STable Coronary Artery Diseases RegisTry (START)

Observational, prospective multicentric, national study, evaluating the diagnostic and therapeutic pathways of patient with cronic coronary artery disease followed in Italian cardiology centers.

Study Overview

• Status: Completed
• Conditions: Chronic Ischemic Heart Disease
• Intervention / Treatment: Other: Data collection on Stable Ischemic heart disease

Detailed Description

Coronary heart disease is still highly prevalent in the world, and chronic stable angina is one of the most common clinical presentations of this disease. The objectives of chronic stable angina treatment include the reduction of symptoms, the inhibition or slowing of the progression of the disease, the prevention of associated cardiovascular events such as myocardial infarction, and the possible improvement of survival.The results of COURAGE Study and of meta-analysis of more recent studies demonstrate that patients in optimized medical therapy (OMT) (aspirin, beta-blocker and statin in association with an ACE-inhibitor and strict control of risk factors). ) the percutaneous coronary revascularization procedure (PCI) did not lead to an improvement in the cardiovascular prognosis. These data led the groups in charge of drafting the guidelines to recommend OMT as an initial treatment of stable angina, reserving the revascularization procedure for those patients with symptoms not adequately controlled by medical therapy.

It is therefore considered appropriate to plan a registry in patients with stable coronary artery disease that has the ability to describe in the heterogeneity of Italian cardiological centers the current characteristics of these patients, their treatment modalities, adherence to the current guidelines both as regards invasive therapy that the optimized medical, the use and the total cost of the resources needed to manage this pathology, the clinical course one year after entering the register.

Consecutive patients discharged (after an ordinary or day hospital admission) or managed as outpatient at Cardiology department participating in the project with a diagnosis of stable coronary artery disease will be included in the register. Enrollment will last 3 months in each center, starting with the first enrolled patient, or up to 50 patients enrolled.

