Treatment of High and Very High riSk Dyslipidemic pAtients for the PreveNTion of CardiOvasculaR Events (SANTORINI)

Treatment of High and Very High riSk Dyslipidemic pAtients for the PreveNTion of CardiOvasculaR Events in Europe - a MultInatioNal ObservatIonal Study (SANTORINI)

High and Very High Risk cardiovascular patient journeys seems to vary from country to country, and current understanding of the process is incomplete. This real-life observational study which documents meaningful patient journey-related parameters can be expected to provide meaningful insight into the care process, country-by-country.

Study Overview

• Status: Completed
• Conditions: Cardiovascular Diseases; Dyslipidemia; Hypercholesterolemia; Atherosclerotic Cardiovascular Disease
• Intervention / Treatment: Other: Non-interventional

Detailed Description

Suffering from hypercholesterolemia is a major health concern in Europe. Appropriate medical treatment lowers low density lipoprotein cholesterol and reduces the incidence of clinical cardiovascular events. Despite the multiple available treatments, many patients remain inadequately treated or even untreated and some lipid-lowering drugs may be associated with an increase in events like side effects or increase in diabetes. As this is a non-interventional study, only data from routine clinical practice will be documented.

• Study Type: Observational
• Enrollment (Actual): 9559

Contacts and Locations

Study Locations

• Austria
  • Braunau Am Inn, Austria, 5280
    • Krankenhaus St. Josef Braunau GmbH
  • Graz, Austria, 8036
    • Lkh-Univ. Klinikum Graz
  • Graz, Austria, 8036
    • Medizinische Universität Graz
  • Innsbruck, Austria, 6020
    • Medizinische Universität Innsbruck
  • Klagenfurt, Austria, 9020
    • KABEG Klinikum Klagenfurt am Wörthersee
  • Linz, Austria, 4020
    • Konventhospital der Barmherzigen Brüder Linz
  • Salzburg, Austria, 5026
    • Privatklinik Wehrle-Diakonissen
  • Sankt Aegyd Am Neuwalde, Austria, 3193
    • Ordination Universitätsdozent Dr. Alexander Kober
  • Sankt Stefan, Austria, 8511
    • Ordination Dr. med. univ. Evelyn Fließer-Görzer
  • Wien, Austria, 1090
    • Allgemeines Krankenhaus der Stadt Wien
  • Wien, Austria, 1130
    • Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel
  • Wien, Austria, 1210
    • Krankenhaus Nord - Klinik Floridsdorf
  • Wien, Austria, 1010
    • Ordination Dr. Thomas Maca / Evangelische KH Wien
  • Wien, Austria, 1010
    • Ordination Dr. Thomas Maca / Evangelisches KH Wien
  • Wien, Austria, 1030
    • Krankenhaus Rudolfstiftung
  • Wien, Austria, 1060
    • Zentrum für Klinische Studien Dr. Hanusch GmbH
  • Wien, Austria, 1100
    • Ordination Dr. Reinhard Sock
  • Zams, Austria, 6511
    • Internistische Facharztpraxis Frau Dr. Carmen Gelsinger
• Belgium
  • Aalst, Belgium, 9300
    • ASZ
  • Bonheiden, Belgium, 2820
    • Imeldaziekenhuis
  • Bouge, Belgium, 5004
    • Clinique Saint-Luc
  • Brasschaat, Belgium, 2930
    • AZ Klina
  • Brussel, Belgium, 1090
    • UZ Brussel
  • Bruxelles, Belgium, 1020
    • CHU Brugmann
  • Bruxelles, Belgium, 1000
    • CHU Saint Pierre
  • Bruxelles, Belgium, 1070
    • CUB Hospital Erasme
  • Bruxelles, Belgium, 1180
    • Cliniques de l'Europe
  • De Haan, Belgium, 8420
    • Private Practice
  • De Pinte, Belgium, 9840
    • Private Practice
  • Dendermonde, Belgium, 9200
    • AZ Sint Blasius
  • Gent, Belgium, 9000
    • Universitair Ziekenhuis Gent
  • Gent, Belgium, 9000
    • AZ Sint Lucas
  • Gribomont, Belgium, 6887
    • Cabinet de médecine générale
  • Haine-Saint-Paul, Belgium, 7100
    • CH Jolimont-Lobbes
  • Huy, Belgium, 4500
    • CHR de Huy
  • Ieper, Belgium, 8900
    • Jan Yperman Hospital
  • Kortrijk, Belgium, 8500
    • AZ Groeninge vzw
  • Liège, Belgium, 4000
    • CHC Liege
  • Roeselare, Belgium, 8800
    • AZ Delta
  • Ronse, Belgium, 9600
    • AZ Glorieux
  • Sint-Truiden, Belgium, 3800
    • Sint Trudo
  • Tienen, Belgium, 3300
    • Private Practice
  • Wetteren, Belgium, 9230
    • BVBA Dr CAPIAU
  • Yvoir, Belgium, 5530
    • Chu Ucl Namur
  • Zottegem, Belgium, 9620
    • Z Sint Elisabeth Zottegem
• Denmark
  • Copenhagen, Denmark, 2300
    • Amager Hospital
  • Copenhagen, Denmark, 2100
    • Hjerteklinik Osterbro
  • Copenhagen, Denmark, 2400
    • Bispebjerg-Frederiksberg Hospital
  • Copenhagen, Denmark, 4200
    • Bispebjerg/ Frederiksberg Hospital
  • Esbjerg, Denmark, 6700
    • Sydvestjysk Sygehus Esbjerg
  • Frederiksberg, Denmark, 2000
    • Frederiksberg Hjerteklinik
  • Frederiksberg, Denmark, 8009
    • Frederiksberg Hjerteklinik
  • Glostrup, Denmark, 232600
    • Stroke center Rigshospitalet
  • Glostrup, Denmark, 2600
    • Rigshospitalet (Copenhagen University Hospital) - Glostrup (Glostrup Hospital)
  • Hellerup, Denmark, 2900
    • Gentofte Hospital
  • Holbæk, Denmark, 4300
    • Kobenhavns Universitet - Holbaek Sygehus
  • Slagelse, Denmark, 4200
    • Slagelse Sygehus
• Finland
  • Espoo, Finland, 02600
    • Mehiläinen Leppävaara
  • Helsinki, Finland, 00100
    • GERI-MED Oy
  • Helsinki, Finland, 00180
    • Pihlajalinna Dextra
  • Joensuu, Finland, 80100
    • Pihlajalinna (Site 04-007)
  • Joensuu, Finland, 80100
    • Pihlajalinna (Site 04-022)
  • Jyväskylä, Finland, 40620
    • StudyCor Oy
  • Kalajoki, Finland, 85100
    • Terveystalo Kalajoki
  • Kerava, Finland, 04200
    • Aava Kerava Medical Center
  • Kokkola, Finland, 67100
    • Terveystalo Kokkola
  • Kuopio, Finland, 70400
    • Mehiläinen Kuopio
  • Lappeenranta, Finland, 53600
    • Lappeenrannan Työterveys - Site 4024
  • Lappeenranta, Finland, 53600
    • Lappeenrannan Työterveys - Site 4025
  • Loimaa, Finland, 32200
    • Terveystalo
  • Oulu, Finland, 90220
    • Oulu University Hospital
  • Pori, Finland, 28500
    • Satasairaala
