        • Contact:
      • Laredo, Texas, United States, 78041
        • Suspended
        • Doctor's Hospital of Laredo
      • League City, Texas, United States, 77573
        • Recruiting
        • MD Anderson League City
        • Principal Investigator:
          • Kelly K. Hunt
        • Contact:
      • Nassau Bay, Texas, United States, 77058
        • Recruiting
        • Houston Methodist Saint John Hospital
        • Principal Investigator:
          • Bin S. Teh
        • Contact:
      • San Antonio, Texas, United States, 78229
        • Active, not recruiting
        • University of Texas Health Science Center at San Antonio
      • Sugar Land, Texas, United States, 77479
        • Recruiting
        • Houston Methodist Sugar Land Hospital
        • Principal Investigator:
          • Bin S. Teh
        • Contact:
          • Site Public Contact
          • Phone Number: 281-242-2873
      • Sugar Land, Texas, United States, 77478
        • Recruiting
        • MD Anderson in Sugar Land
        • Principal Investigator:
          • Kelly K. Hunt
        • Contact:
      • The Woodlands, Texas, United States, 77385
        • Recruiting
        • Houston Methodist The Woodlands Hospital
        • Principal Investigator:
          • Bin S. Teh
        • Contact:
    • Utah
      • American Fork, Utah, United States, 84003
        • Recruiting
        • American Fork Hospital / Huntsman Intermountain Cancer Center
        • Principal Investigator:
          • Dustin Boothe
        • Contact:
      • Cedar City, Utah, United States, 84720
        • Recruiting
        • Sandra L Maxwell Cancer Center
        • Contact:
        • Principal Investigator:
          • Dustin Boothe
      • Farmington, Utah, United States, 84025
        • Recruiting
        • Farmington Health Center
        • Principal Investigator:
          • Matthew M. Poppe
        • Contact:
      • Logan, Utah, United States, 84321
        • Recruiting
        • Logan Regional Hospital
        • Principal Investigator:
          • Dustin Boothe
        • Contact:
      • Murray, Utah, United States, 84107
        • Recruiting
        • Intermountain Medical Center
        • Principal Investigator:
          • Dustin Boothe
        • Contact:
      • Ogden, Utah, United States, 84403
        • Recruiting
        • McKay-Dee Hospital Center
        • Principal Investigator:
          • Dustin Boothe
        • Contact:
      • Provo, Utah, United States, 84604
        • Recruiting
        • Utah Valley Regional Medical Center
        • Principal Investigator:
          • Dustin Boothe
        • Contact:
      • Riverton, Utah, United States, 84065
        • Recruiting
        • Riverton Hospital
        • Principal Investigator:
          • Dustin Boothe
        • Contact:
      • Salt Lake City, Utah, United States, 84106
        • Recruiting
        • University of Utah Sugarhouse Health Center
        • Principal Investigator:
          • Matthew M. Poppe
        • Contact:
      • Salt Lake City, Utah, United States, 84112
        • Recruiting
        • Huntsman Cancer Institute/University of Utah
        • Principal Investigator:
          • Matthew M. Poppe
        • Contact:
      • Salt Lake City, Utah, United States, 84143
        • Recruiting
        • LDS Hospital
        • Principal Investigator:
          • Dustin Boothe
        • Contact:
      • South Jordan, Utah, United States, 84009
        • Recruiting
        • South Jordan Health Center
        • Principal Investigator:
          • Matthew M. Poppe
        • Contact:
      • St. George, Utah, United States, 84770
        • Recruiting
        • Saint George Regional Medical Center
        • Contact:
        • Principal Investigator:
          • Dustin Boothe
    • Vermont
      • Berlin Corners, Vermont, United States, 05602
        • Recruiting
        • Central Vermont Medical Center/National Life Cancer Treatment
        • Contact:
          • Site Public Contact
          • Phone Number: 802-225-5400
        • Principal Investigator:
          • Puyao Li
      • Burlington, Vermont, United States, 05401
        • Recruiting
        • University of Vermont Medical Center
        • Contact:
          • Site Public Contact
          • Phone Number: 802-656-4101
          • Email: rpo@uvm.edu
        • Principal Investigator:
          • Puyao Li
      • Saint Johnsbury, Vermont, United States, 05819
        • Recruiting
        • Dartmouth Cancer Center - North
        • Principal Investigator:
          • Lesley A. Jarvis
        • Contact:
    • Virginia
      • Charlottesville, Virginia, United States, 22908
        • Recruiting
        • University of Virginia Cancer Center
        • Contact:
        • Principal Investigator:
          • Einsley-Marie Janowski
      • Fishersville, Virginia, United States, 22939
        • Terminated
        • Augusta Health Center for Cancer and Blood Disorders
      • Midlothian, Virginia, United States, 23114
        • Recruiting
        • Bon Secours Saint Francis Medical Center
        • Contact:
        • Principal Investigator:
          • Rebecca Krc
      • Portsmouth, Virginia, United States, 23708-2197
        • Suspended
        • Naval Medical Center - Portsmouth
      • Richmond, Virginia, United States, 23230
        • Recruiting
        • Bon Secours Cancer Institute at Reynolds Crossing
        • Contact:
        • Principal Investigator:
          • Rebecca Krc
      • Richmond, Virginia, United States, 23235
        • Recruiting
        • CJW Medical Center - Johnston-Willis Campus
        • Principal Investigator:
          • Andrew S. Kennedy
        • Contact:
          • Site Public Contact
          • Phone Number: 804-330-2199
    • Washington
      • Auburn, Washington, United States, 98001
        • Active, not recruiting
        • MultiCare Auburn Medical Center
      • Gig Harbor, Washington, United States, 98335
        • Active, not recruiting
        • MultiCare Gig Harbor Medical Park
      • Seattle, Washington, United States, 98122
        • Recruiting
        • Swedish Medical Center-First Hill
        • Principal Investigator:
          • Charles W. Drescher
        • Contact:
      • Tacoma, Washington, United States, 98405
        • Active, not recruiting
        • MultiCare Tacoma General Hospital
    • West Virginia
      • Morgantown, West Virginia, United States, 26506
        • Recruiting
        • West Virginia University Healthcare
        • Contact:
        • Principal Investigator:
          • Parvez M. Shaikh
    • Wisconsin
      • Antigo, Wisconsin, United States, 54409
        • Recruiting
        • Langlade Hospital and Cancer Center
        • Contact:
        • Principal Investigator:
          • Christopher S. Platta
      • Appleton, Wisconsin, United States, 54911
        • Active, not recruiting
        • ThedaCare Regional Cancer Center
      • Eau Claire, Wisconsin, United States, 54701
      • Eau Claire, Wisconsin, United States, 54701
        • Active, not recruiting
        • HSHS Sacred Heart Hospital
      • Grafton, Wisconsin, United States, 53024
        • Recruiting
        • Aurora Cancer Care-Grafton
        • Principal Investigator:
          • Ellen L. Ziaja
        • Contact:
      • Green Bay, Wisconsin, United States, 54301
        • Recruiting
        • Bellin Memorial Hospital
        • Contact:
          • Site Public Contact
          • Phone Number: 920-435-8326
        • Principal Investigator:
          • Srinandan Guntupalli
      • Green Bay, Wisconsin, United States, 54311
        • Recruiting
        • Aurora BayCare Medical Center
        • Principal Investigator:
          • Ellen L. Ziaja
        • Contact:
      • Green Bay, Wisconsin, United States, 54301
        • Recruiting
        • Saint Vincent Hospital Cancer Center Green Bay
        • Principal Investigator:
          • Matthew L. Ryan
        • Contact:
      • Green Bay, Wisconsin, United States, 54303
        • Recruiting
        • Saint Vincent Hospital Cancer Center at Saint Mary's
        • Principal Investigator:
          • Matthew L. Ryan
        • Contact:
      • Johnson Creek, Wisconsin, United States, 53038
        • Recruiting
        • University of Wisconsin Carbone Cancer Center - Johnson Creek
        • Principal Investigator:
          • Bethany M. Anderson
        • Contact:
      • Kenosha, Wisconsin, United States, 53142
        • Recruiting
        • Aurora Cancer Care-Kenosha South
        • Principal Investigator:
          • Ellen L. Ziaja
        • Contact:
      • La Crosse, Wisconsin, United States, 54601
        • Recruiting
        • Gundersen Lutheran Medical Center
        • Contact:
        • Principal Investigator:
          • Collin D. Driscoll
      • Madison, Wisconsin, United States, 53792
        • Recruiting
        • University of Wisconsin Carbone Cancer Center - University Hospital
        • Principal Investigator:
          • Bethany M. Anderson
        • Contact:
      • Madison, Wisconsin, United States, 53718
        • Recruiting
        • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
        • Principal Investigator:
          • Bethany M. Anderson
        • Contact:
      • Marinette, Wisconsin, United States, 54143
        • Recruiting
        • Aurora Bay Area Medical Group-Marinette
        • Principal Investigator:
          • Ellen L. Ziaja
        • Contact:
      • Marshfield, Wisconsin, United States, 54449