• Study Type: Observational
• Enrollment (Actual): 5070

Contacts and Locations

Study Locations

• Italy
  • Alessandria, Italy, 15100
    • Clinica Citta' Di Alessandria - Uo Cardiologia
  • Boscotrecase, Italy, 80042
    • Ospedale Civile Di Boscotrecase - Utic Cardiologia
  • Frattamaggiore, Italy, 80027
    • Ospedale San Giovanni Di Dio - Uo Cardiologia - Utic
  • Giugliano In Campania, Italy, 80014
    • Ospedale Generale Di Zona - U.O. Cardiologia - Utic
  • Napoli, Italy, 80136
    • Ospedale San Gennaro - U.O. Cardiologia E Riabilitazione Card.
  • Napoli, Italy, 80122
    • Clinica Mediterranea - U.O. Di Cardiologia
  • Napoli, Italy, 80131
    • Aorn Cardarelli - U.O. Cardiologia Con Utic
  • Napoli, Italy, 80131
    • Aorn Osp. Dei Colli- Po Vincenzo Monaldi - U.O.C. Cardiologia E Utic 'Vanvitelli'
  • Napoli, Italy, 80131
    • Aorn Osp. Dei Colli- Po Vincenzo Monaldi - U.O.C. Cardiologia
  • Napoli, Italy, 80142
    • Ospedale Del Mare - U.O. Cardiologia Con Utic
  • Novara, Italy, 28100
    • Aou Maggiore Della Carita' - Cardiologia Ii
  • Novara, Italy, 28100
    • Aou Maggiore Della Carita' Scdu Clinica Cardiologica-Cardiologia I
  • Novara, Italy, 28100
    • Clinica San Gaudenzio - Uoa Cardiologia
  • San Giuseppe Vesuviano, Italy, 80047
    • Casa Di Salute Santa Lucia - U.O. Cardiologia
  • Veruno, Italy, 28010
    • Ics Maugeri Spa Societa' Benefit - Uo Cardiologia Riabilitativa
  • AG
    • Agrigento, AG, Italy, 92100
      • Ospedale San Giovanni Di Dio - Uo Cardiologia E Utic
  • AN
    • Ancona, AN, Italy, 60131
      • Istituto Scientifico Inrca - Uo Cardiologia/Utic/Telecardiologia
    • Fabriano, AN, Italy, 60044
      • Ospedale Civile Profili - U.O. Cardiologia
    • Jesi, AN, Italy, 60035
      • Ospedale Di Jesi Carlo Urbani - U.O. Di Cardiologia
    • Senigallia, AN, Italy, 60019
      • Ospedale Principe Di Piemonte - Uoc Cardiologia Utic
  • AP
    • Ascoli Piceno, AP, Italy, 63100
      • Ospedale Gen.Le Prov.Le C.G. Mazzoni - Sc Cardiologia
    • San Benedetto Del Tronto, AP, Italy, 63074
      • Ospedale Madonna Del Soccorso - Uoc Cardiologia Indirizzo Riabilitativo
  • AR
    • Cortona, AR, Italy, 52044
      • Ospedale Valdichiana Santa Margherita - Uos Cardiologia E Hdu
  • AV
    • Avellino, AV, Italy, 83100
      • Aorn San Giuseppe Moscati - U.O. Cardiologia/Utic 'D. Rotiroti'
  • BA
    • Bari, BA, Italy, 70123
      • Ospedale San Paolo - Cardiologia-Utic
    • Bari, BA, Italy, 70124
      • Ospedale Policlinico - U.O. Di Cardiologia Ospedaliera
    • Cassano Delle Murge, BA, Italy, 70020
      • Ics Maugeri Spa Societa' Benefit - Uo Cardiologia
    • Corato, BA, Italy, 70033
      • Ospedale Umberto I - Uosd Di Cardiologia
    • Molfetta, BA, Italy, 70056
      • P.O. Don Tonino Bello - Uosd Cardiologia
  • BG
    • Bergamo, BG, Italy, 24127
      • Asst Papa Giovanni Xxiii - Cardiologia 1
    • Osio Sotto, BG, Italy, 24046
      • Iob - Policlinico San Marco - U.O. Cardiologia