  • Sastamala, Finland, 38200
    • Sastamalan seudun sosiaali- ja terveyspalvelut
  • Seinäjoki, Finland, 60220
    • Seinäjoki Central Hospital
  • Tampere, Finland, 33520
    • Tampere University Hospital
  • Tampere, Finland, 33100
    • Terveystalo Tampere
  • Turku, Finland, 20520
    • Turku University Hospital
  • Turku, Finland, 20521
    • Turku University Hospital
  • Turku, Finland, 20100
    • Mehiläinen Turku Kauppiaskatu
  • Vantaa, Finland, 01600
    • Terveystalo Myyrmäki (Site 04015)
  • Vantaa, Finland, 01600
    • Terveystalo Myyrmäki (Site 04017)
  • Vantaa, Finland, 1380
    • Finla Työterveys Vantaa
• France
  • Angers, France, 49900
    • 4 Rue Larrey
  • Anzin, France, 59410
    • Cabinet médical Louis Blanc
  • Argonay, France, 74370
    • Clinique d'Argonay
  • Avignon, France, 84902
    • Hôpital Henri Duffaut
  • Bayonne, France, 64100
    • Centre de Cardiologie et d'exploration de la Côte Basque
  • Breteuil, France, 27160
    • 151 rue Georges Clémenceau
  • Chalon-sur-Saône, France, 71100
    • 4 Rue du Capitaine Drillien
  • Châteauroux, France, 36000
    • Centre Hospitalier de Chateauroux
  • Compiègne, France, 60200
    • CH Compiègne
  • Contamine-sur-Arve, France, 74130
    • Centre Hopsitalier Alpes Leman, 552 Route de Findrol
  • Flesselles, France, 80260
    • 619 Rue de Saint Vaast
  • Grenoble, France, 38000
    • CHU Grenoble
  • Istres, France, 13800
    • 2 Boulevard Victor Hugo
  • La Rochelle, France, 17000
    • 2 Rue du Dr Schweitzer
  • Le Coudray, France, 28630
    • Hopital Louis Pasteur
  • Le Havre, France, 76620
    • 222 Avenue du Mont Gaillard
  • Le Plessis-Robinson, France, 92350
    • Hôpital Marie Lannelongue
  • Lille, France, 59000
    • Institut Cœur Poumons, Boulevard du Pr Leclercq
  • Lisieux, France, 14100
    • Centre Hospitalier de Lisieux, 4 Rue Roger Aini
  • Marseille, France, 13005
    • Centre Hospitalier La Timone
  • Meudon-la-Forêt, France, 92360
    • Clinique de Meudon
  • Montauban, France, 82000
    • Clinique du Pont de Chaume
  • Montpellier, France, 34000
    • Clinique du Millénaire
  • Nantes, France, 44093
    • Centre Hospitalier Universitaire de Nantes
  • Nantes Cedex 1, France, 44093
    • Hôpital Guillaume et René Laënnec
  • Nice, France, 06300
    • Centre Hospitalier de Nice
  • Nîmes, France, 30000
    • CHU Caremeau
  • Paris, France, 75651
    • Hôpital Pitié Salpetrière
  • Paris, France, 75012
    • Cabinet médical du docteur Cohen
  • Paris, France, 75014
    • Cabinet de cardiologie
  • Pau, France, 64000
    • Centre Hospitalier De Pau
  • Rouen, France, 76000
    • Clinique Sant Hilaire
  • Royan, France, 17200
    • 82 Avenue de Pontaillac
  • Toulon, France, 83100
    • Hôpital Sainte Musse
  • Toulouse, France, 31059
    • Centre Hospitalier Toulouse
  • Tourcoing, France, 59200
    • Hôpital Guy Chatillez
• Germany
  • Aachen, Germany, 52062
    • Downtown Clinic Aachen
  • Aachen, Germany, 52062
    • Kardiologische Praxis Aachen
  • Aachen, Germany, 52078
    • Praxis Delonge
  • Aichach, Germany, 86551
    • Kliniken an der Paar - Krankenhaus Aichach
  • Amberg, Germany, 92224
    • Oberpfalz Research GbR
  • Aue, Germany, 08280
    • MVZ Aue
  • Bad Elster, Germany, 08645
    • Kardiologische Praxis
  • Bad Homburg, Germany, 61348
    • Kardiologische Praxis
  • Bad Krozingen, Germany, 79189
    • Universitäts-Herz-Zentrum Freiburg-Bad Krozingen
  • Bad Nauheim, Germany, 61231
    • Kerckhoff-Klinik Forschungsgesellschaft mbH
  • Bad Oeynhausen, Germany, 32545
    • Herz - u. Diabeteszentrum NRW
  • Bad Segeberg, Germany, 23795
    • Praxis am Landratspark
  • Bamberg, Germany, 96049
    • Gemeinschaftspraxis für Herz und Lunge
  • Bechhofen, Germany, 66894
    • Kardiologische Praxis
  • Berlin, Germany, 13353
    • Charite Campus Virchow
  • Berlin, Germany, 10409
    • Diabetespraxis Prenzlauer Allee
  • Berlin, Germany, 13585
    • Vivantes Klinikum Spandau
  • Berlin, Germany, 13509
    • Vivantes Humboldt-Klinikum
  • Berlin, Germany, 10789
    • Praxis Rankestrasse
  • Berlin, Germany, 12034
    • MVZ Dres. Ramdohr - Praxis für Cardiovascular und Ultraschalldiagnostik
  • Berlin, Germany, 12559
    • Praxis Dr. Matthias Claus
  • Berlin, Germany, 13053
    • Kardiologische Facharztpraxis Dr. Anne Winkelmann
  • Bitburg, Germany, 54634
    • Marienhaus-Klinikum Eifel Bitburg
  • Brandenburg an der Havel, Germany, 14770
    • Städtisches Klinikum Brandenburg
  • Braunschweig, Germany, 38102
    • Kardiologie an der Paulikirche
  • Bruchsal, Germany, 76646
    • Kardiologie im Friedrichspalast Bruchsal
  • Burg (Spreewald), Germany, 03096
    • MEDICLIN Reha-Zentrum Spreewald
  • Chemnitz, Germany, 09113
    • MVZ am Küchwald
  • Chemnitz, Germany, 09122
    • Praxis Dipl.med Schermaul
  • Chemnitz, Germany, 09126
    • Kardiologische Praxis
  • Chemnitz, Germany, 09130
    • MVZ Polymed
  • Cloppenburg, Germany, 49661
    • St. Josefs-Hospital Cloppenburg
  • Coburg, Germany, 96450
    • Klinikum Coburg GmbH
  • Dessau, Germany, 06846
    • Praxis Dr. Menzel
  • Detmold, Germany, 32756
    • Klinikum Lippe GmbH
  • Dortmund, Germany, 44137
    • Kardiologische Gemeinschaftspraxis
  • Dortmund, Germany, 44137
    • Sankt-Johannes-Hospital
  • Dortmund, Germany, 44141
    • Kardiologische Gemeinschaftspraxis Dres. Wetzel/Willgeroth
  • Dresden, Germany, 01307
    • Universitatsklinikum Carl Gustav Carus
  • Dresden, Germany, 01099
    • Zentrum für klinische Prüfungen in der Facharztzentrum Dresden-Neustadt GbR
  • Dresden, Germany, 01159
    • Praxis Dr. Methfessel
  • Dresden, Germany, 01277
    • Hausärztlich-Kardiologisches MVZ "Am Felsenkeller" GmbH
  • Dresden, Germany, 01279
    • Studienzentrum Dr. Faulmann
  • Dresden, Germany, 01307
    • Dres. Günther/Kolschmann
  • Dresden, Germany, 01309