      • Menomonee Falls, Wisconsin, United States, 53051
        • Recruiting
        • Froedtert Menomonee Falls Hospital
        • Principal Investigator:
          • Adam D. Currey
        • Contact:
          • Site Public Contact
          • Phone Number: 262-257-5100
      • Milwaukee, Wisconsin, United States, 53215
        • Recruiting
        • Aurora Saint Luke's Medical Center
        • Principal Investigator:
          • Ellen L. Ziaja
        • Contact:
      • Milwaukee, Wisconsin, United States, 53226
        • Recruiting
        • Medical College of Wisconsin
        • Principal Investigator:
          • Adam D. Currey
        • Contact:
          • Site Public Contact
          • Phone Number: 414-805-3666
      • Milwaukee, Wisconsin, United States, 53233
        • Recruiting
        • Aurora Sinai Medical Center
        • Principal Investigator:
          • Ellen L. Ziaja
        • Contact:
      • Minocqua, Wisconsin, United States, 54548
      • Mukwonago, Wisconsin, United States, 53149
        • Recruiting
        • ProHealth D N Greenwald Center
        • Contact:
        • Principal Investigator:
          • Timothy R. Wassenaar
      • New Richmond, Wisconsin, United States, 54017
        • Recruiting
        • Cancer Center of Western Wisconsin
        • Contact:
        • Principal Investigator:
          • David M. King
      • Oak Creek, Wisconsin, United States, 53154
        • Recruiting
        • Drexel Town Square Health Center
        • Principal Investigator:
          • Adam D. Currey
        • Contact:
          • Site Public Contact
          • Phone Number: 414-805-0505
      • Oconomowoc, Wisconsin, United States, 53066
        • Recruiting
        • ProHealth Oconomowoc Memorial Hospital
        • Principal Investigator:
          • Timothy R. Wassenaar
        • Contact:
          • Site Public Contact
          • Phone Number: 262-928-7878
      • Oshkosh, Wisconsin, United States, 54904
        • Recruiting
        • Vince Lombardi Cancer Clinic - Oshkosh
        • Principal Investigator:
          • Ellen L. Ziaja
        • Contact:
      • Rhinelander, Wisconsin, United States, 54501
        • Recruiting
        • Aspirus Cancer Care - James Beck Cancer Center
        • Contact:
        • Principal Investigator:
          • Christopher S. Platta
      • Rice Lake, Wisconsin, United States, 54868
      • Sheboygan, Wisconsin, United States, 53081
        • Recruiting
        • Vince Lombardi Cancer Clinic-Sheboygan
        • Principal Investigator:
          • Ellen L. Ziaja
        • Contact:
      • Sheboygan, Wisconsin, United States, 53081
        • Recruiting
        • HSHS Saint Nicholas Hospital
        • Contact:
        • Principal Investigator:
          • Matthew L. Ryan
      • Stevens Point, Wisconsin, United States, 54482
      • Stevens Point, Wisconsin, United States, 54481
        • Recruiting
        • Aspirus Cancer Care - Stevens Point
        • Contact:
        • Principal Investigator:
          • Christopher S. Platta
      • Sturgeon Bay, Wisconsin, United States, 54235-1495
        • Recruiting
        • Saint Vincent Hospital Cancer Center at Sturgeon Bay
        • Principal Investigator:
          • Matthew L. Ryan
        • Contact:
      • Summit, Wisconsin, United States, 53066
        • Recruiting
        • Aurora Medical Center in Summit
        • Principal Investigator:
          • Ellen L. Ziaja
        • Contact:
      • Two Rivers, Wisconsin, United States, 54241
        • Recruiting
        • Vince Lombardi Cancer Clinic-Two Rivers
        • Principal Investigator:
          • Ellen L. Ziaja
        • Contact:
      • Wausau, Wisconsin, United States, 54401
        • Recruiting
        • Aspirus Regional Cancer Center
        • Contact:
          • Site Public Contact
          • Phone Number: 877-405-6866
        • Principal Investigator:
          • Christopher S. Platta
      • West Allis, Wisconsin, United States, 53227
        • Recruiting
        • Aurora West Allis Medical Center
        • Principal Investigator:
          • Ellen L. Ziaja
        • Contact:
      • West Bend, Wisconsin, United States, 53095
        • Recruiting
        • Froedtert West Bend Hospital/Kraemer Cancer Center
        • Principal Investigator:
          • Adam D. Currey
        • Contact:
          • Site Public Contact
          • Phone Number: 414-805-0505
      • Weston, Wisconsin, United States, 54476
      • Wisconsin Rapids, Wisconsin, United States, 54494
        • Recruiting
        • Aspirus Cancer Care - Wisconsin Rapids
        • Contact:
          • Site Public Contact
          • Phone Number: 715-422-7718
        • Principal Investigator:
          • Christopher S. Platta