  • BL
    • Belluno, BL, Italy, 32100
      • Ospedale Civile - Sc Cardiologia
    • Feltre, BL, Italy, 32032
      • Ospedale Santa Maria Del Prato - U.O. Di Cardiologia
  • BN
    • Benevento, BN, Italy, 82100
      • Azienda Ospedaliera G. Rummo - Cardiologia Interventistica E Utic
  • BR
    • Brindisi, BR, Italy, 72100
      • Ospedale Perrino - U.O.C. Di Cardiologia
    • Francavilla Fontana, BR, Italy, 72021
      • Ospedale Civile Dario Camberlingo - U.O. Di Cardiologia - Utic
  • BS
    • Gavardo, BS, Italy, 25085
      • Ospedale Civile 'La Memoria' - U.O. Di Cardiologia
    • Lumezzane, BS, Italy, 25065
      • Ics Maugeri Spa Societa' Benefit - U.O. Di Cardiologia Riabilitativa
  • BT
    • Andria, BT, Italy, 76123
      • Osp. Andria Canosa - Po Andria - Cardiologia - Utic
    • Barletta, BT, Italy, 76121
      • Ospedale Monsignor Angelo R. Di Miccoli - Unita' Operativa Di Cardiologia
  • CA
    • Cagliari, CA, Italy, 09121
      • Presidio Ospedaliero Ss Trinita' - Sc Di Cardiologia
    • Cagliari, CA, Italy, 09134
      • Azienda Ospedaliera G. Brotzu - Struttura Complessa Di Cardiologia
  • CB
    • Campobasso, CB, Italy, 86100
      • Ospedale A. Cardarelli - U.O. Cardiologia E Utic
  • CE
    • Aversa, CE, Italy, 81031
      • Presidio Ospedaliero Moscati - U.O.C. Cardiologia
    • Caserta, CE, Italy, 81100
      • Az. Ospedaliera S. Anna E S. Sebastiano - Cardiologia E Riabilit. Cardiologica
    • Caserta, CE, Italy, 81100
      • Az. Ospedaliera S. Anna E S. Sebastiano - U.O. Cardiologia-Utic
    • Castel Volturno, CE, Italy, 81030
      • Pineta Grande Hospital - U.O. Cardiologia
    • Piedimonte Matese, CE, Italy, 81016
      • Ospedale Civile Ave Gratia Plena - U.O. Di Cardiologia E Utic
    • Santa Maria Capua Vetere, CE, Italy, 81055
      • Ospedale San Giuseppe E Melorio - U.O.C. Cardiologia Utic
    • Sessa Aurunca, CE, Italy, 81037
      • Presidio Ospedaliero San Rocco - U.O.C. Cardiologia - Utic
  • CL
    • Gela, CL, Italy, 93012
      • Po Vittorio Emanuele Di Gela - U.O.C Cardiologia - Utic
  • CO
    • Gravedona, CO, Italy, 22015
      • Ospedale Moriggia Pelascini - Unita' Operativa Di Cardiologia
  • CR
    • Casalmaggiore, CR, Italy, 26041
      • Ospedale Civile Oglio Po - U.O. Di Cardiologia-Utic
    • Cremona, CR, Italy, 26100
      • Ospedale Di Cremona - Uo Di Cardiologia
  • CS
    • Cariati, CS, Italy, 87063
      • Capt Di Cariati - Ambulatorio Di Cardiologia
    • Cosenza, CS, Italy, 87100
      • Ospedale Annunziata - Uoc Cardiologia
    • Mormanno, CS, Italy, 87026
      • Ospedale Civile Minervini - Medicina Interna
  • CT
    • Catania, CT, Italy, 95122
      • P.O. Garibaldi-Nesima - U.O.C. Di Cardiologia
  • CZ
    • Lamezia Terme, CZ, Italy, 88046
      • Ospedale Giovanni Paolo Ii - U.O. Cardiologia E Utic
  • EN
    • Troina, EN, Italy, 94018
      • I.R.C.C.S. Oasi Maria Ss. - U.O. Cardiologia
  • FC
    • Cesena, FC, Italy, 47023