    • Praxis Dres. Jänsch/Varnai
  • Eisenach, Germany, 99817
    • Praxis Dipl. - Med. Petra Herrmann - Fachärztin für Innere Medizin
  • Elsterwerda, Germany, 04910
    • Kardiologische Praxis
  • Essen, Germany, 45147
    • Universitätsklinikum Essen
  • Essen, Germany, 45355
    • Medizentrum Essen Borbeck
  • Essen, Germany, 45138
    • Elisabeth Krankenhaus Essen
  • Frankfurt, Germany, 65929
    • Klinikum Frankfurt Hoechst GmbH
  • Fulda, Germany, 36037
    • MVZ Altstadt-Carree Fulda GmbH
  • Gelsenkirchen, Germany, 45879
    • Evangelisches Krankenhaus Gelsenkirchen
  • Gera, Germany, 07551
    • Kardiologische Praxis
  • Gotha, Germany, 99867
    • Kardiologische Praxis
  • Greiz, Germany, 07973
    • Praxis für Herzkreislauferkrankungen Greiz
  • Görlitz, Germany, 02827
    • Praxis für Gefäßmedizin
  • Göttingen, Germany, 37075
    • Universitätsmedizin Göttingen
  • Hagen, Germany, 58135
    • Evangelisches Krankenhaus Hagen-Haspe
  • Hainstadt, Germany, 63512
    • Gemeinschaftspraxis Dres. J. Hintze und M. Grundner
  • Hamburg, Germany, 22041
    • Cardiologicum Hamburg-Wandsbek
  • Hamburg, Germany, 22459
    • Kardiologie am Tibarg
  • Hamburg, Germany, 22527
    • MVZ Prof. Detlef Mathey, Prof. Schofer GmbH
  • Hanover, Germany, 30559
    • Kardiologische Praxis
  • Haßloch, Germany, 67454
    • Kardiologische Praxis
  • Heidelberg, Germany, 69115
    • Kardiologische Schwerpunktpraxis
  • Heidelberg, Germany, 69120
    • Praxis für Angiologie und Hämatologie
  • Heidelberg, Germany, 69120
    • Uniklinikum Heidelberg
  • Homburg, Germany, 66424
    • Praxis
  • Isny Im Allgäu, Germany, 88316
    • Kardiologie Oberschwaben - Bodensee Herz- und Gefäßpraxis
  • Jena, Germany, 07743
    • Kardiologische Praxis
  • Kaiserslautern, Germany, 67655
    • Kardiopraxis Schirmer
  • Kamen, Germany, 59174
    • Kardiologie/Internistenteam Kamen
  • Karlsbach, Germany, 76307
    • SRH Klinikum Karlsbad-Langensteinbach
  • Kassel, Germany, 34121
    • B. Braun Ambulantes Herzzentrum MVZ GmbH
  • Kleve, Germany, 47533
    • CC Cleve-Studiencenter
  • Konstanz, Germany, 78464
    • Studienzentrum der Inneren Medizin I & II am Klinikum Konstanz
  • Kornwestheim, Germany, 70806
    • Praxis für Innere Medizin / Kardiologie - Dr. med. E. Persicke / Dr. med. O. Scheuermann
  • Köln, Germany, 51105
    • MVZ Gesundes Herz
  • Leipzig, Germany, 4103
    • Universitätsklinikum Leipzig
  • Leipzig, Germany, 04103
    • Kardiologische Gemeinschaftspraxis
  • Leipzig, Germany, 04109
    • MediClin MVZ Leipzig
  • Leipzig, Germany, 04109
    • Praxis für Gefäßerkrankungen und Gerinnungsstörungen Leipzig
  • Leipzig, Germany, 04249
    • Gemeinschaftspraxis Dr. Täschner/Dr. Bonigut
  • Leipzig, Germany, 04317
    • MVZ Stoffwechselmedizin Leipzig
  • Lengerich, Germany, 49525
    • Kardiologische Fachpraxis
  • Lichtenfels, Germany, 96215
    • Praxis Dr. med. Ilka Simon-Wagner
  • Limburg, Germany, 65549
    • St. Vincenz-Krankenhaus
  • Lohne, Germany, 32584
    • Gemeinschaftspraxis Dr. Jens Biesenbaum und Dr. Uwe Gerbaulet
  • Lohne, Germany, 49393
    • Kardiologische Praxis Lohne
  • Ludwigsburg, Germany, 71634
    • Cardio Centrum Ludwigsburg-Bietigheim
  • Ludwigshafen, Germany, 67071
    • Kardiologische Praxisklinik Ludwigshafen
  • Löhne, Germany, 32584
    • Gemeinschaftspraxis Dr. Jens Biesenbaum und Dr. Uwe Gerbaulet
  • Lüdenscheid, Germany, 58515
    • Klinikum Lüdenscheid
  • Lünen, Germany, 44534
    • Dres. Erdmann/Schütz/Sicken
  • Mainz, Germany, 55131
    • St.Vincenz - u. Elisabeth-Hospital
  • Mainz, Germany, 55131
    • Universitätsklinikum Mainz Site 6186
  • Mainz, Germany, 55131
    • Universitätsklinikum Mainz Site 6187
  • Mannheim, Germany, 68167
    • Universitätsklinikum Mannheim
  • Mannheim, Germany, 68165
    • zero Praxen Mannheim
  • Markkleeberg, Germany, 04416
    • Kardiologische Praxis
  • Meiningen, Germany, 98617
    • Praxis Dr. Ben-Chur
  • Moers, Germany, 47441
    • Kardiologie-Praxis
  • Mühldorf, Germany, 84453
    • Gemeinschaftspraxis Dr. med. Martin Prohaska und Dr. med. Felix Schulte
  • Mühlheim, Germany, 45468
    • Herzquartier Mühlheim, Kardiologische Gemeinschaftspraxis Dres. med. A. Krapivsky & P. Kekes
  • Münster, Germany, 48149
    • Universitatsklinikum Munster
  • Münster, Germany, 48145
    • Zentrum für Diabetes und Gefäßerkrankungen Münster
  • Münster, Germany, 48149
    • Praxis für Innere Medizin
  • Nordhausen, Germany, 99734
    • Praxis für Innere Medizin und Angiologie
  • Northeim, Germany, 37154
    • Kardiologische Praxis Northeim
  • Nürnberg, Germany, 90402
    • Gemeinschaftspraxis Drs. Haggenmiller/Jeserich Kardiologie-Angiologie-Innere Medizin
  • Nürnberg, Germany, 90402
    • Kardiologie am Weißen Turm
  • Paderborn, Germany, 33098
    • St. Vincenz-Krankenhaus GmbH
  • Panitzsch, Germany, 04451
    • Kardiologische Praxis
  • Papenburg, Germany, 26871
    • Kardiologische Praxis Papenburg (Site 6097)
  • Papenburg, Germany, 26871
    • Kardiologische Praxis Papenburg (Site 6098)
  • Pirmasens, Germany, 66954
    • Kardiologische Praxis
  • Pirna, Germany, 01796
    • Cardiologicum Dresden/Pirna
  • Potsdam, Germany, 14471
    • Kardiologie Potsdam
  • Potsdam, Germany, 14471
    • Kardiologische Gemeinschaftspraxis Potsdam
  • Quedlinburg, Germany, 06485
    • Paracelsus-Harz-Klinik Bad Suderode
  • Regensburg, Germany, 93059
    • Drs. Bauer/Buresch/Kösler
  • Riesa, Germany, 01587
    • Gemeinschaftspraxis Herz Riesa
  • Rostock, Germany, 18057
    • Universitätsmedizin Rostock
  • Siegen, Germany, 57072
    • Zentrum für Prävention und Rehabilitation
  • Stahnsdorf, Germany, 14532
    • Kardiologische Praxis
  • Stollberg, Germany, 09366
    • Praxis Dr. Birkenhagen
  • Straubing, Germany, 94315
    • Drs. Knoebel @ Partner