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

35 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Patients must be women with newly diagnosed histologically proven invasive carcinoma of the breast with no evidence of metastases, staged as per site standard of care.
  • Patients must have been treated by BCS or mastectomy with clear margins of excision. Post-mastectomy positive margins for invasive disease and/or DCIS is not allowed. Multifocal disease (i.e. the presence of two or more foci or breast cancer within the same breast quadrant) and multicentric disease (i.e. the presence of two or more foci of breast cancer in different quadrants of the same breast) are allowed.
  • Patients with T3N0 disease are eligible.
  • Patients with disease limited to nodal micrometastases are eligible
  • Patients with nodal macrometastases (>2mm) treated by axillary dissection must have 1-3 positive axillary nodes (macrometastases, > 2 mm).
  • Patients treated by mastectomy and SLNB alone must have only 1-2 positive axillary nodes (macrometastases, > 2 mm).
  • Patients must be ER ≥ 1% and HER2 negative on local testing
  • Patients must have an Oncotype DX recurrence score ≤25 obtained from testing of breast tumour tissue from a core biopsy or from the surgical specimen.
  • Patient must consent to provision of, and investigator(s) must agree to submit to the CCTG Central Tumour Bank, a representative formalin fixed paraffin block of tumour tissue in order that the specific correlative marker assays described in the protocol may be conducted
  • Patient must consent to provision of samples of blood in order that the specific correlative marker assays described in the protocol may be conducted.
  • Patients must have had endocrine therapy initiated or planned for ≥ 5 years. Premenopausal women will receive ovarian ablation plus aromatase inhibitor therapy or tamoxifen if adjuvant chemotherapy was not administered. For all patients, endocrine therapy can be given concurrently or following RT.
  • Patients may or may not have had adjuvant chemotherapy.
  • RT must commence within 16 weeks of definitive surgery if the patient is not treated with chemotherapy. If adjuvant chemotherapy is given, RT must begin within 12 weeks after the last dose. (Note: adjuvant chemotherapy may be ongoing at the time of randomization). Definitive surgery is defined as the last breast cancer-related surgery.
  • Patient's ECOG performance status must be 0, 1 or 2.
  • Patient's age must be ≥ 35 years.
  • For the first 736 eligible English or French-speaking subjects who have agreed to optional questionnaire completion: Patient is able (i.e. sufficiently fluent) and willing to complete the quality of life, health utilities and lost productivity questionnaires in either English or French (note: enrollment completed 2022Aug02)
  • Patient consent must be appropriately obtained in accordance with applicable local and regulatory requirements
  • Patients must be accessible for treatment and follow-up. Investigators must assure themselves the patients randomized on this trial will be available for complete documentation of the treatment, adverse events, and follow-up.
  • In accordance with CCTG policy, protocol treatment is to begin within 6 weeks of patient randomization.
  • Women of childbearing potential must have agreed to use an effective contraceptive method. A woman is considered to be of "childbearing potential" if she has had menses at any time in the preceding 12 consecutive months.

Exclusion Criteria:

  • Patients with nodal disease limited to isolated tumour cells (pN0i+ < 0.2 mm).
  • Patients with pT3N1 and pT4 disease (Note: patients with T3N0 are eligible).
  • Any prior history, not including the index cancer, of ipsilateral invasive breast cancer or ipsilateral DCIS treated with radiation therapy. (Patients with synchronous or previous ipsilateral LCIS are eligible.)
  • Synchronous or previous contralateral invasive breast cancer. (Patients with contralateral DCIS are eligible unless previously treated with radiation.)
  • History of non-breast malignancies except adequately treated non-melanoma skin cancers, in situ cancers treated by local excision or other cancers curatively treated with no evidence of disease for ≥ 5 years.
  • Patients who are pregnant.
  • Patients that have had prior ipsilateral chestwall/thoracic radiation.
  • Patients treated with chemo or endocrine therapy administered in the neoadjuvant setting for breast cancer. Endocrine therapy exposure 12 weeks or less prior to surgery is permitted.
  • Patients with serious non-malignant disease (e.g. cardiovascular, scleroderma etc.) which would preclude RT.
  • Patients with any serious active or co-morbid medical conditions, laboratory abnormality, psychiatric illness, active or uncontrolled infections, or serious illnesses or medical conditions that would prevent the patient from participating or to be managed according to the protocol (according to investigator's decision).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: No Regional Radiotherapy
A. Whole Breast Irradiation (WBI) following BCS or; B. No Radiotherapy (RT) following mastectomy
Radiation: Radiation
Radiotherapy given
Other: No Radiation
No radiotherapy given
Active Comparator: Regional Radiotherapy
A. WBI plus RT to the regional nodes (supraclavicular, non-dissected axillary, and internal mammary) following BCS or; B. RT to the chestwall and regional nodes (supraclavicular, non-dissected axillary, and internal mammary) following mastectomy
Radiation: Radiation
Radiotherapy given