      • Ospedale M.Bufalini - U.O. Di Cardiologia-Utic
  • FE
    • Cento, FE, Italy, 44042
      • Ospedale Ss. Annunziata - U.O. Di Cardiologia
    • Ferrara, FE, Italy, 44124
      • Arcispedale Sant'Anna - U.O. Cardiologia - Utic
  • FG
    • Cerignola, FG, Italy, 71042
      • Ospedale Civile Giuseppe Tatarella - U.O. Di Cardiologia - Utic
    • Foggia, FG, Italy, 71100
      • Ospedali Riuniti - S.C. Di Cardiologia Univ.-Utic
    • San Giovanni Rotondo, FG, Italy, 71013
      • Ospedale Casa Sollievo Della Sofferenza - Cardiologia - Utic - Riabil Cardiologica
  • FM
    • Fermo, FM, Italy, 63900
      • Ospedale Civile Augusto Murri - U.O. Cardiologia
  • GE
    • Genova, GE, Italy, 16153
      • Ospedale Padre Antero Micone - Sc Cardiologia - Utic
  • GO
    • Gorizia, GO, Italy, 34170
      • Ospedale San Giovanni Di Dio - S.O.C. Cardiologia
    • Monfalcone, GO, Italy, 34074
      • Ospedale Civile San Polo - S.O.C. Cardiologia
  • GR
    • Grosseto, GR, Italy, 58100
      • Ospedale Della Misericordia - U.O. Di Cardiologia
  • IM
    • Imperia, IM, Italy, 18100
      • Ospedale Civile - U.O. Cardiologia-Utic
    • Sanremo, IM, Italy, 18038
      • Presidio Ospedaliero - U.O. Cardiologia
  • IS
    • Isernia, IS, Italy, 86170
      • Ospedale F. Veneziale - Ssd Cardiologia Emodinamica
  • LE
    • Copertino, LE, Italy, 73043
      • Ospedale San Giuseppe Da Copertino - U.O. Di Cardiologia-Utic
    • Galatina, LE, Italy, 73013
      • Ospedale Santa Caterina Novella - U.O. Di Cardiologia
    • Lecce, LE, Italy, 73100
      • Casa Di Cura Petrucciani - U.O. Cardiologia - Card. Riabilitativa
    • Lecce, LE, Italy, 73100
      • Ospedale Vito Fazzi - U.O. Card. Interventistica - Emodinamica
    • Lecce, LE, Italy, 73100
      • Ospedale Vito Fazzi - U.O. Di Cardiologia
    • Scorrano, LE, Italy, 73020
      • Ospedale Ignazio Veris Delli Ponti - Uoc Cardiologia-Utic
    • Tricase, LE, Italy, 73039
      • Azienda Osp. Cardinale G. Panico - U.O. Cardiologia - Utic
  • LI
    • Piombino, LI, Italy, 57025
      • Ospedale Villamarina - Cardiologia E Utic
  • LT
    • Aprilia, LT, Italy, 04011
      • Casa Di Cura Citta' Di Aprilia - U.O. Cardiologia
    • Formia, LT, Italy, 04023
      • Ospedale Del Dono Svizzero - U.O.C. Di Cardiologia - Utic
    • Latina, LT, Italy, 04100
      • Polo Ospedaliero Integrato (C/O Icot) - Uoc Cardiologia Ed Emodinamica Univ.
  • LU
    • Lido Di Camaiore, LU, Italy, 55043
      • Nuovo Ospedale Versilia - Sc Cardiologia
  • MB
    • Carate Brianza, MB, Italy, 20048
      • Ospedale Carate Brianza - Cardiologia - Carate Brianza/Giussano
    • Monza, MB, Italy, 20900
      • Policlinico Di Monza - Uo Cardiol. Clinica E Scompenso Cardiaco
  • MC
    • Civitanova Marche, MC, Italy, 62012
      • Presidio Osp. Di Civitanova Marche - Sc Cardiologia
  • ME
    • Sant'Agata Di Militello, ME, Italy, 98076
      • P.O. Sant'Agata Di Militello - Uoc Cardiologia
  • MI
    • Legnano, MI, Italy, 20025