  • Strausberg, Germany, 15344
    • Praxis Dr. Michael Rother
  • Trier, Germany, 54292
    • Krankenhaus der Barmherzigen Brüder Trier
  • Trier, Germany, 54292
    • Diabetologische Schwerpunktpraxis
  • Ulm, Germany, 89077
    • Studienzentrum der Herzklinik Ulm GbR
  • Unterwellenborn, Germany, 07333
    • Praxis Dr. Sabine Hansen
  • Villingen-Schwenningen, Germany, 78048
    • Praxis für Prävention und Therapie
  • Völklingen, Germany, 66333
    • SHG Klinik Völklingen
  • Weinheim, Germany, 69469
    • GRN Klinik Weinheim
  • Witten, Germany, 58455
    • Forschungszentrum-Ruhr KliFoCenter GmbH
  • Worms, Germany, 67550
    • Klinikum Worms
  • Wurzen, Germany, 04808
    • Praxis Dr. Woitek
  • Zwenkau, Germany, 04442
    • Praxis T. Schwarz
• Ireland
  • Cork, Ireland, T23
    • Cork University Hospital
  • Dublin, Ireland, D07 WKW8
    • Mater Private Hospital
  • Dublin, Ireland, D08 NHY1
    • St. James Hospital
  • Dublin, Ireland, D18 AK68
    • Beacon Hospital
  • Galway, Ireland
    • Turloughmore Health Centre
  • Dublin
    • Beaumont, Dublin, Ireland
      • Beaumont Hospital
  • Waterford
    • Tramore, Waterford, Ireland
      • Tramore Medical Clinic
• Italy
  • Abruzzo
    • Chieti, Abruzzo, Italy, 66013
      • Ospedale Civile SS. Annunziata (MEDICINA INTERNA- DIPARTIMENTO DI MEDICINA E SCIENZE DELL'INVECCHIAMENTO)
  • Calabria
    • Catanzaro, Calabria, Italy, 88100
      • Azienda Ospedaliera Universitaria Mater Domini - Site 8042
    • Catanzaro, Calabria, Italy, 88100
      • Azienda Ospedaliera Universitaria Mater Domini - Site 8053
    • Catanzaro, Calabria, Italy, 88100
      • Azienda Ospedaliera Universitaria Mater Domini - Site 8059
    • Vibo Valentia, Calabria, Italy, 89900
      • Ospedale G. Jazzolino
  • Campania
    • Avellino, Campania, Italy, 83100
      • A.O. San Giuseppe Moscati (U.O.C. Cardiologia/UTIC)
    • Avellino, Campania, Italy, 83100
      • A.O. San Giuseppe Moscati
    • Benevento, Campania, Italy, 82100
      • A.O.R.N. San Pio - P.O. RUMMO
    • Caserta, Campania, Italy, 81100
      • Azienda Ospedaliera di Rilievo Nazionale(A.O.R.N.) "Sant'Anna e San Sebastiano" di Caserta
    • Cava Dè Tirreni, Campania, Italy, 84013
      • Ospedale Civile Santa Maria Incoronata dell'Olmo
    • Napoli, Campania, Italy, 80131
      • A.O.R.N. Cardarelli
    • Napoli, Campania, Italy, 80131
      • A.O.R.N. Ospedale dei Colli
    • Napoli, Campania, Italy, 80131
      • A.O.U. FEDERICO II (U.O.C. Diabetologia)
    • Napoli, Campania, Italy, 80131
      • A.O.U. Federico II
    • Salerno, Campania, Italy, 84131
      • A.O.U. "San Giovanni di Dio e Ruggi d'Aragona"
    • Sessa Aurunca, Campania, Italy, 81037
      • Ospedale Civile San Rocco
  • Emilia Romagna
    • Bentivoglio, Emilia Romagna, Italy, 40010
      • Ospedale di Bentivoglio
    • Bologna, Emilia Romagna, Italy, 40133
      • Ospedale Maggiore di Bologna
    • Bologna, Emilia Romagna, Italy, 40138
      • A.O.U di Bologna-Policlinico S.Orsola-Malpighi (U.O. Medicina Interna)
    • Bologna, Emilia Romagna, Italy, 40138
      • Policlinico Sant'Orsola-Malpighi (U.O. Cardiologia)
    • Carpi, Emilia Romagna, Italy, 41012
      • Ospedale di Carpi
    • Ferrara, Emilia Romagna, Italy, 44124
      • Arcispedale Sant'Anna Ferrara (U.O. Cardiologia)
    • Ferrara, Emilia Romagna, Italy, 44124
      • Azienda Ospedaliera-Universitaria S. Anna di Ferrara (Dipartimento medico)
    • Modena, Emilia Romagna, Italy, 41124
      • A.O.U. Policlinico di Modena
    • Modena, Emilia Romagna, Italy, 41126
      • Ospedale Civile di Baggiovara- AOU di Modena
    • Piacenza, Emilia Romagna, Italy, 29015
      • Ospedale Unico della Valtidone
    • Piacenza, Emilia Romagna, Italy, 29121
      • Ospedale Guglielmo da Saliceto
    • Reggio Emilia, Emilia Romagna, Italy, 42123
      • Arcispedale Santa Maria Nuova - Azienda USL/IRCCS Reggio Emilia
  • Friuli
    • Udine, Friuli, Italy, 33100
      • Presidio Ospedaliero "Santa Maria della Misericordia" di Udine
  • Lazio
    • Anzio, Lazio, Italy, 00042
      • ASL Roma 6 - Ospedali Riuniti Anzio - Nettuno
    • Roma, Lazio, Italy, 00040
      • Ospedale dei Castelli - ASL Roma 6
    • Roma, Lazio, Italy, 00128
      • Policlinico Universitario Campus Bio-Medico
    • Roma, Lazio, Italy, 00161
      • Policlinico Umberto I
    • Roma, Lazio, Italy, 00168
      • Fondazione Policlinico Universitario A. Gemelli IRCCS
    • Roma, Lazio, Italy, 00169
      • Ospedale Policlinico Casilino
    • Roma, Lazio, Italy, 00184
      • Azienda Ospedaliera San Giovanni Addolorata
  • Lombardia
    • Bergamo, Lombardia, Italy, 24127
      • Azienda Ospedaliera Papa Giovanni XXIII
    • Brescia, Lombardia, Italy, 25123
      • ASST Spedali Civili P.O di Brescia
    • Brescia, Lombardia, Italy, 25123
      • Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (U.O Medicina Generale 2)
    • Brescia, Lombardia, Italy, 25124
      • Fondazione Poliambulanza Istituto Ospedaliero - Brescia
    • Milano, Lombardia, Italy, 20099
      • IRCCS MultiMedica
    • Milano, Lombardia, Italy, 20122
      • Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico
    • Milano, Lombardia, Italy, 20141
      • Centro Cardiologico Monzino - IRCCS (Unità Prevenzione dell'Aterosclerosi)
    • Milano, Lombardia, Italy, 20141
      • Centro Cardiologico Monzino - IRCCS
    • Milano, Lombardia, Italy, 20149
      • Istituto clinico Sant'Ambrogio
    • Milano, Lombardia, Italy, 20161
      • IRCCS Istituto Ortopedico Galeazzi
    • Milano, Lombardia, Italy, 20162
      • Grande Ospedale Metropolitano di Niguarda
  • Marche
    • Ancona, Marche, Italy, 60124
      • INRCA -Ospedale U. Sestilli di Ancona
    • Ancona, Marche, Italy, 60126
      • Ospedali Riuniti "Umberto I - Lancisi - Salesi
    • Macerata, Marche, Italy, 62100