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
compare the breast cancer recurrence-free interval (BCRFI) between patients that received regional RT or not
Time Frame: 9.5 years
Defined as time from randomization to time of invasive recurrent disease in the ipsilateral chestwall, breast, regional nodes, distant sites or death due to BC.
9.5 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Compare the invasive disease-free survival between patients that received regional RT or not.
Time Frame: 9.5 years
Defined as time from randomization to time of invasive recurrent disease in the ipsilateral chestwall, breast, regional nodes, distant sites or death due to BC
9.5 years
Compare the breast cancer mortality between patients that received regional RT or not.
Time Frame: 9.5 years
Defined as death due to BC
9.5 years
Compare the overall survival (OS) between patients that received regional RT or not
Time Frame: 9.5 years
Defined as the time from randomization to the time of death from any cause
9.5 years
Compare the locoregional recurrence-free interval (LRRFI) between patients that received regional RT or not.
Time Frame: 9.5 years
Defined as time from randomization to time of invasive recurrent disease in the ipsilateral chestwall, breast or regional nodes, or death to due to BC
9.5 years
Compare the distant recurrence-free interval (DRFI) between patients that received regional RT or not.
Time Frame: 9.5 years
Defined as time from randomization to time of invasive recurrent disease in distant sites or death due to BC
9.5 years
Number and severity of adverse events using the current CTCAE version 4
Time Frame: 9.5 years
9.5 years
Compare arm volume and mobility measurements between patients that received regional RT or not
Time Frame: 9.5 years
A Fisher's Exact Test will be used to compare lymphedema and arm abduction deficit between two arms. Defined as a difference in arm abduction of 10% or greater in the comparison of the ipsilateral to the contralateral arm.
9.5 years
Compare patient-reported outcomes (PROs) and the quality of life (QOL) between patients that received regional RT or not
Time Frame: 9.5 years
using the NSABP Questionnaire for patients treated by BCS or mastectomy.
9.5 years
Compare the quality of life (QOL) between patients that received regional RT or not
Time Frame: 9.5 years
Overall QOL (EORTC QLQ-C30) will be compared between the two treatment groups using a similar approach.
9.5 years
Compare the cost-effectiveness between patients that received regional RT or not
Time Frame: 9.5 years
Costs will be expressed in $US and $CAN base currencies based on the final year of the study. An average cost per study subject by treatment arm for an overall mean cost per study arm will be generated
9.5 years
Compare the quality of life (QOL) between patients that received regional RT or not
Time Frame: 9.5 years
breast symptoms (NSABP B32 Questionnaire) will be compared between the two treatment groups using a similar approach.
9.5 years
Compare the quality of life (QOL) between patients that received regional RT or not
Time Frame: 9.5 years
skin symptoms and fatigue (EORTC QLQ-BR23) will be compared between the two treatment groups using a similar approach.
9.5 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Canadian Cancer Trials Group

Collaborators

Alliance for Clinical Trials in Oncology
NRG Oncology
Eastern Cooperative Oncology Group
SWOG Cancer Research Network

Investigators

  • Study Chair: Timothy Whelan, Juravinski Cancer Centre at Hamilton Health Sciences, Ontario Canada

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 16, 2018

Primary Completion (Estimated)

September 1, 2027

Study Completion (Estimated)

December 30, 2027

Study Registration Dates

First Submitted

March 28, 2018

First Submitted That Met QC Criteria

April 4, 2018

First Posted (Actual)

April 5, 2018

Study Record Updates

Last Update Posted (Actual)

May 12, 2026

Last Update Submitted That Met QC Criteria

May 11, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CCTG MA.39
  • NCI-2017-02047 (Other Identifier: NCI CTRP)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

Yes

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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