      • Ospedale Civile - Uo Cardiologia
    • Magenta, MI, Italy, 20013
      • Ospedale Civile Fornaroli - U.O. Cardiologia
    • Milano, MI, Italy, 20131
      • Istituto Clinico Citta' Studi - U.O. Cardiologia
    • Milano, MI, Italy, 20132
      • Ospedale San Raffaele - Utic E Subintensiva
    • Milano, MI, Italy, 20153
      • Ospedale San Carlo Borromeo - Cardiologia-Ucc
    • San Donato Milanese, MI, Italy, 20097
      • Irccs Policlinico San Donato - U.O. Cardiologia Con Utic
    • Sesto San Giovanni, MI, Italy, 20099
      • Irccs Policlinico Multimedica - Uo Di Cardiologia
    • Vizzolo Predabissi, MI, Italy, 20077
      • Ospedale Di Vizzolo Predabissi - Uo Cardiologia E Ucc
  • MO
    • Sassuolo, MO, Italy, 41049
      • Ospedale Di Sassuolo - Cardiologia
  • MS
    • Massa, MS, Italy, 54100
      • Ftgm - Stabilimento Di Massa - Uoc Cardiologia Diagn. E Interventistica
    • Massa, MS, Italy, 54100
      • Ospedale Apuane - U.O. Cardiologia-Utic
  • Mi
    • Rozzano, Mi, Italy, 20089
      • Istituto Clinico Humanitas - Uo Emodinamica Cardiologia Invasiva Ucc
  • NU
    • Nuoro, NU, Italy, 08100
      • Ospedale San Francesco - Cardiologia - Utic
  • PA
    • Palermo, PA, Italy, 90141
      • Casa Di Cura Candela - Uof Cardiologia
    • Palermo, PA, Italy, 90146
      • Aor Villa Sofia-Cervello P.O. Cervello - U.O. Cardiologia - Cervello
  • PD
    • Camposampiero, PD, Italy, 35012
      • Ospedale Di Camposampiero - U.O.A. Cardiologia
  • PE
    • Pescara, PE, Italy, 65124
      • Ospedale Civile Dello Spirito Santo - Utic E Cardiologia Interventistica
  • PG
    • Città Di Castello, PG, Italy, 06012
      • Presidio Ospedaliero Citta' Di Castello - U.O. Di Cardiologia
  • PN
    • Pordenone, PN, Italy, 33170
      • Ospedale Di Pordenone - S.O.C. Cardiologia
    • San Vito Al Tagliamento, PN, Italy, 33078
      • Ospedale Di S. Vito Al Tagliamento - S.O.C. Cardiologia
  • PV
    • Pavia, PV, Italy, 27100
      • Fondazione Irccs Policlinico San Matteo - Cardiologia
    • Pavia, PV, Italy, 27100
      • Ics Maugeri Spa Societa' Benefit - U.O. Di Riabilitazione Cardiologica
    • Pavia, PV, Italy, 27100
      • Istituto Di Cura Citta' Di Pavia - U.O. Cardiologia Ii
    • Vigevano, PV, Italy, 27029
      • Ospedale Civile - Cardiologia
  • PZ
    • Melfi, PZ, Italy, 85025
      • Ospedale S. Giovanni Di Dio - U.O. Cardiologia E Utic
    • Potenza, PZ, Italy, 85100
      • Azienda Ospedaliera San Carlo - S.S.D. Cardiologia Riabilitativa
  • RA
    • Faenza, RA, Italy, 48018
      • Ospedale Per Gli Infermi - U.O. Cardiologia - Utic
    • Lugo, RA, Italy, 48022
      • Ospedale Civile - U.O. Di Cardiologia
    • Ravenna, RA, Italy, 48100
      • Ospedale Civile Santa Maria Delle Croci - U.O. Di Cardiologia
  • RC
    • Locri, RC, Italy, 89044
      • Ospedale Civile - S.O.C. Cardiologia-Utic
    • Melito di Porto Salvo, RC, Italy, 89063
      • Ospedale Tiberio Evoli Riabilitazione - Cardio-Respiratoria
    • Polistena, RC, Italy, 89024