      • Ospedale Macerata
  • Piemonte
    • Asti, Piemonte, Italy, 14100
      • Presidio ospedaliero Cardinal Massaia - A.S.L. AT (SOC Diabetologia e Malattie Metaboliche)
    • Mondovì, Piemonte, Italy, 12084
      • Ospedale Regina Montis Regalis
    • Torino, Piemonte, Italy, 10126
      • A.O.U. Città della Salute e Della Scienza di Torino
    • Torino, Piemonte, Italy, 10098
      • Ospedale degli Infermi di Rivoli
    • Verbania, Piemonte, Italy, 28925
      • Ospedale dei Castelli
  • Puglia
    • Bari, Puglia, Italy, 70021
      • Ente Ecclesiastico Ospedale Generale Regionale "F.Miulli"
    • Bari, Puglia, Italy, 70124
      • A.O.U. Consorziale - Policlinico Bari (Dipartimento di Medicina Interna)
    • Bari, Puglia, Italy, 70124
      • A.O.U. Consorziale - Policlinico Bari
    • Foggia, Puglia, Italy, 71122
      • A.O.U. Ospedali Riuniti
    • Lecce, Puglia, Italy, 73100
      • Presidio Ospedaliero Vito Fazzi
  • Sardegna
    • Sassari, Sardegna, Italy, 07100
      • Ospedale Civile SS Annunziata (Dipartimento di Medicina Clinica e Sperimentale)
  • Sicilia
    • Catania, Sicilia, Italy, 95126
      • Ospedale Cannizzaro
    • Messina, Sicilia, Italy, 98125
      • A.O.U. Policlinico "G. Martino" (U.O. Cardiologia)
    • Palermo, Sicilia, Italy, 90123
      • Ospedale Buccheri La Ferla
    • Palermo, Sicilia, Italy, 90133
      • Triolo Zancle Hospital
    • Ragusa, Sicilia, Italy, 97100
      • Ospedale Giovanni Paolo II
  • Toscana
    • Empoli, Toscana, Italy, 50053
      • Ospedale San Giuseppe
    • Firenze, Toscana, Italy, 50134
      • A.O.U. Careggi (S.O.D. Malattie Aterotrombotiche) - Site 8020
    • Firenze, Toscana, Italy, 50134
      • A.O.U. Careggi - Site 8041
    • Firenze, Toscana, Italy, 50134
      • A.O.U. Careggi - Site 8093
    • Massa Marittima, Toscana, Italy, 58024
      • Ospedale S. Andrea - Usl Toscana Sud Est
    • Pescia, Toscana, Italy, 51017
      • Ospedale SS Cosma e Damiano di Pescia - Azienda Usl Toscana centro
    • Pisa, Toscana, Italy, 56100
      • Universita di Pisa
    • Pisa, Toscana, Italy, 56124
      • Fondazione Toscana Gabriele Monasterio
    • Pisa, Toscana, Italy, 56124
      • Ospedale Cisanello - A.U.O.P. Azienda Ospedaliera Universitaria Pisana
    • Prato, Toscana, Italy, 59100
      • Ospedale di Santo Stefano di Prato - Azienda Usl Toscana centro (UO di Cardiologia)
    • Prato, Toscana, Italy, 59100
      • Ospedale Santo Stefano di Prato - Azienda Usl Toscana Centro
    • Siena, Toscana, Italy, 53100
      • Azienda Ospedaliero-Universitaria Senese Dipartimento Delle Scienze Mediche U.O.C. Medicina Interna e della Complessità
    • Siena, Toscana, Italy, 53100
      • Ospedale Le Scotte
  • Trentino Alto Adige
    • Bolzano, Trentino Alto Adige, Italy, 39100
      • Ospedale di Bolzano (U.O. Cardiologia e Prove Funzionali)
  • Umbria
    • Perugia, Umbria, Italy, 06126
      • USL Umbria I
    • Perugia, Umbria, Italy, 06129
      • A.O. Santa Maria della Misericordia
  • Veneto
    • Arzignano, Veneto, Italy, 36071
      • Ospedale di Arzignano
    • Legnago, Veneto, Italy, 37045
      • Ospedale Mater Salutis
    • Mirano, Veneto, Italy, 30035
      • Presidio Ospedaliero di Mirano - ULSS 3 Serenissima
• Netherlands
  • Almelo, Netherlands, 7609 PP
    • Ziekenhuis Groep Twente (ZGT)
  • Almelo, Netherlands, 7609 PP
    • ZiekenhuisGroepTwente, Zilvermeeuw 1
  • Amersfoort, Netherlands, 3813 TZ
    • Meander Medical Center
  • Amersfoort, Netherlands, 3813 TZ
    • Meander Medisch Centrum, Maatweg 3
  • Amsterdam, Netherlands, 1030 BD
    • Bovenij Zekenhuis
  • Apeldoorn, Netherlands, 7334 DZ
    • Gelre Ziekenhuis
  • Apeldoorn, Netherlands, 7334 DZ
    • Albert Schweitzerlaan 31
  • Blaricum, Netherlands, 1261 AN
    • Tergooi
  • Capelle Aan Den IJssel, Netherlands, 2906 ZC
    • Ijsselland Ziekenhuis, Prins Constanijnweg 2
  • Capelle Aan Den IJssel, Netherlands, 2906 ZC
    • IJsselland Ziekenhuis
  • Delft, Netherlands, 2625 AD
    • Reinier de Graafweg 5
  • Den Haag, Netherlands, 2545 AA
    • Els Borst
  • Deventer, Netherlands, 7416 SE
    • Nico Bolkesteinlaan 75
  • Dirksland, Netherlands, 3247 BW
    • Van Weel Bethesda
  • Doetinchem, Netherlands, 7009 BL
    • Slingeland
  • Ede, Netherlands, 6716 RP
    • Gelderse Vallei
  • Enschede, Netherlands, 7512 KZ
    • Medisch Spectrum Twente
  • Goes, Netherlands, 4462 RA
    • Admiraal de Ruijten Ziekenhuis
  • Gouda, Netherlands, 2800 BB
    • Groene Hart Gouda
  • Haarlem, Netherlands, 2035 RC
    • Boerhaavelaan 22
  • Hardenberg, Netherlands, 7772 SE
    • Ropcke Zweers hospital, Jan Weitkamplaan 4-a
  • Hardenberg, Netherlands, 7772 TS
    • Saxenburgh Medisch Centrum
  • Harderwijk, Netherlands, 3844 DG
    • Ziekenhuis St Jansdal
  • Herzogenbusch, Netherlands, 5223 GV
    • Jeroen Bosch Hospital
  • Hoogeveen, Netherlands, 7909 AA
    • Dr G.H. Amshoffweg 1
  • Hoogeveen, Netherlands, 7909 AA
    • TREANT zorggroep
  • Leiden, Netherlands, 2333 ZA
    • LUMC
  • Rotterdam, Netherlands, 3083 AN
    • Ikazai Ziekenhuis
  • Tiel, Netherlands, 4002 WP
    • Rivierenland ziekenhuis Tiel
  • Tilburg, Netherlands, 5022 GC
    • ETZ
  • Uden, Netherlands, 5406 PT
    • Nistelrodeseweg 10
  • Utrecht, Netherlands, 3584 CX
    • University Medical Center Utrecht
  • Utrecht, Netherlands, 3585 KE
    • Diakonessenhuis Utrecht
  • Veldhoven, Netherlands, 5504 DB
    • Maxima Medisch Centrum
  • Zaandam, Netherlands, 1502 DV
    • Zaans Medisch Centrum
• Portugal
  • Carnaxide, Portugal, 2794-006
    • Instituto do Coracao
  • Faro, Portugal, 8000-386
    • Centro Hospitalar Universitario do Algarve
  • Lisbon, Portugal, 1250-189
    • Associação Protetora de Diabéticos de Portugal
  • Lisbon, Portugal, 1349-019
    • Hospital Egas Moniz (CHLO)
  • Lisbon, Portugal, 1500-458
    • Hospital Lusíadas de Lisboa, Lisboa
  • Lisbon, Portugal, 1649-028
    • Centro Hospitalar Lisboa Norte - Site 10005
  • Lisbon, Portugal, 1649-028
    • Centro Hospitalar Lisboa Norte - Site 10006
  • Mangualde, Portugal, 3530-191
    • Clínica Cuida Mais
  • Porto, Portugal, 4460-188
    • Instituto CUF Porto
  • Porto, Portugal, 4200-319
    • Centro Hospitalar Universitário São João (CHUSJ)
  • Santa Maria Da Feira, Portugal, 4520-179
    • Centro Hospitalar de Entre Douro e Vouga
• Spain
  • Alcorcón, Spain, 28922
    • Hospital Universitario Fundacion Alcorcon
  • Barcelona, Spain, 08003
    • H. del Mar Site 11041
  • Barcelona, Spain, 08003
    • H. del Mar Site 11065
  • Bilbao, Spain, 48013
    • H. Univ. Basurto
  • Colloto, Spain, 33010
    • Centro de Salud Colloto
  • Getafe, Spain, 28905
    • Hospital Univ. Getafe
  • Jerez De La Frontera, Spain, 11407
    • Hospital de Jerez
  • L'Hospitalet De Llobregat, Spain, 08907
    • Hospital Universitari de Bellvitge
  • Madrid, Spain, 28040
    • Fundacion Jimenez Diaz
  • Madrid, Spain, 28027
    • Clinica Universitaria de Navarra
  • Madrid, Spain, 28007
    • Hospital Universitario Gregorio Maranon
  • Madrid, Spain, 28041
    • H. Universitario 12 de Octubre
  • Madrid, Spain, 28006
    • Hospital Universitario de la Princesa Site 11054
  • Madrid, Spain, 28006
    • Hospital Universitario de la Princesa Site 11062
  • Madrid, Spain, 28006
    • Hospital Universitario de la Princesa Site 11075
  • Madrid, Spain, 28007
    • H Gregorio Marañon
  • Madrid, Spain, 28029
    • Fundacion Jimenez Diaz
  • Madrid, Spain, 28029
    • H. Univ. Clínico San Carlos
  • Madrid, Spain, 28029
    • H. Univ. La Paz-Carlos III
  • Madrid, Spain, 28029
    • H. Universitario La Paz-Carlos III
  • Madrid, Spain, 28029
    • Hospital La Paz-Carlos III
  • Madrid, Spain, 28034
    • H. Univ. Ramón y Cajal
  • Murcia, Spain, 30120
    • H. Clínico Virgen de la Arrixaca
  • Ourense, Spain, 32005
    • Complejo Hospitalario Universitario de Ourense (CHOU) Site 11003
  • Ourense, Spain, 32005
    • Complejo Hospitalario Universitario de Ourense (CHOU) Site 11052
  • Reus, Spain, 41009
    • H. San Joan de Reus
  • Sabadell, Spain, 08208
    • Hospital Parc Tauli
  • Salamanca, Spain, 37007
    • Hospital Clínico de Salamanca
  • San Sebastián De Los Reyes, Spain, 28709
    • Hospital Universitario Infanta Sofía
  • Sant Joan Despí, Spain, 8970
    • Hospital de Sant Joan Despi Moises Broggi
  • Santander, Spain, 39008
    • Hospital Universitario Marques de Valdecilla
  • Segovia, Spain, 40002
    • Hospital General de Segovia
  • Sevilla, Spain, 41009
    • Hospital Universitario Virgen de la Macarena
  • Tarragona, Spain, 43003
    • Hospital Sant Pau i Santa Tecla
  • Torrelodones, Spain, 28250
    • Hospital HM de Torrelodones
  • Zaragoza, Spain, 50002
    • Centro de Salud Fuentes Norte
  • Andalucía
    • Constantina, Andalucía, Spain, 41450
      • Hospital de Alta Resolución de Sierra Norte
    • Córdoba, Andalucía, Spain, 14004
      • H. Reina Sofía
    • Huelva, Andalucía, Spain, 21005
      • H Juan Ramón Jiménez de Huelva
    • Huelva, Andalucía, Spain, 21080
      • H. Infanta Elena
    • Jerez De La Frontera, Andalucía, Spain, 11402
      • Centro Médico Puerto
    • Jerez De La Frontera, Andalucía, Spain, 11407
      • HG. Univ. De Jérez
    • Lebrija, Andalucía, Spain, 41570
      • Hospital de Alta Resolución de Lebrija
    • Málaga, Andalucía, Spain, 29010
      • H Carlos Haya
    • Sevilla, Andalucía, Spain, 41009
      • H. Univ. Virgen Macarena
    • Sevilla, Andalucía, Spain, 41700
      • H. San Agustín
    • Utrera, Andalucía, Spain, 41710
      • H. Alta Resolución de Utrera
    • Vejer de la Frontera, Andalucía, Spain, 11150
      • Hospital de Alta Resolución de La Janda
    • Écija, Andalucía, Spain, 41400
      • Hospital de Alta Resolución de Ecija
  • Asturias
    • Oviedo, Asturias, Spain, 33011
      • H Universitario Central de Asturias
  • Canarias
    • La Orotava, Canarias, Spain, 38300
      • Clinica Privada Orotava
  • Castilla-León
    • Colloto, Castilla-León, Spain, 33010
      • C S Colloto
    • León, Castilla-León, Spain, 24008
      • H Universitario De León
    • León, Castilla-León, Spain, 37007
      • H Clínico de Salamanca
    • Salamanca, Castilla-León, Spain, 37003
      • C S de la Alamedilla
    • Segovia, Castilla-León, Spain, 40002
      • H. General de Segovia
    • Zamora, Castilla-León, Spain, 49022
      • Complejo Asistencial de Zamora
  • Cataluña
    • Barcelona, Cataluña, Spain, 08036
      • H. Clínic i Provincial de Barcelona
    • Barcelona, Cataluña, Spain, 08041
      • H de la Santa Creu i Sant Pau
    • L'Hospitalet De Llobregat, Cataluña, Spain, 08907
      • H. Universitari Bellvitge
  • Galicia
    • Coruña, Galicia, Spain, 15006
      • Complejo Hospitalario Universitario A Coruña
    • Ferrol, Galicia, Spain, 15405
      • Complejo Hospitalario Univ. El Ferrol
    • Ourense, Galicia, Spain, 32005
      • Complejo Hospitalario de Ourense
    • Santiago De Compostela, Galicia, Spain, 15706
      • H. Clínico Univ. Santiago de Compostela
  • Madrid
    • Alcalá De Henares, Madrid, Spain, 28805
      • Hospital Príncipe de Asturias
    • Fuenlabrada, Madrid, Spain, 28942
      • H. Universitario Fuenlabrada
    • San Sebastián De Los Reyes, Madrid, Spain, 28709
      • H. Univ. Infanta Sofía
  • Málaga
    • Marbella, Málaga, Spain, 29603
      • H. Costa del Sol
  • País Vasco
    • Barakaldo, País Vasco, Spain, 48902
      • H. San Eloy
    • Bilbao, País Vasco, Spain, 48013
      • H. Univ. Basurto
    • Bilbao, País Vasco, Spain, 48013
      • H. Univ. de Basurto
• Sweden
  • Falun, Sweden, 79182
    • Falu Lasarett, Diab/Endo-mottagning
  • Gustavsberg, Sweden, 13444
    • Värmdö Vårdcentral