      • Ospedale Santa Maria Degli Ungheresi - U.O. Di Cardiologia
    • Reggio Calabria, RC, Italy, 89124
      • Ao Bianchi Melacrino Morelli- Po Riuniti - Divisione Di Cardiologia
  • RE
    • Correggio, RE, Italy, 42015
      • Ospedale Civile San Sebastiano - Sos Cardiologia Area Nord
    • Guastalla, RE, Italy, 42016
      • Ospedale Civile - Sc Cardiologia Area Nord
    • Reggio Emilia, RE, Italy, 42100
      • Arcispedale Santa Maria Nuova - S.C. Cardiologia
  • RG
    • Ragusa, RG, Italy, 97100
      • Giovanni Paolo Ii - U.O.C. Cardiologia-Utic
    • Vittoria, RG, Italy, 97019
      • Ospedale Riccardo Guzzardi - U.O.C. Di Cardiologia-Utic
  • RI
    • Rieti, RI, Italy, 02100
      • P.O. San Camillo de Lellis - U.O.C. Cardiologia
  • RM
    • Anzio, RM, Italy, 00042
      • Ospedali Riuniti Anzio-Nettuno - U.O. Di Cardiologia - Utic
    • Ariccia, RM, Italy, 00040
      • Nuovo Ospedale Dei Castelli - U.O.C. Di Cardiologia E Utic
    • Civitavecchia, RM, Italy, 00053
      • Ospedale Civile San Paolo - U.O. Cardiologia - Utic
    • Pomezia, RM, Italy, 00040
      • Policlinico Citta' Di Pomezia S. Anna - U.O. Cardiologia-Utic
    • Roma, RM, Italy, 00135
      • P.O. San Filippo Neri - Asl Roma 1 - Uoc Cardiologia E Utic
    • Roma, RM, Italy, 00128
      • Campus Biomedico - Cardiologia
    • Roma, RM, Italy, 00149
      • European Hospital - Uo. Cardiologia Interventistica
    • Roma, RM, Italy, 00152
      • Ospedale San Camillo - Cardiologia 2 (Ex Cardio 3)
    • Roma, RM, Italy, 00152
      • Ospedale San Camillo - Uoc Cardiologia 1
    • Roma, RM, Italy, 00157
      • Ospedale Sandro Pertini - Uoc Cardiologia
    • Roma, RM, Italy, 00161
      • Policlinico Umberto Primo - Cardiologia B - Cardiologia E Angiologia
    • Roma, RM, Italy, 00161
      • Policlinico Umberto Primo - Malattie Cardiovascolari A
    • Roma, RM, Italy, 00163
      • Aurelia Hospital - U.O.C Cardiologia
    • Roma, RM, Italy, 00177
      • Ospedale Madre Giuseppina Vannini - U.O.C. Cardiologia
    • Roma, RM, Italy, 00189
      • Ospedale San Pietro Fatebenefratelli - U.O Complessa Di Cardiologia
    • Roma, RM, Italy, 00189
      • Ospedale Sant'Andrea Di Roma - U.O.C. Cardiologia
    • Roma, RM, Italy, 00193
      • Ospedale Santo Spirito - U.O.C. Di Cardiologia
    • Tivoli, RM, Italy, 00019
      • Ospedale San Giovanni Evangelista - U.O.C. Di Cardiologia - Utic
  • RO
    • Rovigo, RO, Italy, 45100
      • Ospedale Santa Maria Della Misericordia - U.O.C. Cardiologia
  • SA
    • Battipaglia, SA, Italy, 84091
      • Presidio Osped. S. Maria Della Speranza - U.O. Di Cardiologia
    • Roccadaspide, SA, Italy, 84069
      • Ospedale Di Roccadaspide - Cardiologia-Utic
    • Salerno, SA, Italy, 84131
      • Aou S. Giovanni Di Dio-Ruggi D'Aragona - Uoc Cardiologia Preventiva
    • Vallo Della Lucania, SA, Italy, 84078
      • Ospedale San Luca - U.O. Utic - Cardiologia
  • SI
    • Poggibonsi, SI, Italy, 53036
      • Ospedale Dell'Alta Val D'Elsa - Uosd Cardiologia-Utic
    • Siena, SI, Italy, 53100
      • Aou Senese Ospedale S. Maria Alle Scotte - U.O.C. Cardiologia Ospedaliera
  • SP
    • Sarzana, SP, Italy, 19038
      • Ospedale San Bartolomeo - U.O. Cardiologia Clinica-Riabilitativa
  • SR
    • Augusta, SR, Italy, 96011
      • Ospedale E. Muscatello - U.O. Di Cardiologia - Utic
    • Avola, SR, Italy, 96012
      • Ospedale G. Di Maria - Cardiologia Utic
    • Siracusa, SR, Italy, 96100
      • Ospedale Umberto I - Uoc Cardiologia E Utic
  • TA
    • Manduria, TA, Italy, 74024
      • Ospedale Civile M. Giannuzzi - Cardiologia E Utic
    • Taranto, TA, Italy, 74100
      • Casa Di Cura Villa Verde - Cardiologia
  • TE
    • Teramo, TE, Italy, 64100
      • Ospedale Civile G. Mazzini -Cardiologia Utic Ed Emodinamica
  • TN
    • Trento, TN, Italy, 38122
      • Ospedale Santa Chiara - Divisione Di Cardiologia
  • TO
    • Ciriè, TO, Italy, 10073
      • Por Cirie'- Lanzo Presidio Cirie' - S.C. Cardiologia Cirie'- Ivrea
    • Ivrea, TO, Italy, 10015
      • Ospedale Civile - S.C. Cardiologia Cirie' Ivrea
    • Torino, TO, Italy, 10132
      • Maria Pia Hospital - U.O. Cardiologia
  • TP
    • Alcamo, TP, Italy, 91011
      • Ospedale Ss. Vito E Spirito - U.O.S. Di Cardiologia
    • Marsala, TP, Italy, 91025
      • Presidio Ospedaliero Paolo Borsellino - U.O.C Cardiologia- Utic
  • TR
    • Orvieto, TR, Italy, 05018
      • Ospedale S. Maria Della Stella - Sc Di Cardiologia
  • TS
    • Trieste, TS, Italy, 34125
      • Ospedali Riuniti - Osp. Maggiore - A.F. Cardiologia E Riabil. Cardiologica
  • TV
    • Conegliano, TV, Italy, 31015
      • Ospedale Santa Maria Dei Battuti - U.O. Di Cardiologia
  • UD
    • Udine, UD, Italy, 33100
      • Pou Santa Maria Della Misericordia - S.O.C. Cardiologia
  • VA
    • Gallarate, VA, Italy, 21013
      • Ospedale S. Antonio Abate - U.O. Di Cardiologia
    • Saronno, VA, Italy, 21047
      • Presidio Ospedaliero Di Saronno - U.O.C. Di Cardiologia
    • Somma Lombardo, VA, Italy, 21019
      • Ospedale Di Circolo A. Bellini - Medicina Generale E Card. Riabilitativa
    • Tradate, VA, Italy, 21049
      • Ospedale Di Circolo Galmarini - Cardiologia
    • Varese, VA, Italy, 21100
      • Ospedale Di Circolo E Fondazione Macchi - Cardiologia I
  • VC
    • Vercelli, VC, Italy, 13100
      • Ospedale Sant'Andrea - Sc Cardiologia
  • VE
    • Chioggia, VE, Italy, 30019
      • Ospedale Civile - U.O.C. Cardiologia
    • Venezia, VE, Italy, 30122
      • Ospedale Civile Di Venezia - U.O. Di Cardiologia
  • VI
    • Arzignano, VI, Italy, 36071
      • Ospedale Civile - U.O.C. Cardiologia
    • Thiene, VI, Italy, 36016
      • Centro Polifunzionale Boldrini - Cardiologia Riabilitativa-Cardioaction
  • VR
    • San Bonifacio, VR, Italy, 37047
      • Ospedale G. Fracastoro - U.O.C. Di Cardiologia
  • VT
    • Viterbo, VT, Italy, 01100
      • Ospedale Belcolle - U.O.C. Cardiologia Utic Emodinamica