  • Göteborg, Sweden, 41345
    • Sahlgrenska University Hospital
  • Göteborg, Sweden, 41685
    • Östra Sahlgrenska Universitetssjukhuset - Ostra Sjukhuse
  • Härnösand, Sweden, 87131
    • Öbackakliniken
  • Jönköping, Sweden, 55305
    • Länssjukhuset Ryhov
  • Lund, Sweden, 22221
    • Capio Citykliniken
  • Malmö, Sweden, 20502
    • Skåne University Hospital
  • Stockholm, Sweden, 14186
    • Karolinska University Hospital, Huddinge
  • Stockholm, Sweden, 11157
    • Cityheart
  • Stockholm, Sweden, 11883
    • Södersjukhuset Stockholm
• Switzerland
  • Baden, Switzerland, 5404
    • Kantonsspital Baden AG
  • Basel, Switzerland, 4031
    • Universitätsspital Basel
  • Geneve, Switzerland, 1205
    • Hôpitaux Universitaires de Genève
  • Lausanne, Switzerland, 1010
    • University of Lausanne Unisanté
  • Luzern, Switzerland, 6003
    • Cardio Center Luzern
  • Olten, Switzerland, 4600
    • Kardiolab
  • Olten, Switzerland, 4600
    • Solothurner Spitäler AG
  • Saint Gallen, Switzerland, 9007
    • Kantonsspital St. Gallen
  • Yverdon-les-Bains, Switzerland, 1400
    • Cardiologue FMH
  • Zürich, Switzerland, 8091
    • UniversitätsSpital Zürich
  • Zürich, Switzerland, 8032
    • Klinik Hirslanden
• United Kingdom
  • Atherstone, United Kingdom, CV9 1EU
    • The Atherstone Surgery
  • Blackpool, United Kingdom, FY3 7EN
    • Layton Medical Centre
  • Blackpool, United Kingdom, FY4 3AD
    • Waterloo Medical Care
  • Cardiff, United Kingdom, CF23 9PN
    • Llanedeyrn Health Centre
  • Cardiff, United Kingdom, CF5 4AD
    • Ely Bridge Surgery
  • Hedon, United Kingdom
    • Holderness Health Surgery
  • Hull, United Kingdom, HU3 2JZ
    • Hull Royal Infirmary
  • Penrith, United Kingdom, CA10 1RW
    • Temple Sowerby Medical Practice
  • Peterborough, United Kingdom, PE8 6PL
    • Wansford and Kings Cliffe Practice
  • Preston, United Kingdom, PR1 6YA
    • Panthera Preston
  • Sheffield, United Kingdom
    • Ecclesfield Group Practice
  • Wigan, United Kingdom, WN6 9EP
    • Royal Albert Edward Infirmary
  • Armagh
    • Craigavon, Armagh, United Kingdom, BT63 5QQ
      • Craigavon Area Hospital
  • Berkshire
    • Reading, Berkshire, United Kingdom, RG8 7DP
      • The Boathouse Sugery
  • Cornwall
    • Liskeard, Cornwall, United Kingdom, PL14 3XA
      • Oak Tree Surgery
    • Newquay, Cornwall, United Kingdom, TR7 1RU
      • Newquay Health Centre
    • Penzance, Cornwall, United Kingdom, TR18 4DX
      • The Alverton Practice
    • Plymouth, Cornwall, United Kingdom, PL5 3JB
      • Knowle House Surgery
    • Truro, Cornwall, United Kingdom, TR1 3LJ
      • Royal Cornwall Hospital
  • County Durham
    • Darlington, County Durham, United Kingdom
      • Carmel Medical Practice
  • Cumbria
    • Whitehaven, Cumbria, United Kingdom, CA28 7QE
      • Fellview Healthcare
  • Dorset
    • Poole, Dorset, United Kingdom
      • The Adam Practice
  • East Midlands
    • Leicester, East Midlands, United Kingdom, LE4 8EA
      • Manor Park Medical Practice
  • Essex
    • Southend, Essex, United Kingdom, SS0 0RY
      • Southend University Hospital
  • Greater London
    • London, Greater London, United Kingdom, EC1M 6BQ
      • Barts Health NHS Trust
    • London, Greater London, United Kingdom, NW10 9HP
      • Church End Medical
  • Hampshire
    • Winchester, Hampshire, United Kingdom, SO22 6EL
      • The Friarsgate Practice
  • Leicestershire
    • Hinckley, Leicestershire, United Kingdom, LE10 2SE
      • Burbage Surgery
  • Merseyside
    • Liverpool, Merseyside, United Kingdom, L14 3PE
      • Liverpool Heart & Chest Hospital NHS Trust
  • Norfolk
    • London, Norfolk, United Kingdom
      • Breckland Alliance
  • North Cumbria
    • Carlisle, North Cumbria, United Kingdom, CA2 7HY
      • Carlisle Healthcare
  • North Yorkshire
    • Pickering, North Yorkshire, United Kingdom, YO18 8BL
      • Pickering Medical Practice
    • Whitby, North Yorkshire, United Kingdom, YO21 1SD
      • Whitby Group Practice
  • Northamptonshire
    • Corby, Northamptonshire, United Kingdom, NN17 2UR
      • Lakeside Surgery
    • Northampton, Northamptonshire, United Kingdom, NN4 0NY
      • Danes Camp Medical Centre
  • Northern Ireland
    • Belfast, Northern Ireland, United Kingdom, BT7 2EB
      • Ormeau Clinical Trials Ltd
  • Northumberland
    • Stocksfield, Northumberland, United Kingdom, NE43 7LL
      • Branch End Surgery
  • Shropshire
    • Shrewsbury, Shropshire, United Kingdom, SY3 8XQ
      • Princess Royal Hospital
    • Telford, Shropshire, United Kingdom, TF1 6TF
      • Princess Royal Hospital
  • Somerset
    • Bath, Somerset, United Kingdom, BA1 2SR
      • Heart of bath Medical Partnership
  • South Yorkshire
    • Rotherham, South Yorkshire, United Kingdom, S65 1DA
      • Clifton Medical Centre
  • Surrey
    • Brockham, Surrey, United Kingdom, RH3 7NJ
      • Brockwood Medical Practice
    • Soham, Surrey, United Kingdom, CB7 5JD
      • Staploe Medical Centre
  • Tyne And Wear
    • North Shields, Tyne And Wear, United Kingdom, NE29 8NH
      • North Tyneside General Hospital
    • Sunderland, Tyne And Wear, United Kingdom, SR4 7TP
      • Sunderland Royal Hospital
  • Wales
    • Bodelwyddan, Wales, United Kingdom, LL18 5UJ
      • Glan Clwyd Hospital
  • Warwickshire
    • Leamington Spa, Warwickshire, United Kingdom, CV32 4RA
      • Sherbourne Medical Centre
  • West Yorkshire
    • Swindon, West Yorkshire, United Kingdom, HD3 3EA
      • Huddersfield Hospital
  • Wiltshire
    • Huddersfield, Wiltshire, United Kingdom, SN3 6BB
      • Great Western Hospital Swindon
    • Swindon, Wiltshire, United Kingdom, SN3 6BB
      • Great Western Hospital Swindon
  • Yorkshire
    • Huddersfield, Yorkshire, United Kingdom, HD3 3EA
      • Huddersfield Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