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients discharged (after a hospitalization or DH hospitalization) or managed as outpatients in Cardiology department with diagnoses of stable coronary heart disease.

Description

Inclusion Criteria:

• Patients aged >/= 18
• Patients discharged from hospital or ambulatory visit with a diagnoses of stable heart disease;
• Written informed consent

Exclusion Criteria:

• Acute coronary syndrome within 30 days from enrollment
• CCS Angina Class IV
• Angina probably not for coronary artery disease

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of patients in medical therapy and that underwent revascularization	Number of patients in medical therapy and that underwent revascularization	Enrollment

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of patient in optimal medical therapy	Patient treated according to International Guidelines	12 months Follow-up
Mortality rate	Rate of patients died	12 months Follow-up
All cause hospitalization rate	Rate of patients hospitalized	12 months Follow-up
Angina recurrence rate	Rate of patients with angina symtoms	12 months Follow-up

Collaborators and Investigators

• Sponsor: Heart Care Foundation
• Investigators: Study Chair: Leonardo De Luca, MD, Heart Care Foundation

Publications and helpful links

General Publications

• De Luca L, Temporelli PL, Lucci D, Colivicchi F, Calabro P, Riccio C, Amico A, Mascia F, Proia E, Di Lenarda A, Gulizia MM; START Investigators. Characteristics, treatment and quality of life of stable coronary artery disease patients with or without angina: Insights from the START study. PLoS One. 2018 Jul 12;13(7):e0199770. doi: 10.1371/journal.pone.0199770. eCollection 2018.
• De Luca L, Arca M, Temporelli PL, Colivicchi F, Gonzini L, Lucci D, Bosco B, Callerame M, Lettica GV, Di Lenarda A, Gulizia MM; START Investigators. Prevalence and pharmacologic management of familial hypercholesterolemia in an unselected contemporary cohort of patients with stable coronary artery disease. Clin Cardiol. 2018 Aug;41(8):1075-1083. doi: 10.1002/clc.23031. Epub 2018 Aug 20.
• Colivicchi F, Massimo Gulizia M, Arca M, Luigi Temporelli P, Gonzini L, Venturelli V, Morici N, Indolfi C, Gabrielli D, De Luca L. Lipid Lowering Treatment and Eligibility for PCSK9 Inhibition in Post-Myocardial Infarction Patients in Italy: Insights from Two Contemporary Nationwide Registries. Cardiovasc Ther. 2020 Jan 3;2020:3856242. doi: 10.1155/2020/3856242. eCollection 2020.
• De Luca L, Arca M, Temporelli PL, Meessen J, Riccio C, Bonomo P, Colavita AR, Gabrielli D, Gulizia MM, Colivicchi F; START Investigators. Current lipid lowering treatment and attainment of LDL targets recommended by ESC/EAS guidelines in very high-risk patients with established atherosclerotic cardiovascular disease: Insights from the START registry. Int J Cardiol. 2020 Oct 1;316:229-235. doi: 10.1016/j.ijcard.2020.05.055. Epub 2020 May 26.
• De Luca L, Formigli D, Meessen J, Uguccioni M, Cosentino N, Paolillo C, Di Lenarda A, Colivicchi F, Gabrielli D, Gulizia MM, Scherillo M; START Investigators. COMPASS criteria applied to a contemporary cohort of unselected patients with stable coronary artery diseases: insights from the START registry. Eur Heart J Qual Care Clin Outcomes. 2021 Sep 16;7(5):513-520. doi: 10.1093/ehjqcco/qcaa054.
• De Luca L, Uguccioni M, Meessen J, Temporelli PL, Tomai F, De Rosa FM, Passamonti E, Formigli D, Riccio C, Gabrielli D, Colivicchi F, Gulizia MM, Perna GP. External applicability of the ISCHEMIA trial: an analysis of a prospective, nationwide registry of patients with stable coronary artery disease. EuroIntervention. 2020 Dec 18;16(12):e966-e973. doi: 10.4244/EIJ-D-20-00610.
• De Luca L, Temporelli PL, Amico AF, Gonzini L, Uguccioni M, Varani E, Brunetti ND, Colivicchi F, Gabrielli D, Gulizia MM. Impact of history of depression on 1-year outcomes in patients with chronic coronary syndromes: An analysis of a contemporary, prospective, nationwide registry. Int J Cardiol. 2021 May 15;331:273-280. doi: 10.1016/j.ijcard.2020.12.086. Epub 2021 Jan 8.
• De Luca L, Temporelli PL, Lucci D, Gonzini L, Riccio C, Colivicchi F, Geraci G, Formigli D, Maras P, Falcone C, Di Lenarda A, Gulizia MM; START Investigators. Current management and treatment of patients with stable coronary artery diseases presenting to cardiologists in different clinical contexts: A prospective, observational, nationwide study. Eur J Prev Cardiol. 2018 Jan;25(1):43-53. doi: 10.1177/2047487317740663. Epub 2017 Nov 10.
• De Luca L, Temporelli PL, Riccio C, Gonzini L, Marinacci L, Tartaglione SN, Costa P, Scherillo M, Senni M, Colivicchi F, Gulizia MM; START Investigators. Clinical outcomes, pharmacological treatment, and quality of life of patients with stable coronary artery diseases managed by cardiologists: 1-year results of the START study. Eur Heart J Qual Care Clin Outcomes. 2019 Oct 1;5(4):334-342. doi: 10.1093/ehjqcco/qcz002.

Study record dates

Study Major Dates

• Study Start (ACTUAL): March 17, 2016
• Primary Completion (ACTUAL): February 28, 2018
• Study Completion (ACTUAL): April 24, 2018

Study Registration Dates

• First Submitted: December 20, 2018
• First Submitted That Met QC Criteria: January 7, 2019
• First Posted (ACTUAL): January 8, 2019

Study Record Updates

• Last Update Posted (ACTUAL): February 3, 2021
• Last Update Submitted That Met QC Criteria: February 2, 2021
• Last Verified: December 1, 2018

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Heart Diseases; Coronary Artery Disease; Myocardial Ischemia; Coronary Disease
• Other Study ID Numbers: K14

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No