High risk and very high-risk participants requiring lipid-modifying therapies

Description

Inclusion Criteria:

• Very High Risk and High Risk dyslipidemic patients requiring LMTs
• Not simultaneously participating in any interventional study
• Providing written informed consent for participation in the study (Informed consent form)
• Life expectancy > 1 year

Exclusion Criteria:

• Not applicable; non-interventional study

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Other

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
High Risk and Very High Risk Dyslipidemic Participants; Participants are classified as High and Very High Risk (as assessed by the Framingham risk score for High Risk participants and the SMART score for Very High Risk participants) as well as if previously or newly diagnosed.	Other: Non-interventional; This is a non-interventional study.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mean Low Density Lipid-Cholesterol (LDL-C) Levels in High and Very High Risk Cardiovascular Participants	Blood plasma samples were used to assess LDL-C levels.	Baseline up to 12 months post-enrollment
Number of Participants Utilizing Any Treatment Modality to Manage Plasma Levels of Low Density Lipid-Cholesterol (LDL-C) in High and Very High Risk Participants Requiring Lipid Modifying Therapies (LMTs)	Clinical events were assessed based on information captured in patient files/medical records.	Baseline up to 12 months post-enrollment

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mean Atherosclerotic Cardiovascular Disease (ASCVD)-Modifying Cholesterol Fragment Levels in High Risk and Very High Risk Dyslipidemic Participants	Blood plasma samples were used to assess ASCVD-modifying cholesterol fragment levels.	Baseline up to 12 months post-enrollment
Mean Apolipoprotein B Levels in High Risk and Very High Risk Dyslipidemic Participants	Blood plasma samples were used to assess Apolipoprotein B levels.	Baseline up to 12 months post-enrollment
Mean Lipid Protein A Levels in High Risk and Very High Risk Dyslipidemic Participants	Blood plasma samples were used to assess lipid Protein A levels.	Baseline up to 12 months post-enrollment
Mean Inflammatory High-Sensitive C-Reactive Protein (hsCRP) in High Risk and Very High Risk Dyslipidemic Participants	Blood plasma samples were used to assess hsCRP levels.	Baseline up to 12 months post-enrollment
Number of Participants With Clinical Events Associated With Treatment Modalities, For Any LMT	The safety outcome measure reports clinical events based on information captured in patient files/medical records. Participants may have reported more than one clinical event associated with any LMT.	Baseline up to 12 months post-enrollment

Collaborators and Investigators

• Sponsor: Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
• Investigators: Study Director: Contact for Clinical Trial Information, Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company

Study record dates

Study Major Dates

• Study Start (Actual): March 17, 2020
• Primary Completion (Actual): April 11, 2022
• Study Completion (Actual): April 11, 2022

Study Registration Dates

• First Submitted: February 7, 2020
• First Submitted That Met QC Criteria: February 13, 2020
• First Posted (Actual): February 17, 2020

Study Record Updates

• Last Update Posted (Actual): February 20, 2024
• Last Update Submitted That Met QC Criteria: February 16, 2024
• Last Verified: February 1, 2024

More Information

Terms related to this study

• Keywords: Cardiovascular disease; Dyslipidemia; Hypercholesterolemia; Atherosclerotic Cardiovascular Disease; High-risk dyslipidemic; Low-density lipoprotein cholesterol; Lipid modifying therapies
• Additional Relevant MeSH Terms: Vascular Diseases; Metabolic Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Lipid Metabolism Disorders; Hyperlipidemias; Cardiovascular Diseases; Dyslipidemias; Hypercholesterolemia; Atherosclerosis
• Other Study ID Numbers: DSE-HCL-01-19-EU

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: De-identified individual participant data (IPD) and applicable supporting clinical trial documents may be available upon request at https://vivli.org/. In cases where clinical trial data and supporting documents are provided pursuant to our company policies and procedures, Daiichi Sankyo will continue to protect the privacy of our clinical trial participants. Details on data sharing criteria and the procedure for requesting access can be found at this web address: https://vivli.org/ourmember/daiichi-sankyo/
• IPD Sharing Time Frame: Studies for which the medicine and indication have received European Union (EU) and United States (US), and/or Japan (JP) marketing approval on or after 01 January 2014 or by the US or EU or JP Health Authorities when regulatory submissions in all regions are not planned and after the primary study results have been accepted for publication.
• IPD Sharing Access Criteria: Formal request from qualified scientific and medical researchers on IPD and clinical study documents from clinical trials supporting products submitted and licensed in the United States, the European Union and/or Japan from 01 January 2014 and beyond for the purpose of conducting legitimate research. This must be consistent with the principle of safeguarding study participants' privacy and consistent with provision of informed consent.
• IPD Sharing Supporting Information Type: Study Protocol; Statistical Analysis Plan (SAP); Clinical Study Report (CSR)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No